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CandActCFTR used public reference

The following publication reference has been reported to contain CFTR related structural information.

"A Edelman" "P Melin-Heschel" "P Zielenkiewicz" "GL Lukacs" "L Wiszniewski" "C Norez" "G Wieczorek" "S Bitam" "MF da Cunha" "A Kupniewska" "M Dadlez" "K Tarnowski" "N Odolczyk" "J Colas" "J Fritsch" "G Faure" "D Tondelier" "EL Saussereau" "A Roldan" "N Servel" "H Herrmann" "M Ollero" "F Becq"

Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=14

ID: 8
InChIKey: RDOBOPJBMQURAT-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=C(C=CC(=C4)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

CID is 1144671
synonyms found at PubChem are:
Corr-4a, RDOBOPJBMQURAT-UHFFFAOYSA-N, 421580-53-2, ST075396, N-(2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, MLS000561131, Oprea1_189688, Oprea1_471654, SCHEMBL837666, CHEMBL260775, DTXSID00360737, MolPort-001-986-142, ZINC888741, AKOS001665304, MCULE-2724995336, BAS 02936954, KB-57187, SMR000156156, EU-0078205, MLS-0094194.0001, SR-01000492559, SR-01000492559-1, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2' -yl]-benzamide, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzami, N-[2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]benzamide, N-{2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, N-(5-{2-[(5-chloro-2-methoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thia zol-2-yl))benzamide

ID: 3042
InChIKey: WDPIZEKLJKBSOZ-UHFFFAOYSA-N
SMILES: CN(C)C1=CC=C(C=C1)C(=C2C=CC(=[N+](C)C)C=C2)C3=C4C=CC(=CC4=CC(=C3O)S(=O)(=O)[O-])S(=O)(=O)O.[Na+]

biological descriptors:

CFTR relevance: CFTR corrector, pocket 2

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 5351640
synonyms found at PubChem are:
NSC11237, NSC-11237, Ammonium,6-disulfo-1-naphthyl)benzylidene]-2,5-cyclohexadien-1-ylidene]dimethyl-, hydroxide, inner salt, sodium salt, Methanaminium,6-disulfo-1-naphthalenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, hydroxide, inner salt, monosodium salt

ID: 20
InChIKey: UFSKUSARDNFIRC-UHFFFAOYSA-N
SMILES: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

CID is 16678941
synonyms found at PubChem are:
936727-05-8, Lumacaftor, VX-809, VX 809, VX809, VRT-826809, 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, UNII-EGP8L81APK, VRT 826809, EGP8L81APK, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoic acid, 3-(6-[[1-(2,2-DIFLUORO-BENZO[1,3]DIOXOL-5-YL)-CYCLOPROPANECARBONYL]-AMINO]-3-METHYL-PYRIDIN-2-YL)-BENZOIC ACID, 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acid, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-be, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)benzoic acid, 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid, Lumacaftor [USAN:INN], Lumacaftor (USAN), PubChem22450, MLS006011120, SCHEMBL377028, Lumacaftor(vx-809 vx809), GTPL7481, CHEMBL2103870, CHEBI:90951, CTK8B5597, AOB2051, DTXSID30239523, EX-A178, C24H18F2N2O5, MolPort-009-198-874, UFSKUSARDNFIRC-UHFFFAOYSA-N, HMS3655E05, BCP02305, ABP000707, ANW-49250, s1565, VX-809/VX809, ZINC64033452, AKOS015920205, API0007686, CS-0479, DB09280, PB19466, QC-7245, NCGC00346550-01, NCGC00346550-05, 3-(6-(1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoic acid, 4CA-0760, AC-23172, AK-36922, AN-16986, AS-31756, BC660192, Benzoic acid, 3-(6-(((1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl)carbonyl)amino)-3-methyl-2-pyridinyl)-, BR-36922, EN002684, HY-13262, KB-81477, SC-95543, SMR004702901, AB0008169, AJ-114588, AX8160252, TC-137995, FT-0757817, ST24028315, W9631, A25628, D10134, S-5955, J-690399, VX809, VX 809, 936727-05-8, 1220975-12-1, 3-(6-([1-(2,2-DIFLUORO-2H-1,3-BENZODIOXOL-5-YL)CYCLOPROPANE]AMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoic acid, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]amino}-3-methyl-pyridin-2-yl)benzoi, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]amino}-3-methyl-pyridin-2-yl)benzoic acid, 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor, 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methyl-2-pyridyl]benzoic acid, 3-{6-[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid, 3-{6-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid

ID: 2915
InChIKey: FYLYSEXHKNLCOF-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)P(=O)(CCP(=O)(C2=CC=CC=C2)O)O

biological descriptors:

CFTR relevance: CFTR corrector, pocket 2

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 348520
synonyms found at PubChem are:
NSC407882, 1089-77-6, NSC-407882, AC1L89QR, NCIStruc1_001723, NCIStruc2_001208, SCHEMBL806049, diphenylethylenediphosphinic acid, CHEMBL1742186, 1,2-Bis(phenylphosphonyl)ethane, DTXSID90324863, ZINC1600154, CCG-37062, NCGC00014903, NCI407882, AKOS030621632, NCGC00014903-02, NCGC00098004-01, NCI60_003901, Ethane-1,2-diylbis(phenylphosphinic acid), 2-(hydroxy-phenyl-phosphoryl)ethyl-phenyl-phosphinic acid, 2-[hydroxy(phenyl)phosphoryl]ethyl-phenylphosphinic acid, {2-[hydroxy(phenyl)phosphoryl]ethyl}(phenyl)phosphinic acid

ID: 2883
InChIKey: BGOJJHGVMOOKAU-UHFFFAOYSA-N
SMILES: C1C2=CC=CC=C2C3=C1C=C(C=C3)NC(=O)C4=C(C=CC(=C4)C(=O)O)C(=O)O

biological descriptors:

CFTR relevance: CFTR corrector, pocket 2

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 252007
synonyms found at PubChem are:
NSC73100, AC1L5L3Q, NCIStruc1_001290, NCIStruc2_001412, SCHEMBL806014, CHEMBL1412139, CTK7F5945, NCI73100, ZINC1698877, CCG-37000, NCGC00013802, NCGC00013802-02, NCGC00096912-01, NCI60_041594, 2-(9H-fluoren-2-ylcarbamoyl)terephthalic acid, 2-((9H-fluoren-2-ylamino)carbonyl)terephthalic acid, 2-(9h-fluoren-2-ylcarbamoyl)benzene-1,4-dicarboxylic acid

ID: 2890
InChIKey: BZRSNJXOHYRQSB-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)SCC(C(=O)O)N

biological descriptors:

CFTR relevance: CFTR corrector, pocket 2

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 276215
synonyms found at PubChem are:
NSC123526, MLS002707308, s-[9-(4-chlorophenyl)-9h-fluoren-9-yl]cysteine, 27486-80-2, 2-amino-3-{[9-(4-chlorophenyl)-9H-fluoren-9-yl]sulfanyl}propanoic acid, S-(9-(4-chlorophenyl)-9H-fluoren-9-yl)cysteine, AC1L5JCI, AC1Q3NO8, SCHEMBL3473170, CHEMBL1898204, DTXSID00298506, NCI60_000557, SMR001574700, 2-amino-3-[9-(4-chlorophenyl)fluoren-9-yl]sulfanylpropanoic acid

ID: 2934
InChIKey: IPGCPQVGKGPJDW-UHFFFAOYSA-N
SMILES: C1=CC=C2C=C(C=CC2=C1)C3=C(C=CC4=C3C(=O)C5=CC=CC=C5C4=O)C(=O)O

biological descriptors:

CFTR relevance: CFTR corrector, pocket 1

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 222760
synonyms found at PubChem are:
NSC9608, NSC-9608, NCIStruc1_001012, NCIStruc2_000716, AC1L5C23, SCHEMBL5022959, CHEMBL1399619, CTK7I8558, NCI9608, ZINC3953831, CCG-36883, NCGC00013098, NCGC00013098-02, NCGC00096220-01, NCI60_042143, 1-naphthalen-2-yl-9,10-dioxoanthracene-2-carboxylic acid, 1-(naphthalen-2-yl)-9,10-dihydroanthracene-2-carboxylic acid, 1-(2-naphthyl)-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid, 1-(naphthalen-2-yl)-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

ID: 2897
InChIKey: CZHKNJDXPPNMFV-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)C3=CC(=C(C=C3)C)C

biological descriptors:

CFTR relevance: CFTR corrector, pocket 2

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 266881
synonyms found at PubChem are:
NSC105687, NSC-105687, N-(2-(3,4-dimethylbenzoyl)phenyl)-4-methylbenzenesulfonamide, N-[2-(3,4-dimethylbenzoyl)phenyl]-4-methylbenzenesulfonamide, AC1L6H0U, NCIStruc1_001377, NCIStruc2_001114, CHEMBL1443168, ZINC1691755, CCG-37452, NCGC00014077, NCI105687, NCGC00014077-02, NCGC00097186-01, NCI60_000136

ID: 2912
InChIKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N
SMILES: C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

biological descriptors:

CFTR relevance: CFTR corrector, pocket 2

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 3151
synonyms found at PubChem are:
domperidone, 57808-66-9, Motilium, Nauzelin, Domperidonum, Domperidona, Domperidon, Motinorm, Costi, Domperidonum [INN-Latin], Domperidona [INN-Spanish], Motillium, R-33812, NSC299589, Motilium (TN), KW-5338, R 33,812, Domperidone (Motilium), Lopac-D-122, 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine, Domperidone [USAN:BAN:INN:JAN], Domperidone Maleate, EINECS 260-968-7, UNII-5587267Z69, KW 5338, BRN 0903774, 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone, MLS000069343, CHEMBL219916, CHEBI:31515, R-33,812, NCI299589, 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one, NSC-299589, HS-0067, D-122, 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone, DSSTox_CID_25116, DSSTox_RID_80682, DSSTox_GSID_45116, 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one, 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, W-105440, 5587267Z69, 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one, 2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one, SMR000326802, CAS-57808-66-9, SR-01000003002, peridon, Nauzelin OD, Domperidone,(S), domperidone betadex, Motillium (TN), Motinorm (TN), 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, 5-chloro-1-{1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one, Domperidone [USAN:INN:BAN:JAN], Prestwick_794, Domperidone,Motilium, Costi (TN), PubChem15679, Spectrum_000391, Opera_ID_616, SpecPlus_000825, AC1L1FAB, Prestwick0_000461, Prestwick1_000461, Prestwick2_000461, Prestwick3_000461, Spectrum4_000087, domperidone betacyclodextrin, Biomol-NT_000022, D0AV3G, NCIStruc1_001686, NCIStruc2_001819, Lopac0_000427, SCHEMBL43729, BSPBio_002350, GTPL965, KBioGR_000354, KBioSS_000871, 5-24-02-00402 (Beilstein Handbook Reference), MLS000859942, MLS001306482, MLS002222324, DivK1c_006921, SPECTRUM2300212, SPBio_002501, Domperidone (JAN/USAN/INN), BPBio1_000620, BPBio1_001185, DTXSID1045116, CTK8B3352, Domperidone (JP17/USAN/INN), KBio1_001865, KBio2_000871, KBio2_003439, KBio2_006007, KS-00000PNZ, BBC/763, 99497-03-7 (maleate), FGXWKSZFVQUSTL-UHFFFAOYSA-N, MolPort-003-666-773, HMS1922N04, HMS2089C14, HMS2093N22, HMS2096C21, HMS2230N18, HMS3261E16, HMS3269O13, HMS3370L03, HMS3656M21, HMS3713C21, Pharmakon1600-02300212, BCP28265, Domperidone 1.0 mg/ml in Methanol, EBD46624, HY-B0411, ZINC4175569, ZX-AS004963, Tox21_110056, Tox21_500427, ANW-42358, BBL028136, BDBM50241107, BG0172, CCG-37870, CD0227, GP3849, MFCD00069256, NCGC00014670, NSC759575, s2461, STK622843, AKOS005555858, Tox21_110056_1, AC-2037, AN-5531, CS-2511, DB01184, Domperidone, powder, >=98% (HPLC), LP00427, MCULE-4430288884, NSC-759575, NCGC00014670-01, NCGC00014670-02, NCGC00014670-03, NCGC00014670-04, NCGC00014670-05, NCGC00014670-06, NCGC00014670-07, NCGC00014670-08, NCGC00014670-09, NCGC00014670-10, NCGC00014670-11, NCGC00014670-12, NCGC00014670-13, NCGC00014670-14, NCGC00014670-16, NCGC00014670-17, NCGC00015306-01, NCGC00021472-02, NCGC00021472-03, NCGC00021472-04, NCGC00021472-05, NCGC00021472-06, NCGC00021472-07, NCGC00021472-08, NCGC00097773-01, NCGC00261112-01, LS-33301, NCI60_002512, SC-18462, SMR000058969, 83898-65-1 (maleate (1:1)), AB0110085, AB1009278, AB00052423, D4125, EU-0100427, FT-0625588, D01745, AB00052423-06, AB00052423-07, AB00052423_08, AB00052423_09, 808D669, L000230, R 33812, I01-0054, SR-01000003002-2, SR-01000003002-4, SR-01000003002-7, BRD-K38305202-001-02-6, BRD-K38305202-001-08-3, I14-14161, Domperidone, European Pharmacopoeia (EP) Reference Standard, 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one, 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]-4-piperidyl]-1H-benzimidazol-2-one, 2H-Benzimidazol-2-one,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one, 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]- 1,3-dihydro-2H-benzimidazol-2-one, 5-Chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1- yl)propyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one, 5-chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidine-4-yl]-1,3-dihydro-2H-benzimidazol-2-one;, 5-chloro-1-{1-[3(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one, 5-chloro-1-{1-[3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one, 5-Chloro-1-{1-[3-(2-hydroxy-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-2,3-dihydro-1H-benzoimidazol-2-ol, 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one, 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one(domperidone), DOMPERIDONE5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one

ID: 2923
InChIKey: HEMNVSCJOZIBEQ-UHFFFAOYSA-N
SMILES: C1=CNC(=C1)C(=O)C2=C(C=CC(=C2)Cl)NC(=O)CN

biological descriptors:

CFTR relevance: CFTR corrector, pocket 1

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 284708
synonyms found at PubChem are:
NSC140873, MLS000766105, 106410-13-3, NSC-140873, 2-amino-N-[4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl]acetamide, Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]-, GCPK, 2-Amino-N-(4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl)acetamide, ACMC-20ma4y, AC1L61GU, NCIStruc1_000814, NCIStruc2_000850, SCHEMBL9851289, CHEMBL1450586, CTK0D7247, ZINC21557, DTXSID00301064, HEMNVSCJOZIBEQ-UHFFFAOYSA-N, CCG-38259, NCGC00014365, NCI140873, AKOS030563283, NCGC00014365-02, NCGC00014365-03, NCGC00014365-04, NCGC00097473-01, NCI60_000895, SMR000528603, MLS000766105-02, MLS000766105-03, 2-Glycineamide-5-chlorophenyl 2-pyrryl ketone, 2-amino-N-(4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl)acetamide

ID: 2926
InChIKey: HRCYEQFRHAXCRH-UHFFFAOYSA-N
SMILES: CN1C2=C(C=N1)C(=NC(=N2)NC3=CC(=CC=C3)Cl)NC4=CC(=CC=C4)Cl

biological descriptors:

CFTR relevance: CFTR corrector, pocket 1

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 223753
synonyms found at PubChem are:
NSC11668, MLS000737956, NSC-11668, 4-N,6-N-bis(3-chlorophenyl)-1-methylpyrazolo[3,4-d]pyrimidine-4,6-diamine, AC1L5CSO, NCIStruc1_001174, NCIStruc2_000793, cid_223753, CHEMBL1335220, SCHEMBL13100664, BDBM32629, MolPort-003-594-732, N4,4-d]pyrimidine-4,6-diamine, NCI11668, ZINC1718486, CCG-36888, NCGC00013125, AKOS024255121, MCULE-2217239478, NCGC00013125-02, NCGC00096246-01, NCI60_000381, SMR000528106, N4,N6-bis(3-chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

ID: 2942
InChIKey: JSMKCCIMZBFWNW-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)CC2=C(C=CC(=C2)NC3=C4C=C(C=CC4=[NH+]C5=C3C=CC(=C5)Cl)OC)O.[Cl-]

biological descriptors:

CFTR relevance: CFTR corrector, pocket 1

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 5458251
synonyms found at PubChem are:
NSC130813, AC1NUQ41, DTXSID60419997, Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-, 4-[(6-chloro-2-methoxyacridin-10-ium-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol chloride, CHEMBL1970271, 4-(6-chloro-2-methoxyacridin-9-ylamino)-2-((4-methylpiperazin-1-yl)methyl)phenol, dihydrochloride

ID: 2881
InChIKey: BAYMNCHSODLCJV-UHFFFAOYSA-N
SMILES: C1=CC2=C(C=CC(=C2)S(=O)(=O)NC3=CC=C(C=C3)C(=O)O)C(=C1)N

biological descriptors:

CFTR relevance: CFTR corrector, pocket 1

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 235593
synonyms found at PubChem are:
NSC37173, NSC-37173, CHEMBL221733, 6305-91-5, 4-{[(5-aminonaphthalen-2-yl)sulfonyl]amino}benzoic acid, 4-[(5-aminonaphthalen-2-yl)sulfonylamino]benzoic acid, D0B3XP, AC1L5UQ8, AC1Q6VU5, NCIStruc1_001028, NCIStruc2_001521, CTK5B7325, DTXSID10284415, NCI37173, ZINC1669798, BDBM50158388, CCG-36845, NCGC00013434, AKOS030548133, NCGC00013434-02, NCGC00096549-01, NCI60_003431, 4-(1-aminonaphthalene-6-sulfonamido)benzoic acid, 4-(5-aminonaphthalene-2-sulfonamido)benzoic acid, 4-(((5-amino-2-naphthyl)sulfonyl)amino)benzoic acid

ID: 2902
InChIKey: DIKVHTCRLXZEJN-UHFFFAOYSA-N
SMILES: C1=CC(=CC(=C1)[N+](=O)[O-])CSC2=NC(=O)C3=C(N2)N=CN3

biological descriptors:

CFTR relevance: CFTR corrector, pocket 1

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment several

CID is 3246417
synonyms found at PubChem are:
2-((3-Nitrobenzyl)thio)-9H-purin-6-ol, 15870-55-0, NSC118208, NSC-118208, 2-((3-nitrobenzyl)thio)-3H-purin-6(7H)-one, AC1MMYGF, NCIStruc1_001314, NCIStruc2_001113, CHEMBL1568233, SCHEMBL16318809, DTXSID00390574, MolPort-038-940-924, ZINC7996341, CCG-36621, NCGC00014199, NCI118208, NSC211342, AKOS024464712, AKOS025328668, NSC-211342, 2-(3-nitrobenzylthio)-9H-purin-6-ol, NCGC00014199-02, NCGC00097308-01, AK162280, NCI60_000435, AX8294627, 2-(3-nitrobenzylthio)-3H-purin-6(7H)-one, 2-((3-(hydroxy(oxido)amino)benzyl)thio)-9H-purin-6-ol, F9994-0116, 2-[(3-nitrophenyl)methylsulfanyl]-3,7-dihydropurin-6-one