ID: 2
InChIKey: VFLDPWHFBUODDF-FCXRPNKRSA-N SMILES: COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
biological descriptors:
CFTR relevance: CFTR correctorCategory:
Influence on CFTR function likely enhances CFTR function
Order of interaction unknown
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)
CID is 969516
synonyms found at PubChem are:
curcumin, 458-37-7, Diferuloylmethane, Natural yellow 3, Turmeric yellow, Curcuma, Turmeric, Kacha haldi, Gelbwurz, Indian saffron, Curcumin I, Souchet, Haidr, Halad, Haldar, Halud, Merita earth, Terra Merita, Yellow Ginger, Yellow Root, Safran d'Inde, Yo-Kin, Golden seal, Orange Root, C.I. Natural Yellow 3, Curcumine, Hydrastis, Indian turmeric, Yellow puccoon, Curcuma oil, Diferaloylmethane, Turmeric extract, Oils, curcuma, Kurkumin [Czech], (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, Tumeric yellow, Turmeric oil, Oil of turmeric, CI Natural Yellow 3, Turmeric oleoresin, Curcuma longa oils, Zlut prirodni 3 [Czech], Cucurmin, Kurkumin, C.I. 75300, Tumeric oleoresin, Zlut prirodni 3, Turmeric root oil, Turmeric, oleoresin, Curcuma oil (Curcuma longa), curouma, E 100, Curcurmin, Diferulylmethane, kachs haldi, safra d'inde, Turmeric oil (Curcuma longa L.), Curcuma longa l. root oil, 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, NSC32982, UNII-IT942ZTH98, NSC 32982, Tu rmeric root oil, Turmeric (>98% curcurmin), 98% curcurmin), FEMA No. 3085, FEMA No. 3086, CCRIS 3257, CCRIS 5804, CHEBI:3962, 1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, MLS000069631, Turmeric oleoresin (79%-85% curcumin), Curcuma longa l. oil, HSDB 4334, Turmeric root oleoresin, 1,5-Di(vanillyliden)acetylaceton, NCI-C61325, C21H20O6, 1,5-Divanillyliden-2,4-pentandion, EINECS 207-280-5, Turmeric extract (Curcuma longa L.), 8024-37-1, 1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione, CHEMBL140, Curcuma longa l. oleoresin, NSC 687842, BRN 2306965, 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-, CI 75300, SMR000058237, 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-, IT942ZTH98, Curcuma longa l. root oleoresin, VFLDPWHFBUODDF-FCXRPNKRSA-N, (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, NSC-32982, NSC687842, NCGC00017159-05, DSSTox_CID_1421, (1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione, (1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione, DSSTox_RID_78861, DSSTox_GSID_31077, CU-01000001305-2, CURCUMIN (SEE ALSO TUMERIC, OLEORESIN (10105-J)), 2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-, Oils, galangal, PREVENTION 4 (CURCUMIN) (SEE ALSO TUMERIC, OLEORESIN (10105-J)), TURMERIC, OLEORESIN (CURCUMIN) (SEE ALSO CURCURMIN (458-37-7)), Yellow, Turmeric, 91884-86-5, CAS-458-37-7, 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, SR-01000000149, diferuloylmethan, E 100 (Dye), Haldar, Souchet, Natural Yellow3, Curcumin,(S), Curcumin (Natural), trans,trans-Curcumin, Opera_ID_1627, D07SDQ, D0H8LC, AC1LJ6T6, SCHEMBL8440, SCHEMBL8441, Curcumin, analytical standard, 4-08-00-03697 (Beilstein Handbook Reference), MLS001148449, BIDD:ER0479, turmeric root oil CO2 extract, AC1Q46A0, cid_969516, GTPL7000, turmeric root oil hydrodistilled, DTXSID8031077, SCHEMBL13521974, BDBM29532, cid_5281767, BIC8500, cMAP_000052, MolPort-001-763-682, HMS2233K04, HMS3649K06, ZINC899824, BB_NC-01422, BCP04695, HY-N0005, ZX-AT003872, Tox21_110803, Tox21_111505, Tox21_201116, BBL027711, BDBM50067040, BDBM50140172, BG0601, CC0179, CCG-36020, CCG-36107, GP8291, LS-125, MFCD00008365, SBB006495, STL371943, AKOS001305497, BCP9000557, CS-1490, curcuma longa l. root oil CO2 extract, DB11672, LS-2189, NSC-687842, OR24598, RTR-032605, curcuma longa l. root oil hydrodistilled, NCGC00017159-04, NCGC00017159-06, NCGC00017159-07, NCGC00017159-09, NCGC00017159-10, NCGC00017159-11, NCGC00017159-12, NCGC00023332-03, NCGC00023332-04, NCGC00023332-05, NCGC00258668-01, AC-24238, AN-23454, BC678109, M212, SC-17381, ST055629, BCP0726000035, DB-002681, KB-251224, TR-032605, WLN: 1OR BQ E1U1V1V1U1R DQ CO1, N1839, 1,3-Di(3-methoxy-4-hydroxystyryl)propanedial, 1790-EP2305629A1, 1790-EP2308861A1, J10108, K00009, W-5038, Curcumin, from Curcuma longa (Turmeric), powder, 458C377, Curcumin, primary pharmaceutical reference standard, 1,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, I06-0010, I06-2497, SR-01000000149-2, SR-01000000149-5, BRD-K07572174-001-02-2, BRD-K07572174-001-19-6, BRD-K07572174-001-22-0, I14-19358, Curcumin, >=94% (curcuminoid content), >=80% (Curcumin), 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione, 1,7-DI(4-HYDROXY-3-METHOXYPHENYL)HEPTA-1,6-DIENE-3, Curcumin, matrix substance for MALDI-MS, >=99.5% (HPLC), Curcumin, United States Pharmacopeia (USP) Reference Standard, 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), (1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-1,6-diene-3,5-dione, (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione #, (1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, (1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (E,E)-, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one, 5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one, Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one, 15845-47-3, 33171-04-9, 73729-23-4, 79257-48-0, Curcumin solution, ~0.1 % (w/v) (in ethanol with 2M HCl (99:1 v/v)), for TLC derivatization
ID: 20
InChIKey: UFSKUSARDNFIRC-UHFFFAOYSA-N SMILES: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
biological descriptors:
CFTR relevance: CFTR correctorCategory:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)
CID is 16678941
synonyms found at PubChem are:
936727-05-8, Lumacaftor, VX-809, VX 809, VX809, VRT-826809, 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, UNII-EGP8L81APK, VRT 826809, EGP8L81APK, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoic acid, 3-(6-[[1-(2,2-DIFLUORO-BENZO[1,3]DIOXOL-5-YL)-CYCLOPROPANECARBONYL]-AMINO]-3-METHYL-PYRIDIN-2-YL)-BENZOIC ACID, 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acid, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-be, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)benzoic acid, 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid, Lumacaftor [USAN:INN], Lumacaftor (USAN), PubChem22450, MLS006011120, SCHEMBL377028, Lumacaftor(vx-809 vx809), GTPL7481, CHEMBL2103870, CHEBI:90951, CTK8B5597, AOB2051, DTXSID30239523, EX-A178, C24H18F2N2O5, MolPort-009-198-874, UFSKUSARDNFIRC-UHFFFAOYSA-N, HMS3655E05, BCP02305, ABP000707, ANW-49250, s1565, VX-809/VX809, ZINC64033452, AKOS015920205, API0007686, CS-0479, DB09280, PB19466, QC-7245, NCGC00346550-01, NCGC00346550-05, 3-(6-(1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoic acid, 4CA-0760, AC-23172, AK-36922, AN-16986, AS-31756, BC660192, Benzoic acid, 3-(6-(((1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl)carbonyl)amino)-3-methyl-2-pyridinyl)-, BR-36922, EN002684, HY-13262, KB-81477, SC-95543, SMR004702901, AB0008169, AJ-114588, AX8160252, TC-137995, FT-0757817, ST24028315, W9631, A25628, D10134, S-5955, J-690399, VX809, VX 809, 936727-05-8, 1220975-12-1, 3-(6-([1-(2,2-DIFLUORO-2H-1,3-BENZODIOXOL-5-YL)CYCLOPROPANE]AMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoic acid, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]amino}-3-methyl-pyridin-2-yl)benzoi, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]amino}-3-methyl-pyridin-2-yl)benzoic acid, 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor, 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methyl-2-pyridyl]benzoic acid, 3-{6-[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid, 3-{6-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid