CandActCFTR Seed Compounds


The following 3114 structures with currently 268914 synonyms are a list compounds which have been reported in 111 CFTR related publications published in the past decade. We collected all structures regardless of an activation of CFTR function or an improvement of CFTR processing, thus also including reported negative compound references or even inhibitors.



ID: 1

chemical graph of compound 1



InChIKey: TZBJGXHYKVUXJN-UHFFFAOYSA-N
SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment several

reference list:

"JM Beekman" "CK van der Ent" "AM Vonk" "JF Dekkers" "P Van Mourik" "HR de Jonge" "I Bronsveld" "KM de Winter-de Groot" "G Berkers" "E Kruisselbrink" "HM Janssens"
"M Carattino" "RC Rubenstein" "L Suaud" "TR Kleyman"
"C Andersson" "GM Roomans" "Z Servetnyk"
"O Moran" "O Zegarra-Moran"
"F Cateni" "M Zacchigna" "M Giampieri" "MT Mazzei" "N Pedemonte" "M Mazzei" "P Fossa" "LJ Galietta"
"X Wang" "T Ai" "TC Hwang" "S Hu" "SG Bompadre" "M Li"
"MJ Baker" "KL Hamilton"
"DW Vermeer" "MJ Welsh" "AL Berger" "CO Randak" "PH Karp" "LS Ostedgaard"
"E Kwon" "PL Zeitlin" "AD Floyd" "M Lim" "K McKenzie"
"SM Rowe" "D Skinner" "EJ Sorscher" "SB Hicks" "S Zhang" "BT Conger" "BA Woodworth"
"MJ Kurth" "MH Nantz" "M Eda" "EJ Niedzinski" "MJ Haddadin" "AS Verkman" "MF Springsteel" "K By" "LJ Galietta"
"NA Bradbury" "I Dey" "K Shah"
"J Fortenberry" "SM Rowe" "PA Sloane" "J Collawn" "EJ Sorscher" "K Varga" "Y Li" "L Fan" "JP Clancy" "B Woodworth" "M Mazur" "A Jurkevante" "LC Pyle" "J Fulton"
"MJ Bijvelds" "K Schoonderwoerd" "HR de Jonge" "CH Lim" "A Nigg" "AB Houtsmuller" "BC Tilly"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"
"PO Strale" "S Noël" "H DeJonge" "F Becq" "Y Mettey" "C Rogier" "L Dannhoffer" "M Wilke"
"A Hanyuda" "H Miki" "Y Matsuzaki" "Y Nakamura" "YC Yu" "TC Hwang" "Y Sohma" "Y Abe" "SG Bompadre" "M Yasui" "K Tanaka"
"E Sage" "F Becq" "L Froux" "C Coraux"
"A Schmidt" "Z Cai" "F Mendes" "DN Sheppard" "MD Amaral" "H Li" "LK Hughes"
"E Caci" "P Fanen" "JM Vierfond" "F Becq" "L Romio" "Y Mettey" "O Zegarra-Moran" "C Folli" "G Cabrini" "LJ Galietta"
"H Dang" "C Cho" "X Liu" "SH Randell" "SE Boyles" "IG Chaudhry" "R Schlegel" "C Cheluvaraju" "M Gentzsch" "NL Quinney"
"YC Yu" "TC Hwang" "Y Sohma"
"W Wang" "K Bernard" "KL Kirk" "G Li"
"U Russ" "A Bachmann" "S Waldegger" "U Quast"
"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"A Tosco" "V Raia" "G Kroemer" "L Maiuri" "VR Villella" "M Piacentini"
"T Neuberger" "P Negulescu" "KS Straley" "T Knapp" "PD Grootenhuis" "JH Stack" "J Rader" "F Van Goor" "J Joubran" "M Miller" "S Hadida" "V Panchenko" "LR Makings" "D Cao" "R Tung" "J González" "E Olson" "A Singh" "A Hazlewood"
"MJ Kurth" "MH Nantz" "L Al-Nakkash" "MF Springsteel"
"PC Chao" "KL Hamilton"
"V Tomati" "O Zegarra-Moran" "R Melani" "LJ Galietta"
"K Cooper" "GE Rottinghaus" "LL Clarke" "L Al-Nakkash" "LJ Rubin" "YJ Chen"


CID is 5280961
synonyms found at PubChem are:
genistein, 446-72-0, Prunetol, Genisteol, 4',5,7-Trihydroxyisoflavone, Genisterin, Sophoricol, 5,7,4'-Trihydroxyisoflavone, 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, Bonistein, Genestein, Differenol A, NPI 031L, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, C.I. 75610, SIPI 807-1, 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one, UNII-DH2M523P0H, NSC 36586, 4,5,7-Trihydroxyiso-flavone, Lactoferrin-genistein, CCRIS 7675, 4',5, 7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, NSC36586, CHEMBL44, EINECS 207-174-9, IN1327, BRN 0263823, PTI G4660 (Genistein), ISOFLAVONE, 4',5,7-TRIHYDROXY-, MLS000738127, DH2M523P0H, STO514, CHEBI:28088, PTI-G4660, SIPI-9764-I, TZBJGXHYKVUXJN-UHFFFAOYSA-N, 4′,5,7-Trihydroxyisoflavone, TNP00151, NSC-36586, GENISTEIN (ENDOCRINE DISRUPTER), GEN, NCGC00015479-09, DSSTox_CID_2308, G 6649, G10000, DSSTox_RID_76542, DSSTox_GSID_22308, ENDOCRINE DISRUPTOR (GENISTEIN) (SEE ALSO GENISTEIN (446-72-0)), CAS-446-72-0, SR-01000075498, HSDB 7475, PTI G4660, 3kgt, 3kgu, 4&prime, Genistein, 8, Genistein,(S), PTI-G 4660, Genistein (flavonoid), PubChem9852, Spectrum_000320, Tocris-1110, 1x7r, 2qa8, Genistein 85% HPLC, SpecPlus_000305, AC1NQXT4, Spectrum2_000638, Spectrum3_000678, Spectrum4_001543, Spectrum5_000106, Lopac-G-6649, 4',7-Trihydroxyisoflavone, D0L4FS, MolMap_000022, UPCMLD-DP096, 4,5,7-Trihydroxyisoflavone, 4,6,7-Trihydroxyisoflavone, Isoflavone,5,7-trihydroxy-, Lopac0_000520, Oprea1_224620, Oprea1_437815, SCHEMBL19166, BSPBio_002375, KBioGR_002006, KBioGR_002564, KBioSS_000800, KBioSS_002573, SPECTRUM210296, 5-18-04-00594 (Beilstein Handbook Reference), BIDD:ER0113, DivK1c_006401, Genistein, analytical standard, SPBio_000636, 4',5,7-Trihydroxy isoflavone, 4',5,7-trihydroxy-Isoflavone, GTPL2826, MEGxp0_000568, 4,5,7-Trihydroxy Iso-Flavone, DTXSID5022308, UPCMLD-DP096:001, ACon1_001065, BDBM19459, cid_5280961, KBio1_001345, KBio2_000800, KBio2_002564, KBio2_003368, KBio2_005132, KBio2_005936, KBio2_007700, KBio3_001595, KBio3_003042, AOB5073, CHEBI: 28088, cMAP_000086, MolPort-000-003-911, Bio1_000445, Bio1_000934, Bio1_001423, HMS2271K09, HMS3261H21, HMS3267K14, HMS3428M01, HMS3649B22, HMS3654D17, ACT05962, ALBB-015886, BCP07581, KS-00000MH8, Prunetol solution, 20 mM in DMSO, Tox21_110161, Tox21_201428, Tox21_300585, Tox21_500520, AC-472, BBL010484, CCG-38551, CG-009, Genistein solution, 20 mM in DMSO, LMPK12050218, MFCD00016952, s1342, SBB066115, STK801619, ZINC18825330, AKOS001590147, Tox21_110161_1, CS-1534, DB01645, KS-5128, LP00520, LS-1266, MCULE-4857649752, RL03694, RP29616, SMP1_000133, Genistein; 4',5,7-Trihydroxyisoflavone, NCGC00015479-01, NCGC00015479-02, NCGC00015479-04, NCGC00015479-05, NCGC00015479-06, NCGC00015479-07, NCGC00015479-08, NCGC00015479-10, NCGC00015479-11, NCGC00015479-12, NCGC00015479-13, NCGC00015479-14, NCGC00015479-15, NCGC00015479-16, NCGC00015479-17, NCGC00015479-18, NCGC00015479-19, NCGC00015479-20, NCGC00025005-01, NCGC00025005-02, NCGC00025005-03, NCGC00025005-04, NCGC00025005-05, NCGC00025005-06, NCGC00025005-07, NCGC00169711-01, NCGC00169711-02, NCGC00254275-01, NCGC00258979-01, NCGC00261205-01, 690224-00-1, AJ-70669, AN-15821, BC200563, HY-14596, KB-52241, NCI60_003369, SC-04581, SMR000112580, ST056352, AB1004490, EU-0100520, FT-0603395, G0272, N1861, Genistein, disposable screening library format, 46G720, C06563, G-2535, Genistein, synthetic, >=98% (HPLC), powder, J10015, K00046, S-7751, US8552057, 2, AB00052696_09, AB00052696_12, A826657, Genistein, primary pharmaceutical reference standard, I06-0431, Q-100484, SR-01000075498-1, SR-01000075498-3, SR-01000075498-6, 3-(4-hydroxyphenyl)-5,7-bis(oxidanyl)chromen-4-one, 4 inverted exclamation marka,5,7-Trihydroxyisoflavone, BRD-K43797669-001-02-3, BRD-K43797669-001-03-1, BRD-K43797669-001-10-6, Genistein, from Glycine max (soybean), ~98% (HPLC), SR-01000075498-10, 5,7-dihydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one, F0001-2388, 4H-1-Benzopyran-4-one,7-dihydroxy-3-(4-hydroxyphenyl)-, UNII-71B37NR06D component TZBJGXHYKVUXJN-UHFFFAOYSA-N, Genistein, United States Pharmacopeia (USP) Reference Standard, Genistein, Pharmaceutical Secondary Standard; Certified Reference Material, 4 inverted exclamation marka,5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one


ID: 2

chemical graph of compound 2



InChIKey: VFLDPWHFBUODDF-FCXRPNKRSA-N
SMILES: COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function likely enhances CFTR function
Order of interaction unknown
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

"JM Beekman" "CK van der Ent" "AM Vonk" "JF Dekkers" "P Van Mourik" "HR de Jonge" "I Bronsveld" "KM de Winter-de Groot" "G Berkers" "E Kruisselbrink" "HM Janssens"
"A Hanyuda" "H Miki" "Y Matsuzaki" "Y Nakamura" "YC Yu" "TC Hwang" "Y Sohma" "Y Abe" "SG Bompadre" "M Yasui" "K Tanaka"
"G Wang"
"YC Yu" "TC Hwang" "Y Sohma"
"SH Randell" "MR Knowles" "BR Grubb" "SE Gabriel" "RC Boucher" "ML Drumm" "M Gentzsch" "A Mengos" "JR Riordan" "AM Van Heeckeren"
"HC Chan" "LL Tsang" "J Chen" "Y Chen" "YZ Peng" "T Zhou" "ZW Dong" "YC Ruan"
"W Wang" "K Bernard" "KL Kirk" "G Li"
"N Davezac" "A Edelman" "M Baudouin-Legros" "F Becq" "J Lipecka" "C Norez" "G Planelles" "N Bensalem"
"WM Saltzman" "MS Cartiera" "C Caputo" "ME Egan" "EC Ferreira" "MJ Caplan"
"R Narlawar" "W Wang" "K Bernard" "B Schmidt" "KL Kirk"
"S Canny" "J Glöckner-Pagel" "D Rubin" "K Du" "V Rajendran" "ME Egan" "M Pearson" "GL Lukacs" "MJ Caplan" "SA Weiner"
"D Salinas" "N Pedemonte" "L Qian" "Y Song" "AS Verkman" "ND Sonawane" "LJ Galietta"
"DW Vermeer" "MJ Welsh" "AL Berger" "CO Randak" "PH Karp" "LS Ostedgaard"
"T Neuberger" "P Negulescu" "KS Straley" "T Knapp" "PD Grootenhuis" "JH Stack" "J Rader" "F Van Goor" "J Joubran" "M Miller" "S Hadida" "V Panchenko" "LR Makings" "D Cao" "R Tung" "J González" "E Olson" "A Singh" "A Hazlewood"
"W Wang" "JS Hong" "EJ Sorscher" "A Rab" "KL Kirk"
"L Hjelte" "J Björstad" "GM Roomans" "A Dragomir"
"NA Bradbury" "I Dey" "K Shah"
"MA Suico" "K Oyokawa" "T Shuto" "T Okiyoneda" "K Harada" "Y Hashimoto" "H Kai" "K Nakamura"
"G Wang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 969516
synonyms found at PubChem are:
curcumin, 458-37-7, Diferuloylmethane, Natural yellow 3, Turmeric yellow, Curcuma, Turmeric, Kacha haldi, Gelbwurz, Indian saffron, Curcumin I, Souchet, Haidr, Halad, Haldar, Halud, Merita earth, Terra Merita, Yellow Ginger, Yellow Root, Safran d'Inde, Yo-Kin, Golden seal, Orange Root, C.I. Natural Yellow 3, Curcumine, Hydrastis, Indian turmeric, Yellow puccoon, Curcuma oil, Diferaloylmethane, Turmeric extract, Oils, curcuma, Kurkumin [Czech], (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, Tumeric yellow, Turmeric oil, Oil of turmeric, CI Natural Yellow 3, Turmeric oleoresin, Curcuma longa oils, Zlut prirodni 3 [Czech], Cucurmin, Kurkumin, C.I. 75300, Tumeric oleoresin, Zlut prirodni 3, Turmeric root oil, Turmeric, oleoresin, Curcuma oil (Curcuma longa), curouma, E 100, Curcurmin, Diferulylmethane, kachs haldi, safra d'inde, Turmeric oil (Curcuma longa L.), Curcuma longa l. root oil, 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, NSC32982, UNII-IT942ZTH98, NSC 32982, Tu rmeric root oil, Turmeric (>98% curcurmin), 98% curcurmin), FEMA No. 3085, FEMA No. 3086, CCRIS 3257, CCRIS 5804, CHEBI:3962, 1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, MLS000069631, Turmeric oleoresin (79%-85% curcumin), Curcuma longa l. oil, HSDB 4334, Turmeric root oleoresin, 1,5-Di(vanillyliden)acetylaceton, NCI-C61325, C21H20O6, 1,5-Divanillyliden-2,4-pentandion, EINECS 207-280-5, Turmeric extract (Curcuma longa L.), 8024-37-1, 1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione, CHEMBL140, Curcuma longa l. oleoresin, NSC 687842, BRN 2306965, 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-, CI 75300, SMR000058237, 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-, IT942ZTH98, Curcuma longa l. root oleoresin, VFLDPWHFBUODDF-FCXRPNKRSA-N, (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, NSC-32982, NSC687842, NCGC00017159-05, DSSTox_CID_1421, (1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione, (1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione, DSSTox_RID_78861, DSSTox_GSID_31077, CU-01000001305-2, CURCUMIN (SEE ALSO TUMERIC, OLEORESIN (10105-J)), 2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-, Oils, galangal, PREVENTION 4 (CURCUMIN) (SEE ALSO TUMERIC, OLEORESIN (10105-J)), TURMERIC, OLEORESIN (CURCUMIN) (SEE ALSO CURCURMIN (458-37-7)), Yellow, Turmeric, 91884-86-5, CAS-458-37-7, 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, SR-01000000149, diferuloylmethan, E 100 (Dye), Haldar, Souchet, Natural Yellow3, Curcumin,(S), Curcumin (Natural), trans,trans-Curcumin, Opera_ID_1627, D07SDQ, D0H8LC, AC1LJ6T6, SCHEMBL8440, SCHEMBL8441, Curcumin, analytical standard, 4-08-00-03697 (Beilstein Handbook Reference), MLS001148449, BIDD:ER0479, turmeric root oil CO2 extract, AC1Q46A0, cid_969516, GTPL7000, turmeric root oil hydrodistilled, DTXSID8031077, SCHEMBL13521974, BDBM29532, cid_5281767, BIC8500, cMAP_000052, MolPort-001-763-682, HMS2233K04, HMS3649K06, ZINC899824, BB_NC-01422, BCP04695, HY-N0005, ZX-AT003872, Tox21_110803, Tox21_111505, Tox21_201116, BBL027711, BDBM50067040, BDBM50140172, BG0601, CC0179, CCG-36020, CCG-36107, GP8291, LS-125, MFCD00008365, SBB006495, STL371943, AKOS001305497, BCP9000557, CS-1490, curcuma longa l. root oil CO2 extract, DB11672, LS-2189, NSC-687842, OR24598, RTR-032605, curcuma longa l. root oil hydrodistilled, NCGC00017159-04, NCGC00017159-06, NCGC00017159-07, NCGC00017159-09, NCGC00017159-10, NCGC00017159-11, NCGC00017159-12, NCGC00023332-03, NCGC00023332-04, NCGC00023332-05, NCGC00258668-01, AC-24238, AN-23454, BC678109, M212, SC-17381, ST055629, BCP0726000035, DB-002681, KB-251224, TR-032605, WLN: 1OR BQ E1U1V1V1U1R DQ CO1, N1839, 1,3-Di(3-methoxy-4-hydroxystyryl)propanedial, 1790-EP2305629A1, 1790-EP2308861A1, J10108, K00009, W-5038, Curcumin, from Curcuma longa (Turmeric), powder, 458C377, Curcumin, primary pharmaceutical reference standard, 1,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, I06-0010, I06-2497, SR-01000000149-2, SR-01000000149-5, BRD-K07572174-001-02-2, BRD-K07572174-001-19-6, BRD-K07572174-001-22-0, I14-19358, Curcumin, >=94% (curcuminoid content), >=80% (Curcumin), 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione, 1,7-DI(4-HYDROXY-3-METHOXYPHENYL)HEPTA-1,6-DIENE-3, Curcumin, matrix substance for MALDI-MS, >=99.5% (HPLC), Curcumin, United States Pharmacopeia (USP) Reference Standard, 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), (1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-1,6-diene-3,5-dione, (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione #, (1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, (1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (E,E)-, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one, 5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one, Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one, 15845-47-3, 33171-04-9, 73729-23-4, 79257-48-0, Curcumin solution, ~0.1 % (w/v) (in ethanol with 2M HCl (99:1 v/v)), for TLC derivatization


ID: 3

chemical graph of compound 3



InChIKey: FJNFVCAHHFNREI-UHFFFAOYSA-N
SMILES: CC(C1=NC2=CC=CC=C2C(=N1)OC3CCCCC3)N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

reference list:

"RA Keyzers" "DY Thomas" "GW Carlile" "R Robert" "CA Gray" "SM Anjos" "KA Teske" "J Liao" "DE Williams" "D Zhang" "RG Linington" "JW Hanrahan" "RJ Andersen" "RM Centko" "HM Sampson" "L Yan"
"DY Thomas" "GW Carlile" "R Robert" "J Liao" "P Lesimple" "B Kus" "HR de Jonge" "JW Hanrahan" "N Liu" "BJ Scholte" "M Wilke" "H Balghi" "D Rotin"
"CE Bear" "L Wellhauser" "M Ramjeesingh" "LJ Huan" "P Kim Chiaw"
"T Neuberger" "P Negulescu" "KS Straley" "T Knapp" "PD Grootenhuis" "JH Stack" "J Rader" "F Van Goor" "J Joubran" "M Miller" "S Hadida" "V Panchenko" "LR Makings" "D Cao" "R Tung" "J González" "E Olson" "A Singh" "A Hazlewood"
"MC Bartlett" "DM Clarke" "TW Loo" "Y Wang"
"DY Thomas" "GW Carlile" "R Robert" "SM Anjos" "J Liao" "D Waller" "P Lesimple" "F Dantzer" "J Goepp" "P Ferraro" "R Phillipe" "DL Zhang" "JW Hanrahan" "F Ciciriello" "H Balghi" "HM Sampson"
"E Caci" "U Pfeffer" "V Tomati" "N Pedemonte" "AI Esposito" "LJ Galietta" "E Sondo"
"J Fortenberry" "SM Rowe" "PA Sloane" "J Collawn" "EJ Sorscher" "K Varga" "Y Li" "L Fan" "JP Clancy" "B Woodworth" "M Mazur" "A Jurkevante" "LC Pyle" "J Fulton"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 11957831
synonyms found at PubChem are:
815592-21-3, 4-(cyclohexyloxy)-2-(1-(4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl)ethyl)quinazoline, CFcor-325, VRT-325, 4-(Cyclohexyloxy)-2-(1-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl}ethyl)quinazoline, ACMC-20p1e2, GTPL4340, SCHEMBL3822809, VRT325, CHEMBL1257047, CTK9A5799, DTXSID00474707, VRT 325, MolPort-006-415-015, KS-000000GF, AKOS030228615, 4-cyclohexyloxy-2-[1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]ethyl]quinazoline, KB-01359, KB-34900, A1-01884, 4-(Cyclohexyloxy)-2-(1-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxyphenyl)sulfonyl]-1-piperazinyl}ethyl)quinazoline


ID: 4

chemical graph of compound 4



InChIKey: UQRORFVVSGFNRO-UTINFBMNSA-N
SMILES: CCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function likely enhances CFTR function
Order of interaction unknown
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

"M Bijvelds" "H Jorna" "P Melin" "S Noel" "H DeJonge" "F Becq" "C Norez" "M Wilke"
"I Adachi" "J Désiré" "S Thibaudeau" "V Cendret" "T Legigan" "A Mingot" "P Parenti" "J Bertrand" "Y Blériot" "A Kato" "M Forcella" "F Becq" "C Norez"
"R Ferru-Clément" "C Boinot" "F Becq" "M Jollivet Souchet"
"S Noël" "AG Bot" "HR De Jonge" "F Becq" "M Wilke"
"J Dingemanse" "T Leal" "P Lebecque" "A Leonard"
"J Lebacq" "T Leal" "P Lebecque" "R Vanbever" "A Leonard" "P Wallemacq" "B Lubamba"
"S Noel" "F Becq" "C Vandebrouck" "C Norez" "F Antigny"


CID is 51634
synonyms found at PubChem are:
Miglustat, Zavesca, N-Butyldeoxynojirimycin, 72599-27-0, NB-DNJ, N-Butylmoranoline, N-butyl-1-deoxynojirimycin, BuDNJ, n-Butyl deoxynojirimycin, Butyldeoxynojirimycin, (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol, n-Butyl dnj, N-(n-Butyl)deoxynojirimycin, SC-48334, Miglustat [USAN], OGT 918, N-Butyl-DNJ, SC 48334, miglustatum, Vevesca, UNII-ADN3S497AZ, Zavesca (TN), OGT-918, 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3r,4R,5S)-, N-Bu-DNJ, Miglustat, Hydrochloride, N-Butyl-deoxynojirimycin, SC48334, ADN3S497AZ, CHEMBL1029, CHEBI:50381, D-Glucitol, 1,5-(butylimino)-1,5-dideoxy-, 1,5-Dideoxy-1,5-N-butylimino-D-glucitol, DSSTox_CID_25618, DSSTox_RID_81006, DSSTox_GSID_45618, N-(n-butyl)-1,5-dideoxy-1,5-imino-D-glucitol, 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-, NBV, CAS-72599-27-0, Brazaves, Miglustat [USAN:INN:BAN], NCGC00018140-02, Brazaves (TN), Miglustat (USAN/INN), AC1L1BHJ, D0HR8Z, Miglustat (JAN/USAN/INN), SCHEMBL246893, BICL4040, GTPL4841, DTXSID6045618, BDBM18355, UQRORFVVSGFNRO-UTINFBMNSA-N, HMS2090N20, ZINC3794711, Tox21_110830, 3917AH, AN-010, MFCD00272581, AKOS028109118, Tox21_110830_1, ACN-025888, API0003392, CS-2776, DB00419, NCGC00024452-03, NCGC00024452-04, BC677641, HY-17020, LS-116261, N-(n-Butyl)-1-deoxynojirimycin min. 99%, N-Butyldeoxynojirimycin, film (dried in situ), D05032, AB00489939-10, SR-01000000043, SR-01000000043-2, W-203639, 134282-77-2


ID: 5

chemical graph of compound 5



InChIKey: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment Apical membrane & subapical compartment

reference list:

"CM McNicholas" "M Chestnut" "DF Skinner" "EJ Sorscher" "JC Kappes" "S Zhang" "BA Woodworth" "AC Blount"
"NA Bradbury" "I Dey" "K Shah"
"A Aissat" "A Edelman" "J Colas" "N Hamdaoui" "M Kelly" "M Baudoin-Legros" "J Fritsch" "G Planelles" "DL Vieu" "S Moriceau"
"S Noel" "T Leal" "P Wallemacq" "C Bouckaert" "A Capron" "B Dhooghe"
"Y Jai" "NA Bradbury" "RJ Bridges" "K Shah"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 445154
synonyms found at PubChem are:
resveratrol, 501-36-0, trans-resveratrol, 3,4',5-Trihydroxystilbene, (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, 3,5,4'-Trihydroxystilbene, (E)-resveratrol, 3,4',5-Stilbenetriol, Resvida, 3,4',5-Trihydroxy-trans-stilbene, 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol, SRT-501, SRT501, Resveratol, SRT 501, 3,5,4'-Trihydroxy-trans-stilbene, 5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol, 3,4',5-trihydroxy-stilbene, Resveratrol, natural, UNII-Q369O8926L, CHEBI:45713, trans-3,4',5-trihydroxystilbene, (E)-5-(p-Hydroxystyryl)resorcinol, trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene, 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol, CHEMBL165, NSC 327430, (E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzendiol, MLS000069735, 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-, LUKBXSAWLPMMSZ-OWOJBTEDSA-N, KUC104385N, PREVENTION 8 (RESVERATROL), C14H12O3, trans-3,4',5 - trihydroxystilbene, NSC327430, KSC-10-164, Q369O8926L, 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol, RM-1812, trans-3,4′,5-Trihydroxystilbene, SMR000058206, R 5010, DSSTox_CID_11980, DSSTox_RID_78898, DSSTox_GSID_31980, CU-01000001503-3, (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol, (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol, 1,3-Benzenediol, 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-, MFCD00133799, STL, SR-01000000163, 5-[(1E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol, CHEBI:27881, CCRIS 8952, HSDB 7571, 3fts, 4jaz, 4qer, Resveratrol, E-, Resveratrol,(S), Stilbene, 2f, TaxusChinensisiRehd, NCGC00015894-02, CAS-501-36-0, Prestwick_619, Trans-3,4&prime, Resveratrol, trans-, Resveratrol, synthetic, Opera_ID_586, AC1L9HIC, Prestwick2_000508, Prestwick3_000508, Spectrum5_000552, D0U3EP, Lopac0_001111, REGID_for_CID_6240, SCHEMBL19425, BSPBio_000435, BSPBio_001114, BSPBio_003461, MLS001055357, MLS001076538, MLS001424228, MLS002207121, MLS002222231, ARONIS24568, SPECTRUM1502223, BPBio1_000479, cid_445154, GTPL8741, SGCUT00007, trans-Stilbene-3,4',5-triol, ZINC6787, Resveratrol, analytical standard, DTXSID4031980, REGID_for_CID_445154, BDBM23926, Resveratrol, >=99% (HPLC), BBC/741, BIK9013, 2l98, MolPort-002-499-801, BCPP000091, HMS1362H15, HMS1569F17, HMS1792H15, HMS1921N04, HMS1990H15, HMS2052I09, HMS2096F17, HMS2232A18, HMS3263O04, HMS3403H15, HMS3649A20, ACT09778, BCP01416, to_000079, ZX-AS004941, ZX-AT013797, Tox21_110257, Tox21_201374, Tox21_303376, Tox21_501111, ABP000376, AC-727, AN-865, BBL028252, BS0159, CCG-38874, CR-003, GP2549, GP5884, LMPK13090005, s1396, SBB055452, STL146386, AKOS005720936, Tox21_110257_1, ACN-034773, API0000480, CS-1050, DB02709, KS-5047, LP01111, LS-2146, MCULE-5678456463, NC00349, NSC-327430, OR46018, RP17549, SDCCGMLS-0002998.P003, IDI1_002152, Resveratrol solution, 100 mM in DMSO, NCGC00017352-05, NCGC00017352-06, NCGC00017352-07, NCGC00017352-08, NCGC00017352-09, NCGC00017352-10, NCGC00017352-11, NCGC00017352-12, NCGC00017352-13, NCGC00017352-14, NCGC00017352-15, NCGC00017352-16, NCGC00017352-17, NCGC00017352-18, NCGC00017352-19, NCGC00017352-24, NCGC00024003-00, NCGC00024003-04, NCGC00024003-05, NCGC00024003-06, NCGC00024003-07, NCGC00024003-08, NCGC00024003-09, NCGC00024003-10, NCGC00024003-11, NCGC00024003-12, NCGC00024003-13, NCGC00024003-14, NCGC00257465-01, NCGC00258925-01, NCGC00261796-01, 375823-41-9, 4CN-0696, AJ-08292, AK-39118, AS-12413, BC202036, BR-39118, CC-34242, CJ-00111, CPD000058206, HY-16561, KB-02515, SAM001246888, SC-11924, ST057251, SY014849, ZB000650, AB0006623, AX8004672, ST2408097, TL8003323, EU-0101111, FT-0082623, N1848, R0071, Resveratrol, Vetec(TM) reagent grade, 98%, 01R360, C03582, J10118, N88795, 5-[2-(4-hydroxyphenyl)vinyl]-1,3-benzenediol, AB00052942-29, AB00052942_31, A827984, 5-[(E)-2-(4-Hydroxyphenyl)vinyl]-1,3-benzoldiol, I06-0437, SR-01000000163-3, SR-01000000163-4, SR-01000000163-9, 5-[(E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol, 5-[(E)-2-(4-Hydroxyphenyl)ethenyl]benzol-1,3-diol, 5-[(E)-2-(4-Hydroxyphenyl)vinyl]-1,3-benzenediol, 5[(E)-2-(4-Hydroxyphenyl)-vinyl]benzene 1,3-diol, BRD-K25591257-001-01-2, BRD-K80738081-001-06-2, BRD-K80738081-001-07-0, BRD-K80738081-001-09-6, BRD-K80738081-001-10-4, BRD-K80738081-001-23-7, SR-01000000163-10, SR-01000000163-11, SR-01000000163-16, (E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene, (E)1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol, Resveratrol, certified reference material, TraceCERT(R), 1,3-Benzenediol, 5-[(E)-2-(4-hydroxyphenyl)ethenyl]-, Resveratrol, European Pharmacopoeia (EP) Reference Standard, 533C1DA0-4104-42B5-9D32-9265F40857E4, trans-Resveratrol, United States Pharmacopeia (USP) Reference Standard, 3,4',5-Trihydroxy-trans-stilbene 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol, (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol(E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol, InChI=1/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1, trans-3,5,4'-Trihydroxystilbene3,4',5-Stilbenetrioltrans-Resveratrol(E)-5-(p-Hydroxystyryl)resorcinol(E)-5-(4-hydroxystyryl)benzene-1,3-diol


ID: 6

chemical graph of compound 6



InChIKey: OHCQJHSOBUTRHG-KGGHGJDLSA-N
SMILES: CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O

biological descriptors:

CFTR relevance: CFTR activator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Seo" "J Park" "AS Verkman" "W Namkung"
"SM Rowe" "D Skinner" "EJ Sorscher" "SB Hicks" "S Zhang" "BT Conger" "BA Woodworth"
"C Andersson" "GM Roomans" "Z Servetnyk"
"J Fortenberry" "SM Rowe" "PA Sloane" "J Collawn" "EJ Sorscher" "K Varga" "Y Li" "L Fan" "JP Clancy" "B Woodworth" "M Mazur" "A Jurkevante" "LC Pyle" "J Fulton"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 47936
synonyms found at PubChem are:
forskolin, Colforsin, 66575-29-9, Coleonol, colforsina, colforsine, colforsinum, Boforsin, Colforsine [French], Colforsinum [Latin], Colforsina [Spanish], Coleonolk, Colforsin [USAN:INN], UNII-1F7A44V6OU, 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one, EINECS 266-410-9, HL 362, NSC 357088, NSC 375489, Forskolin, Coleus forskohlii, CHEMBL52606, 1F7A44V6OU, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate, L 75 1362B, CHEBI:42471, HL-362, NSC375489, 64657-11-0, NCGC00024996-02, L-751362B, 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one, DSSTox_CID_20484, DSSTox_RID_79500, DSSTox_GSID_40484, Forsklin, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate, 66428-89-5, C22H34O7, ForsLean, 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxy-labd-14-en-11-one, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate, 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-, 1H-Naphtho(2,1-b)pyran-1-one, dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-, 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-, FOK, SMR000471881, CAS-66575-29-9, Ocufors, Timsaponin-C, Colforsin (USAN/INN), D0Y7VM, forskolin/ rolipram mixture, MolMap_000021, AC1L2J1R, AC1Q1L8K, SCHEMBL4928, 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, cid_47936, MLS001066384, MLS001333255, MLS001333256, MLS002172462, MLS002695942, Forskolin, analytical standard, Forskohlii Root Extract (ForsLean)(20% forskohlin), REGID_for_CID_47936, GTPL5190, DTXSID8040484, BCBcMAP01_000132, OHCQJHSOBUTRHG-KGGHGJDLSA-, AOB6380, BIF1031, MolPort-002-493-717, OHCQJHSOBUTRHG-KGGHGJDLSA-N, ZX-AFC000211, Bio1_000443, Bio1_000932, Bio1_001421, HMS2235C17, HMS3267I16, ZINC3977779, Tox21_110940, Tox21_302399, BDBM50010261, MFCD00082317, s2449, AKOS024456384, Tox21_110940_1, ACN-035218, AM81249, CS-1454, DB02587, LMPR0104030004, PXT0000105, SMP1_000128, NCGC00024996-03, NCGC00024996-04, NCGC00024996-05, NCGC00024996-06, NCGC00177971-03, NCGC00255526-01, 5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho(2,1-b)pyran-1-one, AS-17443, CC-28833, HY-15371, LS-95557, SC-47275, F0855, FT-0626543, V0151, Y0448, 7088-EP2280000A1, 7088-EP2284169A1, 7088-EP2287147A2, 7088-EP2287161A1, 7088-EP2287162A1, 7088-EP2287165A2, 7088-EP2287166A2, 7088-EP2292620A2, 7088-EP2295550A2, 7088-EP2301931A1, 7088-EP2301937A1, 7088-EP2308562A2, 7088-EP2311806A2, 7088-EP2371811A2, C09076, D03584, MLS-0318096.0001, S-7769, C-21901, SR-01000597378, Forskolin, For use in molecular biology applications, Q-200888, SR-01000597378-1, BRD-K09602097-001-04-5, Forskolin, from Coleus forskohlii, >=98% (HPLC), powder, Forskolin, United States Pharmacopeia (USP) Reference Standard, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate, [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate, [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate, [3R-(3?,4a?,5?,6?,6a?,10?,10a?,10b?)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, 1H-Naphtho[2,1-b]pyran-1-one,5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-, 72569-68-7, InChI=1/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1


ID: 7

chemical graph of compound 7



InChIKey: PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

biological descriptors:

CFTR relevance: CFTR stimulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"M Kissova" "C Mirabelli" "P Vergani" "S Bertoni" "G Tagliavini" "K Lanko" "S Tassini" "G Fontò" "S Palese" "L Delang" "A Mancini" "M Radi" "E Langron" "E Dreassi" "C Giorgio" "C Zamperini" "E Crespan" "F Ravanetti" "J Neyts" "G Maga" "L Ragionieri"
"JM Beekman" "CK van der Ent" "AM Vonk" "JF Dekkers" "P Van Mourik" "HR de Jonge" "I Bronsveld" "KM de Winter-de Groot" "G Berkers" "E Kruisselbrink" "HM Janssens"
"BB Stauffer" "JS Hong" "NA McCarty" "G Cui" "EJ Sorscher" "A Rab" "BR Imhoff"
"BB Stauffer" "N Khazanov" "H Senderowitz" "DT Infield" "NA McCarty" "G Cui" "BR Imhoff"
"E Sage" "F Becq" "L Froux" "C Coraux"
"I Loukou" "AG Kaditis" "A Petrocheilou"
"S Carson" "AT Claudio" "NE West" "N Lechtzin" "MS Christianson" "K Montemayor"
"X Zou" "K Conrath" "TC Hwang" "Y Sohma" "HI Yeh" "L Qiu"
"F Xuan" "SM Rowe" "CM McKee" "J Savage" "JL Taylor-Cousar" "E Tullis" "D Waltz" "EF McKone" "SM Moskowitz" "G Marigowda" "BW Ramsey" "MA Mall"
"A Tosco" "V Raia" "G Kroemer" "L Maiuri" "VR Villella" "M Piacentini"
"CA Loureiro" "JD Santos" "P Matos" "CM Farinha" "AM Matos" "P Jordan" "FR Pinto"
"WY Lin" "TC Hwang" "Y Sohma"
"J Simonin" "A Carsin" "N Stremler-Le Bel" "A Hinzpeter" "P Bonnette" "J Mazenq" "IM Pranke" "V Urbach" "A Hatton" "JP Jais" "I Sermet-Gaudelus" "A Edelman" "M Mesbahi" "E Girodon-Boulandet" "D Grenet" "M Thumerel" "M Fayon" "F Le Pimpec-Barthes"
"CK van der Ent" "C McKee" "A Moeller" "EP Ingenito" "J Lekstrom-Himes" "JS Elborn" "Y Lu" "C Simard" "JL Taylor-Cousar" "EF McKone" "LT Wang" "A Munck"
"W Wang" "JS Hong" "EJ Sorscher" "A Rab" "KL Kirk"
"B Burton" "J McCartney" "CJ Decker" "RA Frizzell" "KS Straley" "PD Grootenhuis" "JH Stack" "F Van Goor" "M Miller" "PA Negulescu" "S Hadida" "M Ashlock" "ER Olson" "JJ Wine"
"K Dejgaard" "Y Luo" "DY Thomas" "GW Carlile" "E Matthes" "R Robert" "A Billet" "JW Hanrahan" "J Goepp"
"CK van der Ent" "AC de Kiviet" "KM de Winter-de Groot" "HGM Heijerman" "MA Kruijswijk" "S Michel" "RW Hofland" "BL Aalbers" "HGM Arets" "S Schotman" "MMM van Oirschot-van de Ven"
"CA Flask" "B Kaminski" "SB Donnola" "K Kutney" "TJ Sferra" "K McBennett" "M O'Riordan" "R Gubitosi-Klug"
"C McKee" "CE Wainwright" "JC Davies" "M Higgins" "J Schneider" "S Cunningham" "D Campbell" "group. ARRIVAL study" "S Tian" "M Rosenfeld" "LT Wang"
"JA Lekstrom-Himes" "L Viswanathan" "M Griese" "JC Davies" "Group. VX11-661-101 Study" "SH Donaldson" "J Cooke" "JM Pilewski" "E Tullis" "LT Wang"


CID is 16220172
synonyms found at PubChem are:
Ivacaftor, 873054-44-5, VX-770, Kalydeco, Ivacaftor (VX-770), N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, VX 770, VX770, UNII-1Y740ILL1Z, Kalydeco (TN), CHEBI:66901, N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide, 1Y740ILL1Z, 3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-, Ivacaftor [USAN:INN], ivacaftorum, 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-, Ivacaftor D18, Tube715, Ivacaftor (USAN/INN), VX-770 - Ivacaftor, D0W7WC, MLS006011119, SCHEMBL351373, GTPL4342, QUI135, VX-770, Ivacaftor, Kalydeco, CHEMBL2010601, DTXSID00236281, EX-A441, QCR-155, MolPort-009-194-229, PURKAOJPTOLRMP-UHFFFAOYSA-N, BCPP000199, HMS3654E10, AOB31714, ABP000259, BDBM50032693, s1144, VX-770/VX770, ZINC52509463, AKOS015994762, AKOS032950001, BCP9000799, CS-0497, DB08820, EX-7211, LE-0002, KS-0000063W, NCGC00242480-01, 4CA-0661, AC-28324, AN-16981, BC660099, HY-13017, KB-81476, SC-95534, SMR004702900, AB0008116, AB2000007, FT-0696681, X7565, A25626, D09916, W-5681, AB01565806_02, VX770, VX 770, Ivacaftor, 873054-44-5, N-(2,4-ditert-butyl-5-hydroxy-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, 1134822-00-6, 1174930-71-2, 1413431-05-6, Kalydeco|||N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide


ID: 8

chemical graph of compound 8



InChIKey: RDOBOPJBMQURAT-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=C(C=CC(=C4)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

reference list:

"R Ferru-Clément" "C Boinot" "F Becq" "M Jollivet Souchet"
"E Caci" "K Du" "N Pedemonte" "O Zegarra-Moran" "AS Verkman" "GL Lukacs" "LJ Galietta"
"MC Bartlett" "DM Clarke" "TW Loo" "Y Wang"
"E Caci" "U Pfeffer" "V Tomati" "N Pedemonte" "AI Esposito" "LJ Galietta" "E Sondo"
"K Tarnowski" "G Faure" "G Wieczorek" "J Colas" "L Wiszniewski" "J Fritsch" "M Dadlez" "GL Lukacs" "P Melin-Heschel" "M Ollero" "EL Saussereau" "N Odolczyk" "N Servel" "H Herrmann" "S Bitam" "A Edelman" "MF da Cunha" "F Becq" "C Norez" "A Kupniewska" "D Tondelier" "A Roldan" "P Zielenkiewicz"
"J Fortenberry" "SM Rowe" "PA Sloane" "J Collawn" "EJ Sorscher" "K Varga" "Y Li" "L Fan" "JP Clancy" "B Woodworth" "M Mazur" "A Jurkevante" "LC Pyle" "J Fulton"


CID is 1144671
synonyms found at PubChem are:
Corr-4a, RDOBOPJBMQURAT-UHFFFAOYSA-N, 421580-53-2, ST075396, N-(2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, MLS000561131, Oprea1_189688, Oprea1_471654, SCHEMBL837666, CHEMBL260775, DTXSID00360737, MolPort-001-986-142, ZINC888741, AKOS001665304, MCULE-2724995336, BAS 02936954, KB-57187, SMR000156156, EU-0078205, MLS-0094194.0001, SR-01000492559, SR-01000492559-1, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2' -yl]-benzamide, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzami, N-[2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]benzamide, N-{2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, N-(5-{2-[(5-chloro-2-methoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thia zol-2-yl))benzamide


ID: 9

chemical graph of compound 9



InChIKey: KZNIFHPLKGYRTM-UHFFFAOYSA-N
SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function inconsistent assignment
Order of interaction unknown
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"E Kwon" "PL Zeitlin" "AD Floyd" "M Lim" "K McKenzie"
"MJ Kurth" "MH Nantz" "M Eda" "EJ Niedzinski" "MJ Haddadin" "AS Verkman" "MF Springsteel" "K By" "LJ Galietta"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5280443
synonyms found at PubChem are:
apigenin, 520-36-5, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Chamomile, Spigenin, Versulin, Apigenol, 4',5,7-Trihydroxyflavone, Apigenine, C.I. Natural Yellow 1, 5,7,4'-Trihydroxyflavone, Pelargidenon 1449, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone, 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone, UCCF 031, NSC 83244, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, UNII-7V515PI7F6, 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one, CCRIS 3789, CHEBI:18388, CHEMBL28, EINECS 208-292-3, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-, BRN 0262620, FLAVONE, 4',5,7-TRIHYDROXY-, 4′,5,7-Trihydroxyflavone, KZNIFHPLKGYRTM-UHFFFAOYSA-N, 7V515PI7F6, NSC83244, NSC-83244, CAS-520-36-5, ST056301, DSSTox_CID_2391, DSSTox_RID_76568, DSSTox_GSID_22391, Q-100586, Q-200822, SMR000326850, SR-01000075663, Chamomile Powder, HSDB 7573, 4der, 4dgm, 4hkk, Naringenin, 18, Prestwick_719, Apigenin, 13, PubChem9831, Tocris-1227, 3cf9, 4',7-Trihydroxyflavone, BiomolKI_000078, Prestwick0_000414, Prestwick1_000414, Prestwick2_000414, Prestwick3_000414, Spectrum2_000428, Spectrum3_001882, Spectrum4_001999, Lopac-A-3145, BiomolKI2_000082, D00RIX, 4,5, 7-Trihydroxyflavone, AC1NQX15, Lopac0_000065, Oprea1_622293, SCHEMBL19428, 4',5,7-trihydroxy-Flavone, Apigenin, analytical standard, BSPBio_000368, BSPBio_003384, KBioGR_002565, SPECTRUM200846, 5-18-04-00574 (Beilstein Handbook Reference), MLS000697626, MLS000859991, MLS001074874, MLS006011839, BIDD:ER0135, DivK1c_000798, SCHEMBL222227, SPBio_000416, SPBio_002307, ghl.PD_Mitscher_leg0.1194, BDBM7458, BPBio1_000406, GTPL4136, MEGxp0_000176, DTXSID6022391, ACon1_002450, cid_5280443, HMS502H20, KBio1_000798, KBio3_002887, BIK9018, OR7265T, MolPort-001-740-354, NINDS_000798, ZX-AFC000435, Bio1_000376, Bio1_000865, Bio1_001354, HMS1569C10, HMS1922P22, HMS2096C10, HMS2230D17, HMS3260M11, HMS3267D21, HMS3373B18, HMS3561P09, HMS3655D18, Apigenin, >=95.0% (HPLC), 4',5,7-Trihydroxyflavone, 97%, ACN-S003241, BCP28288, HY-N1201, ZINC3871576, ZX-AT019281, Tox21_201542, Tox21_302884, Tox21_500065, Apigenin; 4',5,7-Trihydroxyflavone, BBL010499, BS0030, CCG-40061, GP1532, HSCI1_000221, LMPK12110005, MFCD00006831, s2262, SBB066087, STK801630, AKOS002140699, AC-8011, ACN-034762, AN-8432, CS-5432, DB07352, EBD2138579, LP00065, LS-2209, MCULE-6141069907, ND-9076, SDCCGMLS-0066379.P001, TRA0067512, IDI1_000798, SMP2_000338, Apigenin, >=97% (TLC), from citrus, NCGC00015049-01, NCGC00015049-02, NCGC00015049-03, NCGC00015049-04, NCGC00015049-05, NCGC00015049-06, NCGC00015049-07, NCGC00015049-08, NCGC00015049-09, NCGC00015049-10, NCGC00015049-11, NCGC00015049-12, NCGC00015049-13, NCGC00015049-14, NCGC00015049-15, NCGC00015049-16, NCGC00015049-18, NCGC00025057-01, NCGC00025057-02, NCGC00025057-03, NCGC00025057-04, NCGC00025057-05, NCGC00025057-06, NCGC00025057-07, NCGC00025057-08, NCGC00025057-09, NCGC00169835-01, NCGC00169835-02, NCGC00169835-03, NCGC00256419-01, NCGC00259092-01, NCGC00260750-01, 4CN-0925, AJ-46351, AK-88794, CC-24158, CJ-10995, KB-78227, NCI60_041830, SC-05011, SY005957, TS-00897, AB0010536, AB1011450, AX8015784, LY 080400, ST2411642, TC-307820, TR-018510, EU-0100065, FT-0622445, FT-0623582, N1828, 20A365, A 3145, C01477, J10341, K00045, M-6923, Apigenin, >=97% (TLC), from parsley, powder, Biochem Biophys Res Comm 212: 767 (1997), 4 inverted exclamation marka,5,7-Trihydroxyflavone, 5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one, Apigenin, primary pharmaceutical reference standard, C-16977, 4 inverted exclamation mark ,5,7-trihydroxyflavone, I06-0221, SR-01000075663-1, SR-01000075663-3, SR-01000075663-7, SR-01000075663-8, BRD-K01493881-001-10-4, BRD-K01493881-001-17-9, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one #, 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-hydroxyphenyl)-, D50A2D8A-6D8B-4708-B21E-2DE9580D033F, Apigenin, United States Pharmacopeia (USP) Reference Standard, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- (9CI), 461015-54-3, 8002-66-2


ID: 10

chemical graph of compound 10



InChIKey: OBKXEAXTFZPCHS-UHFFFAOYSA-M
SMILES: C1=CC=C(C=C1)CCCC(=O)[O-]

biological descriptors:

CFTR relevance: little or no effect

Category:
Influence on CFTR function likely enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"D Salinas" "N Pedemonte" "L Qian" "Y Song" "AS Verkman" "ND Sonawane" "LJ Galietta"
"E Kwon" "PL Zeitlin" "AD Floyd" "M Lim" "K McKenzie"
"T Neuberger" "P Negulescu" "KS Straley" "T Knapp" "PD Grootenhuis" "JH Stack" "J Rader" "F Van Goor" "J Joubran" "M Miller" "S Hadida" "V Panchenko" "LR Makings" "D Cao" "R Tung" "J González" "E Olson" "A Singh" "A Hazlewood"
"C Andersson" "GM Roomans" "Z Servetnyk"


CID is 22053264
synonyms found at PubChem are:
4-phenylbutanoate, 4-Phenylbutyric acid anion, BDBM36184, CHEBI:75317, OBKXEAXTFZPCHS-UHFFFAOYSA-M, AKOS024437455, CJ-00370, ZB001717, J3.540.463E, AB01275463-01, AB01275463_02, A812651


ID: 11

chemical graph of compound 11



InChIKey: WBSMIPAMAXNXFS-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)CCCNC2=C(C=C(C=C2)[N+](=O)[O-])C(=O)O

biological descriptors:

CFTR relevance: CFTR activator

Category:
Influence on CFTR function inconsistent assignment
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"BB Stauffer" "JS Hong" "NA McCarty" "G Cui" "EJ Sorscher" "A Rab" "BR Imhoff"
"BB Stauffer" "N Khazanov" "H Senderowitz" "DT Infield" "NA McCarty" "G Cui" "BR Imhoff"
"G Wang"
"WY Lin" "TC Hwang" "Y Sohma"
"W Wang" "K Bernard" "KL Kirk" "G Li"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 4549
synonyms found at PubChem are:
NPPB, 5-Nitro-2-(3-phenylpropylamino)benzoic acid, 107254-86-4, UNII-3A35O9G3YZ, 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid, 3A35O9G3YZ, CHEBI:34457, HOE 144, HOE-144, Benzoic acid,5-nitro-2-[(3-phenylpropyl)amino]-, Benzoic acid, 5-nitro-2-((3-phenylpropyl)amino)-, IN1196, 5-NITRO-2-(3-PHENYLPROPYLAMINO)-BENZOIC ACID, 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB], 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB), SR-01000075336, Spectrum_001814, Tocris-0593, ACMC-20c9kv, AC1L1IEV, Spectrum2_001477, Spectrum3_001518, Spectrum4_000338, Spectrum5_001244, Lopac-N-4779, (NPPB), D08DQL, D0HW9P, UPCMLD-DP143, CBiol_001838, Lopac0_000857, BSPBio_001423, BSPBio_003195, KBioGR_000715, KBioSS_002311, MLS000859983, DivK1c_000619, SCHEMBL159244, SPBio_001433, AC1Q20U0, GTPL4270, CHEMBL1256759, UPCMLD-DP143:001, UPCMLD-DP143:002, CTK4A5098, HMS501O21, KBio1_000619, KBio2_002309, KBio2_004877, KBio2_007445, KBio3_002695, DTXSID90147978, MolPort-003-959-000, NINDS_000619, WBSMIPAMAXNXFS-UHFFFAOYSA-N, Bio1_000124, Bio1_000613, Bio1_001102, HMS1791H05, HMS1989H05, HMS2235P03, HMS3262L15, HMS3266O16, HMS3373B17, HMS3402H05, ZINC3873822, Tox21_500857, BN0393, CCG-39187, MFCD00153851, AKOS024458574, CS-8179, LP00857, IDI1_000619, NCGC00015740-01, NCGC00015740-02, NCGC00015740-03, NCGC00015740-04, NCGC00015740-05, NCGC00015740-06, NCGC00015740-07, NCGC00015740-08, NCGC00015740-09, NCGC00015740-10, NCGC00024671-01, NCGC00024671-02, NCGC00024671-03, NCGC00024671-04, NCGC00024671-05, NCGC00024671-06, NCGC00024671-07, NCGC00024671-08, NCGC00261542-01, SMR000326842, Brit J Pharmacol 117: 175 (1996), HY-101012, LS-186884, LS-187538, RT-010388, 2-PHENPROPYLAMINO-5-NITROBENZOIC ACID, 5 nitro 2 (3 phenylpropylamino)benzoic acid, B6367, EU-0100857, X6841, 5-nitro-2-(3-phenylpropylamino) benzoic acid, 5-Nitro-2-(3'-phenylpropyl-amino)benzoic acid, 5-Nitro-2-(3-phenyl-propylamino)-benzoic acid, C13705, N 4779, J-001745, SR-01000075336-1, SR-01000075336-3, 5-Nitro-2-(3-phenylpropylamino)benzoic acid, >=98%, BRD-K89272762-001-02-8, BRD-K89272762-001-04-4, BRD-K89272762-001-07-7


ID: 12

chemical graph of compound 12



InChIKey: WMBWREPUVVBILR-WIYYLYMNSA-N
SMILES: C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

biological descriptors:

CFTR relevance: CFTR activator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

reference list:

"S Esposito" "G Kroemer" "S Lusa" "L Salvadori" "MC Maiuri" "F De Gregorio" "E Ferrari" "G Bona" "A Di Pasqua" "S Guido" "A Tosco" "CA Leone" "V Raia" "I Sana" "A Sepe" "L Maiuri" "P Buonpensiero" "G De Rosa" "G Stoll" "A Mehta" "D De Stefano" "R Grassia"
"L Zhu" "L Chen" "T Ma" "X Gao" "H Yang" "B Yu" "Y Zhang"
"S Esposito" "G Kroemer" "L Salvadori" "A Zolin" "A Bossi" "MC Maiuri" "VR Villella" "F De Gregorio" "LA Pinna" "G Bona" "S Guido" "A Tosco" "CA Leone" "V Raia" "A Sepe" "L Maiuri" "M Pettoello-Mantovani" "G De Rosa" "A Venerando" "A Mehta" "D De Stefano" "R Grassia"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 65064
synonyms found at PubChem are:
(-)-Epigallocatechin gallate, EGCG, Epigallocatechin gallate, 989-51-5, Epigallocatechin 3-gallate, Epigallocatechin-3-gallate, Tea catechin, (-)-Epigallocatechin-3-o-gallate, Teavigo, (-)-Epigallocatechol gallate, Epigallocatechin-3-monogallate, (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate, Catechin deriv., UNII-BQM438CTEL, Green tea extract, CCRIS 3729, (-)-epigallocatechin 3-gallate, C22H18O11, BQM438CTEL, CHEBI:4806, CHEMBL297453, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, WMBWREPUVVBILR-WIYYLYMNSA-N, Epigallocatechol, 3-gallate, (-)-, (-)-Epigallocatechin gallate (EGCG), [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate, DSSTox_CID_567, DSSTox_RID_78830, DSSTox_GSID_29889, Sunphenon, [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate, EGCG cpd, (-)-Epigallocatechin gallate (85% (-)-epigallocatechin gallate, 10% (-)-epigallocatechin, 5% (-)- epicatechin gallate), (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol-3-(3,4,5-trihydroxybenzoate), CAS-989-51-5, SMR000449288, epigallo-catechin gallate, SR-01000759328, L-Epigallocatechin gallate, PF-EGCg 90, Epigallocate, NVP-XAA 723, (-)-EGCG, Epigallocic acid, Teavigo;, EGCG analogs, GTPs,Anagen, 2kdh, 3oob, 4awm, EGCG, Anagen, KDH, Epigallocatcchin Gallate, Spectrum_000316, SpecPlus_000277, Spectrum2_000168, Spectrum3_000244, Spectrum4_001541, Spectrum5_000102, Galloyl-L-epigallocatechol, D0E9DB, D0U2BH, AC1L22IG, AC1Q5X0Z, (-)-Epigallocatechin gallat, (-)-Epigallocatehin gallate, SCHEMBL35258, BSPBio_001628, KBioGR_002002, KBioSS_000796, SPECTRUM210239, cid_65064, EPIGALOCATECHIN GALLATE, MLS000758300, MLS001424000, DivK1c_006373, Green tea polyphenols, Anagen, SPBio_000035, Epigallocatechin gallate(EGCG), Epigallocatechin monogallate, B, GTPL7002, MEGxp0_001166, Epigallocatechin gallate, Anagen, DTXSID1029889, ACon1_001054, KBio1_001317, KBio2_000796, KBio2_003364, KBio2_005932, KBio3_001128, AOB2839, (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, EGCG solution, 20 mM in DMSO, MolPort-001-741-358, (-)-EpigallocatechinGallateHydrate, HMS2051K21, HMS3649E08, ZINC3870412, Tox21_201468, Tox21_303457, BDBM50070942, CCG-38378, FR-109, LMPK12030005, MFCD00075940, s2250, AKOS015918182, ACN-035233, CS-1258, DB12116, DS-9030, EBD2138593, LS-2197, MCULE-3341525983, MCULE-7760530136, NC00078, SDCCGMLS-0066550.P001, (-)-Epigallocatechin gallate, >=95%, Epigallocatechin gallate analogs, Anagen, KS-0000132O, NCGC00164319-01, NCGC00164319-02, NCGC00164319-03, NCGC00164319-04, NCGC00164319-06, NCGC00257243-01, NCGC00259019-01, AN-15867, BP-30205, CPD000449288, HY-13653, K791, SAM001247031, SC-47284, ST097428, AB0014381, KB-206444, E0694, FT-0082796, FT-0604392, N1874, C09731, W-5069, (-)-Epigallocatechin gallate, >=97.0% (HPLC), (-)-Epigallocatechin gallate, analytical standard, 989E515, Epigallocatechin Gallate solution, 20 mM in DMSO, Gallic acid, 3-ester with epigallocatechol, (-)-, SR-01000946601, epigallocatechin-3-gallate solution, 20 mM in DMSO, I14-7747, Q-100914, SR-01000759328-5, SR-01000759328-6, SR-01000946601-1, (-)-EPIGALLOCATECHIN GALLATE (GREEN TEA EXTRACT), (-)-Epigallocatechin Gallate solution, 20 mM in DMSO, (-)-cis-3,3',4',5,5',7-Hexahydroxy-flavane-3-gallate, ANTIOXIDANT MODEL (TRAMP) -EPIGALLOCATECHIN GALLATE, UNII-T432289GYZ component WMBWREPUVVBILR-WIYYLYMNSA-N, (-)-Epigallocatechin gallate, >=80% (HPLC), from green tea, (-)-Epigallocatechin Gallate, disposable screening library format, Epigallocatechin gallate, primary pharmaceutical reference standard, (-)-Epigallocatechin-3-O-gallate, United States Pharmacopeia (USP) Reference Standard, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxyb enzoate, [5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 2,3,4-trihydroxybenzoate, Epigallocatechin gallate, Pharmaceutical Secondary Standard; Certified Reference Material, (-)-cis-3,4-Dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2H)-benzopyran-3-yl Gallate, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate, (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl-3,4,5-trihydroxybenzoate, 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, 3,4-Dihydro-5,7-dihydroxy-2R-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3R-yl-3,4,5-trihydroxybenzoate, 863-65-0, Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, (2R-cis)-, Benzoic acid, 3,4,5-trihydroxy-,(2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester


ID: 13

chemical graph of compound 13



InChIKey: BNRNXUUZRGQAQC-UHFFFAOYSA-N
SMILES: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "SM Anjos" "JW Hanrahan" "J Liao" "N Liu" "C Pavel" "D Zhang"
"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5212
synonyms found at PubChem are:
sildenafil, 139755-83-2, Revatio, VIAGRA, Sildenafil [INN:BAN], UK-92480, UNII-3M7OB98Y7H, Aphrodil (TN), Sildenafil (INN), UK-92,480-10, C22H30N6O4S, HSDB 7305, CHEMBL192, 3M7OB98Y7H, CHEBI:9139, UK 92480-10, 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine, BNRNXUUZRGQAQC-UHFFFAOYSA-N, Caverta, 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, NCX-911, Revatio (TN), Viagra (TN), 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-(ethyloxy)-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, Piperazine, 1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-, SMR000752512, 171599-83-0 (citrate), SR-05000001934, NCGC00159496-02, mysildecard, Aphrodil, Vizarsin, Rhucin, Sildenafil#, 1udt, 1xos, 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo(4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, Rhucin (TN), Spectrum_001555, SpecPlus_000798, AC1L1JUI, Spectrum2_001648, Spectrum3_001892, Spectrum4_000586, Spectrum5_001508, D08KTT, D0Z7ZM, Cambridge id 7030299, SCHEMBL1895, BSPBio_003424, KBioGR_001052, KBioSS_002035, MLS001240224, MLS001304737, MLS006011565, BIDD:GT0352, DivK1c_006894, SPECTRUM1504099, SPBio_001775, GTPL4743, SCHEMBL5795456, SCHEMBL8100377, Jsp002373, DTXSID6023579, BDBM14390, KBio1_001838, KBio2_002035, KBio2_004603, KBio2_007171, KBio3_002927, KS-00000XMX, 2h42, MolPort-002-885-861, HMS1684K08, HMS1922B19, HMS2089M12, HMS2093O17, HMS2233L22, HMS3372N07, HMS3715P17, Sildenafil 1.0 mg/ml in Methanol, ACT02662, BCP05337, AC-938, CCG-21806, CCG-39076, s4684, STL483201, STL483720, ZINC19796168, AKOS008901403, AKOS025397193, CS-1577, DB00203, MCULE-2481702478, NCGC00095099-01, NCGC00095099-02, NCGC00095099-03, NCGC00095099-04, NCGC00370976-03, 5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, AN-15436, AS-48884, BAS 04213629, BC202768, HY-15025, M901, SC-83326, SMR004703325, SBI-0051920.P002, AB0015440, LS-111655, FT-0601554, C07259, D08514, W-2194, AB00052444-02, AB00052444-03, AB00052444_04, AB00052444_05, 755S832, SR-01000504734, I06-0023, J-007309, SR-01000504734-1, SR-05000001934-1, SR-05000001934-2, BRD-K50128260-001-01-6, BRD-K79759585-001-02-1, BRD-K79759585-048-01-4, 4-((4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydr, Z1522567175, Sildenafil solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, 5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (Sildenafil or Viagra), 5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one(Sildenafil), 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-Ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-Ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1-methyl-3-n-propyl-1.6-dihydro-7H-pyrazolo[4,3-d]Pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazine-1-sulfonyl)phenyl]-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one


ID: 14

chemical graph of compound 14



InChIKey: FFBDFADSZUINTG-UHFFFAOYSA-N
SMILES: CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3

biological descriptors:

CFTR relevance: CFTR activator

Category:
Influence on CFTR function inconsistent assignment
Order of interaction unknown
subcellular compartment unknown

reference list:

"JL Teem" "A Tsopmo" "AC deCarvalho" "JD Connolly" "CP Ndi" "J Ayafor" "P Tane"
"E Caci" "P Fanen" "JM Vierfond" "F Becq" "L Romio" "Y Mettey" "O Zegarra-Moran" "C Folli" "G Cabrini" "LJ Galietta"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 1329
synonyms found at PubChem are:
8-Cyclopentyl-1,3-dipropylxanthine, DPCPX, 102146-07-6, 8-cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione, 1,3-Dpcpx, 1,3-dipropyl-8-cyclopentylxanthine, PD-116,948, PD-116948, GNF-PF-2224, UNII-9PTP4FOI9E, dipropylcyclopentylxanthine, 9PTP4FOI9E, CHEMBL183, MLS000069347, 8-Cyclopentyl-3,7-dihydro-1,3-dipropyl-1H-purin-2,6-dione, CHEBI:73282, 8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione, SMR000058434, DPCPX, 1,3-Dipropyl-8-cyclopentylxanthine, 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX], 8-cyclopentyl-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione, 8-Cyclopentyl-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione, 1H-Purine-2,6-dione, 8-cyclopentyl-3,7-dihydro-1,3-dipropyl-, PD 116948, Spectrum_000271, Tocris-0439, Opera_ID_160, Lopac-C-101, Spectrum2_001808, Spectrum3_001073, Spectrum4_001228, Spectrum5_001887, [DPCPX], D0K0OT, D0OW4Q, AC1L1B8K, Lopac0_000381, BSPBio_002686, GTPL386, KBioGR_001696, KBioSS_000751, MLS001076525, DivK1c_000177, SCHEMBL382422, SPECTRUM2300063, SPBio_001795, SCHEMBL1094807, SCHEMBL12648692, BCBcMAP01_000212, BDBM21173, CTK8B4471, HMS500I19, KBio1_000177, KBio2_000751, KBio2_003319, KBio2_005887, KBio3_001906, DTXSID50144706, OR9885T, FFBDFADSZUINTG-UHFFFAOYSA-N, MolPort-003-666-763, NINDS_000177, HMS2235C14, HMS3261M03, HMS3266O21, HMS3369D05, ZINC3977757, ZX-AT022179, DPCPX; PD 116,948, Tox21_500381, ANW-45129, CCG-39732, PDSP1_000448, PDSP1_001208, PDSP2_000446, PDSP2_001192, AKOS015900114, AKOS024458134, CCG-221685, DB12946, EX-3308, LP00381, VZ31021, IDI1_000177, KS-0000186U, NCGC00015177-01, NCGC00015177-02, NCGC00015177-03, NCGC00015177-04, NCGC00015177-05, NCGC00015177-06, NCGC00015177-07, NCGC00015177-08, NCGC00015177-09, NCGC00015177-10, NCGC00015177-11, NCGC00023294-02, NCGC00023294-04, NCGC00023294-05, NCGC00023294-06, NCGC00023294-07, NCGC00261066-01, AJ-47554, AK-88727, CC-23366, KB-53263, PD116948, SC-91856, 8-Cyclopentyl-1,3-dipropylxanthine, solid, AX8008808, LS-126534, ST2406601, B6305, EU-0100381, FT-0621530, X8593, C13709, C-18978, L000233, SR-01000003000, SR-01000075202, SR-01000003000-2, SR-01000075202-1, W-200660, BRD-K01824921-001-02-9, BRD-K01824921-001-10-2, I14-10012, 8-Cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H);-dione, 8-cyclopentyl-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione


ID: 15

chemical graph of compound 15



InChIKey: FLJBLCAZPFDCPE-UHFFFAOYSA-O
SMILES: C1=CC2=CC(=O)C3=C([NH+]2C=C1)C(=CC=C3)Cl

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function inconsistent assignment
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"PO Strale" "S Noël" "H DeJonge" "F Becq" "Y Mettey" "C Rogier" "L Dannhoffer" "M Wilke"
"E Caci" "P Fanen" "JM Vierfond" "F Becq" "L Romio" "Y Mettey" "O Zegarra-Moran" "C Folli" "G Cabrini" "LJ Galietta"
"E Nicolis" "M Colombatti" "R Gambari" "A Vella" "M Borgatti" "BM Assael" "F Becq" "I Mancini" "Y Mettey" "MC Dechecchi" "V Bezzerri" "G Cabrini"


CID is 9795308
synonyms found at PubChem are:
CHEMBL175225, SCHEMBL5738619, CHEMBL1181524, BDBM50139822, 10-Chloro-6-hydroxy-pyrido[1,2-a]quinolinylium; chloride, MPB-07


ID: 16

chemical graph of compound 16



InChIKey: JWZZKOKVBUJMES-UHFFFAOYSA-N
SMILES: CC(C)NCC(C1=CC(=C(C=C1)O)O)O

biological descriptors:

CFTR relevance: stimulates Cl- conductance as agonist of β2 adrenergic receptor

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"SH Randell" "MR Knowles" "BR Grubb" "SE Gabriel" "RC Boucher" "ML Drumm" "M Gentzsch" "A Mengos" "JR Riordan" "AM Van Heeckeren"
"S Noel" "T Leal" "P Wallemacq" "C Bouckaert" "A Capron" "B Dhooghe"


CID is 3779
synonyms found at PubChem are:
isoproterenol, Isoprenaline, Isoprenalin, Norisodrine, Novodrin, Isopropydrin, Isopropylarterenol, Asiprenol, Assiprenol, Bellasthman, Respifral, Aludrin, Aludrine, Asmalar, Isadrine, N-Isopropylnoradrenaline, Bronkephrine, Isonorene, Isopropyladrenaline, Lomupren, Neodrenal, Proternol, N-Isopropylnorepinephrine, Isopropylnorepinephrine, 7683-59-2, neo-Epinine, Isonorin, Isorenin, Saventrine, Isopropylnoradrenaline, Isopropyl noradrenaline, Racemic isoprenaline, dl-Isadrine, Isuprel, Racemic isoproterenol, (+-)-Isoproterenol, Vapo-N-iso, Epinephrine isopropyl homolog, Isoprenalinum, Isoproterenolum, Aleudrine, Isupren, (+-)-Isoprenaline, dl-Ipr, Isoprenalina, Isadrin, Isoproterenol [JAN], Dihydroxyphenylethanolisopropylamine, WIN 5162, DL(+-)-Isoproterenol, Medihaler-ISO, dl-Isopropylnoradrenaline, DL-Isopropylnorepinephrine, dl-N-Isopropylnoradrenaline, Isoprenalinum [INN-Latin], Isoprenalina [INN-Spanish], Isoproterenol Chloride, 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol, ICI 46399, l-Isoproterenol, d-Isoprenaline, d-Isoproterenol, alpha-(Isopropylaminomethyl)protocatechuyl alcohol, Isuprel Mistometer, N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine, (S)-Isoproterenol, (+)-Isoprenaline, d-Isopropylarterenol, Aleudrin, 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol, Isoprenaline (INN), ISOPROP, CCRIS 3081, 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol, l-Isopropylnoradrenaline, NSC 9975, EINECS 231-687-7, NSC 33791, (S)-(+)-Isoproterenol, Isoproterenol sulfate, Isopropylaminomethyl-3,4-dihydroxyphenyl carbinol, CHEMBL434, d-N-Isopropylnorepinephrine, 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, BRN 2213857, 3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol, 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol, CHEBI:64317, 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, JWZZKOKVBUJMES-UHFFFAOYSA-N, (S)-Isoprenaline, Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol, NSC33791, (+)-Isoproterenol, Isoprenaline [INN], Protocatechuyl alcohol, alpha-(isopropylaminomethyl)-, DL-ISOPROTERENOL, NCGC00015558-06, 3,4-Dihydroxy-.alpha.-(isopropylaminomethyl)-benzyl alcohol, Protocatechuyl alcohol,-, Isoprenaline sulfate, Isuprel (TN), DSSTox_CID_3175, 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (+-)-, BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((ISOPROPYLAMINO)METHYL)-, (+-)-, DSSTox_RID_76904, DSSTox_GSID_23175, 149-53-1, .alpha.-(Isopropylaminomoethyl)protocatechuyl alcohol, 4-(1-Hydroxy-2(isopropylamino)ethyl)-benzene 1,2-diol, 4-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol, 3,4-dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol, WLN: QR BQ DYQ1MY1&1, 3,4-Dihydroxy-.alpha.-[(isopropylamino)methyl]benzyl alcohol, 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol, Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-, CAS-7683-59-2, 1, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, 4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol, 4-{1-hydroxy-2-[(methylethyl)amino]ethyl}benzene-1,2-diol, Benzyl alcohol,4-dihydroxy-.alpha.-[(isopropylamino)methyl]-, Isoproterenol-l, Isoproterenol;, Isoprenalinesulphate, Isoproterenol (-), Isoproterenol,(+), DL-isoprenaline HCl, ISOPROTERONOL, Isuprel (Salt/Mix), Izadrin (Salt/Mix), Euspiran (Salt/Mix), (+/-)-isoprenaline, (+/-)-isoproterenol, Spectrum_000949, AC1L1GOZ, AC1Q1QBS, 6700-39-6, Prestwick0_001097, Prestwick1_001097, Prestwick2_001097, Spectrum2_001061, Spectrum3_000474, Spectrum4_000024, Spectrum5_000880, (.+/-.)-Isoprenaline, (.+/-.)-Isoproterenol, D0I8FI, D0IF0C, D0P1IS, SCHEMBL4165, DL(.+/-.)-Isoproterenol, Lopac0_000711, Oprea1_009434, BSPBio_002208, GTPL536, KBioGR_000427, KBioSS_001429, 3-13-00-02387 (Beilstein Handbook Reference), DivK1c_000894, SPBio_001042, SPBio_003057, SGCUT00015, BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((ISOPROPYLAMINO)METHYL)-, (+)-, DTXSID4023175, BDBM25392, KBio1_000894, KBio2_001429, KBio2_003997, KBio2_006565, KBio3_001428, NSC9975, NINDS_000894, HMS2089A12, BCP09043, NSC-9975, to_000062, (A+/-)-Isoproterenol hydrochloride, Tox21_110172, AS1409, NSC-33791, PDSP1_001425, PDSP2_001409, SBB005855, AKOS015913894, Tox21_110172_1, API0006523, CCG-204727, CCG-204796, DB01064, MCULE-6061231962, IDI1_000894, NCGC00015558-04, NCGC00015558-05, NCGC00015558-07, NCGC00015558-08, NCGC00015558-09, NCGC00015558-10, NCGC00015558-11, NCGC00015558-12, NCGC00015558-14, NCGC00016665-02, NCGC00025274-03, NCGC00025274-04, NCGC00162220-01, LS-42866, LS-42868, LS-42869, ST077771, SBI-0050689.P004, FT-0724367, C07056, D08090, EN300-148243, AB00053487-09, AB00053487-10, AB00053487_11, AB00053487_12, 683I592, alpha-(Isopropylaminomoethyl)protocatechuyl alcohol, L000936, .alpha.-(Isopropylaminomethyl)protocatechuyl alcohol, I14-45263, Protocatechuyl alcohol,.alpha.-(isopropylamino-methyl),-, 3,4-dihydroxy-alpha-[(isopropylamino)methyl]-benzyl alcohol, 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol #, N-Isopropyl-.beta.-dihydroxyphenyl-.beta.-hydroxyethylamine, 4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;hydrochloride, 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol, 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol, 2, Benzyl alcohol, 3,4-dihydroxy-.alpha.-((isopropylamino)methyl)-, 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)- (9CI), 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-(9CI), 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)-, 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)-(9CI), 46388-38-9


ID: 17

chemical graph of compound 17



InChIKey: LUKBXSAWLPMMSZ-UPHRSURJSA-N
SMILES: C1=CC(=CC=C1/C=C\C2=CC(=CC(=C2)O)O)O

biological descriptors:

CFTR relevance: CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment Apical membrane & subapical compartment

reference list:

"CM McNicholas" "M Chestnut" "DF Skinner" "EJ Sorscher" "JC Kappes" "S Zhang" "BA Woodworth" "AC Blount"
"A Aissat" "A Edelman" "J Colas" "N Hamdaoui" "M Kelly" "M Baudoin-Legros" "J Fritsch" "G Planelles" "DL Vieu" "S Moriceau"
"Y Jai" "NA Bradbury" "RJ Bridges" "K Shah"


CID is 1548910
synonyms found at PubChem are:
cis-resveratrol, (Z)-resveratrol, 61434-67-1, Cis resveratrol, Resveratrol, (Z)-, UNII-AUA0K06FSB, cis-3,4',5-trihydroxystilbene, AUA0K06FSB, CHEMBL87333, CHEBI:36002, 5-[(Z)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol, 5-[(Z)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol, 5-[(1Z)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol, 1,3-Benzenediol, 5-((1Z)-2-(4-hydroxyphenyl)ethenyl)-, Resveratrol (Z)-form [MI], Z-Resveratrol, Resveratrol, Z-, NCGC00015894-02, CAS-501-36-0, Tocris-1418, AC1LU7HY, Lopac-R-5010, cis-3,4,5-Trihydroxystilbene, SCHEMBL1931746, cis-3,5,4'-trihydroxystilbene, LUKBXSAWLPMMSZ-UPHRSURJSA-, (Z)-3,4',5-trihydroxystilbene, (Z)-3,5,4'-trihydroxystilbene, 4q93, MolPort-003-850-143, TNP00294, 1684AH, BDBM50131698, ZINC12353732, AKOS025395422, NCGC00015894-01, NCGC00017352-01, NCGC00017352-02, NCGC00017352-03, NCGC00017352-04, NCGC00024003-02, AC-24235, CJ-13797, DB-072954, 434C671, I14-7425, Z-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol, cis-5-[2-(4-Hydroxyphenyl)ethenyl]benzene-1,3-diol, 05F9DB2A-D7E6-4063-8E5B-F7842CF74A5E, 5-[(1Z)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol, InChI=1/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1-


ID: 18

chemical graph of compound 18



InChIKey: REFJWTPEDVJJIY-UHFFFAOYSA-N
SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

biological descriptors:

CFTR relevance: CFTR activator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"C Azbell" "SM Rowe" "N Smith" "EJ Sorscher" "S Zhang" "BA Woodworth" "D Schuster"
"E Kwon" "PL Zeitlin" "AD Floyd" "M Lim" "K McKenzie"


CID is 5280343
synonyms found at PubChem are:
quercetin, 117-39-5, Meletin, Sophoretin, Quercetine, Xanthaurine, Quercetol, Quercitin, Quertine, 3,3',4',5,7-Pentahydroxyflavone, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one, Flavin meletin, Cyanidelonon 1522, T-Gelb bzw. grun 1, 3,5,7,3',4'-Pentahydroxyflavone, C.I. Natural Yellow 10, Quercetin content, Kvercetin, Quertin, C.I. Natural red 1, Kvercetin [Czech], Natural Yellow 10, C.I. 75670, CI Natural Yellow 10, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3',4',5,7-Tetrahydroxyflavan-3-ol, 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, C.I. Natural yellow 10 & 13, CCRIS 1639, HSDB 3529, Flavone, 3,3',4',5,7-pentahydroxy-, NCI-C60106, UNII-9IKM0I5T1E, NSC 9219, 3',4',5,7-tetrahydroxyflavon-3-ol, 3,5,7-Trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-on, Cyanidenolon 1522, CHEBI:16243, AI3-26018, NSC9219, CHEMBL50, EINECS 204-187-1, MixCom3_000183, BRN 0317313, C.I . natural yellow 10, 9IKM0I5T1E, CI 75670, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one, 2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-one, REFJWTPEDVJJIY-UHFFFAOYSA-N, KUC104418N, KUC107684N, 3,3',4,5,7-Pentahydroxyflavone, LIM-5662, LNS-5662, NSC-9219, TNP00070, TNP00089, KSC-23-76, KSC-10-126, P0042, DSSTox_CID_1218, Q 0125, DSSTox_RID_76017, DSSTox_GSID_21218, 74893-81-5, QUE, CU-01000012502-3, Q-200333, BRD9794, 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one, BRD-9794, CAS-117-39-5, NSC57655, NSC58588, SR-01000076098, Ritacetin, Quer, 4dfu, 4mra, Quercetin_sathishkumar, Quercetin (Sophoretin), Quercetin - Sophoretin, Spectrum_000124, Tocris-1125, 3cf8, AC1NQWX8, BiomolKI_000062, 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, zirconium(2+) salt (1:1), Maybridge1_008992, Prestwick0_000507, Prestwick1_000507, Prestwick2_000507, Prestwick3_000507, Spectrum2_000059, Spectrum3_000642, Spectrum4_000807, Spectrum5_001389, Lopac-Q-0125, C.I. natural yellow 13, BiomolKI2_000068, D0K8KX, Enicostemma Littorale Blume, UPCMLD-DP081, NCIOpen2_007628, NCIOpen2_007882, BIDD:PXR0007, Lopac0_000999, SCHEMBL19723, BSPBio_000433, BSPBio_001068, BSPBio_002243, KBioGR_000408, KBioGR_001293, KBioSS_000408, KBioSS_000584, 5-18-05-00494 (Beilstein Handbook Reference), KSC497C4F, MLS006011766, BIDD:ER0315, DivK1c_000485, SCHEMBL219729, SPECTRUM1500672, SPBio_000217, SPBio_002354, AC1Q795S, AC1Q795T, BDBM7460, BPBio1_000477, GTPL5346, MEGxp0_000381, SGCUT00001, 3,4',5,7-Pentahydroxyflavone, DTXSID4021218, UPCMLD-DP081:001, ACon1_000560, CTK3J7142, HMS501I07, KBio1_000485, KBio2_000408, KBio2_000584, KBio2_002976, KBio2_003152, KBio2_005544, KBio2_005720, KBio3_000775, KBio3_000776, KBio3_001463, 3,7,3',4'-Pentahydroxyflavone, MolPort-001-740-557, NINDS_000485, 3',5,7-Tetrahydroxyflavan-3-ol, Bio1_000369, Bio1_000858, Bio1_001347, Bio2_000374, Bio2_000854, HMS1362F09, HMS1792F09, HMS1923O19, HMS1990F09, HMS3263G19, HMS3267M12, HMS3649D04, HMS3656C15, to_000078, ZINC3869685, 3,5,7,3',4'-Pentahydroxyflavon, Tox21_202308, Tox21_300285, Tox21_500999, ANW-73134, BBL005513, BS0155, CCG-40054, CQ0011, Flavone,3',4',5,7-pentahydroxy-, GP9232, LMPK12110004, LS-589, MFCD00006828, NSC324608, Quercetin solution, 20 mM in DMSO, s2391, SBB012521, STK365650, Quercetin, >=95% (HPLC), solid, 3,4',5,5',7-pentahydroxy-Flavone, AKOS000511724, CS-3981, DB04216, DS-3416, EBD2197934, LP00999, MCULE-2433372790, NUT0000107, RTX-012622, IDI1_000485, IDI1_002129, KS-0000021G, SMP1_000252, Flavone, 3,4',5,5',7-pentahydroxy-, NCGC00015870-01, NCGC00015870-02, NCGC00015870-03, NCGC00015870-05, NCGC00015870-06, NCGC00015870-07, NCGC00015870-08, NCGC00015870-09, NCGC00015870-10, NCGC00015870-11, NCGC00015870-12, NCGC00015870-13, NCGC00015870-14, NCGC00015870-15, NCGC00015870-16, NCGC00015870-17, NCGC00015870-18, NCGC00015870-19, NCGC00015870-21, NCGC00015870-22, NCGC00015870-23, NCGC00015870-24, NCGC00025016-01, NCGC00025016-02, NCGC00025016-03, NCGC00025016-04, NCGC00025016-05, NCGC00025016-06, NCGC00025016-07, NCGC00025016-08, NCGC00168962-01, NCGC00168962-02, NCGC00168962-03, NCGC00168962-04, NCGC00254218-01, NCGC00259857-01, NCGC00261684-01, 4CN-0923, AC-19596, AC-29756, AJ-46321, AK106169, AN-22768, BAS 00649429, CJ-10980, HY-18085, KB-66753, LS-69030, NCI60_042036, S295, SC-25667, SMR000112559, ST024706, ST057237, Quercetin, Sophoretin, Meletin, Quercetine, AX8030401, KB-221421, EU-0100999, FT-0603318, FT-0655108, N1841, Q0025, ST24039236, Quercetin, disposable screening library format, Quercetin; 3,3',4',5,7-Pentahydroxyflavone, 17Q395, A-8821, C00389, K00029, S00057, WLN: T66 BO EVJ CR CQ DQ & DQ GQ IQ, SR-01000076098-1, SR-01000076098-3, SR-01000076098-7, SR-01000076098-8, BRD-K97399794-001-02-1, BRD-K97399794-001-07-0, BRD-K97399794-001-09-6, BRD-K97399794-001-11-2, BRD-K97399794-335-03-1, SR-01000076098-11, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate, 3,3',4',5,7-pentahydroxyflavone solution, 20 mM in DMSO, A1784/0075599, 49643640-FD4C-4B93-BD28-0D7C2021CC52, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one #, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one solution, 20 mM in DMSO, 73123-10-1


ID: 19

chemical graph of compound 19



InChIKey: RFDOKDAIYRJYJJ-UHFFFAOYSA-N
SMILES: CC1=CC(=C2C=C(NN2)C3=CC=CC=C3)C(=O)C=C1

biological descriptors:

CFTR relevance: CFTR modulators

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"SM Rowe" "D Skinner" "EJ Sorscher" "SB Hicks" "S Zhang" "BT Conger" "BA Woodworth"
"CE Bear" "L Wellhauser" "M Ramjeesingh" "LJ Huan" "P Kim Chiaw"
"T Neuberger" "P Negulescu" "KS Straley" "T Knapp" "PD Grootenhuis" "JH Stack" "J Rader" "F Van Goor" "J Joubran" "M Miller" "S Hadida" "V Panchenko" "LR Makings" "D Cao" "R Tung" "J González" "E Olson" "A Singh" "A Hazlewood"


CID is 6742696
synonyms found at PubChem are:
VRT-532, VRT532, VRT 532, 4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol, Cambridge id 5478102, AC1OA052, GTPL4341, CTK8I5138, ZINC4576484, 4-methyl-6-(5-phenyl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,4-dien-1-one


ID: 20

chemical graph of compound 20



InChIKey: UFSKUSARDNFIRC-UHFFFAOYSA-N
SMILES: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

"M Kissova" "C Mirabelli" "P Vergani" "S Bertoni" "G Tagliavini" "K Lanko" "S Tassini" "G Fontò" "S Palese" "L Delang" "A Mancini" "M Radi" "E Langron" "E Dreassi" "C Giorgio" "C Zamperini" "E Crespan" "F Ravanetti" "J Neyts" "G Maga" "L Ragionieri"
"R Ferru-Clément" "C Boinot" "F Becq" "M Jollivet Souchet"
"BB Stauffer" "JS Hong" "NA McCarty" "G Cui" "EJ Sorscher" "A Rab" "BR Imhoff"
"E Sage" "F Becq" "L Froux" "C Coraux"
"A Meissner" "FA Malik" "F Matthes" "WD Foltz" "M Sauvé" "L Vanherle" "H Zhang" "JT Kroetsch" "M Husain" "JC Fares" "SP Heximer" "H Wan" "FE Uhl" "SS Bolz" "M Sumiyoshi" "RL Macdonald" "DD Dinh" "PH Backx" "R Aschar-Sobbi" "D Lidington" "A Adel" "A Momen"
"H Dang" "C Cho" "X Liu" "SH Randell" "SE Boyles" "IG Chaudhry" "R Schlegel" "C Cheluvaraju" "M Gentzsch" "NL Quinney"
"S Carson" "AT Claudio" "NE West" "N Lechtzin" "MS Christianson" "K Montemayor"
"HC Chan" "LL Tsang" "J Chen" "Y Chen" "YZ Peng" "T Zhou" "ZW Dong" "YC Ruan"
"K Tarnowski" "G Faure" "G Wieczorek" "J Colas" "L Wiszniewski" "J Fritsch" "M Dadlez" "GL Lukacs" "P Melin-Heschel" "M Ollero" "EL Saussereau" "N Odolczyk" "N Servel" "H Herrmann" "S Bitam" "A Edelman" "MF da Cunha" "F Becq" "C Norez" "A Kupniewska" "D Tondelier" "A Roldan" "P Zielenkiewicz"
"CA Loureiro" "JD Santos" "P Matos" "CM Farinha" "AM Matos" "P Jordan" "FR Pinto"
"DY Thomas" "GW Carlile" "CV Lam" "RM de Vries" "C Ottmann" "LG Milroy" "FA Meijer" "LM Stevers" "DS van Scheppingen" "SF Leysen" "L Brunsveld"
"J Simonin" "A Carsin" "N Stremler-Le Bel" "A Hinzpeter" "P Bonnette" "J Mazenq" "IM Pranke" "V Urbach" "A Hatton" "JP Jais" "I Sermet-Gaudelus" "A Edelman" "M Mesbahi" "E Girodon-Boulandet" "D Grenet" "M Thumerel" "M Fayon" "F Le Pimpec-Barthes"
"B Burton" "J McCartney" "CJ Decker" "RA Frizzell" "KS Straley" "PD Grootenhuis" "JH Stack" "F Van Goor" "M Miller" "PA Negulescu" "S Hadida" "M Ashlock" "ER Olson" "JJ Wine"
"K Dejgaard" "Y Luo" "DY Thomas" "GW Carlile" "E Matthes" "R Robert" "A Billet" "JW Hanrahan" "J Goepp"
"CK van der Ent" "AC de Kiviet" "KM de Winter-de Groot" "HGM Heijerman" "MA Kruijswijk" "S Michel" "RW Hofland" "BL Aalbers" "HGM Arets" "S Schotman" "MMM van Oirschot-van de Ven"
"CA Flask" "B Kaminski" "SB Donnola" "K Kutney" "TJ Sferra" "K McBennett" "M O'Riordan" "R Gubitosi-Klug"


CID is 16678941
synonyms found at PubChem are:
936727-05-8, Lumacaftor, VX-809, VX 809, VX809, VRT-826809, 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, UNII-EGP8L81APK, VRT 826809, EGP8L81APK, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoic acid, 3-(6-[[1-(2,2-DIFLUORO-BENZO[1,3]DIOXOL-5-YL)-CYCLOPROPANECARBONYL]-AMINO]-3-METHYL-PYRIDIN-2-YL)-BENZOIC ACID, 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acid, 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-be, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)benzoic acid, 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid, Lumacaftor [USAN:INN], Lumacaftor (USAN), PubChem22450, MLS006011120, SCHEMBL377028, Lumacaftor(vx-809 vx809), GTPL7481, CHEMBL2103870, CHEBI:90951, CTK8B5597, AOB2051, DTXSID30239523, EX-A178, C24H18F2N2O5, MolPort-009-198-874, UFSKUSARDNFIRC-UHFFFAOYSA-N, HMS3655E05, BCP02305, ABP000707, ANW-49250, s1565, VX-809/VX809, ZINC64033452, AKOS015920205, API0007686, CS-0479, DB09280, PB19466, QC-7245, NCGC00346550-01, NCGC00346550-05, 3-(6-(1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoic acid, 4CA-0760, AC-23172, AK-36922, AN-16986, AS-31756, BC660192, Benzoic acid, 3-(6-(((1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl)carbonyl)amino)-3-methyl-2-pyridinyl)-, BR-36922, EN002684, HY-13262, KB-81477, SC-95543, SMR004702901, AB0008169, AJ-114588, AX8160252, TC-137995, FT-0757817, ST24028315, W9631, A25628, D10134, S-5955, J-690399, VX809, VX 809, 936727-05-8, 1220975-12-1, 3-(6-([1-(2,2-DIFLUORO-2H-1,3-BENZODIOXOL-5-YL)CYCLOPROPANE]AMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoic acid, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]amino}-3-methyl-pyridin-2-yl)benzoi, 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]amino}-3-methyl-pyridin-2-yl)benzoic acid, 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor, 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methyl-2-pyridyl]benzoic acid, 3-{6-[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid, 3-{6-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-3-methylpyridin-2-yl}benzoic acid


ID: 21

chemical graph of compound 21



InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

biological descriptors:

CFTR relevance: CFTR proteostasis regulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

reference list:

"R Ferru-Clément" "C Boinot" "F Becq" "M Jollivet Souchet"
"S Noel" "T Okiyoneda" "DM Hutt" "WR Skach" "EJ Sorscher" "RA Frizzell" "Y Matsumura" "D Herman" "M Gentzsch" "GL Lukacs" "JW Kelly" "A Schmidt" "B Hoch" "PJ Thomas" "JM Gottesfeld" "G Manning" "JR_3rd Yates" "J Matteson" "W Kellner" "JM Pilewski" "WE Balch" "JR Riordan" "AP Rodrigues"
"E Caci" "U Pfeffer" "V Tomati" "N Pedemonte" "AI Esposito" "LJ Galietta" "E Sondo"


CID is 5311
synonyms found at PubChem are:
Vorinostat, 149647-78-9, SAHA, suberoylanilide hydroxamic acid, Zolinza, N-hydroxy-N'-phenyloctanediamide, Suberanilohydroxamic acid, N1-hydroxy-N8-phenyloctanediamide, SAHA cpd, MK-0683, MK0683, Vorinostat [USAN], Octanediamide, N-hydroxy-N'-phenyl-, CCRIS 8456, Vorinostat (SAHA, MK0683), N-Hyrdroxy-N'-phenyloctanediamide, Vorinostat MSD, UNII-58IFB293JI, Zolinza (TN), OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, SHH, N'-hydroxy-N-phenyloctanediamide, CHEMBL98, Vorinostat (JAN/USAN), 58IFB293JI, SKI390, CHEBI:45716, WAEXFXRVDQXREF-UHFFFAOYSA-N, WIN64652, NSC701852, SAHA, Suberoylanilide hydroxamic acid, NSC-701852, NCGC00168085-01, NCGC00168085-02, SW-064652, 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide, Zolinza (TN) (Merck), DSSTox_CID_21133, DSSTox_RID_79632, DSSTox_GSID_41133, N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide, SMR000486344, NHNPODA, CAS-149647-78-9, SR-05000000373, Vorinostat [USAN:INN], vorinostatum, HSDB 7930, 4lxz, N-Hydroxy-N'-phenyl octanediamide, Zolinza; SAHA, Vorinostat (SAHA), Vorinostat - SAHA, MK 0683, 1zz1, Merck brand of Vorinostat, cc-95, D0E7PQ, AC1L1K2K, cid_5311, SCHEMBL9018, Vorinostat (HDAC inhibitor), Suberoylanilidehydroxamic Acid, MLS001065855, MLS006011941, GTPL6852, Zolinza, MK-0683, SAHA, DTXSID6041133, BDBM19149, CTK8B4125, AOB6083, n-hydroxy-n'-phenyl-octanediamide, QCR-121, SUBERANILOHYDROXAMINIC ACID, SYN3006, 1t69, MolPort-003-850-293, N-hydroxy-N''-phenyloctanediamide, BCPP000018, HMS2219L20, HMS3264D20, HMS3327C12, HMS3650D09, HMS3654G11, HMS3715E22, Pharmakon1600-01502267, BCP01858, KS-00000H3B, N1-hydroxy-N8-phenyl-octanediamide, SAHA, >=98% (HPLC), Vorinostat,SAHA,Zolinza,MK-0683, ZINC1543873, Tox21_112605, Tox21_113623, Vorinostat,CAS:149647-78-9, ANW-43951, MFCD00945317, NSC748799, NSC759852, Octanediamide, N1-hydroxy-N8-phenyl, s1047, SK1390, AKOS015966648, Octanediamide, N1-hydroxy-N8-phenyl-, Tox21_112605_1, AC-1923, AN-5256, CCG-208659, CS-0589, DB02546, DG-0025, MCULE-4234367506, NSC-748799, NSC-759852, RP29421, Suberoylanilide hydroxamic acid (SAHA), NCGC00168085-03, NCGC00168085-04, NCGC00168085-05, NCGC00168085-13, BC677687, BP-30216, HY-10221, KB-60639, SC-20040, AB0009911, LS-186548, LS-186997, LS-187780, RT-015807, AM20030018, FT-0082592, FT-0650593, D06320, K-4759, AB00375377-07, AB00375377-08, AB00375377-09, AB01644613_25, 647S789, P111011, Vorinostat, SAHA, suberoylanilide hydroxamic acid, SR-05000000373-2, SR-05000000373-6, SR-05000000373-8, W-201327, BRD-K81418486-001-01-2, BRD-K81418486-001-10-3, BRD-K81418486-001-12-9, BRD-K81418486-001-13-7, BRD-K81418486-001-17-8, BRD-K81418486-001-18-6, Z1541632802


ID: 22

chemical graph of compound 22



InChIKey: XWSYQZVZZMFGFW-UHFFFAOYSA-N
SMILES: CC1=NC(=NC2=C1C=C(C=C2)OC)NC3=NC(=O)C=C(N3)CSC4=NC5=CC=CC=C5N4

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"E Caci" "K Du" "N Pedemonte" "O Zegarra-Moran" "AS Verkman" "GL Lukacs" "LJ Galietta"
"MC Bartlett" "DM Clarke" "TW Loo" "Y Wang"
"J Fortenberry" "SM Rowe" "PA Sloane" "J Collawn" "EJ Sorscher" "K Varga" "Y Li" "L Fan" "JP Clancy" "B Woodworth" "M Mazur" "A Jurkevante" "LC Pyle" "J Fulton"


CID is 1386410
synonyms found at PubChem are:
MLS000587783, STK562693, 362000-44-0, SMR000211743, 6-(1H-Benzoimidazol-2-ylsulfanylmethyl)-2-(6-methoxy-4-methyl-quinazolin-2-ylamino)-pyrimidin-4-ol, 6-(1H-benzimidazol-2-ylsulfanylmethyl)-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-1H-pyrimidin-4-one, 6-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]pyrimidin-4-ol, Corr-3a, AC1LR1AE, Oprea1_443670, Oprea1_685675, SCHEMBL837686, CHEMBL1374384, BDBM68023, cid_1386410, CTK8I4173, DTXSID30362587, MolPort-000-717-537, MolPort-002-553-491, HMS2527M03, STK017630, ZINC15987756, AKOS005378152, AKOS005488273, MCULE-9390583364, KB-44178, SR-01000450464, SR-01000450464-1, 4-pyrimidinol, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-2-quinazolinyl)amino]-, 6-(1H-benzimidazol-2-ylsulfanylmethyl)-2-[(6-methoxy-4-methyl-quinazolin-2-yl)amino]-1H-pyrimidin-4-one, 6-(1H-Benzoimidazol-2-ylsulfanylmethyl)-2-(6-methoxy-4-methylquinazolin-2-ylamino)pyrimidin-4-ol, 6-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]pyrimidin-4(3H)-one, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-2-quinazolinyl)amino]-1H-pyrimidin-4-one, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-quinazolin-2-yl)amino]-1H-pyrimidin-4-one


ID: 23

chemical graph of compound 23



InChIKey: ZNNLBTZKUZBEKO-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

biological descriptors:

CFTR relevance: CFTR Blocker

Category:
Influence on CFTR function inhibits CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"MJ Baker" "KL Hamilton"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 3488
synonyms found at PubChem are:
Glibenclamide, glyburide, 10238-21-8, Glybenclamide, Micronase, Diabeta, Glynase, Daonil, Euglucon, Maninil, Semi-daonil, Apo-Glibenclamide, Euglucon 5, Azuglucon, Bastiverit, Benclamin, Betanase, Duraglucon, Euglucan, Euglykon, Glibenil, Glucolon, Neogluconin, Orabetic, Prodiabet, Renabetic, Yuglucon, Dibelet, Gilemal, Glibens, Glibil, Glimel, Glimide, Humedia, Libanil, Suraben, Tiabet, Adiab, Glybenzcyclamide, Melix, Pira, Med-Glionil, Gewaglucon, Glibenbeta, Glibenclamida, Glibenclamidum, Glucohexal, Glucoremed, Hexaglucon, Lisaglucon, Normoglucon, Praeciglucon, Calabren, Cytagon, Euclamin, Glamide, Glibesyn, Glibetic, Gliboral, Glidiabet, Glisulin, Glitisol, Glubate, Glucobene, Glucomid, Glucoven, Glycomin, Lederglib, Miglucan, Debtan, Gliban, Gliben, Glibet, Glicem, Gluben, Glyben, Nadib, Sugril, Novo-Glyburide, Glibenclamid AL, Gen-Glybe, Norglicem 5, Betanese 5, Glibenclamid Fabra, Glibenclamid Basics, Glibenclamid-Cophar, Glibenclamid Heumann, Semi-Euglucon, Glibenclamid Genericon, Hemi-Daonil, Glibenclamid-Ratiopharm, Glibenclamidum [INN-Latin], Glibenclamida [INN-Spanish], Abbenclamide, HB 419, Diabiphage, Glibadone, Semi-Gliben-Puren N, GBN 5, Glibenclamid Riker M., Glyburide (micronized), Euglucon N, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide, Micronized glyburide, Glyburide [USAN], UR 606, Glimidstata, Glycolande, Glycron, PresTab, Gluco-Tablimen, Dia-basan, UNII-SX6K58TVWC, 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea, Gliben-Puren N, Micronase (TN), C23H28ClN3O5S, Glyburide (USP), HB-419, 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea, Diabeta (TN), Glynase (TN), Glibenclamid Riker M, 5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide, U 26452, glyburide (glibenclamide), EINECS 233-570-6, HB-420, SX6K58TVWC, CHEMBL472, BRN 2230085, N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea, MLS000069721, CHEBI:5441, 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide, Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-, Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-, NCGC00015467-11, SMR000058229, CAS-10238-21-8, 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, G 0639, Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-, 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide, DSSTox_CID_17237, DSSTox_RID_79313, N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff, DSSTox_GSID_37237, U-26452, Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-, W-108874, 1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, 5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, 1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea;1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea, GIBENCLAMIDE, SR-01000000196, Glyburide [USAN:USP], glicuformine, Delmide, HB419, HB420, Euglucon (TN), Glibenclamide,(S), 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide, GBM, Prestwick_569, Glibenclamide B.P., Daonil (TN), Glyburide (Diabeta), HB 420, Semi-Daonil (TN), Glibenclamide [INN], RP-1127, Spectrum_000250, Tocris-0911, Opera_ID_801, Prestwick0_000316, Prestwick1_000316, Prestwick2_000316, Prestwick3_000316, Spectrum2_001816, Spectrum3_001327, Spectrum4_001199, Spectrum5_001631, Lopac-G-0639, ACMC-20a66i, D05LYX, Probes1_000431, Probes2_000378, UPCMLD-DP006, AC1L1G1Q, Glibenclamide (JP15/INN), Glibenclamide (JP17/INN), CBiol_001790, Lopac0_000499, Oprea1_764617, SCHEMBL22009, BSPBio_000312, BSPBio_001351, BSPBio_003053, KBioGR_000071, KBioGR_001897, KBioSS_000071, KBioSS_000730, MLS001077262, BIDD:GT0239, DivK1c_000481, SPECTRUM2300229, SPBio_001831, SPBio_002531, AC1Q44V7, BPBio1_000344, GTPL2414, DTXSID0037237, UPCMLD-DP006:001, CTK8B7917, HMS501I03, KBio1_000481, KBio2_000071, KBio2_000730, KBio2_002639, KBio2_003298, KBio2_005207, KBio2_005866, KBio3_000141, KBio3_000142, KBio3_002273, AOB6214, SYN3026, Glybenclamide, >=99% (HPLC), MolPort-000-784-850, NINDS_000481, ZNNLBTZKUZBEKO-UHFFFAOYSA-N, Bio1_000076, Bio1_000565, Bio1_001054, Bio2_000071, Bio2_000551, HMS1361D13, HMS1568P14, HMS1791D13, HMS1922L08, HMS1989D13, HMS2089L06, HMS2093P04, HMS2095P14, HMS3259O12, HMS3261D19, HMS3267A15, HMS3402D13, HMS3428D15, HMS3651E17, HMS3712P14, Pharmakon1600-02300229, ZINC537805, BCP05327, Tox21_110158, Tox21_300758, Tox21_500499, ANW-58936, BDBM50012957, BG0207, CCG-39618, GP8701, HD 419, MFCD00056625, NSC759618, SBB057426, STK362992, AKOS001487495, Tox21_110158_1, BCP9000729, CS-1075, DB01016, KS-5326, LP00499, MCULE-2351642942, NC00566, NSC-759618, IDI1_000481, IDI1_033821, Glibenclamide 1.0 mg/ml in Acetonitrile, NCGC00015467-01, NCGC00015467-02, NCGC00015467-03, NCGC00015467-04, NCGC00015467-05, NCGC00015467-06, NCGC00015467-07, NCGC00015467-08, NCGC00015467-09, NCGC00015467-10, NCGC00015467-12, NCGC00015467-13, NCGC00015467-14, NCGC00015467-15, NCGC00015467-16, NCGC00015467-17, NCGC00015467-18, NCGC00015467-20, NCGC00015467-36, NCGC00016689-01, NCGC00023447-02, NCGC00023447-04, NCGC00023447-05, NCGC00023447-06, NCGC00023447-07, NCGC00023447-08, NCGC00023447-09, NCGC00023447-10, NCGC00023447-11, NCGC00023447-12, NCGC00254662-01, NCGC00261184-01, 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide, AJ-23371, AN-20367, CPD000058229, HY-15206, KB-73471, SAM002564212, SC-17437, ST024780, SBI-0050483.P003, AB0012611, AB2000243, Glyburide, meets USP testing specifications, LS-159295, RT-000122, AB00051949, EU-0100499, FT-0601608, G0382, S1716, A19539, C07022, D00336, J10021, W-5054, 78637-EP2270001A1, 78637-EP2270011A1, 78637-EP2272825A2, 78637-EP2272841A1, 78637-EP2275414A1, 78637-EP2287165A2, 78637-EP2287166A2, 78637-EP2292620A2, 78637-EP2298750A1, 78637-EP2298776A1, 78637-EP2298779A1, 78637-EP2301923A1, 78637-EP2301936A1, 78637-EP2305648A1, 78637-EP2308847A1, AB00051949-16, AB00051949-17, AB00051949_18, AB00051949_19, C-22898, I06-0716, SR-01000000196-2, SR-01000000196-4, SR-01000000196-5, SR-01000000196-6, SR-01000000196-8, U-26,452, BRD-K36927236-001-06-0, BRD-K36927236-001-17-7, Z277540138, Glybenclamide, European Pharmacopoeia (EP) Reference Standard, Glyburide, United States Pharmacopeia (USP) Reference Standard, 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea, 5-Chloro-N-[4-(3-cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)-phenethyl)-2-methoxybenzamide, 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide, 5-chloro-N-[4-({[(cyclohexylamino)carbonyl]amino}sulfonyl)phenethyl]-2-methoxybenzamide, Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard, Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material, N-(4-(.beta.-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff, N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N -cyclohexylurea, N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N'-cyclohexylurea, N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N-cyclohexylurea, (5-chloro-2-methoxyphenyl)-N-[2-(4-{[(cyclohexylamino)carbonylamino]sulfonyl}p henyl)ethyl]carboxamide, 5-Chloro-N-(2-[4-(([(cyclohexylamino)carbonyl]amino)sulfonyl)phenyl]ethyl)-2-methoxybenzamide #, 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide, N-[(4-{2-[(5-chloro-2-methoxyphenyl)carbonylamino]ethyl}phenyl)sulfonyl](cyclo hexylamino)carboxamide


ID: 24

chemical graph of compound 24



InChIKey: ZQSIJRDFPHDXIC-UHFFFAOYSA-N
SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O

biological descriptors:

CFTR relevance: medium CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5281708
synonyms found at PubChem are:
daidzein, 486-66-8, 4',7-Dihydroxyisoflavone, Daidzeol, 7,4'-Dihydroxyisoflavone, 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, Diadzein, 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-, 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one, 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, UNII-6287WC5J2L, CCRIS 7600, K 251b, 4,7-Dihydroxyisoflavone, EINECS 207-635-4, BRN 0231523, CHEMBL8145, 4',7-Dihydroxy-iso-flavone, d-(+)-alpha-methylbenzylamine, 4′,7-Dihydroxyisoflavone, CHEBI:28197, ZQSIJRDFPHDXIC-UHFFFAOYSA-N, 6287WC5J2L, Daidzein,(S), 7-Hydroxy-3-(4-hydroxy-phenyl)-chromone, DSSTox_CID_2310, DSSTox_RID_76543, DSSTox_GSID_22310, Q-200924, CAS-486-66-8, SMR000326832, Daidzein (6CI), SR-01000075492, NPI 031E, PubChem9841, AC1NQYXY, Spectrum_000255, Tocris-1417, BiomolKI_000060, Spectrum2_000053, Spectrum3_000191, Spectrum4_001964, Spectrum5_000857, Lopac-D-7802, 4 ,7-Dihydroxyisoflavone, BiomolKI2_000066, D0N9CG, D0SY2M, UPCMLD-DP052, 4',7-dihydroxy isoflavone, 4',7-dihydroxy-Isoflavone, Lopac0_000412, Oprea1_182317, Oprea1_305345, SCHEMBL19814, BSPBio_001741, Daidzein, analytical standard, KBioGR_002432, KBioSS_000735, SPECTRUM200789, 5-18-04-00089 (Beilstein Handbook Reference), MLS000859973, MLS001304056, MLS006011853, BIDD:ER0120, DivK1c_001023, SPBio_000205, Daidzein, >=98%, synthetic, Isoflavone, 4',7-dihydroxy-, BIMB2005, BMK1-F12, GTPL2828, MEGxm0_000123, NPI-031E, d-(+)-alpha-methylbenzyl amine, DTXSID9022310, UPCMLD-DP052:001, ACon0_001477, ACon1_000543, BDBM23420, HMS503M07, K-251b, KBio1_001023, KBio2_000735, KBio2_003303, KBio2_005871, KBio3_001241, KS-00000MGD, AOB5524, OR1035T, 4',7-Dihydroxyisoflavone, 97%, MolPort-000-003-017, NINDS_001023, ZX-AFC000144, 7,4'-Dihydroxy-isoflavone (3a), HMS1922P18, HMS2233H24, HMS3261C06, HMS3267J04, HMS3370C03, HMS3468L18, HMS3649B20, HMS3655A18, ALBB-015933, BCP28286, HY-N0019, ZX-AN014640, ZX-AT022124, Tox21_201444, Tox21_303650, Tox21_500412, BBL010490, BS0244, CCG-38357, CD-190, LMPK12050038, MFCD00016954, s1849, SBB066056, STK801626, ZINC18847034, Daidzein (4',7-Dihydroxyisoflavone), 7-hydroxy-3-(4-hydroxyphenyl)-4H-, AKOS002385052, Isoflavone, 4',7-dihydroxy- (8CI), AC-6035, ACN-034764, CS-2332, Daidzein, purum, >=98.0% (TLC), KS-5260, LP00412, LS-2143, MCULE-8239511422, SDCCGMLS-0066422.P001, IDI1_001023, SMP1_000089, NCGC00015365-01, NCGC00015365-02, NCGC00015365-03, NCGC00015365-04, NCGC00015365-05, NCGC00015365-06, NCGC00015365-07, NCGC00015365-08, NCGC00015365-09, NCGC00015365-10, NCGC00015365-11, NCGC00015365-12, NCGC00015365-13, NCGC00015365-14, NCGC00015365-15, NCGC00015365-16, NCGC00015365-17, NCGC00015365-18, NCGC00025156-01, NCGC00025156-02, NCGC00025156-03, NCGC00025156-04, NCGC00025156-05, NCGC00025156-06, NCGC00025156-07, NCGC00025156-08, NCGC00025156-09, NCGC00025156-10, NCGC00168978-01, NCGC00168978-02, NCGC00257367-01, NCGC00258995-01, NCGC00261097-01, AJ-70673, AK-94232, AN-45238, CC-17424, KB-49550, SC-46504, ST057515, AB0010476, AB1004493, BB 0259520, D2668, EU-0100412, FT-0080019, FT-0603419, FT-0665448, N1862, R1341, 7-hydroxy-3-(4-hydroxyphenyl)-chromen-4-one, 7-Hydroxy-3-(4-hydroxy-phenyl)-chromen-4-one, 7-HYDROXY-3-(4-HYDROXYPHENYL)CHROMONE, C10208, D 7802, D17500, S00273, US8552057, 7, AB00052712-08, AB00052712_10, 486D668, C-15745, Daidzein, primary pharmaceutical reference standard, I06-0011, SR-01000075492-1, SR-01000075492-3, SR-01000075492-7, SR-01000075492-8, BRD-K42095107-001-02-3, BRD-K42095107-001-05-6, BRD-K42095107-001-08-0, SR-01000075492-12, 80E3ED75-D852-4D97-9BD6-B5ADE7EA25A1, 7-Hydroxy-3-(4-hydroxy-phenyl)-4H-1-benzo-pyran-4-one, UNII-71B37NR06D component ZQSIJRDFPHDXIC-UHFFFAOYSA-N, Daidzein, United States Pharmacopeia (USP) Reference Standard, Daidzein, Pharmaceutical Secondary Standard; Certified Reference Material, 4 inverted exclamation marka,7-Dihydroxyisoflavone; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 7-Hydroxy-3-(4-hydroxyphenyl)chromone


ID: 25

chemical graph of compound 25



InChIKey: AGBQKNBQESQNJD-UHFFFAOYSA-N
SMILES: C1CSSC1CCCCC(=O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 864
synonyms found at PubChem are:
dl-Thioctic acid, thioctic acid, alpha-Lipoic acid, 1077-28-7, 5-(1,2-Dithiolan-3-yl)pentanoic acid, DL-alpha-Lipoic acid, 1,2-dithiolane-3-pentanoic acid, Thioctacid, 6,8-Thioctic acid, 6-Thioctic acid, alpha Lipoic Acid, Lipothion, Biletan, dl-Lipoic acid, Liposan, Thioctsan, Tioctacid, Rac-lipoate, DL-6,8-Thioctic acid, alpha-Liponsaeure, DL-6-Thioctic acid, alpha-liponic acid, 1,2-Dithiolane-3-valeric acid, Thioktsaeure, Tioctidasi, (RS)-Lipoic acid, 6,8-Dithiooctanoic acid, espa-lipon, Thioctic acid dl-form, 62-46-4, 5-(1,2-Dithiolan-3-yl)valeric acid, Acetate-replacing factor, 6,8-Thiotic acid, Thioctansaeure, 5-(Dithiolan-3-yl)valeric acid, Protogen A, 6-Thiotic acid, 5-(dithiolan-3-yl)pentanoic acid, DL-1,2-Dithiolane 3-valeric acid, Thioktsaeure [German], Thioctsaeure, liponic acid, Thiooctic acid, Pyruvate oxidation factor, DL-Thiocticacid, DL-.alpha.-Lipoic acid, alpha-Liponsaeure [German], DL-1,2-Dithiolane-3-valeric acid, NSC 90788, Lipoic acid, alpha, NSC 628502, (+-)-1,2-Dithiolane-3-pentanoic acid, .alpha.-Liponic acid, CHEBI:16494, (+/-)-1,2-Dithiolane-3-pentanoic acid, Thioctic acid [JAN], C8H14O2S2, Tioctidasi acetate replacing factor, DL-1,2-Dithiolan-3-valeriansaeure, (.+-.)-Lipoic acid, EINECS 200-534-6, EINECS 214-071-2, (RS)-.alpha.-Lipoic acid, BRN 0081853, BRN 0122410, lipoate, 5-[3-(1,2-dithiolanyl)]pentanoic acid, CHEMBL33864, DL-1,2-Dithiolan-3-valeriansaeure [German], (.+-.)-.alpha.-Lipoic acid, AGBQKNBQESQNJD-UHFFFAOYSA-N, 1,2-DITHIOLANE-3-VALERIC ACID, (+-)-, NSC90788, Thioctic acid (JAN), NCGC00016032-06, 1,2-Dithiolane-3-pentanoic acid, (+-)-, DSSTox_CID_5508, DSSTox_RID_77816, DSSTox_GSID_25508, Berlition, Thiogamma, biomolipon, duralipon, Thioctidase, Alipure, AlphaLipogamma, Thiotacid, biomo lipon, espa lipon, Alpha Lipogamma, Alpha-Lipogamma, Pleomix Alpha, Thioctacide T, Verla Lipon, AlphaLipon Stada, .alpha.-Lipoic acid, Alpha Lippon AL, Alpha Lipon Stada, Alpha-Lipon Stada, Liponsaureratiopharm, alpha-lipon 300, SMR000058198, CAS-1077-28-7, Liponsaure-ratiopharm, (+-)-Lipoic acid, (+-)-Thioctic acid, alpha Liponsaure von ct, SR-01000737460, (RS)-alpha-Lipoic acid, (+-)-alpha-lipoic acid, alphalipoic acid, Alpha Lipoic, Alphalipoic-acid, a-lipoic acid, Thioctic acid [INN:BAN:JAN], HSDB 7818, D,L-Lipoic acid, Thiotomin (TN), D,L-Thioctic acid, lipoic acid (LA), ( )-a-Lipoic acid, LIPOIC-ACID, ()-alpha-Lipoic acid, PubChem14559, Spectrum_001618, 5-(1,2-dithiolan-3-yl)-pentanoate, Thioctic acid, dl-form, R(+)Alpha Lipoic Acid, Lip(S2), Spectrum2_001605, Spectrum3_001188, Spectrum4_000217, Spectrum5_001298, cid_864, (.+-.)-Thioctic acid, Lipoic acid, alpha [NF], ACMC-209ug2, bmse000542, D0P6PQ, Epitope ID:150922, (.+/-.)-Lipoic acid, AC1Q5W3Z, ACMC-1BU44, SCHEMBL51065, BSPBio_002835, KBioGR_000853, KBioSS_002098, 5-19-07-00237 (Beilstein Handbook Reference), MLS000069736, MLS001332379, MLS001332380, MLS002153365, DivK1c_000912, SPECTRUM1503941, (R)-(+)- a-Lipoic acid, SPBio_001609, AC1L1A75, DL-Thioctic acid, 98% 5g, DTXSID7025508, BDBM10515, CTK8G6693, HMS502N14, KBio1_000912, KBio2_002098, KBio2_004666, KBio2_007234, KBio3_002335, MolPort-002-461-878, NINDS_000912, thioctic acid (alpha-lipoic acid), HMS1922M22, HMS3649H08, Pharmakon1600-01503941, ACT14091, ALBB-030318, BCP13221, BCP14048, BCP18944, DL-6,8-DITHIOOCTANOIC ACID, HY-N0492, KS-000001JT, Tox21_110285, Tox21_201808, Tox21_303092, BBL013878, CCG-39063, dl-1,2-Dithiolane-3-pentanoic acid, LS-448, MFCD00005474, NSC-90788, NSC628502, NSC758651, SBB003484, STK801969, ()-1,2-Dithiolane-3-pentanoic acid, AKOS000121582, AKOS016339634, Tox21_110285_1, AM84329, AN-6965, CS-4370, EBD2203019, KS-1322, LS40210, MCULE-1034910084, NSC-758651, RP26250, TRA0030345, ( )-1,2-Dithiolane-3-pentanoic acid, 1,?2-?Dithiolane-?3-?pentanoic acid, IDI1_000912, NCGC00016032-02, NCGC00016032-03, NCGC00016032-04, NCGC00016032-05, NCGC00016032-07, NCGC00016032-08, NCGC00016032-09, NCGC00016032-11, NCGC00090872-01, NCGC00090872-02, NCGC00090872-03, NCGC00090872-04, NCGC00090872-05, NCGC00256970-01, NCGC00259357-01, (+/-)-alpha-Lipoic acid, >=98.0%, AC-22673, AN-41842, BR-72974, KB-50374, LS-63315, NCI60_042014, O217, SC-12524, SC-16262, SC-83283, ST073359, SBI-0051871.P002, 5-(1,2-Dithiolan-3-yl)pentanoic acid #, AB0010770, TR-001856, 1,2-Dithiolane-3-valeric acid, (.+-.)-, FT-0622068, FT-0625429, L0058, ST24032861, 1,2-Dithiolane-3-pentanoic acid, (.+-.)-, 1,2-Dithiolane-3-valeric acid, (.+/-.)-, 1,2-Dithiolane-3-pentanoic acid, (.+/-.)-, 3049-EP2316827A1, C00725, D00086, J10446, M-5249, AB00052393_09, 1,2-Dithiolane-3-pentanoic acid, (+-)- (9CI), I09-0884, J-002007, J-520421, SR-01000737460-2, SR-01000737460-6, F2191-0208, Thioctic acid, European Pharmacopoeia (EP) Reference Standard, (+/-)-alpha-Lipoic acid, BioReagent, cell culture tested, >=99%, (+/-)-alpha-Lipoic acid, synthetic, >=99% (titration), powder, Alpha Lipoic Acid, United States Pharmacopeia (USP) Reference Standard, AfAE'A centa' notA inverted exclamation markAfasA'A|AfAE'Adaggeratrade mark?-Lipoic Acid, Thioctic acid containing impurity B, European Pharmacopoeia (EP) Reference Standard, Thioctic acid for system suitability, European Pharmacopoeia (EP) Reference Standard, 27779-68-6


ID: 26

chemical graph of compound 26



InChIKey: APIXJSLKIYYUKG-UHFFFAOYSA-N
SMILES: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2

biological descriptors:

CFTR relevance: induced chloride efflux only in Calu-3 cells

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

reference list:

"C Andersson" "GM Roomans" "Z Servetnyk"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 3758
synonyms found at PubChem are:
3-Isobutyl-1-methylxanthine, IBMX, 28822-58-4, isobutylmethylxanthine, 1-METHYL-3-ISOBUTYLXANTHINE, Methylisobutylxanthine, 3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione, Xanthine, 3-isobutyl-1-methyl-, 3-Isobutyl-1-methyxanthine, 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-, Methyl-isobutylxanthine, 3-Isobutyl 1-methylxanthine, UNII-TBT296U68M, NSC 165960, CCRIS 4290, 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione, CHEBI:34795, 3-isobutyl-1-methyl-7H-xanthine, 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione, 3-isobutyl-1-methyl-3,9-dihydro-1H-purine-2,6-dione, 2-Acetoxy-Benzoic Acid, 3-Isobutyl-Methylxanthine, EINECS 249-259-3, NSC165960, CHEMBL275084, TBT296U68M, 1-methyl-3-(2-methylpropyl)-3,7-dihydro-1H-purine-2,6-dione, APIXJSLKIYYUKG-UHFFFAOYSA-N, 3-isobutyl-1-methylxanthine (ibmx), IN1293, 3,7-Dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione, J-640140, 1-methyl-3-(2-methylpropyl)-1,3,7-trihydropurine-2,6-dione, 1H-purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, Isobutyltheophylline, IMX, SMR000326697, SR-01000075185, 3 Isobutyl 1 methylxanthine, 1zkl, 1zkn, 3ecn, 3itu, 3jwr, 2hd1, 2r8q, 3qi4, AC1L1GNB, Spectrum2_001705, Spectrum2_001735, Spectrum3_001958, Spectrum4_001052, Spectrum5_001856, Lopac-I-5879, D03ADX, D0GY2T, D0R6MT, MolMap_000030, AC1Q1PM4, Lopac0_000642, Oprea1_135287, Oprea1_228781, SCHEMBL50315, 3-isobutyl-1-methylxantliine, BSPBio_001153, BSPBio_003558, GTPL388, KBioGR_000493, KBioGR_001344, KBioGR_002566, KBioSS_000493, KBioSS_002575, 1-methyl-3-isobutyl-xanthine, MLS001056732, MLS001066424, 3-Isobutyl-1-methyl-xanthine, DivK1c_000922, SPECTRUM1505298, SPECTRUM2300204, SPBio_001690, SPBio_001810, DTXSID0040549, BCBcMAP01_000110, BDBM15336, CHEBI:43253, CTK3J1633, HMS502O04, KBio1_000922, KBio2_000493, KBio2_002566, KBio2_003061, KBio2_005134, KBio2_005629, KBio2_007702, KBio3_000905, KBio3_000906, KBio3_002878, KBio3_003044, KS-00001CXM, 3-isobutyl-1-methyl-9H-xanthine, cMAP_000087, MolPort-001-737-339, MolPort-001-792-510, NINDS_000922, Bio1_000456, Bio1_000945, Bio1_001434, Bio2_000407, Bio2_000887, HMS1362I15, HMS1792I15, HMS1990I15, HMS2090J10, HMS2231C11, HMS3262A05, HMS3369E16, HMS3403I15, HMS3604D14, HMS3648O18, ALBB-024315, ZINC3861807, Tox21_500642, 3-ISOBUTHYL-1-METHYLXANTHINE, ANW-54495, BDBM50027176, BS0316, CCG-39513, CCG-39624, GL2425, HSCI1_000261, MFCD00005584, PDSP1_000324, PDSP2_000322, SC2964, AKOS003390599, AKOS015903085, CS-3361, DB07954, LP00642, MCULE-3854999514, NSC-165960, SC 2964, VZ21530, IDI1_000922, IDI1_002162, NCGC00015559-01, NCGC00015559-02, NCGC00015559-03, NCGC00015559-04, NCGC00015559-05, NCGC00015559-06, NCGC00015559-07, NCGC00015559-08, NCGC00015559-09, NCGC00015559-10, NCGC00015559-11, NCGC00094009-01, NCGC00094009-02, NCGC00094009-03, NCGC00094009-04, NCGC00094009-05, NCGC00094009-06, NCGC00261327-01, Xanthine, 1-methyl-3-(2-methylpropyl), AJ-46242, AK-84450, BC219667, HY-12318, SC-84962, ST055758, IBMX(NSC165960; SC2964), 3-isobutyl-1-methyl-7H-purine-2,6-dione, AX8087568, DB-047466, LS-162537, [Eur J Pharmacol 170: 35 (1989)], B7206, EU-0100642, FT-0615920, R4973, WLN: T56 BM DN FNVNVJ F1Y1&1 H1, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, C13708, I 5879, 3-Isobutyl-1-methylxanthine, BioUltra, >=99%, 822I584, L001156, 3-Isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione, 3-Isobutyl-1-methyl-3,9-dihydro-purine-2,6-dione, J-800144, SR-01000075185-1, SR-01000075185-6, 3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder, BRD-K94979336-001-06-9, BRD-K94979336-001-09-3, I14-18716, 1H-Purine-2, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-, 1-methyl-3-(2-methylpropyl)-3,9-dihydro-1H-purine-2,6-dione, 1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione


ID: 27

chemical graph of compound 27



InChIKey: AUYYCJSJGJYCDS-LBPRGKRZSA-N
SMILES: C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O

biological descriptors:

CFTR relevance: medium CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5920
synonyms found at PubChem are:
liothyronine, triiodothyronine, 3,3',5-Triiodo-L-thyronine, 6893-02-3, Liothyronin, Tresitope, 3,5,3'-triiodothyronine, L-Liothyronine, triothyrone, Liothyroninum, Liotironina, 3,5,3'-Triiodo-L-thyronine, L-T3, T3, Triiodo-L-thyronine, Lyothyronine, 3,3',5-Triiodothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, L-3,5,3'-Triiodothyronine, 3,5,3'TRIIODOTHYRONINE, (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid, T3 (amino acid), T3 (Hormone), L-3,3',5-TriioDOThyronine, T3 liothyronine, Liothyronine [INN:BAN], Euthroid-1, Euthroid-2, Euthroid-3, Thyrolar-1, Thyrolar-2, Thyrolar-3, Liotironina [INN-Spanish], Tri-Thyrotope, Euthroid-0.5, Thyrolar-0.5, Liothyronine (INN), T3 (VAN), Triiodothyronine, l-, Thyrolar-0.25, THYROID HORMONE, 3,5,3'-Tri-iodo-L-thyronine, CHEBI:18258, T3 (Triiodothyronine), Triiodothyronine (T3), L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Triomet-131, T3 (LIOTRIX), Liothyroninum [INN-Latin], CHEMBL1544, UNII-06LU7C9H1V, 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylalanine, (S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid, 06LU7C9H1V, 3,3',5-Triiodothyronine, L-, HSDB 3110, Triiodo-thyroninum, AUYYCJSJGJYCDS-LBPRGKRZSA-N, EINECS 229-999-3, MFCD00002593, NSC 80203, 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine, BRN 2710227, 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine, L-triiodothyronine, L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine, Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L-, Cytomel (TN), DSSTox_CID_3216, DSSTox_RID_76928, DSSTox_GSID_23216, TRIIODOTHYRONINE (T3 OR LIOTHYRONINE, ACTIVE) (6-11%), CAS-6893-02-3, SR-05000000455, Cyronine, NSC-46046, C15H12I3NO4, 1xzx, Tertroxin (TN), 5714-08-9, Prestwick_135, PubChem20012, Spectrum_001445, Prestwick0_000853, Prestwick1_000853, Prestwick2_000853, Prestwick3_000853, Spectrum2_001984, Spectrum3_001887, Spectrum4_000326, Spectrum5_001793, T-3, Liothyroninum[INN-Latin], L-T3|||L-Liothyronine, D0D8QI, D0S6JG, Epitope ID:131324, AC1L1LF0, SCHEMBL8300, NCIStruc1_000449, Liothyronine modified release, REGID_for_CID_5920, BSPBio_000865, BSPBio_003394, KBioGR_000671, KBioGR_002568, KBioSS_001925, KBioSS_002577, 3,3'5-Triiodo-L-thyronine, MLS000028458, 3,5,3'-triodo-L-thyronine, SPBio_002167, SPBio_002786, BPBio1_000953, GTPL2634, L-3,3',5-triiodo-Thyronine, 3,3',5-Trichloro-L-thyromine, 3,3\',5-triiodo-L-thyronine, DTXSID8023216, BCBcMAP01_000192, BDBM18860, CTK1A2555, HY-A0070A, KBio2_001925, KBio2_002568, KBio2_004493, KBio2_005136, KBio2_007061, KBio2_007704, KBio3_002897, KBio3_003046, (2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid, cMAP_000088, MolPort-003-850-717, HMS1570L07, HMS2097L07, HMS2235A22, HMS3714L07, ZINC3830999, Tox21_110029, Tox21_301943, ANW-60592, CT-833, NCGC00013556, 3,5,3'-triiodo-L-thyronine (T3), Thyronine, 3,3',5-triiodo-, L-, AKOS016003266, 3,3',5-Triiodo-L-thyronine, 95%, AM83597, CCG-220853, CS-4141, DB00279, SMP1_000179, NCGC00013556-01, NCGC00013556-02, NCGC00013556-03, NCGC00013556-04, NCGC00096669-01, NCGC00096669-02, NCGC00255336-01, [125I]T3, AS-17446, KB-28438, KB-99685, LS-16137, SC-11044, SMR000058402, SBI-0206718.P001, DB-021796, Thyronine, 3,3',5-triiodo-, L-(6CI), TR-031350, Thyronine, 3,3',5-triiodo-, L- (6CI), C02465, D08128, 893T023, SR-01000003143, SR-01000003143-4, SR-05000000455-2, SR-05000000455-3, 3,5,3 inverted exclamation marka-Triiodo-L-thyronine, BRD-K89152108-001-03-3, 3,3',5-Triiodo-L-thyronine, >=95% (HPLC), powder, Z2216208625, L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(9CI), UNII-O48UO55HR0 component AUYYCJSJGJYCDS-LBPRGKRZSA-N, L-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-Alanine, L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- (9CI), Liothyronine, United States Pharmacopeia (USP) Reference Standard, 3,3',5 Triiodothyronine (T3), IRMM(R) certified Reference Material, (2S)-2-AMINO-3-[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]PROPANOIC ACID, (S)-2-Amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoicacid, Liothyronine, Pharmaceutical Secondary Standard; Certified Reference Material, 3,3',5-Triiodo-L-thyronine (T3) solution, 100 mug/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, 57164-27-9, 7013-53-8, (2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate, AC1OFCLR, CHEBI:533015, 3,3',5-triiodo-L-thyronine zwitterion, 4-(3-iodo-4-hydroxy-phenoxy)-3,5-diiodophenylalanine, (S)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid


ID: 28

chemical graph of compound 28



InChIKey: AVBSIKMUAFYZAV-UHFFFAOYSA-N
SMILES: C1=C2C(=CC(=C1Cl)Cl)NC(=O)C(=O)N2

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 1845
synonyms found at PubChem are:
25983-13-5, 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione, DCQX, 6,7-DICHLORO-1,4-DIHYDRO-2,3-QUINOXALINEDIONE, 6,7-dichloroquinoxaline-2,3-diol, 6,7-dichloro-1,4-dihydroquinoxaline-2,3-dione, 6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione, 2,3-Dihydroxy-6,7-dichloroquinoxaline, CHEMBL284028, 2,3-Quinoxalinedione,6,7-dichloro-1,4-dihydro-, Spectrum_001661, ACMC-209gnv, SpecPlus_000650, Lopac-D-133, AC1L1CDC, Spectrum2_000537, Spectrum3_001668, Spectrum4_000630, Spectrum5_001426, Biomol-NT_000181, D0S6TW, AC1Q3Q7M, Lopac0_000418, Benzil-related compound, 58, BSPBio_003455, KBioGR_001220, KBioSS_002141, DivK1c_006746, SCHEMBL463608, SPECTRUM1504232, SPBio_000553, BPBio1_001174, SCHEMBL8122389, BDBM22778, CTK4F6896, KBio1_001690, KBio2_002141, KBio2_004709, KBio2_007277, KBio3_002675, KS-00001AMJ, DTXSID70274337, AVBSIKMUAFYZAV-UHFFFAOYSA-N, CHEBI:113553, MolPort-001-758-250, ZX-AT029321, 6,7-Dichloro-2,3-quinoxalinedione, ANW-25865, CCG-39598, MFCD00078575, AKOS015850366, AKOS022421095, ZINC100004920, 6,7-dichloro-2,3-dihydroxyquinoxaline, FCH1322390, NCGC00015311-01, NCGC00015311-02, NCGC00015311-03, NCGC00015311-04, NCGC00015311-05, NCGC00093842-01, NCGC00093842-02, NCGC00093842-03, NCGC00095336-01, NCGC00095336-02, AJ-70442, DB-014624, CS-0038531, D-133, EU-0100418, FT-0609662, V4741, 6,7-dichloro-quinoxaline-2,3(1H,4H)-dione, I08-631, SR-01000075444, 2,3-Quinoxalinedione, 6,7-dichloro-1,4-dihydro-, J-016207, SR-01000075444-1, BRD-K80576679-001-03-1, 6,7-dichloro-1,2,3,4-tetrahydroquinoxaline-2,3-dione, 6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline


ID: 29

chemical graph of compound 29



InChIKey: CEUMONXVSJOJIH-UHFFFAOYSA-N
SMILES: C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC(=CC3=NC=C2)Cl.Cl

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "R Robert" "J Liao" "P Lesimple" "B Kus" "HR de Jonge" "JW Hanrahan" "N Liu" "BJ Scholte" "M Wilke" "H Balghi" "D Rotin"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 3085326
synonyms found at PubChem are:
Glafenine hydrochloride, 65513-72-6, Glafenine (hydrochloride), DSSTox_CID_25497, DSSTox_RID_80916, DSSTox_GSID_45497, SR-01000473478, C19H17ClN2O4.ClH, 1-Glyceryl N-(7-chloro-4-quinolyl)anthranilate, Prestwick_628, Glafenin hydrochloride, Glafenine(hydrochloride), AC1MJ4AX, NCGC00016909-01, CAS-65513-72-6, MLS002154254, SCHEMBL970807, CHEMBL1572751, DTXSID7045497, CTK8G0041, HY-B1153A, KS-00001FBC, MolPort-004-964-888, HMS1568L08, Tox21_110678, 2430AH, AKOS024374941, Tox21_110678_1, CCG-220293, CS-6517, MCULE-3160845237, Benzoic acid, 2-((7-chloro-4-quinolinyl)amino)-, 2,3-dihydroxypropyl ester, monohydrochloride, NCGC00094881-07, SMR001233515, Glafenine hydrochloride, analytical standard, ST51015012, SR-01000473478-1, SR-01000473478-3, 2,3-dihydroxypropyl 2-(7-chloroquinolin-4-ylamino)benzoate hydrochloride, 2,3-dihydroxypropyl 2-[(7-chloro-4-quinolyl)amino]benzoate, chloride, 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate hydrochloride, AKOS026749774


ID: 30

chemical graph of compound 30



InChIKey: DCFXOTRONMKUJB-QMDUSEKHSA-N
SMILES: CCCN1CCO[C@H]2[C@H]1COC3=C2C=C(C=C3)O.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 11957668
synonyms found at PubChem are:
300576-59-4, (+)-PD 128907 hydrochloride, (+/-)-PD 128,907 hydrochloride, 112960-16-4, S(+)-PD 128,907 hydrochloride, PD 125,530, (+)-PD 128,907 hydrochloride, rel-(4aR,10bR)-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol hydrochloride, (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride, (4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride, PD128907 HCl, MFCD00210210, PD128907 Hydrochloride, SR-01000075396, (4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol hydrochloride, EU-0101038, MLS002153393, CHEMBL1256778, SCHEMBL15937756, MolPort-003-959-173, (y)-PD 128,907 hydrochloride, (?)-PD 128,907 hydrochloride, Tox21_501038, R(-)-PD 128,908 hydrochloride, (+/-)-PD 128907 hydrochloride, AKOS015900216, API0008818, DS-8408, EX-3305, LP00988, LP01038, SPD-128907, NCGC00094286-01, NCGC00094286-02, NCGC00261723-01, AK164058, SMR001230774, AX8300668, KB-277078, LS-191187, EU-0100988, P-183, P-216, ST24034753, (+)PD 128907, S(+)-(4aR,10bR)-3,4,4a,10b-, (+)-PD 128,907 hydrochloride, >97%, solid, A820165, SR-01000597915, J-002884, J-017752, R(-)-PD 128,908 hydrochloride, >97%, solid, SR-01000075396-1, SR-01000075396-2, SR-01000597915-1, ( inverted question mark)-PD 128,907 hydrochloride, I14-10033, ( inverted exclamation markA)-PD 128,907 hydrochloride, (+/-)-PD 128,907 hydrochloride, solid, >=98% (HPLC), Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride, (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride, (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-[1]benzopyrano[4,3-b][1,4]oxazin-9-ol hydrochloride, (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride, R( C)-(4aS,10bS)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol, trans-( inverted exclamation markA)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride, trans-(+/-)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride


ID: 31

chemical graph of compound 31



InChIKey: DEFVIWRASFVYLL-UHFFFAOYSA-N
SMILES: C(COCCOCCN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O

biological descriptors:

CFTR relevance: Fe3+ chelator

Category:
Influence on CFTR function none
Order of interaction indirect
subcellular compartment unknown

reference list:

"G Wang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6207
synonyms found at PubChem are:
EGTA, 67-42-5, Egtazic acid, Ethylenebis(oxyethylenenitrilo)tetraacetic acid, Gedta, Ebonta, 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)-, 1,2-Bis[2-[bis(carboxymethyl)amino]ethoxy]ethane, Ethylene glycol bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Ethylene Glycol Tetraacetic Acid, H4egta, Egtazic acid [USAN:INN], Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid, NSC 615010, [Ethylenebis(oxyethylenenitrilo)]tetraacetic acid, Acide egtazique [INN-French], Acido egtazico [INN-Spanish], Acidum egtazicum [INN-Latin], Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid, Glycoletherdiaminetetraacetic Acid, 1,2-Bis(2-dicarboxymethylaminoethoxy)ethane, Glycol-etherdiaminetetraacetic acid, UNII-526U7A2651, Ethylenedioxybis(ethyleneamino)tetraacetic acid, C14H24N2O10, EINECS 200-651-2, (Ethylenebis(oxyethylenenitrilo))tetraacetic acid, 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid, BRN 1717370, CHEBI:30740, Glycoletherdiamine-N,N,N',N'-tetraacetic Acid, DEFVIWRASFVYLL-UHFFFAOYSA-N, Glycoletherdiamine-tetraacetic acid, ethylene glycol bis(2-aminoethyl)tetraacetic acid, Ethylene glycol bis(aminoethyl ether)tetraacetate, Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid, Ethylenebis(oxyethylenenitrilo)tetra(acetic acid), Glycol ether diamine tetraacetic acid, NSC615010, NCGC00015416-02, ACETIC ACID, (ETHYLENEBIS(OXYETHYLENENITRILO))TETRA-, Ethylene glycol, di(2-(N,N-dicarboxylmethyl)amino)ethyl ether, Ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid, Ethyleneglycol-bis(beta-aminoethyl ether)-N,N1-tetra-acetic acid, 526U7A2651, 2-[2-[2-[2-[bis(carboxymethyl)amino]ethoxy]ethoxy]ethyl-(carboxymethyl)amino]acetic acid, DSSTox_CID_25151, DSSTox_RID_80705, DSSTox_GSID_45151, [ethylenebis-(oxyethylenenitrilo)]-tetraacetic acid, W-104715, Acide egtazique, Acido egtazico, Acidum egtazicum, ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Ethyleneglycol-bis(beta-aminoethyl)-N,N,N&prime;,N&prime;-tetraacetic Acid, Magnesium-EGTA, Tetrasodium EGTA, 2,2',2'',2'''-[ethane-1,2-diylbis(oxyethane-2,1-diylnitrilo)]tetraacetic acid, CAS-67-42-5, EGATA, 31571-71-8, Egtazic Acid Disodium Salt, ethylene glycol bis[2-aminoethyl ether]tetraacetic acid, titriplex(r) vi, idranal(tm) vi, idranal(r) vi, 2-[2-[2-[2-(Bis(carboxymethyl)amino)ethoxy]ethoxy]ethyl-(carboxymethyl)amino]acetic acid, 2-{[2-(2-{2-[bis(carboxymethyl)amino]ethoxy}ethoxy)ethyl](carboxymethyl)amino} acetic acid, ETHYLENE GLYCOL-bis-(beta-AMINO-ETHYLETHER)-N,N,N',N'-TETRAACETIC ACID, OAEuEa, Chel&trade;-DE, EDGA, EGTA; Egtazic acid, Egtazic acid (USAN), AC1Q5WJB, Lopac-E-4378, Ethylenebis(oxyethylenenitrile)tetraacetic Acid, bmse001011, D0O5VI, AC1L1M0X, Lopac0_000512, SCHEMBL22901, KSC353A5B, MLS000069445, CHEMBL240390, DTXSID2045151, CTK2F3050, MolPort-001-794-631, HMS3261H05, ZINC3861663, Tox21_110141, Tox21_500512, ANW-43739, GE7249, MFCD00004291, SBB053599, 31571-71-8 (hydrochloride salt), AKOS004910388, Tox21_110141_1, API0002646, CCG-204603, LP00512, MCULE-9762822541, NSC-615010, RTR-031285, NCGC00015416-01, NCGC00015416-03, NCGC00015416-04, NCGC00015416-05, NCGC00093909-01, NCGC00093909-02, NCGC00261197-01, AJ-73376, AK-50026, AN-23760, CC-27442, LS-12095, SC-74749, SMR000059072, U228, AX8127175, KB-254014, TR-031285, B7195, E0106, E0805, EU-0100512, FT-0606293, ST24030705, ST50308400, D03967, E 4378, Ethylene-bis(oxyethylenenitrilo)tetraacetic acid, ethylenebis(oxyethylenenitrilo) tetraacetic acid, [ethylenebis-(oxyethylenenitrilo)]tetraacetic acid, C-21321, Ethyleneglycol-bis(aminoethylether)-tetraacetic ac, SR-01000075861, ethyleneglycol-bis(aminoethyl ether)-tetraacetic acid, ethyleneglycol-bis-(aminoethylether)-tetraacetic acid, I06-0315, SR-01000075861-1, 1,2-di(2-aminoethoxy)ethane-nnn'n'-tetra-acetic acid, 1,2-di(2-aminoethoxy)ethane-n,n,n',n'-tetraacetic acid, Ethylene glycol bis-(2-aminoethyl ether)tetraacetic acid, ethylenedioxybis(ethylamine)-n,n,n',n'-tetraacetic acid, Ethyleneglycol bis-(2-aminoethyl)ether tetraacetic acid, 1,2-Bis(2-aminoethoxyethane)-N,N,N',N'-tetraacetic acid, 3,6-Dioxaoctane-1,8-diamine-N,N,N',N'-tetraacetic acid, 2,2'-Ethylenedioxybis(ethylamine)-N,N,N',N'-tetraacetic acid, ethylene glycol bis(b-aminoethyl ether)-n,n'-tetracetic acid, ethyleneglycol-bis(beta-aminoethyl)-n,n,n',n'-tetraacetic acid, OO paragraph signthorn (1/4)E<< degrees +/-OO>>uANEAOOEa, Acetic acid, [ethylenebis(oxyethylenenitrilo)]tetra- (6CI,8CI), ethylene glycol bis (2-aminoethylether)-n,n,n',n'-tetraacetic acid, ethylene glycol bis(2-aminoethylether)-n,n,n',n'-tetraacetic acid, Ethylene glycol bis(b-aminoethyl ether)-N,N,N',N'-tetraacetic acid, ethylene glycol bis(beta-aminoethylether)-n,n,n',n'-tetraacetic acid, 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid, 6,9-Dioxa-3,12-diazatetradecanedioicacid, 3,12-bis(carboxymethyl)-, Ethylene glycol bis(.beta.-aminoethyl ether)-N,N,N',N'-tetraacetic acid, ethylene glycol-bis(.beta.-aminoethyl ether)-n,n,n',n'-tetraacetic acid, Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), ethylene glycol-bis(beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid, ethylene glycol-bis-(beta-amino-ethyl ether)-n,n,n',n'-tetraacetic acid, ethylene glycol-bis-(beta-amino-ethyl ether)-n,n,n',n-tetraacetic acid, 2,11-bis(carboxymethyl)-5,8-dioxa-2,11-diazadodecane-1,12-dicarboxylic acid, 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid #, 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- (9CI), Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid, >=97.0%, Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid, >=98.0% (T), Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid, BioXtra, >=97 .0%, Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid (EGTA), Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid, 97% 10g, OO paragraph signthorn (1/4) paragraph signthornOOAN paragraph signthorn degrees .EAOOEa, 33382-61-5, 56618-01-0, Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid, BioUltra, for molecular biology, >=99.0% (T), Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid, for molecular biology, >=97.0%


ID: 32

chemical graph of compound 32



InChIKey: DHKIZPIDZINAAO-UHFFFAOYSA-N
SMILES: CCOC1=CC=CC=C1NC2=NC(=CS2)C3=C(N=C(S3)NC(=O)C4=CC=CC=C4)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"E Caci" "K Du" "N Pedemonte" "O Zegarra-Moran" "AS Verkman" "GL Lukacs" "LJ Galietta"
"MC Bartlett" "DM Clarke" "TW Loo" "Y Wang"


CID is 1144666
synonyms found at PubChem are:
MLS000561135, Oprea1_004830, Oprea1_493857, SCHEMBL837737, CHEMBL1451149, MolPort-001-986-136, ZINC888726, AKOS000562160, MCULE-3678609376, BAS 02936934, SMR000156160, ST075397, EU-0078236, SR-01000492602, SR-01000492602-1, N-[2-(2-Ethoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzamide, N-(5-{2-[(2-ethoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thiazol-2-yl)) benzamide


ID: 33

chemical graph of compound 33



InChIKey: DUEPRVBVGDRKAG-UHFFFAOYSA-N
SMILES: CC1(CC2=C(O1)C(=CC=C2)OC(=O)NC)C

biological descriptors:

CFTR relevance: medium CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 2566
synonyms found at PubChem are:
carbofuran, Furadan, 1563-66-2, Curaterr, Yaltox, Chinufur, Crisfuran, Furacarb, Furadan 3G, Furadan G, Furadan 4f, Carbofurane, Pillarfuran, Kenofuran, Niagara 10242, Karbofuranu, Brifur, BAY 70143, Niagara nia-10242, Bayer 70143, FMC 10242, NIA 10242, Carbodan, Furodan, Karbofuranu [Polish], Me f248, Caswell No. 160A, Carbofuran [ANSI:BSI:ISO], 2,2-Dimethyl-7-coumaranyl N-methylcarbamate, ENT 27,164, 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, methylcarbamate, OMS 864, 2,2-Dimethyl-2,3-dihydro-7-benzofuranyl N-methylcarbamate, BAY 78537, CCRIS 4017, Furadane, D 1221, CHEBI:34611, 2,3-Dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate, HSDB 1530, OMS-864, C2292-59A, EINECS 216-353-0, UNII-SKF77S6Y67, NIA-10242, 2,3-Dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate, 2,3-Dihydro-2,2-dimethylbenzofuranyl-7-N-methylcarbamate, EPA Pesticide Chemical Code 090601, NSC 167822, BRN 1428746, Furadan 75 WP, AI3-27164, Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester, Spectrum_001895, SpecPlus_000516, 2,2-Dimethyl-2,2-dihydrobenzofuranyl-7 N-methylcarbamate, Spectrum2_001871, Spectrum3_000848, Spectrum4_000688, Spectrum5_002012, 2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate, Methyl carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester, Carbamic acid, methyl-, 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester, Oprea1_828936, BSPBio_002435, KBioGR_001155, KBioSS_002425, SPECTRUM330057, DivK1c_006612, 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate, SPBio_001742, SKF77S6Y67, C12H15NO3, KBio1_001556, KBio2_002419, KBio2_004987, KBio2_007555, KBio3_001935, DUEPRVBVGDRKAG-UHFFFAOYSA-N, 5-17-04-00048 (Beilstein Handbook Reference), N-Metylokarbaminian 2,3-dwuwodoro-2,2-dwumetylobenzofuranylu-7 [Polish], LS-900, NSC167822, (2,2-dimethyl-3H-1-benzofuran-7-yl) N-methylcarbamate, NCGC00094541-01, NCGC00094541-02, WLN: T56 BOT&J C1 C1 IOVM1, 2,3-Dihydro-2,2-dimethyl-7-benzofuranol N-methylcarbamate, 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, 7-(N-methylcarbamate), DSSTox_CID_249, C14291, CARBOFURAN (PESTICIDE/FERTILIZER MIXTURE), DSSTox_RID_75463, DSSTox_GSID_20249, Q-200797, 2,2-Dimethyl-2,3-dihydrobenzoduranyl-7-N-methylcarbamate, 7-Benzofurano, 2,3-dihydro-2,2-dimethyl, methylcarbamate, Diafuran, Sunfuran, Terafuran, Brifer, Furadan F, CAS-1563-66-2, Curater, Tripart nex, Carbofuran mixture, Carbofuran, 98%, Niagaral 242, Sipcam UK carbosip 5G, AC1L1DYQ, SCHEMBL21656, BIDD:ER0379, Carbofuran, analytical standard, 426008_ALDRICH, 45370_RIEDEL, CHEMBL416081, DTXSID9020249, CTK8F8460, ZINC56963, N-Metylokarbaminian 2,3-dwuwodoro-2,2-dwumetylobenzofuranylu-7, Tox21_201955, Tox21_300623, BDBM50064619, CCG-39409, ZINC00056963, AKOS015907855, Carbofuran 100 microg/mL in Methanol, NA 2757, NSC-167822, Carbofuran 10 microg/mL in Cyclohexane, NCGC00094541-03, NCGC00094541-04, NCGC00094541-05, NCGC00254481-01, NCGC00259504-01, AC-10588, AN-49451, CC-25405, O719, ZB001897, SBI-0052542.P002, 2,2-dimethyl-7-benzofuranyl methylcarbamate, 2,2-dihydrobenzofuranyl-7 N-methylcarbamate, 2,2-dimethylbenzofuranyl-7-N-methylcarbamate, FT-0602922, Carbofuran, PESTANAL(R), analytical standard, 563C662, A809741, C-12281, I14-2658, (2,2-dimethyl-3H-benzofuran-7-yl) N-methylcarbamate, 2,2-DIMETHYL-7-BENZOFURANOL, METHYLCARBAMATE, BRD-K53570330-001-01-2, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-yl methylcarbamate, 7-Benzofuranol,3-dihydro-2,2-dimethyl-, methylcarbamate, 2, 3-Dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate, 2, 3-Dihydro-2,2-dimethylbenzofuranyl-7-N-methylcarbamate, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl N-methylcarbamate, 2,3-dihydro-2,2-dimethyl-benzofurane-7-yl methyl-carbamate, 2,3-dihydro-2,2-dimethylbenzofuran-7-yl N-methyl-carbamate, 2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate #, 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl N-methylcarbamate, 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate, 9CI, Carbamic acid, 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester, Carbamic acid, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester, N-methylcarbamic acid (2,2-dimethyl-3H-benzofuran-7-yl) ester, 2,3-DIHYDRO-2,2-DIMETHYL-7-BENZOFURANOL, METHYLCARBAMATE, Benzofuran-7-ol, 2,3-dihydro, 2,2-dimethyl, N-methylcarbamate, Carbamic acid, methyl-, 2,2-dimethyl-2,3-dihydro-7-benzofuranyl ester, Carbofuran;2,2-Dimethyl-2,2-dihydrobenzofuranyl-7-N-methylcarbamate; 2,2-Dimethyl-2,3-dihydrobenzofuranyl 7-methylcarbamate; 2,3-Dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate;, InChI=1/C12H15NO3/c1-12(2)7-8-5-4-6-9(10(8)16-12)15-11(14)13-3/h4-6H,7H2,1-3H3,(H,13,14


ID: 34

chemical graph of compound 34



InChIKey: FFINMCNLQNTKLU-UHFFFAOYSA-N
SMILES: C1=C(C(=C(C(=C1I)NC(=O)CCCCC(=O)NC2=C(C=C(C(=C2I)C(=O)O)I)I)I)C(=O)O)I

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 3739
synonyms found at PubChem are:
IODIPAMIDE, Adipiodone, Iodipamic acid, 606-17-7, Biligrafin, Bilignostum, Cholografin, Cholospect, Transbilix, Adipiodon, Bilignost, Adipiodona, Adipiodonum, Adipiodonum [INN-Latin], Adipiodona [INN-Spanish], Iodipamide [USAN], UNII-TKQ858A3VW, Iodipamide (USP), 3,3'-[(1,6-DIOXOHEXANE-1,6-DIYL)DIIMINO]BIS(2,4,6-TRIIODOBENZOIC ACID), 3,3'-(Adipoyldiimino)bis(2,4,6-triiodobenzoic acid), Adipiodone (JAN/INN), Adipiodone meglumine, EINECS 210-105-5, Cholografin Meglumine, BRN 2230896, TKQ858A3VW, N,N''-Adipoyl-bis(3-amino-2,4,6-triiodbenzoesaeure), IDB, IODIPAMIDE MEGLUMINE, NCGC00016523-03, CAS-606-17-7, DSSTox_CID_3153, Radio-cholografin, Benzoic acid, 3,3'-((1,6-dioxo-1,6-hexanediyl)diimino)bis(2,4,6-triiodo-, Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-, 3-[[6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl]amino]-2,4,6-triiodobenzoic acid, DSSTox_RID_76893, DSSTox_GSID_23153, 3,3-Adipoyldiiminobis(2,4,6-Triiodobenzoic Acid), 3,3'-Adipoyldiiminobis(2,4,6-triiodobenzoic Acid), 3,3'(Adipoyldiimino)bis(2,4,6-triiodobenzoic acid), Benzoic acid, 3,3'-(adipoyldiimino)bis(2,4,6-triiodo-, 3-[5-[(3-CARBOXY-2,4,6-TRIIODO-PHENYL)CARBAMOYL]PENTANOYLAMINO]-2,4,6-TRIIODO-BENZOIC ACID, Iodipamide [USP:INN], HSDB 8066, C20H14I6N2O6, meglumine adipiodone, 3-{5-[N-(3-carboxy-2,4,6-triiodophenyl)carbamoyl]pentanoylamino}-2,4,6-triiodo benzoic acid, Adipiodone [INN], AC1L1GLQ, Prestwick0_000939, Prestwick1_000939, Prestwick2_000939, Prestwick3_000939, D07OIX, AC1Q5M0A, SCHEMBL37678, BSPBio_000878, 4-14-00-01122 (Beilstein Handbook Reference), MLS001066414, SPBio_003047, BPBio1_000966, GTPL7400, CHEMBL1165268, DTXSID6023153, CHEBI:31176, CTK5B1937, FFINMCNLQNTKLU-UHFFFAOYSA-N, MolPort-001-783-518, HMS1570L20, HMS2097L20, HMS2232C09, HMS3370I13, HMS3714L20, Tox21_113504, SBB058156, AKOS015964892, Tox21_113504_1, API0001390, CCG-220939, DB04711, MCULE-6605409948, VA10176, NCGC00016523-01, NCGC00016523-02, NCGC00016523-05, CC-23800, LS-35555, SMR000471884, AB00513970, FT-0627253, I0299, ST51015022, X6858, D01774, C-23613, Iodipamide, analytical standard, for drug analysis, SR-01000760542, SR-01000760542-2, BRD-K67261995-001-03-4, I14-92724, Iodipamide, United States Pharmacopeia (USP) Reference Standard, Benzoic acid,3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-, 3-{5-[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]pentanamido}-2,4,6-triiodobenzoic acid, 3-[[6-[(3-carboxy-2,4,6-triiodophenyl)amino]-6-oxohexanoyl]amino]-2,4,6-triiodobenzoic acid


ID: 35

chemical graph of compound 35



InChIKey: FTVWIRXFELQLPI-UHFFFAOYSA-N
SMILES: C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

biological descriptors:

CFTR relevance: ΔF508 CFTR activation

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 932
synonyms found at PubChem are:
naringenin, 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, 67604-48-2, 4',5,7-Trihydroxyflavanone, Naringenine, (+/-)-Naringenin, 480-41-1, naringetol, salipurpol, (-)-Naringenin, NARIGENIN, Salipurol, 93602-28-9, 5,7,4'-Trihydroxyflavanone, (S)-Naringenin, NSC 34875, ( inverted exclamation markA)-Naringenin, CHEMBL32571, MLS000028739, MLS000738094, CHEBI:50202, Flavanone, 4',5,7-trihydroxy-, FTVWIRXFELQLPI-UHFFFAOYSA-N, NSC11855, NSC34875, SMR000059039, 4',7-Trihydroxyflavanone, NSC 11855, Flavanone,5,7-trihydroxy-, Q-100521, EINECS 207-550-2, 5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one, pelargidanon 1602, 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (S)-, naringenin-7-sulfate, NSC-34875, Narngenn, rac Naringenin, CCRIS 8135, (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone, NSC-11855, 4H-1-Benzopyran-4-one,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (S)-, Naringenin (NAR), Prestwick_531, EINECS 266-769-1, Naringenin, 90%, (R,S)-Naringenin, BE 14348A, BE-14348A, Opera_ID_106, AC1L1ACN, AC1Q6KJD, Prestwick0_000466, Prestwick1_000466, Prestwick2_000466, Prestwick3_000466, Oprea1_194140, SCHEMBL20571, 4 ,5,7-Trihydroxyflavanone, BSPBio_000572, MLS001146907, SPBio_002511, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one, BPBio1_000630, MEGxp0_000358, SCHEMBL1934259, ACon1_000582, BDBM19461, CTK7J9188, DTXSID50274239, MolPort-000-861-091, (+/-)-Naringenin, >=95%, HMS1569M14, HMS2096M14, HMS2231O18, HMS3352B08, HMS3373N07, HMS3656G15, Naringenin, natural (US), 98%, KS-000001ZW, ZX-AT026530, ANW-43843, BN0800, CN0031, SBB006461, Naringenin solution, 20 mM in DMSO, (+/-)-5,7,4'-Trihydroxyflavanone, 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, AKOS015895052, (+/-)-Naringenin, analytical standard, CS-W012357, KS-5142, LS-5089, MCULE-5489217450, RL05877, (+/-)-Naringenin, ~95% (HPCE), KS-00000R53, SMP1_000060, NCGC00017346-02, NCGC00017346-03, NCGC00017346-04, NCGC00095963-01, NCGC00095963-02, NCGC00095963-03, 4CN-0924, AC-20273, AK122638, AN-45184, K702, LS-39547, SC-18078, ST057236, AB1003941, AB1009825, AX8246816, KB-187979, KB-196356, ST2418556, TR-017609, TR-037462, 4CH-012369, FT-0082287, FT-0630981, N0072, M-7677, Naringenin, disposable screening library format, S00279, 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-one, I06-0445, I06-0536, J-523457, 4',5,7-Trihydroxyflavanone solution, 20 mM in DMSO, BRD-A94669766-001-02-6, BRD-A94669766-001-04-2, 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one, EC19096C-4404-4A16-9BF9-92F9F358E005, ( )-Naringenin; 4?,5,7-Trihydroxyflavanone; H-1-benzopyran-4-one, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one, (S)- #, ( inverted exclamation markA)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4 inverted exclamation marka,5,7-Trihydroxyflavanone


ID: 36

chemical graph of compound 36



InChIKey: HEFNNWSXXWATRW-UHFFFAOYSA-N
SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 3672
synonyms found at PubChem are:
ibuprofen, 15687-27-1, 2-(4-Isobutylphenyl)propanoic acid, Motrin, Brufen, Advil, Nurofen, Dolgit, Liptan, Nuprin, Anflagen, Buburone, Butylenin, Ibumetin, Ibuprocin, Medipren, Ebufac, Lamidon, Mynosedin, Apsifen, Epobron, Haltran, Roidenin, Trendar, Adran, Andran, Bluton, Nobfen, Nobgen, PediaProfen, Rufen, Nobfelon, Brufort, Inabrin, Pantrop, Rebugen, Suspren, Tabalon, (RS)-Ibuprofen, Anco, Urem, 2-[4-(2-methylpropyl)phenyl]propanoic acid, Ibu-slo, Brufanic, Ibuprohm, Napacetin, Ibufen, Ibren, 4-Isobutylhydratropic acid, p-Isobutylhydratropic acid, Novoprofen, Proartinal, Amersol, Dibufen, Dolocyl, Ibuprin, Lidifen, Optifen, Ostofen, Panafen, Paxofen, Proflex, Quadrax, Uprofen, Burana, Carol, Dolgin, Midol, Profen, Rafen, Cobo, Ifen, (+-)-Ibuprofen, Cap-Profen, Tab-Profen, Artril 300, Ibu-Tab, Midol 200, duralbuprofen, Butacortelone, Amibufen, Antalfene, Antarene, Antiflam, Balkaprofen, Betaprofen, Bukrefen, Buracaps, Citalgan, Combiflam, Daiprophen, Dentigoa, Dignoflex, Dolgirid, Dolmaral, Dolofort, Dolormin, Doltibil, Dysdolen, Esprenit, Exneural, Femapirin, Fibraflex, Gelufene, Ibucasen, Ibudolor, Ibuflamar, Ibugesic, Ibuhexal, Ibulagic, Ibumerck, Ibupirac, Ibuprofeno, Jenaprofen, Kratalgin, Lebrufen, Librofem, Malafene, Manypren, Mensoton, Neobrufen, Novogent, Nuprilan, Oralfene, Relcofen, Rhinadvil, Seclodin, Sednafen, Seklodin, Seskafen, Solpaflex, Suprafen, Syntofene, Alaxan, Algofen, Amelior, Anafen, Antagil, Artofen, Artril, Brofen, Bruflam, Bufeno, Bufigen, Bupron, Dansida, Dolibu, Dolofen, Dolofin, Dologel, Dolomax, Doloren, Dolven, Dorival, Duafen, Duobrus, Easifon, Emflam, Eputex, Faspic, Femadon, Femafen, Femidol, Fenbid, Fendol, Fenspan, Grefen, Gynofug, Ibubest, Ibubeta, Ibudol, Ibufug, Ibugel, Ibugen, Ibular, Ibulav, Ibuleve, Ibulgan, Ibumed, Ibusal, Ibutid, Inflam, Inoven, Isodol, Junifen, Lopane, Melfen, Moment, Narfen, Nerofen, Noalgil, Nobafon, Noritis, Norton, Novadol, Opturem, Ostarin, Ozonol, Paduden, Perofen, Provon, Ranofen, Sadefen, Salivia, Siyafen, Solufen, Stelar, Sugafen, Tatanal, Tempil, Unipron, Bloom, Cesra, Cunil, Dalsy, Ergix, Gofen, Ipren, Irfen, Kesan, Rofen, Rufin, Rupan, Tofen, Tonal, Upfen, Zafen, Zofen, alpha-(4-Isobutylphenyl)propionic acid, Drin, Ibol, Pediatric Advil, Apo-Ibuprofen, Brufen Retard, 4-Isobutyl-alpha-methylphenylacetic acid, Ibu-Attritin, Neo-Helvagit, (+/-)-Ibuprofen, Deep Relief, Dolo-Dolgit, Ibu-slow, Novo-Profen, Neo-Mindol, Dolofen-F, Donjust B, Nagifen-D, Children's Advil, Dura-Ibu, Motrin IB, Togal N, Children's Motrin, IP-82, Ibu-Tab 200, Children's Ibuprofen, Dularbuprofen, Ibuprofenum, Caldolor, Ibuprofene, Ibuprophen, Salprofen, Tabalon 400, (+-)-p-Isobutylhydratropic acid, Brufen 400, Emflam-200, Junior Strength Advil, Kontagripp Mono, DOLO PUREN, Junior Strength Motrin, Novo Dioxadol, Schmerz-Dolgit, Act-3, Ak+C2278tren, ACHES-N-PAIN, Hemagene Tailleur, Hydratropic acid, p-isobutyl-, Advil Liqui-Gels, (4-Isobutylphenyl)-alpha-methylacetic acid, Adex 200, Junior Strength Ibuprofen, Advil, Children's, Am-Fam 400, Codral Period Pain, Children's Elixsure, p-Isobutyl-2-phenylpropionic acid, (+-)-Ibuprophen, (+-)-2-(p-Isobutylphenyl)propionic acid, 58560-75-1, 2-(4-ISOBUTYLPHENYL)PROPIONIC ACID, Actiprofen, alpha-(p-isobutylphenyl)propionic acid, Midol IB Cramp Relief, Genpril, Codral, VUFB 9649, Bayer Select Pain Relief, Pedia-Profen, Ibuprofene [INN-French], Ibuprofenum [INN-Latin], Novogent N, RD 13621, Apsifen-F, Racemic ibuprofen, Ibuprofeno [INN-Spanish], U-18,573, alpha-p-Isobutylphenylpropionic acid, MOTRIN MIGRAINE PAIN, IB-100, Motrin IB Gelcaps, UCB 79171, (+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid, 2-(4-Isobutyl-phenyl)-propionic acid, Motrin (TN), CCRIS 3223, CHEBI:5855, Advil (TN), alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid, CHILDREN'S ADVIL-FLAVORED, Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, HSDB 3099, Children's Elixsure IB, Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)-, 2-(p-Isobutylphenyl)propionic acid, EINECS 239-784-6, CHEMBL521, U 18573, NSC 256857, BRN 2049713, MLS000069733, Ibu, (S)-4-Isobutyl-alpha-methylphenylacetic acid, R.D. 13621, HEFNNWSXXWATRW-UHFFFAOYSA-N, (R)-Ibuprofen, (+/-)-p-Isobutylhydratropic acid, Acide (isobutyl-4-phenyl)-2 propionique [French], C13H18O2, U-18573, NSC256857, .alpha.-(p-isobutylphenyl)propionic acid, NCGC00015529-09, .alpha.-(4-Isobutylphenyl)propionic acid, Acide (isobutyl-4 phenyl)-2 propionique, SMR000058184, 4-Isobutyl-.alpha.-methylphenylacetic acid, alpha-Methyl-4-(isobutyl)phenylacetic acid, DSSTox_CID_732, (+/-)-2-(4-Isobutylphenyl)Propanoic Acid, [(+/-)-2-(4-Isobutylphenyl)-propionic Acid, I 4883, DSSTox_RID_75759, DSSTox_GSID_20732, alpha-Methyl-4-[2-methylpropyl] benzeneacetic Acid, .alpha.-Methyl-4-(2-methylpropyl)benzeneacetic acid, Alivium, Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (+-)-, Pedea, Advil migraine, Ibuprofen-Zinc, Perrigo ibuprofen, Trauma-Dolgit Gel, CAS-15687-27-1, SR-01000000214, Ibuprofen I.V. Solution, Advil Migraine Liqui-Gels, Ibupril, Ibuprox, Aktren, Ibup, Ibux, Fenbid Spansule, IP82, CDT-ibuprofen, Nurofen Meltlets, (y)-Ibuprofen, Ratiodolor (TN), Arthrofen (TN), Calprofen (TN), Espidifen (TN), Finalflex (TN), Galprofen (TN), Ibuprofen,(S), Ibuprosyn (TN), IP 82, Kratalgin (TN), Midol Liquid Gels, Neobrufen (TN), Norvectan (TN), Salvarina (TN), Solpaflex (TN), (+) ibuprofen, Algoflex (TN), Caldolor (TN), Dismenol (TN), Dolofort (TN), Dolormin (TN), EmuProfen (TN), Ibumetin (TN), Ibuprofen (Advil), Nureflex (TN), Spedifen (TN), Spidifen (TN), (?)-Ibuprofen, Alivium (TN), Bonifen (TN), Bugesic (TN), Diverin (TN), Doloraz (TN), Dorival (TN), Fenpaed (TN), Ibalgin (TN), Ibuleve (TN), Ibuprom (TN), Medicol (TN), Nurofen (TN), Orbifen (TN), Panafen (TN), Perifar (TN), Rimafen (TN), Alaxan (TN), Brufen (TN), Burana (TN), Dolgit (TN), Ebufac (TN), Fenbid (TN), Herron Blue (TN), Ibu-Vivimed (TN), Ibugel (TN), Ibumax (TN), Ibuxin (TN), Moment (TN), Narfen (TN), Neofen (TN), Nuprin (TN), Profin (TN), Retard (TN), I-profen (TN), ibuprofen lysine salt, Aktre (TN), Dalsy (TN), Hedex (TN), Ibuprofen (Dolgesic), Ipren (TN), p-Isobutylhydratropate, Upfen (TN), Dolo-Spedifen (TN), Ibuprofen [USAN:USP:INN:BAN:JAN], Combunox (Salt/Mix), (A+/-)-Ibuprofen, Ibum (TN), Ibux (TN), IBU-Ratiopharm (TN), IbuHEXAL (TN), PubChem16054, Spectrum_000849, Acide (isobutyl-4-phenyl)-2 propionique, Speedpain NANO (TN), Opera_ID_554, Eve (TN), AC1L1GGE, Spectrum2_000129, Spectrum3_000465, Spectrum4_000015, Spectrum5_000862, IBUFEN (TN), WLN: QVY&R DIY, CBMicro_005634, IBUPROFEN USP GRADE, ACMC-209df0, ACMC-209ks2, D03SHR, D0R1QE, Epitope ID:139973, p-isobutyl-hydratropic acid, EC 239-784-6, Act-3 (TN), Cambridge id 5152402, SCHEMBL3001, Isobutylpropanoicphenolic acid, Lopac0_000691, Para-Isobutylhydratropic Acid, BSPBio_002170, Ibuprofen - Adooq Bioscience, KBioGR_000389, KBioSS_001329, KSC492A1B, MLS001146965, p-Isobutyl-2-phenylpropionate, ARONIS23835, BIDD:GT0050, DivK1c_000887, SPECTRUM1500347, Ibuprofen, >=98% (GC), SPBio_000178, Ibuprofen (JP17/USP/INN), AC1Q1P84, AC1Q1P85, alpha-p-Isobutylphenylpropionate, GTPL2713, Motrin IB Gelcaps (Salt/Mix), 2-p-isobutylphenylpropionic acid, DTXSID5020732, CTK3J2010, HEFNNWSXXWATRW-UHFFFAOYSA-, HMS502M09, KBio1_000887, KBio2_001329, KBio2_003897, KBio2_006465, KBio3_001390, Advil Cold & Sinus (Salt/Mix), Ibuprofen [USAN:BAN:INN:JAN], Ibuprofen 1.0 mg/ml in Methanol, MolPort-001-791-802, NINDS_000887, Sine-Aid IB Caplets (Salt/Mix), 2-(4-Isobutylphenyl)propanoicAcid, alpha-(4-Isobutylphenyl)propionate, HMS1920F15, HMS2089P05, HMS2091N03, HMS2230N04, HMS3259G05, HMS3262K03, HMS3372M09, HMS3649M11, HMS3651A15, Pharmakon1600-01500347, ACT03248, ALBB-025647, BCP10423, BCP20325, BCP25225, KS-00000CJ0, KS-000047NV, ZAG-1701, ( inverted question mark)-Ibuprofen, (.+-.)-p-Isobutylhydratropic acid, 79261-49-7 (potassium salt), Children's Elixsure IB (Salt/Mix), Tox21_110170, Tox21_201384, Tox21_302829, Tox21_500691, 2-(4'-isobutylphenyl)propionic acid, 2-(4-isobutylphenyl) propanoic acid, 2-(4-isobutylphenyl) propionic acid, 2-(4-isobutylphenyl)-propionic acid, ANW-21658, BBL010660, BDBM50009859, CCG-38947, MFCD00010393, NSC757073, s1638, SBB064160, STK177358, (.+/-.)-p-Isobutylhydratropic acid, 2-(4-isobutylphenyl)-propionoic acid, 2-(4'-isobutylphenyl)-propionic acid, 31121-93-4 (hydrochloride salt), AKOS003237488, AKOS016340658, Propanoic acid, 2-(4-isobutylphenyl), Tox21_110170_1, CS-1931, DB01050, KS-5029, LP00691, LS-7454, MCULE-9475454445, NC00458, NSC-256857, NSC-757073, RP26239, RTR-006580, ST-1482, TRA0047278, ( inverted exclamation markA)-Ibuprofen, alpha-(4-isobutylphenyl)-propionic acid, alpha-(p-isobutylphenyl)-propionic acid, IDI1_000887, NCGC00015529-04, NCGC00015529-05, NCGC00015529-06, NCGC00015529-07, NCGC00015529-08, NCGC00015529-10, NCGC00015529-12, NCGC00015529-13, NCGC00015529-14, NCGC00015529-15, NCGC00015529-18, NCGC00089819-02, NCGC00089819-03, NCGC00089819-04, NCGC00089819-05, NCGC00089819-06, NCGC00089819-07, NCGC00256416-01, NCGC00258935-01, NCGC00261376-01, AC-11312, AN-18584, BR-47272, CPD000058184, HY-78131, NCI60_002065, SAM002264619, SC-18867, ST024750, Ibuprofen, Vetec(TM) reagent grade, 97%, SBI-0050669.P004, (+/-)-2-(p-isobutylphenyl)propionic acid, .alpha.-2-(p-Isobutylphenyl)propionic acid, AB1009266, Ibuprofen, meets USP testing specifications, KB-222912, TL8001184, TR-006580, (.+-.)-2-(p-Isobutylphenyl)propionic acid, 4-Isobutylphenyl)-.alpha.-methylacetic acid, AM20060782, BB 0258487, EU-0100691, FT-0601629, FT-0655194, I0415, ST24032335, (.+/-.)-2-(p-Isobutylphenyl)propionic acid, Ibuprofen, VETRANAL(TM), analytical standard, (r/s)-alpha-methyl-4-isobutylphenylacetic acid, C01588, D00126, J10135, M-4957, AB00052020-16, AB00052020-17, AB00052020_18, AB00052020_19, (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid, 687I271, A831926, I01-7039, J-009349, SR-01000000214-2, SR-01000000214-4, BRD-A17655518-001-02-0, BRD-A17655518-001-12-9, SR-01000000214-13, Ibuprofen, British Pharmacopoeia (BP) Reference Standard, Z1695709473, (+/-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid, Ibuprofen, European Pharmacopoeia (EP) Reference Standard, Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (+/-)-, Ibuprofen, United States Pharmacopeia (USP) Reference Standard, (? inverted exclamation markA)-2-(4-Isobutylphenyl)Propanoic Acid, Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl), (.+/-.)-, Ibuprofen, Pharmaceutical Secondary Standard; Certified Reference Material, Ibuprofen for peak identification, European Pharmacopoeia (EP) Reference Standard, N4,N4' -Di(naphthalen-1-yl)-N4,N4' -bis(4-vinylphenyl)biphenyl-4,4'-diamine, (2s)-2-[4-(2-methylpropyl)phenyl]propionic acid DEXIBUPROFEN (S)-(+)-2-(4-ISOBUTYLPHENYL)PROPIONIC ACID (S)-(+)-4-ISOBUTYL-ALPHA-ME, 139466-08-3, 2-(4-Isobutylphenyl)-propionic acid ; alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid ; p-Isobutylhydratropic acid, InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)


ID: 37

chemical graph of compound 37



InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

biological descriptors:

CFTR relevance: Phosphodiesterase 4 inhibitor

Category:
Influence on CFTR function none
Order of interaction indirect
subcellular compartment several

reference list:

"PC Chao" "KL Hamilton"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5092
synonyms found at PubChem are:
rolipram, 61413-54-5, ZK 62711, Rolipramum, Rolipramum [Latin], 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, Adeo, (+/-)-Rolipram, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one, Rolipram [USAN:INN], [3H]rolipram, 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one, (R,S)-rolipram, [3H]-rolipram, ZK-62711, CHEMBL63, EINECS 262-771-1, BRN 1588548, MLS000069691, CHEBI:104872, HJORMJIFDVBMOB-UHFFFAOYSA-N, 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone, IN1123, 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one, ME-3167, 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, SB 95952, SMR000058510, DSSTox_CID_24124, DSSTox_RID_80104, DSSTox_GSID_44124, 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one, 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (4R)-4-[3-(Cyclopentyloxy)-4 Methoxyphenyl)pyrrolidin-2-one, CPD000058510, SR-01000000162, (plusmn)-rolipram, NCGC00016899-01, CAS-61413-54-5, AC1L1JLC, Opera_ID_1749, Prestwick0_000924, Prestwick1_000924, Prestwick2_000924, Prestwick3_000924, D05HPY, D0T5PO, UPCMLD-DP110, AC1Q6O0R, Lopac0_001072, SCHEMBL27930, BSPBio_000828, BSPBio_001356, KBioGR_000076, KBioSS_000076, Rolipram (JAN/USAN/INN), MLS000758273, MLS000759531, MLS001146912, MLS001424084, MLS006010272, SPBio_003007, BPBio1_000912, GTPL5260, GTPL5313, Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-, DTXSID3044124, UPCMLD-DP110:001, UPCMLD-DP110:002, BDBM14361, CTK5F4996, KBio2_000076, KBio2_002644, KBio2_005212, KBio3_000151, KBio3_000152, AOB5326, MolPort-000-860-686, Bio2_000076, Bio2_000556, HMS1361D18, HMS1570J10, HMS1791D18, HMS1989D18, HMS2051N15, HMS2090J16, HMS2097J10, HMS2232F06, HMS3263G06, HMS3267A05, HMS3369J08, HMS3393N15, HMS3402D18, HMS3654P06, HMS3655J21, HMS3714J10, Pharmakon1600-01505683, BCP21910, BCP23388, KS-000004QI, ZX-AN014777, Tox21_110672, Tox21_501072, 2028AH, 2691AH, BS0164, MFCD00270906, NSC760125, Rolipram, solid, >=98% (HPLC), s1430, AKOS015959793, Tox21_110672_1, CCG-100965, CCG-205149, CS-1754, DB01954, INB0003603, KS-1400, LP01072, NC00215, NSC-760125, IDI1_033826, NCGC00015898-03, NCGC00015898-04, NCGC00015898-05, NCGC00015898-06, NCGC00015898-07, NCGC00015898-08, NCGC00015898-09, NCGC00015898-11, NCGC00015898-12, NCGC00015898-15, NCGC00089796-02, NCGC00089796-04, NCGC00089796-05, NCGC00089796-06, NCGC00089796-07, NCGC00089796-08, NCGC00261757-01, AK174013, AN-39288, BC660173, HY-16900, KB-86388, SAM001246766, SAM001246998, SC-47452, ZK-62771, SBI-0051042.P002, AB0109850, LS-138709, ZK 62 711, AB00513966, EU-0101072, FT-0738515, R0110, ST50405218, D01783, R 6520, AB00384360-17, AB00384360_19, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidinone, SR-01000000162-3, SR-01000000162-4, SR-01000000162-5, SR-01000000162-9, 4-[3-Cyclopentyloxy-4-methoxyphenyl]-2-pyrrolidinone, BRD-A34255068-001-04-8, BRD-A34255068-001-26-1, SR-01000000162-12, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon, 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one, 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one, 4-(3-cyclopentyloxy-4-methoxyphenyl)-pyrrolidin-2-one, 4-[4-Methoxy-3-(cyclopentyloxy)phenyl]-2-pyrrolidinone, 2-Pyrrolidinone,4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]- (9CI), ZK 62711, SB 95952, ME-3167, Adeo, 61413-54-5


ID: 38

chemical graph of compound 38



InChIKey: HKQYGTCOTHHOMP-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5280378
synonyms found at PubChem are:
formononetin, 485-72-3, Biochanin B, Formononetol, 7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one, 7-Hydroxy-4'-methoxyisoflavone, 4'-O-methyldaidzein, 7-hydroxy-3-(4-methoxyphenyl)chromen-4-one, 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-, UNII-295DQC67BJ, 7-Hydroxy-3-(4-methoxyphenyl)-4-benzopyrone, CHEBI:18088, Isoflavone, 7-hydroxy-4'-methoxy-, EINECS 207-623-9, NSC 93360, NSC-93360, 7-Hydroxy-3-(4-methoxyphenyl)chromone, 295DQC67BJ, HKQYGTCOTHHOMP-UHFFFAOYSA-N, NSC93360, IN1330, 7-hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one, Q-100540, 7-Hydroxy-3-(4&prime;-methoxyphenyl)-4H-benzopyran-4-one, SMR000470932, SR-01000765510, formononetine, 7-hydroxy-4'-methoxy-isoflavone, Formononetin,(S), PubChem9850, AC1NQWYT, Spectrum_000373, SpecPlus_000223, Daidzein 4-methyl ether, Spectrum2_000560, Spectrum3_000660, Spectrum4_001429, Spectrum5_000258, DSSTox_CID_2311, D0M7BR, Formononetin (Formononetol), DSSTox_RID_76544, NCIOpen2_005983, DSSTox_GSID_22311, Oprea1_139748, Oprea1_815287, SCHEMBL62915, BSPBio_002299, KBioGR_001878, KBioSS_000853, SPECTRUM102007, MLS000697593, MLS006011897, BIDD:ER0119, DivK1c_006319, SPBio_000639, CHEMBL242341, DTXSID4022311, CTK8C4788, Formononetin, analytical standard, KBio1_001263, KBio2_000853, KBio2_003421, KBio2_005989, KBio3_001519, KS-00000HZV, MolPort-000-450-946, HMS1922N18, HMS2231I04, HMS3369C07, HMS3655N22, ALBB-030789, Formononetin, >=99.0% (TLC), HY-N0183, TNP00176, Tox21_301848, ANW-73131, BBL010458, BDBM50021398, CCG-38727, CF0045, LMPK12050037, MFCD00016948, s2299, SBB016445, STK801612, ZINC18847036, AKOS000270811, AC-8001, AN-8422, CS-3081, MCULE-4171151967, SDCCGMLS-0066428.P001, 7-hydroxy-4'-methoxy-Isoflavone (8CI), NCGC00017269-01, NCGC00017269-02, NCGC00017269-03, NCGC00017269-04, NCGC00017269-05, NCGC00017269-06, NCGC00095207-01, NCGC00095207-02, NCGC00095207-03, NCGC00178715-01, NCGC00255167-01, 4CN-0880, AJ-70674, AK106172, AS-11642, BC216233, CAS-485-72-3, CC-28828, LS-39701, NCI60_042081, SC-04770, ST024713, AB0010475, AX8016260, Isoflavone, 7-hydroxy-4'-methoxy- (8CI), Neochanin; Flavosil;NEOCHANIN;Formononetol, F0868, FT-0626540, FT-0632204, K-080, N1625, 3-(4-methoxyphenyl)-7-oxidanyl-chromen-4-one, C00858, AB00052676-07, 485F723, A827555, AE-641/01968055, C-16842, 7-hydroxy-3-(4-methoxyphenyl)-1-benzopyran-4-one, I06-0241, SR-01000765510-3, SR-01000765510-4, BRD-K55567017-001-02-4, BRD-K55567017-001-06-5, F3139-1207, 7-hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one(9CI), 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (9CI), Formononetin, United States Pharmacopeia (USP) Reference Standard, 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one, 7-Hydroxy-3-(4-methoxyphenyl)chromone, 7-Hydroxy-4'-methoxyisoflavone


ID: 39

chemical graph of compound 39



InChIKey: IAZDPXIOMUYVGZ-UHFFFAOYSA-N
SMILES: CS(=O)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"S Canny" "J Glöckner-Pagel" "D Rubin" "K Du" "V Rajendran" "ME Egan" "M Pearson" "GL Lukacs" "MJ Caplan" "SA Weiner"
"R Narlawar" "W Wang" "K Bernard" "B Schmidt" "KL Kirk"


CID is 679
synonyms found at PubChem are:
dimethyl sulfoxide, DMSO, Methyl sulfoxide, 67-68-5, Methylsulfinylmethane, Dimethylsulfoxide, Dimethyl sulphoxide, Methane, sulfinylbis-, Demsodrox, Demasorb, Demavet, Dimexide, Domoso, Dromisol, Durasorb, Infiltrina, Somipront, Syntexan, Deltan, Demeso, Dolicur, Hyadur, sulfinylbismethane, Dimethyl sulfur oxide, Dermasorb, Dipirartril-tropico, Doligur, Kemsol, Topsym, Gamasol 90, Sclerosol, Sulfinylbis(methane), Rimso-50, Dimethylsulfoxid, Dimethylsulfoxyde, Rimso 50, Dimethylsulphoxide, Caswell No. 381, SQ 9453, Dimetil sulfoxido, Sulfinylbis-methane, Dimethyli sulfoxidum, Topsym (rescinded), Rimso-5, NSC-763, methanesulfinylmethane, Domoso (Veterinary), CCRIS 943, (methylsulfinyl)methane, methylsulfoxide, (CH3)2SO, Dimexidum, DMS-90, sulfinyldimethane, NSC 763, Dimetilsolfossido [DCIT], A 10846, Dimethyl sulpoxide, M 176, UNII-YOW8V9698H, HSDB 80, Methane, 1,1'-sulfinylbis-, EPA Pesticide Chemical Code 000177, DMS 70, DMS 90, DMS-70, Dimethylsulfoxyde [INN-French], AI3-26477, Dimetil sulfoxido [INN-Spanish], Dimethyli sulfoxidum [INN-Latin], Methyl Sulfoxide: DMSO, EINECS 200-664-3, CHEMBL504, S(O)Me2, NSC763, YOW8V9698H, CHEBI:28262, IAZDPXIOMUYVGZ-UHFFFAOYSA-N, SQ-9453, DIMETHYL SULFOXIDE- D6, Rimso, Dimethylsulphinyl, Dimetilsolfossido, Sulfoxide, dimethyl, Rimso 100, Diluent, dimethysulfoxide, Decap, dimethlysulfoxide, dimethvlsulfoxide, dimethyisulfoxide, dimethylsulphoxid, dimethy sulfoxide, dimetyl sulfoxide, dimethyisulphoxide, Dimethyl sulfoxide [USAN:INN], Methyl sulphoxide, dimethyl sulfoxyde, dimethyl-sulfoxide, dimethyl-sulfoxyde, Diemthyl sulfoxide, dimethyl suiphoxide, dimethyl-sulphoxide, dirnethyl sulfoxide, Dimethyl sulfoxixde, methylsulfmylmethane, Dimethyl Sulfoxydum, dimethyl sulf oxide, qCbPPAD]h@, Dimethyl sulfoxide BP, 2-Thiapropane2-oxide, (methanesulfinyl)methane, Dimethyl sulfoxide [USAN:USP:INN:BAN], DMSO, sterile filtered, DMSO; Methyl sulfoxide, AC1Q4GSG, Methyl sulfoxide (8CI), Rimso-50 (TN), DMSO, Dimethyl Sulfoxide, DSSTox_CID_1735, (DMSO), C2H6OS, D08HVE, EC 200-664-3, Sulfinylbis-methane (9CI), AC1L19RZ, ACMC-1BH88, DSSTox_RID_76298, H3C-SO-CH3, BIDD:PXR0182, DSSTox_GSID_21735, Dimethyl sulfoxide, >=99%, Dimethyl sulfoxide, for HPLC, KSC353A9L, DMSO, 80% aqueous solution, Methane, sulfinylbis- (9CI), Dimethyl sulfoxide (USP/INN), DIMETHYL SULFOXIDE, ACS, WLN: OS1&1, Dimethyl sulfoxide, >=99.5%, Dimethyl sulfoxide, PCR Reagent, DTXSID2021735, CTK2F3095, Dimethyl sulfoxide, ACS reagent, Methyl sulfoxide, >=99%, FG, Dimethyl sulfoxide, p.a., 99%, MolPort-002-317-295, Dimethyl sulfoxide, 99% 500g, Dimethyl sulfoxide, LR, >=99%, Pharmakon1600-01506122, KS-00000VT9, ZINC5224188, Tox21_300957, ANW-42740, BDBM50026472, MFCD00002089, NSC760436, STL264194, Dimethyl sulfoxide, AR, >=99.5%, AKOS000121107, CCG-213615, DB01093, Dimethyl sulfoxide, analytical standard, LS-1568, MCULE-2005841258, NSC-760436, RL04586, RP18373, RTR-022725, CAS-67-68-5, MRF-0000764, (methanesulfinyl)methanedimethyl sulfoxide, Dimethyl sulfoxide, for molecular biology, NCGC00163958-01, NCGC00163958-02, NCGC00163958-03, NCGC00254859-01, AN-20755, AN-23766, Dimethyl sulfoxide, anhydrous, >=99.9%, Dimethyl sulfoxide, HPLC grade, 99.9%, SC-16101, Dimethyl Sulfoxide [for Spectrophotometry], Dimethyl sulfoxide, for HPLC, >=99.5%, Dimethyl sulfoxide, for HPLC, >=99.7%, AB1004054, AB1004058, TL8004767, TR-022725, D0798, D5293, Dimethyl sulfoxide, ACS reagent, >=99.9%, Dimethyl sulfoxide, AldraSORB(TM), 99.8%, FT-0625099, InChI=1/C2H6OS/c1-4(2)3/h1-2H, 1926-EP1441224A2, 1926-EP2269977A2, 1926-EP2269978A2, 1926-EP2269979A1, 1926-EP2269985A2, 1926-EP2269989A1, 1926-EP2269990A1, 1926-EP2269991A2, 1926-EP2269992A1, 1926-EP2269993A1, 1926-EP2269994A1, 1926-EP2269996A1, 1926-EP2270003A1, 1926-EP2270004A1, 1926-EP2270006A1, 1926-EP2270008A1, 1926-EP2270010A1, 1926-EP2270011A1, 1926-EP2270012A1, 1926-EP2270013A1, 1926-EP2270014A1, 1926-EP2270015A1, 1926-EP2270018A1, 1926-EP2272509A1, 1926-EP2272510A1, 1926-EP2272517A1, 1926-EP2272813A2, 1926-EP2272817A1, 1926-EP2272822A1, 1926-EP2272825A2, 1926-EP2272827A1, 1926-EP2272834A1, 1926-EP2272835A1, 1926-EP2272839A1, 1926-EP2272840A1, 1926-EP2272841A1, 1926-EP2272842A1, 1926-EP2272844A1, 1926-EP2272848A1, 1926-EP2272972A1, 1926-EP2272973A1, 1926-EP2274983A1, 1926-EP2275102A1, 1926-EP2275403A1, 1926-EP2275409A1, 1926-EP2275412A1, 1926-EP2275413A1, 1926-EP2275414A1, 1926-EP2275416A1, 1926-EP2275420A1, 1926-EP2275421A1, 1926-EP2275422A1, 1926-EP2275425A1, 1926-EP2277848A1, 1926-EP2277858A1, 1926-EP2277866A1, 1926-EP2277872A1, 1926-EP2277875A2, 1926-EP2277876A1, 1926-EP2277878A1, 1926-EP2277881A1, 1926-EP2277898A2, 1926-EP2277945A1, 1926-EP2279741A2, 1926-EP2279750A1, 1926-EP2280001A1, 1926-EP2280006A1, 1926-EP2280008A2, 1926-EP2280009A1, 1926-EP2280011A1, 1926-EP2280012A2, 1926-EP2280013A1, 1926-EP2280014A2, 1926-EP2281559A1, 1926-EP2281563A1, 1926-EP2281810A1, 1926-EP2281813A1, 1926-EP2281815A1, 1926-EP2281817A1, 1926-EP2281819A1, 1926-EP2281823A2, 1926-EP2281899A2, 1926-EP2284150A2, 1926-EP2284151A2, 1926-EP2284152A2, 1926-EP2284153A2, 1926-EP2284154A1, 1926-EP2284155A2, 1926-EP2284156A2, 1926-EP2284157A1, 1926-EP2284159A1, 1926-EP2284160A1, 1926-EP2284164A2, 1926-EP2284166A1, 1926-EP2284167A2, 1926-EP2284168A2, 1926-EP2284172A1, 1926-EP2284174A1, 1926-EP2284178A2, 1926-EP2284179A2, 1926-EP2286811A1, 1926-EP2286915A2, 1926-EP2287140A2, 1926-EP2287148A2, 1926-EP2287150A2, 1926-EP2287153A1, 1926-EP2287156A1, 1926-EP2287163A1, 1926-EP2287164A1, 1926-EP2287165A2, 1926-EP2287166A2, 1926-EP2287168A2, 1926-EP2289871A1, 1926-EP2289876A1, 1926-EP2289882A1, 1926-EP2289883A1, 1926-EP2289885A1, 1926-EP2289886A1, 1926-EP2289890A1, 1926-EP2289891A2, 1926-EP2289892A1, 1926-EP2289893A1, 1926-EP2289894A2, 1926-EP2292088A1, 1926-EP2292227A2, 1926-EP2292228A1, 1926-EP2292233A2, 1926-EP2292234A1, 1926-EP2292576A2, 1926-EP2292589A1, 1926-EP2292590A2, 1926-EP2292592A1, 1926-EP2292593A2, 1926-EP2292595A1, 1926-EP2292597A1, 1926-EP2292606A1, 1926-EP2292609A1, 1926-EP2292611A1, 1926-EP2292613A1, 1926-EP2292614A1, 1926-EP2292615A1, 1926-EP2292617A1, 1926-EP2292619A1, 1926-EP2292620A2, 1926-EP2292630A1, 1926-EP2295053A1, 1926-EP2295055A2, 1926-EP2295401A2, 1926-EP2295402A2, 1926-EP2295406A1, 1926-EP2295407A1, 1926-EP2295408A1, 1926-EP2295410A1, 1926-EP2295411A1, 1926-EP2295412A1, 1926-EP2295413A1, 1926-EP2295414A1, 1926-EP2295415A1, 1926-EP2295416A2, 1926-EP2295417A1, 1926-EP2295418A1, 1926-EP2295419A2, 1926-EP2295422A2, 1926-EP2295423A1, 1926-EP2295424A1, 1926-EP2295425A1, 1926-EP2295426A1, 1926-EP2295427A1, 1926-EP2295429A1, 1926-EP2295432A1, 1926-EP2295433A2, 1926-EP2295434A2, 1926-EP2295439A1, 1926-EP2295503A1, 1926-EP2295550A2, 1926-EP2298305A1, 1926-EP2298312A1, 1926-EP2298731A1, 1926-EP2298732A1, 1926-EP2298734A2, 1926-EP2298735A1, 1926-EP2298736A1, 1926-EP2298742A1, 1926-EP2298743A1, 1926-EP2298744A2, 1926-EP2298745A1, 1926-EP2298746A1, 1926-EP2298747A1, 1926-EP2298748A2, 1926-EP2298750A1, 1926-EP2298761A1, 1926-EP2298764A1, 1926-EP2298765A1, 1926-EP2298767A1, 1926-EP2298768A1, 1926-EP2298769A1, 1926-EP2298770A1, 1926-EP2298773A1, 1926-EP2298774A1, 1926-EP2298776A1, 1926-EP2298778A1, 1926-EP2298779A1, 1926-EP2298780A1, 1926-EP2298783A1, 1926-EP2301534A1, 1926-EP2301536A1, 1926-EP2301538A1, 1926-EP2301627A1, 1926-EP2301909A1, 1926-EP2301912A2, 1926-EP2301913A1, 1926-EP2301914A1, 1926-EP2301916A2, 1926-EP2301922A1, 1926-EP2301923A1, 1926-EP2301925A1, 1926-EP2301926A1, 1926-EP2301928A1, 1926-EP2301929A1, 1926-EP2301930A1, 1926-EP2301932A1, 1926-EP2301933A1, 1926-EP2301935A1, 1926-EP2301936A1, 1926-EP2301937A1, 1926-EP2301939A1, 1926-EP2301940A1, 1926-EP2302382A2, 1926-EP2302383A2, 1926-EP2305250A1, 1926-EP2305254A1, 1926-EP2305629A1, 1926-EP2305637A2, 1926-EP2305640A2, 1926-EP2305641A1, 1926-EP2305642A2, 1926-EP2305643A1, 1926-EP2305647A1, 1926-EP2305648A1, 1926-EP2305651A1, 1926-EP2305652A2, 1926-EP2305655A2, 1926-EP2305658A1, 1926-EP2305659A1, 1926-EP2305660A1, 1926-EP2305663A1, 1926-EP2305666A1, 1926-EP2305667A2, 1926-EP2305668A1, 1926-EP2305671A1, 1926-EP2305672A1, 1926-EP2305674A1, 1926-EP2305677A1, 1926-EP2305679A1, 1926-EP2305681A1, 1926-EP2305682A1, 1926-EP2305684A1, 1926-EP2305687A1, 1926-EP2305688A1, 1926-EP2305689A1, 1926-EP2305695A2, 1926-EP2305696A2, 1926-EP2305697A2, 1926-EP2305698A2, 1926-EP2305769A2, 1926-EP2305808A1, 1926-EP2308510A1, 1926-EP2308562A2, 1926-EP2308812A2, 1926-EP2308832A1, 1926-EP2308833A2, 1926-EP2308838A1, 1926-EP2308840A1, 1926-EP2308841A2, 1926-EP2308844A2, 1926-EP2308845A2, 1926-EP2308846A2, 1926-EP2308847A1, 1926-EP2308848A1, 1926-EP2308852A1, 1926-EP2308854A1, 1926-EP2308855A1, 1926-EP2308857A1, 1926-EP2308861A1, 1926-EP2308863A1, 1926-EP2308866A1, 1926-EP2308867A2, 1926-EP2308868A1, 1926-EP2308869A1, 1926-EP2308870A2, 1926-EP2308871A1, 1926-EP2308872A1, 1926-EP2308873A1, 1926-EP2308874A1, 1926-EP2308875A1, 1926-EP2308877A1, 1926-EP2308878A2, 1926-EP2308879A1, 1926-EP2308880A1, 1926-EP2308960A1, 1926-EP2311451A1, 1926-EP2311453A1, 1926-EP2311455A1, 1926-EP2311494A1, 1926-EP2311796A1, 1926-EP2311797A1, 1926-EP2311798A1, 1926-EP2311799A1, 1926-EP2311801A1, 1926-EP2311806A2, 1926-EP2311807A1, 1926-EP2311809A1, 1926-EP2311811A1, 1926-EP2311815A1, 1926-EP2311818A1, 1926-EP2311823A1, 1926-EP2311824A1, 1926-EP2311825A1, 1926-EP2311827A1, 1926-EP2311829A1, 1926-EP2311830A1, 1926-EP2311831A1, 1926-EP2311837A1, 1926-EP2311838A1, 1926-EP2311840A1, 1926-EP2311842A2, 1926-EP2311850A1, 1926-EP2314295A1, 1926-EP2314574A1, 1926-EP2314576A1, 1926-EP2314580A1, 1926-EP2314583A1, 1926-EP2314584A1, 1926-EP2314585A1, 1926-EP2314586A1, 1926-EP2314587A1, 1926-EP2314588A1, 1926-EP2314590A1, 1926-EP2314593A1, 1926-EP2315303A1, 1926-EP2316450A1, 1926-EP2316452A1, 1926-EP2316459A1, 1926-EP2316824A1, 1926-EP2316827A1, 1926-EP2316828A1, 1926-EP2316829A1, 1926-EP2316831A1, 1926-EP2316832A1, 1926-EP2316833A1, 1926-EP2316834A1, 1926-EP2316835A1, 1926-EP2316836A1, 1926-EP2316905A1, 1926-EP2316906A2, 1926-EP2371797A1, 1926-EP2371798A1, 1926-EP2371800A1, 1926-EP2371804A1, 1926-EP2371805A1, 1926-EP2371809A1, 1926-EP2371810A1, 1926-EP2371811A2, 1926-EP2374454A1, 1926-EP2374790A1, 1926-EP2374791A1, 1926-EP2374895A1, 1926-EP2377849A2, 1926-EP2380873A1, 1926-EP2380874A2, 4606-EP2269975A2, 4606-EP2269977A2, 4606-EP2269993A1, 4606-EP2269996A1, 4606-EP2269997A2, 4606-EP2270000A1, 4606-EP2270006A1, 4606-EP2270009A1, 4606-EP2270011A1, 4606-EP2270012A1, 4606-EP2270013A1, 4606-EP2270014A1, 4606-EP2270113A1, 4606-EP2270114A1, 4606-EP2272509A1, 4606-EP2272813A2, 4606-EP2272827A1, 4606-EP2272835A1, 4606-EP2272843A1, 4606-EP2272844A1, 4606-EP2272848A1, 4606-EP2272935A1, 4606-EP2275395A2, 4606-EP2275409A1, 4606-EP2275412A1, 4606-EP2275415A2, 4606-EP2275425A1, 4606-EP2275427A1, 4606-EP2277858A1, 4606-EP2277866A1, 4606-EP2277876A1, 4606-EP2277880A1, 4606-EP2277881A1, 4606-EP2280001A1, 4606-EP2280008A2, 4606-EP2280009A1, 4606-EP2280013A1, 4606-EP2280014A2, 4606-EP2281563A1, 4606-EP2281812A1, 4606-EP2281813A1, 4606-EP2281817A1, 4606-EP2281818A1, 4606-EP2284154A1, 4606-EP2284160A1, 4606-EP2284169A1, 4606-EP2286811A1, 4606-EP2287141A1, 4606-EP2287147A2, 4606-EP2287153A1, 4606-EP2287161A1, 4606-EP2287162A1, 4606-EP2287168A2, 4606-EP2289509A2, 4606-EP2289879A1, 4606-EP2289883A1, 4606-EP2289885A1, 4606-EP2289887A2, 4606-EP2289888A2, 4606-EP2289890A1, 4606-EP2289891A2, 4606-EP2289893A1, 4606-EP2289897A1, 4606-EP2292088A1, 4606-EP2292228A1, 4606-EP2292233A2, 4606-EP2292589A1, 4606-EP2292592A1, 4606-EP2292593A2, 4606-EP2292596A2, 4606-EP2292606A1, 4606-EP2292610A1, 4606-EP2292612A2, 4606-EP2292614A1, 4606-EP2292619A1, 4606-EP2292630A1, 4606-EP2295053A1, 4606-EP2295401A2, 4606-EP2295409A1, 4606-EP2295415A1, 4606-EP2295417A1, 4606-EP2295418A1, 4606-EP2295434A2, 4606-EP2295439A1, 4606-EP2298312A1, 4606-EP2298734A2, 4606-EP2298738A1, 4606-EP2298747A1, 4606-EP2298750A1, 4606-EP2298761A1, 4606-EP2298767A1, 4606-EP2298768A1, 4606-EP2298772A1, 4606-EP2301922A1, 4606-EP2301933A1, 4606-EP2301934A1, 4606-EP2305629A1, 4606-EP2305633A1, 4606-EP2305641A1, 4606-EP2305647A1, 4606-EP2305648A1, 4606-EP2305651A1, 4606-EP2305658A1, 4606-EP2305667A2, 4606-EP2305668A1, 4606-EP2305679A1, 4606-EP2305681A1, 4606-EP2305684A1, 4606-EP2305687A1, 4606-EP2305808A1, 4606-EP2308471A1, 4606-EP2308562A2, 4606-EP2308812A2, 4606-EP2308833A2, 4606-EP2308839A1, 4606-EP2308848A1, 4606-EP2308854A1, 4606-EP2308855A1, 4606-EP2308857A1, 4606-EP2308861A1, 4606-EP2308869A1, 4606-EP2308873A1, 4606-EP2308875A1, 4606-EP2309564A1, 4606-EP2309584A1, 4606-EP2311804A2, 4606-EP2311806A2, 4606-EP2311808A1, 4606-EP2311811A1, 4606-EP2311820A1, 4606-EP2311821A1, 4606-EP2311824A1, 4606-EP2311825A1, 4606-EP2311827A1, 4606-EP2311829A1, 4606-EP2311830A1, 4606-EP2311831A1, 4606-EP2311838A1, 4606-EP2311842A2, 4606-EP2314295A1, 4606-EP2314574A1, 4606-EP2314575A1, 4606-EP2314576A1, 4606-EP2314583A1, 4606-EP2314584A1, 4606-EP2314585A1, 4606-EP2314586A1, 4606-EP2315303A1, 4606-EP2315502A1, 4606-EP2316452A1, 4606-EP2316459A1, 4606-EP2316824A1, 4606-EP2316832A1, 4606-EP2316833A1, 4606-EP2316836A1, 4606-EP2371797A1, 4606-EP2371798A1, 4606-EP2371800A1, 4606-EP2371804A1, 4606-EP2371810A1, 4606-EP2371811A2, 4606-EP2374454A1, 4606-EP2374790A1, 4606-EP2374792A1, 4606-EP2374895A1, 4606-EP2377845A1, 6129-EP0930075A1, 6129-EP2269986A1, 6129-EP2269987A1, 6129-EP2269988A2, 6129-EP2269989A1, 6129-EP2269990A1, 6129-EP2269994A1, 6129-EP2270003A1, 6129-EP2270014A1, 6129-EP2270113A1, 6129-EP2272510A1, 6129-EP2272516A2, 6129-EP2272822A1, 6129-EP2272832A1, 6129-EP2272835A1, 6129-EP2272841A1, 6129-EP2272844A1, 6129-EP2272849A1, 6129-EP2272935A1, 6129-EP2272972A1, 6129-EP2272973A1, 6129-EP2274983A1, 6129-EP2275401A1, 6129-EP2275404A1, 6129-EP2275407A1, 6129-EP2275411A2, 6129-EP2275413A1, 6129-EP2275414A1, 6129-EP2275420A1, 6129-EP2275469A1, 6129-EP2277867A2, 6129-EP2277872A1, 6129-EP2277875A2, 6129-EP2277878A1, 6129-EP2277945A1, 6129-EP2279750A1, 6129-EP2280001A1, 6129-EP2280003A2, 6129-EP2280007A1, 6129-EP2280008A2, 6129-EP2280010A2, 6129-EP2280014A2, 6129-EP2281810A1, 6129-EP2281821A1, 6129-EP2281899A2, 6129-EP2284159A1, 6129-EP2284165A1, 6129-EP2284174A1, 6129-EP2287155A1, 6129-EP2287156A1, 6129-EP2287160A1, 6129-EP2287165A2, 6129-EP2287166A2, 6129-EP2287168A2, 6129-EP2287940A1, 6129-EP2289876A1, 6129-EP2289887A2, 6129-EP2289888A2, 6129-EP2289890A1, 6129-EP2289894A2, 6129-EP2289965A1, 6129-EP2292228A1, 6129-EP2292589A1, 6129-EP2292595A1, 6129-EP2292596A2, 6129-EP2292597A1, 6129-EP2292611A1, 6129-EP2292619A1, 6129-EP2292620A2, 6129-EP2292624A1, 6129-EP2292630A1, 6129-EP2295055A2, 6129-EP2295402A2, 6129-EP2295406A1, 6129-EP2295410A1, 6129-EP2295414A1, 6129-EP2295416A2, 6129-EP2295425A1, 6129-EP2298731A1, 6129-EP2298735A1, 6129-EP2298743A1, 6129-EP2298747A1, 6129-EP2298748A2, 6129-EP2298755A1, 6129-EP2298760A1, 6129-EP2298763A1, 6129-EP2298764A1, 6129-EP2298765A1, 6129-EP2298766A1, 6129-EP2298768A1, 6129-EP2298770A1, 6129-EP2298772A1, 6129-EP2298774A1, 6129-EP2298778A1, 6129-EP2298828A1, 6129-EP2299509A1, 6129-EP2299510A1, 6129-EP2301911A1, 6129-EP2301922A1, 6129-EP2301924A1, 6129-EP2301925A1, 6129-EP2301926A1, 6129-EP2301933A1, 6129-EP2301936A1, 6129-EP2301939A1, 6129-EP2301983A1, 6129-EP2305243A1, 6129-EP2305625A1, 6129-EP2305629A1, 6129-EP2305633A1, 6129-EP2305640A2, 6129-EP2305642A2, 6129-EP2305651A1, 6129-EP2305652A2, 6129-EP2305658A1, 6129-EP2305667A2, 6129-EP2305672A1, 6129-EP2305673A1, 6129-EP2305676A1, 6129-EP2305679A1, 6129-EP2305682A1, 6129-EP2305685A1, 6129-EP2305686A1, 6129-EP2308479A2, 6129-EP2308510A1, 6129-EP2308562A2, 6129-EP2308828A2, 6129-EP2308838A1, 6129-EP2308839A1, 6129-EP2308844A2, 6129-EP2308845A2, 6129-EP2308846A2, 6129-EP2308848A1, 6129-EP2308854A1, 6129-EP2308857A1, 6129-EP2308858A1, 6129-EP2308861A1, 6129-EP2308874A1, 6129-EP2308877A1, 6129-EP2308879A1, 6129-EP2308880A1, 6129-EP2308926A1, 6129-EP2311453A1, 6129-EP2311801A1, 6129-EP2311802A1, 6129-EP2311803A1, 6129-EP2311807A1, 6129-EP2311815A1, 6129-EP2311816A1, 6129-EP2311817A1, 6129-EP2311822A1, 6129-EP2311823A1, 6129-EP2311827A1, 6129-EP2311834A1, 6129-EP2311837A1, 6129-EP2311840A1, 6129-EP2314576A1, 6129-EP2314582A1, 6129-EP2314585A1, 6129-EP2314587A1, 6129-EP2314590A1, 6129-EP2316831A1, 6129-EP2316937A1, 6129-EP2371809A1, 6129-EP2371811A2, 6129-EP2371814A1, 6129-EP2380568A1, 6129-EP2380873A1, C11143, D01043, Dimethyl sulfoxide solution, 50 wt. % in H2O, Dimethyl sulfoxide, >=99.6%, ReagentPlus(R), Dimethyl sulfoxide, ReagentPlus(R), >=99.5%, 25534-EP2272846A1, 25534-EP2275422A1, 25534-EP2277868A1, 25534-EP2277869A1, 25534-EP2277870A1, 25534-EP2284166A1, 25534-EP2287164A1, 25534-EP2292608A1, 25534-EP2298076A1, 25534-EP2298077A1, 25534-EP2298769A1, 25534-EP2298773A1, 25534-EP2301353A1, 25534-EP2305031A1, 25534-EP2305034A1, 25534-EP2305035A1, 25534-EP2308866A1, 25534-EP2308878A2, 25534-EP2314580A1, 25534-EP2374784A1, 25534-EP2374785A1, 25534-EP2374791A1, 44657-EP2272517A1, 44657-EP2281819A1, 44657-EP2287153A1, 44657-EP2292615A1, 44657-EP2298746A1, 44657-EP2298761A1, 44657-EP2301928A1, 44657-EP2305250A1, 44657-EP2305659A1, 44657-EP2311818A1, 52178-EP2284172A1, 52178-EP2287153A1, 52178-EP2292228A1, 52178-EP2292615A1, 52178-EP2292621A1, 52178-EP2292622A1, 52178-EP2295426A1, 52178-EP2295427A1, 52178-EP2301928A1, 52178-EP2301929A1, 52178-EP2301935A1, 52178-EP2305674A1, 52178-EP2305684A1, 52178-EP2305685A1, 52178-EP2305686A1, 52178-EP2308844A2, 52178-EP2308845A2, 52178-EP2308846A2, 61519-EP2270006A1, 61519-EP2308848A1, 68881-EP2270006A1, 68881-EP2277867A2, 68881-EP2280003A2, 68881-EP2292595A1, 68881-EP2308861A1, AB01563146_01, Dimethyl sulfoxide, p.a., ACS reagent, 99.9%, Dimethyl sulfoxide, SAJ first grade, >=99.0%, 300067X, Dimethyl sulfoxide, JIS special grade, >=99.0%, Dimethyl sulfoxide, Vetec(TM) reagent grade, 99%, Dimethyl sulfoxide, UV HPLC spectroscopic, 99.9%, Dimethyl sulfoxide, anhydrous, ZerO2(TM), >=99.9%, I14-14298, Dimethyl sulfoxide, meets EP, USP testing specifications, Dimethyl sulfoxide, ACS spectrophotometric grade, >=99.9%, Dimethyl sulfoxide, puriss. p.a., dried, <=0.02% water, (Methyl sulfoxide)-d6; DMSO-d6; Hexadeuterodimethyl sulfoxide, Dimethyl sulfoxide, >=99.5% (GC), plant cell culture tested, Dimethyl sulfoxide, BioUltra, for molecular biology, >=99.5% (GC), Dimethyl sulfoxide, European Pharmacopoeia (EP) Reference Standard, Dimethyl sulfoxide, puriss. p.a., ACS reagent, >=99.9% (GC), Dimethyl sulfoxide, Vetec(TM) reagent grade, anhydrous, >=99.7%, Dimethyl sulfoxide, >=99.0%, suitable for absorption spectrum analysis, Dimethyl sulfoxide, United States Pharmacopeia (USP) Reference Standard, Dimethyl sulfoxide, for inorganic trace analysis, >=99.99995% (metals basis), Dimethyl sulfoxide, meets EP testing specifications, meets USP testing specifications, 103759-08-6, 164071-41-4, 705301-21-9, 8070-53-9, Dimethyl sulfoxide, Hybri-Max(TM), sterile-filtered, BioReagent, suitable for hybridoma, >=99.7%, Dimethyl sulfoxide, puriss., absolute, over molecular sieve (H2O <=0.005%), >=99.5% (GC), Dimethyl sulfoxide, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma


ID: 40

chemical graph of compound 40



InChIKey: IXFPJGBNCFXKPI-FSIHEZPISA-N
SMILES: CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O

biological descriptors:

CFTR relevance: no effect on maturation

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

reference list:

"SH Randell" "MR Knowles" "BR Grubb" "SE Gabriel" "RC Boucher" "ML Drumm" "M Gentzsch" "A Mengos" "JR Riordan" "AM Van Heeckeren"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 446378
synonyms found at PubChem are:
thapsigargin, 67526-95-8, UNII-Z96BQ26RZD, Z96BQ26RZD, CHEMBL96926, CHEBI:9516, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER, Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2-methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)azuleno(4,5-b)furan-7-yl ester, (3S-(3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha))-, TG1, SR-01000076181, (-)-Thapsigargin, Octanoic Acid [3s-[3alpha, 3abeta, 4alpha, 6beta,6abeta, 7beta, 8alpha(Z), 9balpha]]-6-(Acetyloxy)-2,3,-3a,4,5,6,6a,7,8,9b-Decahydro-3,3a-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]furan-7-Yl Ester, Octanoic Acid [3s-[3alpha, 3abeta, 4alpha,6beta, 6abeta, 7beta, 8alpha(Z), 9balpha]]-6-(Acetyloxy)-2,3,-3a,4,5,6,6a,7,8,9b-Decahydro-3,3a-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]furan-7-Yl Ester, THAPSINGARGIN, AC1L9JLO, Azuleno[4,5-b]furan, octanoic acid deriv., n-7-yl ester (9CI), D02KGR, Lopac0_001262, SCHEMBL82423, BSPBio_001501, MLS006010944, GTPL5351, CHEBI:93212, MolPort-003-959-790, HMS1361L03, HMS1791L03, HMS1989L03, HMS3263N06, HMS3402L03, ZINC8195655, Tox21_501262, BDBM50035612, C28H38O12.C7H16, MFCD00083511, AKOS024456410, CCG-205336, LMPR0103410001, LP01262, IDI1_033971, NCGC00016060-08, NCGC00162381-05, NCGC00162381-06, NCGC00261947-01, SMR001456557, LS-176600, Thapsigargin, >=98% (HPLC), solid film, B6614, EU-0101262, C09561, T 9033, alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]]-, SR-01000076181-1, SR-01000076181-5, BRD-K69023402-001-02-5, I14-60634, (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-7-yl octanoate, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate, Octanoic Acid (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester, Octanoic Acid [3S-[3|A,3a|A,4|A,6|A,6a|A,7|A,8|A(Z),9b|A]]-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester, octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester, octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(-oxobutoxy)azuleno[4,5-b]furan, Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]fura, Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester, [3S-[3alpha,3abeta,4


ID: 41

chemical graph of compound 41



InChIKey: IYRMWMYZSQPJKC-UHFFFAOYSA-N
SMILES: C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

biological descriptors:

CFTR relevance: influence of intracellular CFTR distribution

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

"E Kwon" "PL Zeitlin" "AD Floyd" "M Lim" "K McKenzie"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5280863
synonyms found at PubChem are:
kaempferol, 520-18-3, Kempferol, Kaempherol, Populnetin, Rhamnolutein, Robigenin, Trifolitin, Pelargidenolon, Rhamnolutin, Swartziol, 3,4',5,7-Tetrahydroxyflavone, Indigo Yellow, Kampherol, Campherol, Kampferol, Nimbecetin, Kaemferol, 5,7,4'-Trihydroxyflavonol, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Pelargidenolon 1497, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, C.I. 75640, CCRIS 41, NSC 407289, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one, 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, Flavone, 3,4',5,7-tetrahydroxy-, NSC 656277, UNII-731P2LE49E, EINECS 208-287-6, CHEMBL150, BRN 0304401, AI3-36096, CHEBI:28499, IYRMWMYZSQPJKC-UHFFFAOYSA-N, 731P2LE49E, 3,4&prime;,5,7-Tetrahydroxyflavone, NSC656277, NSC-407289, NSC-656277, CAS-520-18-3, DSSTox_CID_768, DSSTox_RID_75781, DSSTox_GSID_20768, Q-100584, SMR000112585, Pelargidenon, Kampcetin, 3,5,7,4'-Tetrahydroxyflavone, HSDB 7703, 4det, Kaempferol,(S), AC1NQXP1, 5,4'-Trihydroxyflavonol, Prestwick0_001098, Prestwick1_001098, Prestwick2_001098, Prestwick3_001098, D0G3TK, 3,5,7-Tetrahydroxyflavone, 4',5,7-trihydroxyflavonol, BIDD:PXR0073, Oprea1_650954, SCHEMBL18817, BSPBio_001176, 5-18-05-00251 (Beilstein Handbook Reference), MLS000697730, MLS001055391, MLS001074884, MLS006010737, BIDD:ER0134, SPBio_003058, 3,4,5,7-Tetrahydroxyflavone, Kaempferol, analytical standard, BDBM7462, BPBio1_001294, MEGxp0_001283, DTXSID7020768, Flavone,4',5,7-tetrahydroxy-, ACon1_001867, cid_5280863, CHEBI: 28499, MolPort-001-741-568, HMS1571K18, HMS2098K18, HMS2267I09, HMS3656M03, KAEMPFEROL ROBIGENIN; 3,4',5,7-TETRAHYDRO-XY-FLAVONE, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1- benzopyran-4-one, Kaempferol, >=97.0% (HPLC), TNP00039, ZINC3869768, Tox21_201165, Tox21_303363, AC-544, CK0011, GP7425, HSCI1_000027, LMPK12110003, LS-176, MFCD00016938, NSC407289, s2314, SBB066091, Kaempferol solution, 20 mM in DMSO, AKOS015895240, Kaempferol, >=90% (HPLC), powder, CCG-202823, CS-1273, DB01852, GS-3570, MCULE-8965218413, NCGC00016480-01, NCGC00016480-02, NCGC00016480-03, NCGC00016480-04, NCGC00016480-05, NCGC00016480-06, NCGC00016480-07, NCGC00016480-09, NCGC00091036-01, NCGC00091036-02, NCGC00164322-01, NCGC00179275-01, NCGC00179275-02, NCGC00257464-01, NCGC00258717-01, AN-15750, BC215517, CC-29746, HY-14590, KB-79581, SC-17291, ST030560, AB0010534, TR-018501, AB00514046, FT-0614420, K0018, N1719, W1682, 3,4',5,7-tetrahydroxy-Flavone (7CI,8CI), C05903, J10449, Kaempferol, disposable screening library format, S00111, W-2776, Flavone, 3,4',5,7-tetrahydroxy- (7CI,8CI), 520K183, A828886, C-18018, SR-01000765646, I06-0240, Kaempferol, primary pharmaceutical reference standard, SR-01000765646-3, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one, BRD-K12807006-001-05-2, BRD-K12807006-001-10-2, 2-(4-hydroxyphenyl)-3,5,7-tris(oxidanyl)chromen-4-one, 3,4',5,7-tetrahydroxyflavone solution, 20 mM in DMSO, A91A6666-86C8-4B33-B3EF-F74CD3CD7F47, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one #, 3,5,7-Trihydroxy-2-[4-hydroxy-phenyl]-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, 4H-1-Benzopyran-4-one,5,7-trihydroxy-2-(4-hydroxyphenyl)-, Kaempferol, United States Pharmacopeia (USP) Reference Standard, 3,5,7-Trihydroxy-2-[4-hydroxy- phenyl]-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)- (9CI), 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one solution, 20 mM in DMSO, 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-5,7,4'-Trihydroxyflavonol


ID: 42

chemical graph of compound 42



InChIKey: JIMHYXZZCWVCMI-RIYZIHGNSA-N
SMILES: C1=CC(=CC(=C1)N2C(=O)/C(=C\C3=CC=C(C=C3)C(=O)O)/SC2=S)C(F)(F)F

biological descriptors:

CFTR relevance: CFTR inhibitor

Category:
Influence on CFTR function inhibits CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"X Liu" "TH Ma" "S Lin" "WL Na" "SG Hou" "H Yang" "LN Xu"
"SM Rowe" "D Skinner" "EJ Sorscher" "SB Hicks" "S Zhang" "BT Conger" "BA Woodworth"


CID is 1554210
synonyms found at PubChem are:
CFTR Inhibitor 172, C18H10F3NO3S2, 307510-92-5, CFTRinh 172, CFTR(inh)-172, 4-[(E)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid, CFTRinh-172, CFTRinh - 172, AC1LT95D, CFTR-172, SCHEMBL1881897, CHEMBL1554655, 5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone, 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl]-4-thiazolidinone, MolPort-008-130-993, MolPort-028-751-092, 4-[4-oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-(5z)-ylidenemethyl]-benzoic acid, 4-[4-OXO-2-THIOXO-3-(3-TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-5-YLIDENEMETHYL]-BENZOIC ACID, 2313AH, s7139, ZINC13829351, AKOS003140113, NCGC00165765-01, KB-41399, BB0220685, BB 0220685, CFTR(inh)-172, >=98% (HPLC), powder, 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid, 4-{[(5E)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl}benzoic acid, benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-


ID: 43

chemical graph of compound 43



InChIKey: JIMHYXZZCWVCMI-ZSOIEALJSA-N
SMILES: C1=CC(=CC(=C1)N2C(=O)/C(=C/C3=CC=C(C=C3)C(=O)O)/SC2=S)C(F)(F)F

biological descriptors:

CFTR relevance: CFTR inhibitor

Category:
Influence on CFTR function inhibits CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"SM Rowe" "D Skinner" "EJ Sorscher" "SB Hicks" "S Zhang" "BT Conger" "BA Woodworth"


CID is 1554208
synonyms found at PubChem are:
CFTRinh-172, CFTR(inh)-172, CFTR Inhibitor-172, 307510-92-5, CHEMBL461939, 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh 172, 4-[4-oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-(5z)-ylidenemethyl]-benzoic acid, CFinh-172, CFTR Inh-172, AC1LT95A, AOB6719, 5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone, JIMHYXZZCWVCMI-ZSOIEALJSA-N, MolPort-000-501-417, ZINC966859, BDBM50244767, MFCD06411408, STL032754, AKOS000365470, CS-3185, BAS 00786641, HY-16671, BIM-0044592.P001, ST50148666, EC-000.1908, Z-2135, J-018109, 4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, 4-[[4-Oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid, 4-[4-Oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-5Z)-ylidenemethyl]-benzoic acid, (Z)-4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, 4-({4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}met hyl)benzoic acid, 4-[(Z)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid, 4-[(Z)-{4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, 4-{[(5Z)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl}benzoic acid


ID: 44

chemical graph of compound 44



InChIKey: JUVIOZPCNVVQFO-HBGVWJBISA-N
SMILES: CC(=C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC

biological descriptors:

CFTR relevance: weak CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6758
synonyms found at PubChem are:
rotenone, 83-79-4, Dactinol, Paraderil, (-)-Rotenone, Tubatoxin, Barbasco, (-)-cis-Rotenone, Derrin, Derris, Cube root, Nicouline, Rotocide, Noxfish, Ronone, Rotenon, Canex, Deril, Liquid Derris, Cube-Pulver, Dri-Kil, Rotessenol, Noxfire, Rotefive, Rotefour, Rotenox, Cubor, Haiari, Mexide, Derris root, Powder and root, Chem-Mite, Pro-nox fish, Cenol garden dust, Curex flea duster, Prenfish, Tubotoxin, Gerane, Prentox, Ro-Ko, Synpren, Derris (insecticide), Chem fish, Pb-nox, Rotenox 5EC, 5'-beta-Rotenone, Green Cross Warble Powder, Chem-Fish Synergized, Prentox Synpren-Fish, Nekoe, Caswell No. 725, Extrax, Cube extract, Foliafume E.C., Fish-Tox, ENT 133, Rotenona [Spanish], Rotenone, commercial, CCRIS 895, Rotenone [BSI:ISO], HSDB 1762, NCI-C55210, 5'beta-Rotenone, EPA Pesticide Chemical Code 071003, UNII-03L9OT429T, AI3-00133, NSC26258, EINECS 201-501-9, NSC 26258, Rotenona, Derris resins, MLS000738056, CHEMBL429023, CHEBI:28201, 03L9OT429T, Rotacide E.C., CUBE, (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-alpha-isopropenyl-8,9-dimethoxy-, (12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano[3,4-b]furano [2,3-h]chroman-6-one, (2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one, (2R-(2alpha,6aalpha,12aalpha))-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)(1)benzopyrano(3,4-b)furo(2,3-h)benzopyran-6(6aH)-one, 1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12aalpha-Tetrahydro-2a-isopropenyl-8,9-dimethoxy(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, NCGC00017358-05, DSSTox_CID_1248, DSSTox_RID_76038, DSSTox_GSID_21248, (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R-(2alpha,6aalpha,12aalpha))-, (2R-(6aalpha,12aalpha)-1,2-Dihydro-2-isopropenyl-8,9-dimethoxychromano(3,4-b)furo(2,3-h)chroman-6-on, [2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one, Green cross warble, Rotacide, Protax, 5'.beta.-Rotenone, CAS-83-79-4, (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-, (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, (2R,6aS,12aS)-1,2,6,6a,12,12a- hexahydro-2-isopropenyl-8,9- dimethoxychromeno[3,4-b] furo(2,3-h)chromen-6-one, (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno(3,4-b)furo(2,3-h)chromen-6-one, (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one, (2R,6aS,12aS)-2-isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one, [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-, SR-01000076110, Foliafume, Rotenoid, Roteonone, Nusyn, rote five, WLN: T G5 D6 B666 CV HO MO POT&TT&J IY1&U1 SO1 TO1, Chem-Fish, Foliafume E.C, Rotacide E.C, 5''beta-rotenone, 5'b-Rotenone, Rotocide E.C., (1)Benzopyrano[3,3-h](1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-.alpha.-iospropenyl-8,9-dimethoxy-, [1]Benzopyrano[3,3-h][1]benzopyran-6(6a.alpha.H)-one, 1,2,12,12a.alpha.-tetrahydro-2.alpha.-isopropenyl-8,9-dimethoxy-, [1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2.alpha.,6a.alpha.,12a.alpha.)]-, [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2alpha,6aalpha,12aalpha)]-, Derris, JMAF, Prestwick_542, Hydrogenated rotenone, Rotenone (7CI), Rotenone, hydrogenated, Rotenone, >=95%, Spectrum_000065, Spectrum2_000457, Spectrum3_000158, Spectrum4_001638, Spectrum5_000455, D0F7CS, AC1L1N8M, AC1Q4EW8, Lopac0_001112, SCHEMBL42253, BSPBio_001896, isopropenyl(dimethoxy)[?]one, KBioGR_002075, KBioSS_000465, SPECTRUM200013, DivK1c_000947, Rotenone E.C. (7.5%), SPBio_000534, DTXSID6021248, HMS502P09, KBio1_000947, KBio2_000465, KBio2_003033, KBio2_005601, KBio3_001116, inhibits NADH2 oxidation to NAD, NSC8505, JUVIOZPCNVVQFO-HBGVWJBISA-N, MolPort-002-507-351, NINDS_000947, HMS3263O06, 2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-H]chromen-6(6ah)-one, BCP07278, HY-B1756, NSC-8505, TNP00301, ZINC3860715, Tox21_110819, Tox21_201904, Tox21_300695, Tox21_501112, 2901AC, BDBM50135527, CCG-39886, LMPK12060007, MFCD09025614, NSC-26258, SBB006465, AKOS004910398, Tox21_110819_1, API0004105, CS-6067, DB11457, LP01112, LS-1830, MCULE-7287067191, MCULE-7415617623, RL05168, SDCCGMLS-0066415.P001, IDI1_000947, NCGC00017358-01, NCGC00017358-02, NCGC00017358-03, NCGC00017358-04, NCGC00017358-06, NCGC00017358-07, NCGC00017358-08, NCGC00017358-09, NCGC00017358-10, NCGC00017358-11, NCGC00017358-14, NCGC00017358-15, NCGC00094382-01, NCGC00094382-02, NCGC00094382-03, NCGC00094382-04, NCGC00094382-05, NCGC00254603-01, NCGC00259453-01, NCGC00261797-01, AJ-46043, AK115691, AN-24066, AS-10183, NCI60_002093, SC-66514, SMR000393729, ST057261, AX8150549, ST2413787, EU-0101112, R0090, Rotenone, PESTANAL(R), analytical standard, TRANSGENIC MODEL EVALUATION (ROTENONE), C07593, R 8875, 26914-EP2275422A1, 26914-EP2280009A1, 26914-EP2305662A1, 26914-EP2308857A1, 26914-EP2314583A1, 599T610, SR-01000076110-2, SR-01000076110-5, SR-01000076110-6, W-104134, BRD-K08316444-001-01-9, BRD-K08316444-001-05-0, ROTENONE (SEE ALSO TRANSGENICMODEL EVALUATION (ROTENONE)), (1S,6R,13S)-16,17-dimethoxy-6-(prop-1-en-2-yl)-2,7,20-trioxapentacyclo[11.8.0.0^{3,11}.0^{4,8}.0^{14,19}]henicosa-3(11),4(8),9,14(19),15,17-hexaen-12-one, (2R,6a5,12axS)-1,2,12,12a-tetrahydro-2a-isopropenyl-8,9-dimethoxy(1)benzopyrano(3,4-b)furo(2,3-H)(1)benzopyran-6(6aH)-one, (2r,6as,12as)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxybenzopyrano(3,4-b)furo(2,3-h)benzopyran-6-one, (2R-(6aalpha,12aalpha)-1,2-Dihydro-2-isopropenyl-8,9-dimethoxychromano(3,4-b)furo(2,3-h)chroman-6-one, [1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-.alpha.-isopropenyl-8,9-dimethoxy-, [1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-isopropenyl-8,9-dimethoxy-, [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aalphaH)-one, 1,2,12,12aalpha-tetrahydro-2alpha-isopropenyl-8,9-dimethoxy- (8CI), [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)- (9CI), [2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-o ne, [2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2alpha-isopropenyl-8,9-dimethoxy(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1)benzopyrano(3,4-b)furo(2,3-h) (1)benzopyran-6(6aH)-one, (2R-(2alpha, 6alpha-12aalpha))-, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, (2R-(2alpha, 6alpha-12aalpha))-, 1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 9CI, 12679-58-2, Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-on e, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, ([2.2.1]R-([2.2.1]alpha,6aalpha,[2.2.1][2.2.1]aalpha))-, Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, ([2.2.1]R-([2.2.1]alpha,6aalpha,[2.2.1][2.2.1]aalpha))-, Tubatoxin 1,2,12,12a,-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]-benzopyran-6(6aH)-one


ID: 45

chemical graph of compound 45



InChIKey: JZJXEPNQMCFBIS-UHFFFAOYSA-N
SMILES: C=CC1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=CC=C3

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

"E Caci" "K Du" "N Pedemonte" "O Zegarra-Moran" "AS Verkman" "GL Lukacs" "LJ Galietta"
"MC Bartlett" "DM Clarke" "TW Loo" "Y Wang"


CID is 683025
synonyms found at PubChem are:
Corr-2b, AC1LEAGY, SCHEMBL837831, ZINC48933, ST007156, EU-0084361, Phenyl-[4-(4-vinyl-phenyl)-thiazol-2-yl]-amine, SR-01000511692, 4-(4-ethenylphenyl)-N-phenyl-1,3-thiazol-2-amine, phenyl[4-(4-vinylphenyl)(1,3-thiazol-2-yl)]amine, SR-01000511692-1, A0861/0040368


ID: 46

chemical graph of compound 46



InChIKey: LAZPBGZRMVRFKY-HNCPQSOCSA-N
SMILES: C1CSC2=N[C@H](CN21)C3=CC=CC=C3.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 27944
synonyms found at PubChem are:
Levamisole hydrochloride, 16595-80-5, Levamisole HCl, Ergamisol, Tramisol, Tramisole, Decaris, (-)-Tetramisole hydrochloride, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride, Niratic hydrochloride, Ascaridil, Dekaris, Levacide, Levadin, Levasole, Solaskil, Meglum, Nilverm forte, Worm-chek, Stimamizol hydrochloride, Ripercol-L, Citarin L, Niratic-puron hydrochloride, Levomysol hydrochloride, (-)-Tetramisole, Levamisole (hydrochloride), KW 2LE-T, Nemicide, Spartakon, KW-2-LE-T, NSC-177023, UNII-DL9055K809, EINECS 240-654-6, L-Tetramisole hydrochloride, R 12564, R 12,564, R-12,564, C11H12N2S.HCl, Levamisol hydrochloride, CHEBI:6433, (6S)-6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole hydrochloride, DL9055K809, Ergamisol (TN), (-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole monohydrochloride, L-(-)-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride, DSSTox_CID_27518, DSSTox_RID_82391, Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S)-, DSSTox_GSID_47518, 74191-78-9, (S)-(-)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride, L(-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride, Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, L-(-)-, SMR001230807, NSC177023, SR-01000075969, L-tetramisol, R-12564, (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole Hydrochloride, Levamisole hydrochloride [USAN], LEV hydrochloride, (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride, NCGC00094446-03, Prestwick_294, Levamisole hydrochloride [USAN:USP], AC1L1EAA, Levamisole HCl(Ergamisol), Ergamisol (TN) (Janssen), CAS-16595-80-5, CHEMBL1770, SCHEMBL19226, BMK1-H6, Levamisole Hydrochloride,(S), Imidazo[2, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, MLS002153440, MLS002222198, MLS002695941, SPECTRUM1503245, Levamisole hydrochloride (USP), ((-)-Tetramisole hydrochloride, DTXSID7047518, CTK8B8704, KS-00000GHI, LAZPBGZRMVRFKY-HNCPQSOCSA-N, MolPort-003-666-467, HMS1568F05, HMS1922M11, 14769-73-4 (Parent), BCP13755, Levamisole Hydrochloride (Ergamisol), Tox21_111282, Tox21_500690, ANW-61085, CCG-40301, MFCD00012675, s1939, AKOS015951350, Tox21_111282_1, CS-2372, EBD2199095, KW-2299, LP00690, MCULE-7118728152, NE43217, RTR-030849, NCGC00094046-01, NCGC00261375-01, NCGC00263461-01, AC-23973, AS-13370, BC201679, HY-13666, I013, LS-80641, SC-26016, AB0013424, AB1009509, TL8001274, EU-0100690, FT-0625516, L0231, ST24026614, (-)-Tetramisole hydrochloride, >=99% (GC), C07906, D00750, L 9756, J-010244, J-521642, SR-01000075969-1, SR-01000075969-6, Z1550648764, Levamisol hydrochloride, VETRANAL(TM), analytical standard, UNII-0NDK265MCV component LAZPBGZRMVRFKY-HNCPQSOCSA-N, Levamisole Hydrochloride 1.0 mg/ml in Methanol (as free base), Imidazo[2, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (-)-, Imidazo[2, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S)-, (-)-2,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole monohydrochloride, (7S)-7-phenyl-4-thia-1,6-diazabicyclo[3.3.0]oct-5-ene hydrochloride, Imidazo[2, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, L-(-)-, Levamisole hydrochloride, European Pharmacopoeia (EP) Reference Standard, (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride, Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (-)-, Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (-)- (8CI), Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (6S)-, Levamisole Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material, Levamisole hydrochloride, United States Pharmacopeia (USP) Reference Standard, (S)-(-)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride; L(-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride; Levamisole hydrochloride, 24593-45-1, 39170-95-1, Levamisole hydrochloride for system suitability, European Pharmacopoeia (EP) Reference Standard, AKOS015898619, I09-1966


ID: 47

chemical graph of compound 47



InChIKey: LZCOBWKVDSSOBB-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C=CC3=C2OC(=CC3=O)C4=CC=NC=C4

biological descriptors:

CFTR relevance: effective CFTR activator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"MJ Kurth" "MH Nantz" "L Al-Nakkash" "MF Springsteel"
"MJ Kurth" "MH Nantz" "M Eda" "EJ Niedzinski" "MJ Haddadin" "AS Verkman" "MF Springsteel" "K By" "LJ Galietta"


CID is 3163532
synonyms found at PubChem are:
2-Pyridin-4-yl-benzo[h]chromen-4-one, UCCF-029, 2110-25-0, CHEMBL177991, 2-(pyridin-4-yl)-4H-benzo[h]chromen-4-one, BAS 12813734, AC1MKUU0, D0T9DI, MLS001209162, GTPL4335, SCHEMBL4069839, ZINC9006, CTK7H2722, DTXSID20390354, CHEBI:116557, HMS2841G23, BDBM50159612, 2-(4-pyridyl)benzo[h]chromen-4-one, 2-pyridin-4-ylbenzo[h]chromen-4-one, AKOS000507523, MCULE-4590967836, 2-(pyridin-4-yl)benzo[h]chromen-4-one, SMR000525005, TR-043515, ST50294170, EC-000.1914, 4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium, J-013846, 4-(4-Oxo-4H-benzo[h]chromen-2-yl)-pyridinium bisulfate


ID: 48

chemical graph of compound 48



InChIKey: MBRLOUHOWLUMFF-UHFFFAOYSA-N
SMILES: CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"X Liu" "TH Ma" "S Lin" "WL Na" "SG Hou" "H Yang" "LN Xu"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 10228
synonyms found at PubChem are:
Osthole, Osthol, 484-12-8, Ostol, Ostole, 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one, 7-Methoxy-8-isopentenylcoumarin, 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-, 8-(3-Methyl-2-butenyl)herniarin, 7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-chromen-2-one, 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, UNII-XH1TI1759C, NSC 31868, 7-METHOXY-8-(3-METHYL-2-BUTENYL)-COUMARIN, 7-methoxy-8-(3-methyl-2-butenyl)coumarin, Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-, CHEMBL52229, XH1TI1759C, CHEBI:69832, C15H16O3, NSC31868, 7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one, Q-100535, 7-methoxy-8-(3-methylbut-2-enyl)-2H-chromen-2-one, SMR000156202, Osthole (Osthol), Osthole,(S), Cnidium Fruit Extract, Spectrum_001542, SpecPlus_000946, Spectrum2_000723, Spectrum3_001645, Spectrum4_001687, Spectrum5_000334, AC1L1UR5, Osthole, analytical standard, Oprea1_642606, Oprea1_873803, SCHEMBL50436, BSPBio_003369, KBioGR_001954, KBioSS_002022, ZINC566, MLS000574904, MLS001048988, MLS006011425, DivK1c_007042, SPECTRUM1504165, SPBio_000646, MEGxp0_000155, ACon1_002155, CTK7A8592, KBio1_001986, KBio2_002022, KBio2_004590, KBio2_007158, KBio3_002589, DTXSID20197507, MBRLOUHOWLUMFF-UHFFFAOYSA-N, MolPort-000-881-851, HMS2267O21, HMS3656A07, BCP10832, EBD33224, HY-N0054, KS-00000N3A, ANW-50075, BBL013019, BDBM50240512, CCG-40172, CO0040, MFCD00076049, NSC-31868, s2337, STK396321, AKOS000277663, AC-8041, AN-8395, CS-2125, DS-0881, MCULE-5691054147, RP28651, RTR-017689, SDCCGMLS-0066780.P001, NCGC00095694-01, NCGC00095694-02, NCGC00095694-03, NCGC00095694-05, WLN: T66 BOVJ IO1 J2UY1&1, 4CN-0704, AJ-07908, AK-35300, BAS 00015470, BR-35300, CC-33366, CJ-00015, LS-55250, ZB000125, AB0021820, AX8007596, KB-250032, ST2412572, TR-017689, FT-0082540, FT-0601535, N1825, O0426, ST50909221, W1256, C09280, J10077, S-3211, 484O128, A827530, C-14815, Osthole, primary pharmaceutical reference standard, SR-01000721624, I06-0435, SR-01000721624-4, BRD-K78294846-001-03-3, 7-Methoxy-8-(3-methyl-2-butenyl)-2H-chromen-2-one #, 7-methoxy-8-(3-methylbut-2-enyl)-1-benzopyran-2-one, Osthole, European Pharmacopoeia (EP) Reference Standard, 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)- (9CI), 1440642-68-1, InChI=1/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H


ID: 49

chemical graph of compound 49



InChIKey: MUNWAHDYFVYIKH-RITPCOANSA-N
SMILES: C[N+]1(C[C@@H](C[C@H]1C(=O)[O-])O)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 164642
synonyms found at PubChem are:
Betonicine, 515-25-3, (-)-Betonicine, Achillein, trans-4-hydroxy-L-proline betaine, UNII-FBA654632Q, 4-hydroxy-stachydrine, FBA654632Q, (2S-trans)-2-Carboxylato-4-hydroxy-1,1-dimethylpyrrolidinium, 4-Hydroxy-1,1-dimethylpyrrolidinium-2-carboxylate, (2,4R)-4-hydroxy-1,1-dimethylpyrrolidinium-2-carboxylate, Achilleine, (2s,4r)-4-Hydroxy-1,1-Dimethylpyrrolidinium-2-Carboxylate, (2S,4R)-4-hydroxy-1,1-dimethylpyrrolidin-1-ium-2-carboxylate, l-4-hydroxystachydrine, Betonicin, EINECS 208-195-6, NSC 655264, 4-Hydroxyproline betaine, L-4-Hydroxyproline betaine, trans-hydroxyproline betaine, AC1Q5BF7, SCHEMBL893616, AC1L4V67, Pyrrolidinium, 2-carboxy-4-hydroxy-1,1-dimethyl-, inner salt, (2S,4S)-, CHEBI:85533, FCH3878294, CC-24644, Pyrrolidinium, 2-carboxy-4-hydroxy-1,1-dimethyl-, hydroxide, inner salt, (2S-trans)-, C08269, C-25726, (2S,4R)-4-hydroxy-1,1-dimethyl-pyrrolidin-1-ium-2-carboxylic acid, 4476-22-6


ID: 50

chemical graph of compound 50



InChIKey: NBLBCGUCPBXKOV-UHFFFAOYSA-N
SMILES: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC(=N2)COC

biological descriptors:

CFTR relevance: Phosphodiesterase 1 inhibitor

Category:
Influence on CFTR function none
Order of interaction indirect
subcellular compartment several

reference list:

"PC Chao" "KL Hamilton"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 155806
synonyms found at PubChem are:
78033-08-6, 8-Methoxymethyl-IBMX, 8-methoxymethyl-3-isobutyl-1-methylxanthine, MMPX, 3-Isobutyl-8-(methoxymethyl)-1-methyl-1H-purine-2,6(3H,7H)-dione, 8-METHOXYMETHYL-1-METHYL-3-(2-METHYLPROPYL)XANTHINE, CHEMBL307639, IN1237, MI-methylxanthine, 1H-Purine-2,6-dione, 3,7-dihydro-8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-, 8MM-IBMX, 8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione, 3-isobutyl-8-methoxymethyl-1-methylxanthine, SR-01000075985, Tocris-0552, AC1Q4FLL, Lopac-M-2547, Lopac0_000764, BSPBio_001462, KBioGR_000182, KBioSS_000182, MLS002153423, SCHEMBL782824, AC1L4F09, SCHEMBL9927457, CHEBI:92940, CTK7B2646, KBio2_000182, KBio2_002750, KBio2_005318, KBio3_000363, KBio3_000364, DTXSID30228679, MolPort-003-848-632, Bio2_000182, Bio2_000662, HMS1361J04, HMS1791J04, HMS1989J04, HMS2230A04, HMS3262I10, HMS3266K14, HMS3373L09, HMS3402J04, Tox21_500764, 2228AC, ANW-54494, BDBM50059035, HSCI1_000291, MFCD00211081, ZINC14806781, AKOS016001307, AKOS024458560, CCG-204849, LP00764, 3,7-Dihydro-8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, IDI1_033932, NCGC00015658-01, NCGC00015658-02, NCGC00015658-03, NCGC00015658-04, NCGC00015658-05, NCGC00015658-06, NCGC00015658-07, NCGC00015658-08, NCGC00024647-01, NCGC00024647-02, NCGC00024647-03, NCGC00024647-04, NCGC00024647-05, NCGC00261449-01, AJ-65376, CC-23404, SMR001230798, AX8000924, DB-056279, B6348, EU-0100764, FT-0641660, M 2547, A839315, C-16701, SR-01000075985-1, SR-01000075985-3, 8-Methoxymethyl-3-isobutyl-1-methylxanthine, >=98%, BRD-K53878242-001-02-4, BRD-K56077740-001-03-5, 8-Methoxymethyl-1-Methyl-1-3-(2-Methylpropyl)Xanthine, 3-Isobutyl-8-methoxymethyl-1-methyl-3,7-dihydro-purine-2,6-dione, 3-Isobutyl-8-methoxymethyl-1-methyl-3,9-dihydro-purine-2,6-dione


ID: 51

chemical graph of compound 51



InChIKey: NCNXULVCMORARX-NYMFISLZSA-N
SMILES: C[C@@]12CCC3[C@]4(C=C[C@H](C(C4CC(=O)O[C@]3(C1=CC(=O)O[C@H]2C5=COC=C5)C)(C)C)O)C

biological descriptors:

CFTR relevance: weak CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6708582
synonyms found at PubChem are:
DEOXYANDIROBIN LACTONE, KBio2_003732, Spectrum_000684, SpecPlus_000167, Spectrum2_000257, Spectrum3_000049, Spectrum4_001331, Spectrum5_000201, BSPBio_001777, KBioGR_001821, KBioSS_001164, DivK1c_006263, SPBio_000074, CHEMBL3039179, SCHEMBL12998316, KBio1_001207, KBio2_001164, KBio2_006300, KBio3_000937, NCGC00179013-01, SR-05000002674, SR-05000002674-1, BRD-A58269583-001-02-0


ID: 52

chemical graph of compound 52



InChIKey: NHTGHBARYWONDQ-JTQLQIEISA-N
SMILES: C[C@](CC1=CC=C(C=C1)O)(C(=O)O)N

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 441350
synonyms found at PubChem are:
METYROSINE, 672-87-7, Metirosine, alpha-Methyl-L-tyrosine, (S)-alpha-Methyltyrosine, Demser, Methyltyrosine, alpha-Methyltyrosine, L-alpha-Methyltyrosine, Metirosina, Metirosinum, L-alpha-Methyl-p-tyrosine, Alpha-Methyl-L-P-Tyrosine, (S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid, L-Metyrosine, (-)-alpha-Methyl-L-tyrosine, (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid, UNII-DOQ0J0TPF7, ALPHA-METHYL-L-TYR, L(-)-Metyrosine, MK 781, alpha-Methyl-p-tyrosine, L-AMPT, MK-781, DOQ0J0TPF7, A-METHYL-L-TYROSINE, L-2-ME-TYR-OH, CHEBI:6912, (S)-2-(4-Hydroxybenzyl)-2-aminopropanoic Acid, NCGC00094144-03, Metirosinum [INN-Latin], alpha-Methyl-para-tyrosine, DSSTox_CID_3315, Metirosina [INN-Spanish], L-2-METHYL-3-(4-HYDROXYPHENYL)ALANINE, DSSTox_RID_76972, DSSTox_GSID_23315, L-588357-0, Metirosine [INN], Metyrosine (USP), EINECS 211-599-5, Demser (TN), l-alpha-MT, a-methyl-L-p-tyrosine, CAS-672-87-7, alpha-methyl-paratyrosine, Metyrosine [USAN:USP], L 588357-0, (-)-(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure, Metirosin, L-Tyrosine, alpha-methyl-, (-)-, alpha-Me-Tyr-OH, L-2-Methyl-3-(4-hydroxy-phenyl)alanine, L-?-Methyltyrosine, L-|A-Methyltyrosine, M 8131, L-Tyrosine, a-methyl-, (S)-|A-Methyltyrosine, A-METHYL-L-TYR, Metirosine (JAN/INN), L-|A-Methyl-p-tyrosine, Spectrum3_001846, H-A-ME-TYR-OH, H-(ME)TYR-OH, L-ALPHA-METHYLROSINE, AC1L9B0V, AC1Q29EO, Lopac0_000811, SCHEMBL50398, (S)-A-METHYLTYROSINE, BSPBio_003232, H-ALPHA-ME-L-TYR-OH, L-|A-MT, ZINC693, SPECTRUM2300312, GTPL6956, CHEMBL1200862, DTXSID6023315, KBio3_002732, MolPort-001-792-900, MolPort-044-812-316, NHTGHBARYWONDQ-JTQLQIEISA-N, HMS3262D03, Tox21_111253, Tox21_500811, MFCD00064201, Tox21_111253_1, AB02561, AM83582, CCG-204895, CM-2293, DB00765, FCH4035313, LP00811, MCULE-5340647798, NCGC00015701-06, NCGC00094144-01, NCGC00094144-04, NCGC00094144-05, NCGC00094144-06, NCGC00094144-07, NCGC00261496-01, AJ-07916, AK164271, alpha-Methyl-L-tyrosine, >=98% (TLC), AS-47139, CC-24015, CPD000466921, SAM001246895, AX8022058, TR-022622, EU-0100811, FT-0622266, (S)-ALPHA-METHYL-4-HYDROXYPHENYLALANINE, C07921, D00762, 672M877, A835693, C-23996, Z1617901128, UNII-X88TTO174Z component NHTGHBARYWONDQ-JTQLQIEISA-N, (2S)-2-azanyl-3-(4-hydroxyphenyl)-2-methyl-propanoic acid, Metyrosine, United States Pharmacopeia (USP) Reference Standard, (S)-2-AMINO-2-METHYL-3-(4'-HYDROXYPHENYL)PROPANOIC ACID, (S)-2-AMINO-3-(2-METHYL-4-HYDROXYPHENYL)PROPANOIC ACID, 23239-48-7, alpha-methyl-tyrosine, AC1OCG2D, ZB000155, (2S)-2-azaniumyl-3-(4-hydroxyphenyl)-2-methylpropanoate


ID: 53

chemical graph of compound 53



InChIKey: NIDUTZAIIODVCH-FHNSGPDVSA-N
SMILES: CCC(C)C(C(=O)O[C@H]1[C@@H](C(C(=C)C2([C@@]1([C@@H](CC2=O)C3=COC=C3)C)O)[C@]4([C@H](CC(=O)O[C@](C4CC(=O)OC)(C)COC(=O)C)OC(=O)C)C)OC=O)OC(=O)C

biological descriptors:

CFTR relevance: weak CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6710640
synonyms found at PubChem are:
PRIEURANIN ACETATE, KBio2_006186, Spectrum_000570, AC1O8JTI, Spectrum2_000243, Spectrum3_000024, Spectrum4_001305, Spectrum5_000089, BSPBio_001687, KBioGR_001709, KBioSS_001050, SPECTRUM100069, SPBio_000026, KBio2_001050, KBio2_003618, KBio3_000807, CHEBI:110188, CCG-39804, SDCCGMLS-0066356.P001, NCGC00179087-01, BRD-A64374397-001-02-6, [(3S,3aR,4R,5R)-6-[(2S,4R,5S)-5-acetyloxy-2-(acetyloxymethyl)-3-(2-methoxy-2-oxoethyl)-2,4-dimethyl-7-oxooxepan-4-yl]-5-formyloxy-3-(furan-3-yl)-7a-hydroxy-3a-methyl-7-methylidene-1-oxo-3,4,5,6-tetrahydro-2H-inden-4-yl] 2-acetyloxy-3-methylpentanoate


ID: 54

chemical graph of compound 54



InChIKey: NPOJQCVWMSKXDN-UHFFFAOYSA-N
SMILES: COC(=O)C1=C(C(=C(C(=C1Cl)Cl)C(=O)OC)Cl)Cl

biological descriptors:

CFTR relevance: strong CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 2943
synonyms found at PubChem are:
Chlorthal-dimethyl, dacthal, 1861-32-1, DIMETHYL TETRACHLOROTEREPHTHALATE, Dacthalor, Fatal, Chlorthal-methyl, Tetral, Dimethyl 2,3,5,6-tetrachloroterephthalate, Tetrachloroterephthalic acid dimethyl ester, DAC 4, Chlorthal dimethyl ester, Daktal [Czech], Caswell No. 382, 1,4-Benzenedicarboxylic acid, 2,3,5,6-tetrachloro-, dimethyl ester, UNII-ZU3X5G2QLR, DCPA (VAN), Chlorthal dimethyl, 2,3,5,6-Tetrachloroterephthalic acid dimethyl ester, Dimethyl 2,3,5,6-tetrachlorobenzene-1,4-dicarboxylate, NSC 155745, Chlorthal-dimethyl [BSI:ISO], HSDB 358, DAC 893, EINECS 217-464-7, Terephthalic acid, tetrachloro-, dimethyl ester, ZU3X5G2QLR, EPA Pesticide Chemical Code 078701, BRN 1888840, AI3-52124, 2,3,5,6-Tetrachlorphthalsaure-dimethylester, Dimethyl tetrachloro-1,4-benzenedicarboxylate, CHEBI:34664, DAC-893, NPOJQCVWMSKXDN-UHFFFAOYSA-N, Dimethylester kyseliny tetrachlortereftalove [Czech], 2,3,5,6-Tetrachlorphthalsaure-dimethylester [German], FR-0596, NCGC00094521-05, DSSTox_CID_4000, DSSTox_RID_77254, DSSTox_GSID_24000, W-107783, Daktal, CAS-1861-32-1, methyl 2,3,5,6-tetrachloro-4-(methoxycarbonyl)benzoate, Diformic Acid Chlorotitanate, Chlorothal, C10H6Cl4O4, Dactal, CCRIS 9261, Chlorothal-methyl, PubChem20581, Spectrum_001803, ACMC-1CMRC, SpecPlus_000394, Dimethylester kyseliny tetrachlortereftalove, AC1L1ETN, Spectrum2_001876, Spectrum3_000817, Spectrum4_000657, Spectrum5_001944, SCHEMBL53477, BSPBio_002313, KBioGR_001033, KBioSS_002296, SPECTRUM330025, DivK1c_006490, SPBio_001752, AC1Q42F6, Jsp003807, CHEMBL1888079, DTXSID0024000, CTK8B1069, KBio1_001434, KBio2_002294, KBio2_004862, KBio2_007430, KBio3_001813, KS-00002WWL, MolPort-000-627-710, ZINC156678, HY-B2062, Tox21_300379, Tox21_400071, Vegetable turf and ornamental weeder, ANW-23263, CCG-39414, LS-953, NSC155745, SBB007929, AKOS002380307, WLN: 1OVR BG CG EG FG DVO1, ACM1861321, CS-5219, KS-5362, MCULE-3486663201, NSC-155745, RTR-008590, ACM20098413, Dimethyl 2,5,6-tetrachloroterephthalate, NCGC00094521-01, NCGC00094521-02, NCGC00094521-03, NCGC00094521-04, NCGC00094521-06, NCGC00094521-07, NCGC00254510-01, 2,5,6-Tetrachlorphthalsaure-dimethylester, AC-19871, AN-50004, CC-06682, SC-52602, Terechloroterephthalic acid dimethyl ester, ZB006419, DB-044581, Tetrachloroterephthalic acid, dimethyl ester, TR-008590, 1, 2,3,5,6-tetrachloro-, dimethyl ester, DACTHAL (PESTICIDE/FERTILIZERMIXTURE), FT-0625047, ST50409271, Dimethyl ester of tetrachloroterephthalic acid, 61D321, C14744, Chlorthal-dimethyl 10 microg/mL in Cyclohexane, Chlorthal-dimethyl 100 microg/mL in Cyclohexane, A813007, C-20067, DIMETHYL-2,3,5,6-TETRACHLOROTEREPHTHALATE, 2,5,6-Tetrachloroterephthalic acid, dimethyl ester, I01-8411, 2,3,5,6-Tetrachloroterephthalic acid, dimethyl ester, Chlorthal-dimethyl, PESTANAL(R), analytical standard, Dimethyl 2,5,6-tetrachloro-1,4-benzenedicarboxylate, Dimethyl 2,3,5,6-tetrachloro-1,4-benzenedicarboxylate, Terephthalic acid, 2,3,5,6-tetrachloro-,dimethyl ester, Chlorthal-dimethyl (RM, ISO Guide 34) 200 mg/L in n-Hexane, dimethyl 2,3,5,6-tetrakis(chloranyl)benzene-1,4-dicarboxylate, 2,3,5,6-Tetrachloro-1,4-benzenedicarboxilic acid dimethyl ester, 2,3,5,6-Tetrachloro-1,4-benzenedicarboxylic acid dimethyl ester, 2,3,5,6-tetrachlorobenzene-1,4-dicarboxylic acid dimethyl ester, 65862-98-8, 87209-56-1


ID: 55

chemical graph of compound 55



InChIKey: NRFJZTXWLKPZAV-UHFFFAOYSA-N
SMILES: CC(=O)NC1CCSC1=O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 14520
synonyms found at PubChem are:
citiolone, 1195-16-0, 17896-21-8, Citiolase, Thioxidrene, Ahctl, Achtl, AHCT, N-Acetylhomocysteine thiolactone, Acetamide, N-(tetrahydro-2-oxo-3-thienyl)-, DL-N-Acetylhomocysteine thiolactone, 3-Acetamidotetrahydro-2-thiophenone, N-(2-Oxotetrahydrothiophen-3-yl)acetamide, N-(TETRAHYDRO-2-OXO-3-THIENYL)ACETAMIDE, N-Acetylhmocysteinethiolactone, N-Acetyl-dl-homocysteine thiolactone, BO 714, cythiolone, 2-Acetamido-4-mercaptobutyric acid gamma-thiolactone, Citiolone [INN:DCF], Citiolonum [INN-Latin], Citiolona [INN-Spanish], C6H9NO2S, N-Acetylhomocysteinthiolakton, NSC 22878, 2-Acetamido-4-mercaptobutyric acid thiolactone, alpha-Acetamido-gamma-thiobutyrolactone, N-(2-oxothiolan-3-yl)acetamide, EINECS 214-793-8, EINECS 241-841-5, N-(Tetrahydro-2-oxothienyl)acetamide, N-(TETRAHYDRO-2-OXO-3-THIENYL)-ACETAMIDE, N-Acetylhomocysteinthiolakton [German], BRN 0004338, NRFJZTXWLKPZAV-UHFFFAOYSA-N, .alpha.-Acetamido-.gamma.-thiobutyrolactone, (1)-N-(Tetrahydro-2-oxothien-3-yl)acetamide, DSSTox_CID_25888, DSSTox_RID_81202, DSSTox_GSID_45888, Citiolonum, Citiolona, Mucorex, Sitilon, N-(2-oxo-3-3,4,5-trihydrothienyl)acetamide, SR-01000872700, Reducdyn, Prestwick_1, N-Acetyl-DL-homocystein thiolacton, Citiolone (INN), NCGC00016568-01, CAS-1195-16-0, BILE SAC POWDER, Prestwick0_000644, Prestwick1_000644, Prestwick2_000644, Prestwick3_000644, bo714, 2-Thiolanone, 3-acetamido-, BSPBio_000647, 5-18-11-00320 (Beilstein Handbook Reference), n-acetylhomocysteinethiolactone, SCHEMBL364495, SPBio_002568, ACMC-209a31, BPBio1_000713, CHEMBL2104457, DTXSID0045888, CHEBI:94403, CTK8A9399, KS-00000ZKF, N-(2-oxo-3-thiolanyl)acetamide, dl-N-Acetylhomocysteinethiolactone, MolPort-000-395-703, HMS1570A09, HMS2097A09, HMS3714A09, Pharmakon1600-01503205, N-Acetyl-DL-homocysteinethiolactone, AC1L2406, HY-B0931, KS-000016BQ, N-Acetyl-DL-homocystein Thiolactone, NSC22878, Tox21_111388, Tox21_113346, ANW-17339, NSC-22878, NSC758402, s4558, SBB056942, AKOS002808092, AKOS016162043, Tox21_113346_1, CCG-213865, FCH1113174, MCULE-3189072897, NSC-758402, VC31147, VZ23451, ACM17896218, N-(2-Oxotetrahydro-3-thienyl)acetamide, NCGC00179491-01, NCGC00179491-04, AK122075, AN-48828, AS-11951, DL-N-Acetylhomocysteine thiolactone, 98%, LS-10265, n-(tetrahydro-2-oxo-3-thienyl)-acetamid, SC-75542, SBI-0207034.P001, 2-acetamido-4-mercaptobutyricacidthiolactone, AX8126584, DL-3-(Acetylamino)tetrahydro-2-thiophenone, TC-106084, FT-0637623, ST24031306, ST50989901, D07105, K-5482, 2-Acetamido-4-mercaptobutyric acid $g-thiolactone, C-03925, 2-Acetamido-4-mercaptobutyric acid beta-thiolactone, 2-Acetamido-4-mercaptobutyric acid I(3)-thiolactone, I04-0035, J-011416, SR-01000872700-1, SR-01000872700-2, BRD-A57957888-001-01-5, BRD-A57957888-001-06-4, I14-11945, 2-Acetamide-4-mercaptobutyric acid .gamma.-thiolactone, 2-Acetamido-4-mercaptobutyric acid .gamma.-thiolactone, 2-ACETAMIDO-4-MERCAPTOBUTYRIC ACID G-THIOLACTONE, 34148-12-4


ID: 56

chemical graph of compound 56



InChIKey: OARGPFMFRLLKPF-UHFFFAOYSA-N
SMILES: CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 73332
synonyms found at PubChem are:
H-7 dihydrochloride, H-7, Dihydrochloride, 108930-17-2, 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, CHEBI:82739, IN1302, 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl, 1-(5-ISOQUINOLINE-SULFONYL)-2-METHYLPIPERAZINE, 5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride, SR-01000000121, 1-(5-isoquinolylsulfonyl)-2-methylpiperazine, chloride, chloride, 1-(5-Isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride, AC1Q6UWH, AC1L2JO7, BMK1-B4, CHEMBL540848, SCHEMBL1064436, CTK5F2403, MolPort-003-983-768, to_000064, Tox21_500682, BS0093, MFCD00036961, Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-, dihydrochloride, SBB027327, AKOS024458555, CCG-221986, LP00682, H-7 dihydrochloride, >=98% (HPLC), NCGC00094040-01, NCGC00261367-01, RT-013180, EU-0100598, EU-0100682, H-121, ST50826284, I 7016, Isoquinoline,5-[(2-methyl-1-piperazinyl)sulfonyl]-, J-002210, SR-01000000121-2, SR-01000000121-3, SR-01000000121-6, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine hydrochloride, 5-(2-methylpiperazin-1-yl)sulfonylisoquinoline dihydrochloride, (-)-1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Di-HCl salt, 5-[(2-methylpiperazin-1-yl)sulfonyl]isoquinoline dihydrochloride, 5-[(2-methylpiperazin-4-ium-1-yl)sulfonyl]isoquinolinium dichloride, (+/-)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride


ID: 57

chemical graph of compound 57



InChIKey: ODLCLZLDYDHRGT-NEGPAABLSA-N
SMILES: CC(=O)O[C@@H]1C[C@@H]2[C@@]([C@@H]3[C@@]1([C@]45[C@H](O4)C(=O)O[C@H]([C@@]5(CC3)C)C6=COC=C6)C)([C@H](C[C@H](C2(C)C)OC(=O)C)OC(=O)C)C

biological descriptors:

CFTR relevance: weak CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 21596331
synonyms found at PubChem are:
Khivorin, 2524-38-1, D-Homo-24-nor-17-oxachola-20,22-dien-16-one, 1,3,7-tris(acetyloxy)-14,15:21,23-diepoxy-4,4,8-trimethyl-, (1a,3alpha,5alpha,7alpha,13alpha,14beta,15beta,17aalpha)-, SCHEMBL598261, CHEMBL1075850, DTXSID70179898, 1,3,7-Tris(acetyloxy)-14,15:21,23-diepoxy-4,4,8-trimethyl-D-homo-24-nor-17-oxachola-20,22-dien-16-one (1a,3alpha,5alpha,7alpha,13alpha,14beta,15beta,17aalpha)-


ID: 58

chemical graph of compound 58



InChIKey: OENHQHLEOONYIE-JLTXGRSLSA-N
SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(CCCC2(C)C)C)\C)\C)/C)/C

biological descriptors:

CFTR relevance: weak CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5280489
synonyms found at PubChem are:
beta-carotene, 7235-40-7, beta Carotene, beta,beta-Carotene, Betacarotene, Provitamin A, Solatene, Carotaben, Provatene, all-trans-beta-Carotene, Serlabo, Natural Yellow 26, Karotin, KPMK, C.I. Food Orange 5, Solatene (caps), Karotin [Czech], Food orange 5, Zlut prirodni 26, Betacarotenum [Latin], Betacaroteno [Spanish], Lucaratin, BetaVit, beta-Carotin, beta-Karotin, beta;-Carotene, .beta. Carotene, .beta.-Carotene, beta-Carotene, all-trans-, Betacarotenum [INN-Latin], C.I. 75130, Betacaroteno [INN-Spanish], Zlut prirodni 26 [Czech], UNII-01YAE03M7J, NSC 62794, CCRIS 3245, HSDB 3264, Diet,beta-carotene supplementation, E160A, EINECS 230-636-6, all-trans-.beta.-Carotene, CI 40800, CI 75130, MLS001066383, .beta.,.beta.-Carotene, 01YAE03M7J, CHEBI:17579, OENHQHLEOONYIE-JLTXGRSLSA-N, NSC62794, Betacarotene (INN), Betacarotene [INN], (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene), 1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene), (all E)-, 1,3,3-trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene, NCGC00096081-01, SMR000112037, 116-32-5, 2,2'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(1,3,3-trimethylcyclohex-1-ene), Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethyl-, (all-E)-, .beta.-Carotene, all-trans-, b-Carotene, Provitamin A1, Betacaroteno, Betacarotenum, Vetoron, trans-B-Carotene, 1,1'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene), trans-beta-Carotene, beta carotene [USAN], SR-01000763803, Beta carotene [USAN:USP], Solate, beta-Carotine, beta -carotene, Carotene, .beta., Solatene (TN), Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethyl-, (all-E)-, I(2)-Carotene, Beta Carotene Natural, beta Carotene (USP), trans-.beta.-Carotene, Carotene, Provitamin A, all trans beta-Carotene, all-E-.beta.-Carotene, AC1NQX3D, DSSTox_CID_253, Spectrum5_000505, .beta., .beta.-Carotene, bmse000832, D0MY8N, EC 230-636-6, AC1Q28DI, (9Z,13Z)-beta-Carotene, CHEMBL1293, DSSTox_RID_75466, BIDD:PXR0110, DSSTox_GSID_20253, BSPBio_003404, DTXSID3020253, BDBM54988, cid_5280489, HMS501A12, .beta.,.beta.-Carotene, neo B, MolPort-001-785-959, HMS2091M17, Pharmakon1600-01500143, ZINC6845076, beta-Carotene, >=97.0% (UV), Tox21_111557, C39H54, CC0205, CCG-36062, LMPR01070001, NSC755910, s1767, AKOS015896682, AC-1869, DB06755, LS-1621, NSC-755910, SDCCGMLS-0066579.P001, IDI1_000330, NCGC00096081-02, 31797-85-0, AN-14537, AS-13354, BC208855, H982, SC-19470, ST097774, CAS-7235-40-7, SBI-0051295.P003, AB2000280, N1547, 3046-EP2298772A1, 3046-EP2308839A1, C02094, D03101, J10299, AB00051925_06, AB00051925_07, beta-Carotene, Vetec(TM) reagent grade, >=93%, 117179-EP2292227A2, 117179-EP2298776A1, C-23129, I06-2213, Q-200706, SR-01000763803-2, SR-01000763803-3, SR-01000763803-4, I14-38736, beta-Carotene, Type I, synthetic, >=93% (UV), powder, UNII-N53I4V2IA6 component OENHQHLEOONYIE-JLTXGRSLSA-N, 89648336-F9B2-44A0-9BF8-62E73369CB9B, Beta Carotene, United States Pharmacopeia (USP) Reference Standard, beta-Carotene, Type II, synthetic, >=95% (HPLC), crystalline, 3,7,12,16-tetramethyl-1,18-bis-(2,2,6-trimethyl-cyclohexyl)-octadecane, beta-Carotene, Pharmaceutical Secondary Standard; Certified Reference Material, (1E,3E,5E,7E,9E,11E,13E,15E,17E)-1,18-bis(2,6,6-trimethylcyclohex-1-enyl)-3,7, 12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene, (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5, 7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6, 6-trimethylcyclohexene], 1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene, 1,18-Bis(2,6,6-trimethyl-1-cyclohexenyl)-3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonene


ID: 59

chemical graph of compound 59



InChIKey: OLOOJGVNMBJLLR-UHFFFAOYSA-N
SMILES: CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"X Liu" "TH Ma" "S Lin" "WL Na" "SG Hou" "H Yang" "LN Xu"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 10212
synonyms found at PubChem are:
IMPERATORIN, 482-44-0, Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen, 8-Isopentenyloxypsoralene, Marmelide, NSC 402949, CCRIS 4346, UNII-K713N25C78, 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one, HSDB 3497, EINECS 207-581-1, 9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one, AI3-61725, CHEBI:5885, CHEMBL453805, OLOOJGVNMBJLLR-UHFFFAOYSA-N, 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]-, 9-(3-Methylbut-2-enyloxy)furo[3,2-g]chromen-7-one, K713N25C78, 9-(3-Methylbut-2-enyloxy)-7H-furo(3,2-g)chromen-7-one, NCGC00095209-01, 9-((3-Methyl-2-butenyl)oxy)-7H-furo(3,2-g)(1)benzopyran-7-one, 9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one, 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((3-methyl-2-butenyl)oxy)-, 6-Hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylic acid omega-lactone, 9-[(3-METHYL-2-BUTEN-1-YL)OXY]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE, 5-Benzofuranacrylic acid, 6-hydroxy-7-((3-methyl-2-butenyl)oxy)-, delta-lactone, DSSTox_CID_28663, DSSTox_RID_82933, DSSTox_GSID_48737, Q-100532, 9-(3-methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one, 9-((3-methylbut-2-en-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one, 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one, 9-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]-1-benzopyran-7-one, CAS-482-44-0, Pentosalen [BAN], Enoxypsoralen, 7H-Furo[3,2-g][1]benzopyran-7-one, 9-((3-methyl-2-butenyl)oxy)-, Pentasalen, BAN, Imperatorin,(S), 8-Prenyloxypsoralen, Spectrum_000755, 8-isopentenyloxypsoralen, 5-hydroxy-8-(1,1-dimethylallyl)psoralen, SpecPlus_000755, AC1L1UPZ, Spectrum2_000376, Spectrum3_000145, Spectrum4_001422, Spectrum5_000244, [3,2-g]chromen-7-one, D09ROW, Oprea1_407817, SCHEMBL50437, BSPBio_001850, KBioGR_001864, KBioSS_001235, SPECTRUM102076, MLS000574838, DivK1c_006851, SPBio_000531, Marmelosin, analytical standard, MEGxp0_000089, ZINC1904, DTXSID8048737, ACon1_001117, CTK5J8942, KBio1_001795, KBio2_001235, KBio2_003803, KBio2_006371, KBio3_001050, MolPort-000-881-264, HMS1922N22, HMS2218G08, HMS3261C08, HMS3354E04, BCP28280, HY-N0285, 8-(3-Methyl-2-butenyloxy)psoralen, Tox21_113179, Tox21_500413, BDBM50308719, CCG-38649, CI0030, MFCD00016881, NSC402949, 9-(3-methylbut-2-enyloxy)-7H-furo, AKOS000277029, Tox21_113179_1, AC-8046, AN-8400, API0002987, CS-5800, Imperatorin, >=98% (HPLC), powder, LP00413, MCULE-3248623364, NSC-402949, SDCCGMLS-0066373.P001, NCGC00095209-02, NCGC00095209-03, NCGC00095209-04, NCGC00095209-05, NCGC00095209-06, NCGC00169661-01, NCGC00169661-02, NCGC00261098-01, CC-29497, LS-70737, SC-16643, SMR000156241, ZB000436, TR-036857, WLN: T C566 DO LVOTJ BO2UY1&1, FT-0603414, I0904, N1859, ST45000841, W1274, 7H-Furo[3, 9-[(3-methyl-2-butenyl)oxy]-, C09269, 482I440, A827504, C-16983, SR-01000721772, I06-0320, SR-01000721772-2, 9-(3-Methyl-2-butenyloxy)-7-oxofuro[3,2-g]chromene, 9-(3-methylbut-2-enyloxy)furano[3,2-g]chromen-2-one, 9-(3-methylbut-2-enoxy)-7-furo[3,2-g][1]benzopyranone, Imperatorin, European Pharmacopoeia (EP) Reference Standard, 9-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g]chromen-7-one #, 9-[(3-methylbut-2-en-1-yl)oxy]-2H-furo[3,2-g]chromen-2-one, 9-[(3-Methylbut-2-enyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one, (9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one), 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-buten-1-yl)oxy]-, 7H-Furo[3,2-g][1]benzopyran-7-one,9-[(3-methyl-2-buten-1-yl)oxy]-, 9-[(3-Methyl-2-butenyl)-oxy]-7H-furo[3,2-g][1][benzopyran-7-one, 9-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one, 9CI, 5-Benzofuranacrylic acid, 6-hydroxy-7-((3-methyl-2-butenyl)oxy)-, .delta.-lactone, 70102-00-0, InChI=1/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H


ID: 60

chemical graph of compound 60



InChIKey: OPYKHUMNFAMIBL-UHFFFAOYSA-L
SMILES: C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C.[Br-].[Br-]

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 9399
synonyms found at PubChem are:
Hemicholinium-3, Hemicholinium bromide, 312-45-8, HEMICHOLINIUM 3, Hemicholine, Hemicholinium dibromide, Hemicholinium-3 bromide, Hemicholinium 3 dibromide, Hemicholinium-3 dibromide, [3H]hemicholinium-3, [3H]-hemicholinium-3, EINECS 206-227-3, HC-3, NSC 527583, [3H]HC-3, [3H]-HC-3, Morpholinium, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl-, dibromide, 2,2'-(4,4'-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide, Morpholinium, 2,2'-(4,4'-biphenylylene)bis(2-hydroxy-4,4-dimethyl-, dibromide, Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, dibromide, SR-01000075620, Morpholinium, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl-, bromide (1:2), Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, bromide (1:2), Prestwick_566, AC1L1SYD, D05AFI, SCHEMBL564623, CHEMBL197027, GTPL4493, C24H34N2O4.2Br, MolPort-003-941-587, HMS1569O07, HMS2096O07, HMS3261D18, HMS3713O07, Tox21_500578, 2461AH, ACM312458, MFCD00011978, AKOS026750387, CCG-220393, CCG-221882, LP00578, NCGC00093959-01, NCGC00261263-01, LS-93529, Hemicholinium-3, solid, >=95% (HPLC), EU-0100578, FT-0741707, H-108, C-45763, J-018290, SR-01000075620-1, SR-01000075620-5, 2,2'-(4,4'-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium bromide), 2,2'-(1,1'-Biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl-morpholinium) dibromide, 2,2'-(1,1'-Biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl-morpholinium) dibromide (9CI), 2,2'-(biphenyl-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide, 2,2 inverted exclamation marka-(4,4 inverted exclamation marka-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium bromide), 2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol dibromide, 2-hydroxy-2-{4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl}-4,4-dimethylmorpholin-4-ium dibromide


ID: 61

chemical graph of compound 61



InChIKey: PFTAWBLQPZVEMU-DZGCQCFKSA-N
SMILES: C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

biological descriptors:

CFTR relevance: no effect

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

reference list:

"L Zhu" "L Chen" "T Ma" "X Gao" "H Yang" "B Yu" "Y Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 9064
synonyms found at PubChem are:
(+)-catechin, CATECHIN, Cianidanol, 154-23-4, Catechuic acid, Cyanidanol, Catechinic acid, D-Catechin, Catergen, Cianidol, (+)-Cyanidanol, (+)-Catechol, (+)-Cyanidan-3-ol, Biocatechin, D-(+)-Catechin, Catechin (flavan), Catechol (flavan), Dexcyanidanol, D-Catechol, (+)-Catechin Hydrate, (2R,3S)-Catechin, 3-Cyanidanol, (+)-, (2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol, Cianidanolum, Catechu, Gambier, Transepar, Katha, (+)-Cyanidanol-3, (2R,3S)-(+)-Catechin, (+)-Cianidanol, Cutch (dye), 3,3',4',5,7-Flavanpentol, KB-53, CCRIS 6855, (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol, Cianidanol [INN:JAN], C.I. Natural Brown 3, Cianidanolum [INN-Latin], NSC 2819, UNII-8R1V1STN48, Catechol (+), 2,3-trans-catechin, 2,3-Dihydro-4-desoxoquercetin, CHEBI:15600, AI3-22757, NSC2819, (+)-(2R,3S)-5,7,3',4'-Tetrahydroxyflavan-3-ol, CATECHIN, D, (2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol, 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)-, EINECS 205-825-1, Catechin-(+,-) hydrate, 7295-85-4, (2R,3S)-3,3',4',5,7-Flavanpentol, 8R1V1STN48, CHEMBL311498, PFTAWBLQPZVEMU-DZGCQCFKSA-N, NSC-2819, (2R-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol, 2H-1-benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-, C15H14O6, trans-(+)-3,3',4',5,7-Flavanpentol, Zyma, Cyanidanol-3, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol, (+)-Cyanidol-3, (+)-(2R:3S)-5,7,3',4'-Tetrahydroxyflavan-3-ol, (3S,2R)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol, (+/-)-Catechin hydrate, Epicatechin-(-), dl-Catechol, (-)-Catechol, MLS001056745, Catechine dl-form, (+/-)-Catechin, 321-01-7, (+-)-catechin, KB 53, SR-01000075742, SMR000326724, Catechinate, Catechuate, Ent-Catechin, Z 7300, Procyanidin polymer, Teafuran 30A, KXN, Prestwick_998, Sunkatol No. 1, EINECS 230-731-2, (+)-catechinhydrate, Spectrum_000395, (+)-Catechin,(S), 2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol #, Prestwick0_000642, Prestwick0_000817, Prestwick1_000642, Prestwick1_000817, Prestwick2_000642, Prestwick2_000817, Prestwick3_000642, Spectrum2_000167, Spectrum3_000242, Spectrum4_001763, Spectrum5_000345, Epitope ID:116872, AC1L1S8M, Lopac0_000219, SCHEMBL19741, BSPBio_000643, BSPBio_001624, KBioGR_002245, KBioSS_000875, BIDD:ER0378, DivK1c_000647, ( )-2-(3,4-Dihydroxyphenyl)-3,5,7-chromantriol, (+)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromantriol, (-)-trans-3,3',4',5,7-Pentahydroxyflavane, SPBio_000033, SPBio_002564, SPBio_002634, BPBio1_000709, cid_107957, DTXSID3022322, ACon1_001489, BDBM23416, BDBM60836, HMS502A09, KBio1_000647, KBio2_000875, KBio2_003443, KBio2_006011, KBio3_001124, KS-00000ZEC, 3,3',4',5,7 Cflavanpentol, YK-85 Light Yellow Powder 85, 4c94, MolPort-001-740-277, NINDS_000647, HMS1570A05, HMS1570D15, HMS2097A05, HMS3260L19, Pharmakon1600-00210205, ZINC119983, (+)-Catechin, analytical standard, HY-N0898, TNP00270, Tox21_500219, 6282AF, ANW-46737, CCG-40007, LMPK12020001, NSC755824, s4722, Cianidanol solution, 20 mM in DMSO, trans3,3,4,5,7 pentahydroxyflavane, AKOS015960546, trans-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol, CS-3759, LP00219, MCULE-1532117250, ND-0342, NSC-755824, SDCCGMLS-0066526.P001, IDI1_000647, NCGC00017331-01, NCGC00017331-02, NCGC00017331-03, NCGC00017331-04, NCGC00017331-05, NCGC00093689-01, NCGC00093689-02, NCGC00093689-03, NCGC00260904-01, (+)-Catechin solution, 20 mM in DMSO, 100786-01-4, AC-11608, AJ-11643, AN-44045, BC202817, LS-39923, LS-53711, NCI60_002303, SC-46023, ST057176, ZB004048, SBI-0050207.P003, AX8035583, ST2407915, TC-135482, EU-0100219, FT-0613995, ST24039239, (-)-trans-3,3',4',5,7-Pentahydroxyflavan, (2S,3R)-3,3',4',5,7-Pentahydroxyflavane, C 1251, C06562, Cianidanol, disposable screening library format, AB00051886_13, 154C234, A809512, NATURAL BROWN 3 (CUTCH EXTRA OR GAMBIER), Q-100183, SR-01000075742-1, SR-01000075742-7, SR-01000075742-8, SR-01000075742-9, BRD-K58736316-001-07-9, BRD-K58736316-001-08-7, SR-01000075742-10, SR-01000075742-12, SR-01000075742-14, D4A04A57-7609-451F-A446-53F4DFAD15F5, UNII-5J4Y243W61 component PFTAWBLQPZVEMU-DZGCQCFKSA-N, (2R,3S)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol;hydrate, (+)-Catechin, United States Pharmacopeia (USP) Reference Standard, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1H-chromene-3,5,7-triol, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol;hydrate, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol;hydrate, (2R,3S)-2-[3,4-bis(oxidanyl)phenyl]-3,4-dihydro-2H-chromene-3,5,7-triol, (2R,3S)-2-[3,4-bis(oxidanyl)phenyl]-3,4-dihydro-2H-chromene-3,5,7-triol;hydrate, (2R-trans)-2-(3,4-Dihydroxyphenyl)-3-4-dihydro-2H-1-benzopyran-3,5,7-triol, 2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol, (2R-trans), 2H-1-Benzopyran-3,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)-, 2H-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-, 159761-73-6, 16198-00-8, 29907-20-8, 4211-28-3, 5323-80-8, 72690-97-2, InChI=1/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s


ID: 62

chemical graph of compound 62



InChIKey: PSCZYIVKEHPWIP-VYRMFUMRSA-N
SMILES: CN1CCC2=C[C@H](C3C([C@H]21)C4=CC5=C(C=C4C(=O)O3)OCO5)OC.[N+](=O)(O)[O-]

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6419925
synonyms found at PubChem are:
ungerine nitrate, Prestwick_198, HMS1570I19, CCG-208376


ID: 63

chemical graph of compound 63



InChIKey: PZRHRDRVRGEVNW-UHFFFAOYSA-N
SMILES: Cc1c(cc(c(=O)[nH]1)C#N)c2ccncc2

biological descriptors:

CFTR relevance: Phosphodiesterase 3 inhibitor

Category:
Influence on CFTR function none
Order of interaction indirect
subcellular compartment several

reference list:

"PC Chao" "KL Hamilton"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 4197
synonyms found at PubChem are:
milrinone, 78415-72-2, Primacor, Corotrope, Corotrop, Milrinona, Milrinonum, Milrinonum [Latin], Milrinona [Spanish], Milrila, UNII-JU9YAX04C7, YM 018, Milrila (TN), Milrinone [USAN:BAN:INN], WIN 47203-2, CCRIS 3795, 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile, 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile, Win-47203, Win-47203-2, 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone, 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile, EINECS 278-903-6, CHEMBL189, BRN 3546821, JU9YAX04C7, C12H9N3O, 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile, CHEBI:50693, 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile, PZRHRDRVRGEVNW-UHFFFAOYSA-N, 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile, NCGC00015675-08, NCGC00164390-01, 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile, 111GE027, (3,4'-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-, Primacor (TN), 1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)NICOTINONITRILE, CAS-78415-72-2, M1663, (3,4'-BIPYRIDINE)-5-CARBONITRILE, 1,6-DIHYDRO-2-METHYL-6-OXO-, DSSTox_CID_3324, M 4659, DSSTox_RID_76978, DSSTox_GSID_23324, 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile, PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER, W-104284, MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER, [3,4'-Bipyridine]-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo-, 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile, 1,6-Dihydro-2-methyl-6-oxo-(3,4&prime;-bipyridine)-5-carbonitrile, SMR000058475, SR-01000075524, Milrinone [USAN:USP:INN:BAN], Milrinone(Primacor), WIN 47203, Milrinone (Primacor), Tocris-1504, AC1L1HMP, AC1Q2EBX, Prestwick0_001065, Prestwick1_001065, Prestwick2_001065, Prestwick3_001065, Lopac-M-4659, D0Y9ZE, (non-labelled)Milrinone-d3, Milrinone (JAN/USP/INN), Lopac0_000737, SCHEMBL36947, BSPBio_001050, Milrinone (JAN/USAN/INN), MLS000028818, MLS001424052, MLS006011946, BIDD:GT0197, SPBio_002965, BPBio1_001156, GTPL5225, SCHEMBL8309385, DTXSID5023324, BDBM15296, CTK7C7151, KS-00000GSZ, AOB5617, BIM0128, MolPort-003-666-840, ZX-AFC000063, HMS1571E12, HMS2051L10, HMS2090J14, HMS2098E12, HMS2234A23, HMS3262C16, HMS3267P12, HMS3370H18, HMS3393L10, HMS3656G06, HMS3715E12, Pharmakon1600-01505489, BCP02956, ZINC9224016, Tox21_112113, Tox21_400069, Tox21_500737, ANW-42920, BG0378, CM0151, MFCD00133539, Milrinone, >=97% (TLC), powder, NSC760072, s2484, SBB055743, AKOS015836135, Tox21_112113_1, AC-4730, API0003394, BCP9000926, CCG-101020, CCG-204822, CS-1367, DB00235, KS-1440, LP00737, MCULE-8377851655, NC00270, NSC-760072, WIN-472032, NCGC00015675-01, NCGC00015675-02, NCGC00015675-03, NCGC00015675-04, NCGC00015675-05, NCGC00015675-06, NCGC00015675-07, NCGC00015675-09, NCGC00015675-11, NCGC00025189-01, NCGC00025189-02, NCGC00025189-03, NCGC00261422-01, AJ-59392, AK174563, AN-11687, BC208811, CC-30960, CPD000058475, EN002063, HY-14252, LS-44610, SAM001246611, SC-46003, SMR004703527, WIN 47,203-2, BCP0726000256, 1,6-Dihydro-2-methyl-6-oxo-(3,4&prime, AB0010910, AB1009542, AX8014448, AB00514027, EU-0100737, FT-0630859, C07224, D00417, AB00514027-02, AB00514027-03, AB00514027_04, AB00514027_05, AB00597139-08, 415M722, A839417, C-10984, I06-0259, SR-01000075524-1, SR-01000075524-3, SR-01000075524-4, SR-01000075524-6, BRD-K67080878-001-05-5, Z1522568219, 6-methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carbonitrile, 6-methyl-2-oxo-5-(4-pyridyl)hydropyridine-3-carbonitrile, 1,2-dihydro-6-methyl-2-oxo-5-(4 -pyridinyl)nicotinonitrile, 1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)-NICOTIN, Milrinone, United States Pharmacopeia (USP) Reference Standard, 6-methyl-2-oxidanylidene-5-pyridin-4-yl-1H-pyridine-3-carbonitrile, 2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile (Milrinone)


ID: 64

chemical graph of compound 64



InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N
SMILES: CC1=NN(C(=O)C1)C2=CC=CC=C2

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"MJ Kurth" "MH Nantz" "M Eda" "EJ Niedzinski" "MJ Haddadin" "AS Verkman" "MF Springsteel" "K By" "LJ Galietta"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 4021
synonyms found at PubChem are:
edaravone, 89-25-8, Radicut, 1-Phenyl-3-methyl-5-pyrazolone, 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE, Norphenazone, Developer Z, Methylphenylpyrazolone, Norantipyrine, C.I. Developer 1, MCI-186, Phenylmethylpyrazolone, 3-Methyl-1-phenyl-5-pyrazolone, Phenyl methyl pyrazolone, Radicava, 1-Phenyl-3-methyl-5-oxo-2-pyrazoline, 1-Phenyl-3-methylpyrazolone, CI Developer 1, 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-, edarabone, 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one, edaravone(jan), 1-Phenyl-3-methylpyrazolone-5, 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, 3-Methyl-1-phenylpyrazol-5-one, 3-Methyl-1-phenyl-2-pyrazoline-5-one, NCI-C03952, 2-Pyrazolin-5-one, 3-methyl-1-phenyl-, 5-Pyrazolone, 3-methyl-1-phenyl-, 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one, 5-methyl-2-phenyl-4H-pyrazol-3-one, Monopyrazolone, NSC 12, Edaravone (MCI-186), 1-Fenyl-3-methyl-2-pyrazolin-5-on, CCRIS 512, Radicut (TN), 3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one, CHEBI:31530, HSDB 4102, 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech], EINECS 201-891-0, IN1263, BRN 0609575, AI3-03557, MLS000069602, QELUYTUMUWHWMC-UHFFFAOYSA-N, NSC-2629, (MCI-186), NSC-26139, CDS1_000986, NCGC00164015-01, SMR000059020, M0687, DSSTox_CID_1130, DSSTox_RID_75961, DSSTox_GSID_21130, AE-641/00371017, 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE (MCI-186), WLN: T5NMV DHJ BR& E1, 1-Phenyl-3-methyl-2-pyrazolin-5-on, CAS-89-25-8, Edaravone [INN], 3H-Pyrazol-3-one,4-dihydro-5-methyl-2-phenyl-, SR-01000000135, MCI 186, Radicava (TN), Radicut;MCI-186, PubChem13301, Spectrum_000267, Tocris-0786, Edaravone (JAN/INN), Edaravone [USAN:INN], AC1Q2PHG, AC1Q6EYP, Maybridge1_005738, Opera_ID_1057, Spectrum2_001574, Spectrum3_000971, Spectrum4_001091, Spectrum5_001217, Edaravone (JP17/INN), D06DLI, EC 201-891-0, AC1L1H8H, SCHEMBL4704, BSPBio_001235, BSPBio_002601, KBioGR_000575, KBioGR_001502, KBioSS_000575, KBioSS_000747, KSC448M1D, MLS001146878, MLS002415675, MLS006011753, DivK1c_001018, DivK1c_002026, SPECTRUM1503635, SPBio_001508, CHEMBL290916, DTXSID9021130, BCBcMAP01_000127, CTK3E8611, HMS503K17, HMS557M18, KBio1_001018, KBio2_000575, KBio2_000747, KBio2_003143, KBio2_003315, KBio2_005711, KBio2_005883, KBio3_001029, KBio3_001030, KBio3_001821, NSC2629, edaravone and MCI-186 and PMP, MolPort-000-182-197, NINDS_001018, BCPP000246, Bio1_000438, Bio1_000927, Bio1_001416, Bio2_000448, Bio2_000928, HMS1362M17, HMS1792M17, HMS1990M17, HMS2234M19, HMS3266F04, HMS3403M17, HMS3654L15, Pharmakon1600-01503635, ACT07289, BCP26336, HY-B0099, KS-00000X6I, NSC26139, Tox21_112077, Tox21_201747, Tox21_302819, BBL011741, BDBM50200541, CCG-39352, MFCD00003138, NSC758622, s1326, STK201315, ZINC18203737, 3-methyl-1-phenyl-2-pyrazolin-5one, AKOS000313817, Tox21_112077_1, AC-4745, BCP9000635, CS-1832, DB12243, LS-1892, MCI-186, Radicut, 89-25-8, NE10266, NSC-758622, RL05601, RTR-028045, IDI1_001018, IDI1_002203, 1-PEHNYL-3-METHYL-5-PYRAZALONE, NCGC00018218-01, NCGC00018218-02, NCGC00018218-03, NCGC00018218-04, NCGC00018218-05, NCGC00018218-06, NCGC00018218-07, NCGC00018218-08, NCGC00018218-10, NCGC00018218-17, NCGC00022665-02, NCGC00022665-04, NCGC00022665-05, NCGC00022665-06, NCGC00256515-01, NCGC00259296-01, 4CA-0486, AJ-70469, AN-11638, BC205186, SC-13582, ST012744, SBI-0051836.P002, AB2000046, DB-002517, KB-183502, ST2410773, TR-028045, AM20060748, FT-0608243, 5-methyl-2-phenyl-2,4-dihydro-3-pyrazolone, 5-methyl-2-phenyl-2,4-dihydropyrazol-3-one, 3-Methyl-1-phenyl-2-pyrazoline-5-one, 99%, 4E-901, 5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one, C13008, D01552, AB00375776_14, AB00375776_15, 2 4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one, 2,4-dihydro-2-phenyl-5-methyl-3H-pyrazol-3-one, I01-2810, Q-200386, SR-01000000135-2, SR-01000000135-3, SR-01000000135-5, 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one #, BRD-K35458079-001-04-2, BRD-K35458079-001-12-5, BRD-K35458079-001-23-2, Z50145861, F0391-0021, 3-Methyl-1-phenyl-2-pyrazoline-5-one, SAJ special grade, 3-Methyl-1-phenyl-2-pyrazoline-5-one, purum, >=98.0% (NT), 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (Edaravone), Phenazone impurity A, European Pharmacopoeia (EP) Reference Standard, Antipyrine Related Compound A, United States Pharmacopeia (USP) Reference Standard, InChI=1/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H, 115566-83-1, 12235-58-4, 206195-95-1, 52224-17-6, 62495-97-0, 72134-66-8


ID: 65

chemical graph of compound 65



InChIKey: QGXBDMJGAMFCBF-LUJOEAJASA-N
SMILES: C[C@]12CC[C@@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O

biological descriptors:

CFTR relevance: weak CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 441302
synonyms found at PubChem are:
EPIANDROSTERONE, 481-29-8, trans-Androsterone, Isoandrosterone, 3Beta-hydroxy-5alpha-androstan-17-one, 3beta-Hydroxyetioallocholan-17-one, epi-andosterone, 5alpha-Androstan-3beta-ol-17-one, iso-Androsterone, d-Epiandrosterone, UNII-8TR252Z538, 3-Epiandrosterone, (3beta,5alpha)-3-hydroxyandrostan-17-one, CHEMBL272195, 3beta-Hydroxy-androstan-17-one, CHEBI:541975, QGXBDMJGAMFCBF-LUJOEAJASA-N, Androsterone, epi-, MFCD00064134, NSC 93996, 8TR252Z538, ST072176, Androstan-17-one, 3-hydroxy-, (3b,5a)-, epi-Androsterone, C19H30O2, (1S,2S,5S,7S,11S,15S,10R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0<2,7>.0<11, 15>]heptadecan-14-one, SMR000718744, Androsterone, (3beta)-, AOX, Prestwick_699, EINECS 207-563-3, 3-beta-Hydroxy-5-alpha-androstan-17-one, AC1L9AXM, Prestwick0_000440, Prestwick1_000440, Prestwick2_000440, Prestwick3_000440, EC 207-563-3, BSPBio_000460, MLS000563092, MLS001304190, MLS001333976, MLS001333977, MLS002153812, SCHEMBL295167, SPBio_002399, BPBio1_000506, MolPort-002-506-907, HMS1569G22, HMS2096G22, HMS2235I04, HMS3713G22, ACT02601, Epiandrosterone (3|A-androsterone), HY-I0352, ZINC3861661, BBL030012, BDBM50236240, LMST02020023, s2832, SBB012505, STK801866, AKOS001582886, CCG-220440, CHM0029415, CS-5183, EBD2157888, NCGC00142619-02, NCGC00142619-04, AC-16141, AS-13045, CC-27483, H110, KB-50541, SC-16224, (3beta, 5alpha)-androstan-3-ol- 17-one, Androstan-17-one,3-hydroxy-, (3b,5a)-, TL8003251, E0374, C07635, J10456, M-1324, 5alpha-Androstan-17-one, 3beta-hydroxy- (8CI), C-18233, SR-01000837513, SR-01000837513-2, W-106055, Androstan-17-one, 3-hydroxy-, (3beta,5alpha)- (9CI), (3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one


ID: 66

chemical graph of compound 66



InChIKey: QIVBCDIJIAJPQS-VIFPVBQESA-N
SMILES: C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6305
synonyms found at PubChem are:
L-tryptophan, tryptophan, 73-22-3, L-Tryptophane, (S)-Tryptophan, Tryptophane, h-Trp-oh, Optimax, trofan, tryptacin, Ardeytropin, Pacitron, Indole-3-alanine, Kalma, L-beta-3-Indolylalanine, (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid, L-Tryptofan, L-Trp, L-(-)-Tryptophan, 3-Indol-3-ylalanine, Tryptophan (VAN), 1-beta-3-Indolylalanine, Tryptophan (H-3), Triptofano [Spanish], Tryptophanum [Latin], 1H-Indole-3-alanine, 1beta-3-Indolylalanine, 2-Amino-3-indolylpropanoic acid, triptofano, Tryptophanum, Lyphan, Tryptan, (S)-alpha-Amino-1H-indole-3-propanoic acid, Tryptophane [French], (L)-TRYPTOPHAN, (-)-Tryptophan, alpha'-Amino-3-indolepropionic acid, Tryptophan [USAN:INN], L-alpha-amino-3-indolepropionic acid, L-alpha-Aminoindole-3-propionic acid, Sedanoct, (S)-alpha-Aminoindole-3-propionic acid, 1H-Indole-3-alanine (VAN), EH 121, Tryptophan, L-, trp, L(-)-Tryptophan, Alanine, 3-indol-3-yl-, CCRIS 617, l-b-3-Indolylalanine, L-Alanine, 3-(1H-indol-3-yl)-, 1H-Indole-3-alanine, (S)-, alpha-Amino-3-indolepropionic acid, L-, Alti-Tryptophan, HSDB 4142, (S)-alpha-amino-beta-(3-indolyl)-propionic acid, NCI-C01729, AI3-18478, UNII-8DUH1N11BX, L-Ttp, Indole-3-propionic acid, alpha-amino-, 1H-Indole-3-propanoic acid, alpha-amino-, (S)-, L-(-)-Tryptophane, Propionic acid, 2-amino-3-indol-3-yl-, CHEBI:16828, L-Tryptophan (9CI), (S)-2-Amino-3-(3-indolyl)propionic acid, Tryptophan (USP/INN), (S)-(-)-Tryptophan, (S)-a-Amino-b-indolepropionic acid, (S)-a-Aminoindole-3-propionic acid, Alanine, 3-indol-3-yl, EINECS 200-795-6, Lopac-T-0254, NSC 13119, (S)-(-)-Tryptopha n, 8DUH1N11BX, (S)-a-Amino-1H-indole-3-propanoic acid, (S)-alpha-Amino-beta-indolepropionic acid, CHEMBL54976, TRP-01, L-TRYPTOPHAN SIGMA GRADE, alpha-Amino-beta-(3-indolyl)-propionic acid, l-a-Aminoindole-3-propionic acid, (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid, 2-amino-3-indol-3-ylpropionic acid, Propionic acid, 2-amino-3-indol-3-yl, 2-Amino-3-(lH-indol-3-yl)-propanoic acid, S(-)-1-alpha-Aminoindole-3-propionic acid, DSSTox_CID_1419, alpha-amino-beta-(3-indolyl)-pr opionic acid, T 0254, DSSTox_RID_76152, (S)-(-)-2-Amino-3-(3-indolyl)propionic Acid, DSSTox_GSID_21419, L-Trytophane, 151A3008-4CFE-40C9-AC0B-467EF0CB50EA, D-Trp-OH, CAS-73-22-3, 80206-30-0, trytophan, alpha-Amino-3-Indoleproprionic Acid, L-Trytophan, 1qaw, L-Tryptophan premix, L-Tryptophan,(S), L-Trp-OH, PubChem10984, 2a4m, L-Tryptophan (JP15), L-Tryptophan (JP17), Tryptophan, L-(8CI), TRP NH3+ COOH, Tryptophan (L-Tryptophan), Tryptophan, L- (8CI), bmse000050, bmse000868, bmse001017, D05EJG, Epitope ID:136043, EC 200-795-6, AC1L1M8F, SCHEMBL7328, 2-Amino-3-indolylpropanoate, (S)-1H-Indole-3-alanine, Lopac0_001183, GTPL717, KSC377I3D, MLS001056750, DivK1c_000457, (s)-a-amino-b-indolepropionate, AC1Q4U80, DTXSID5021419, (S)-a-Aminoindole-3-propionate, BDBM21974, CTK2H7431, HMS501G19, KBio1_000457, ZINC83315, BIT0720, 3-(1H-indol-3-yl)-L-Alanine, MolPort-001-794-499, MolPort-044-812-611, NINDS_000457, QIVBCDIJIAJPQS-VIFPVBQESA-N, ZX-AFC000605, alpha-Aminoindole-3-propionic acid, D-2-Amino-3-indolepropionic acid, HMS3263N07, L-2-Amino-3-indolepropionic acid, Pharmakon1600-01500600, ACT08662, STR02722, ZX-AT022248, (S)-alpha-Aminoindole-3-propionate, Tox21_201246, Tox21_300359, Tox21_501183, ANW-36308, GM0674, HTS001390, MFCD00064340, NSC757373, (s)-alpha-amino-beta-indolepropionate, L-Tryptophan, Vetec(TM), 98.5%, (S)-a-Amino-1H-indole-3-propanoate, AKOS015854052, Indoe-3-propionic acid, alpha-amino-, AM82273, AN-8742, CCG-205257, CS-W020011, DB00150, LP01183, LS-1622, MCULE-8004234494, NSC-757373, OR28930, RP26086, RTC-066620, IDI1_000457, NCGC00015994-01, NCGC00094437-01, NCGC00094437-02, NCGC00094437-03, NCGC00094437-04, NCGC00254424-01, NCGC00258798-01, NCGC00261868-01, (S)-alpha-Amino-1H-indole-3-propanoate, AC-17050, AJ-10635, AK-50074, BP-13286, BR-50074, KB-53414, SMR000326686, AB1007074, AX8034769, DB-029986, L-Tryptophan, BioUltra, >=99.5% (NT), LS-185087, ST2419449, TC-066620, A7403, EU-0101183, FT-0627592, (S)-Tryptophan 1H-Indole-3-alanine, (S)-, 73T223, C00078, D00020, L-Tryptophan, reagent grade, >=98% (HPLC), M02943, AB00373874_05, L-Tryptophan, Vetec(TM) reagent grade, >=98%, (S)-2-amino-3-(1H-Indol-3-yl)-propionic acid, C-48302, SR-01000075590, SR-01000075590-1, F0001-2364, Z1245635763, L-Tryptophan, certified reference material, TraceCERT(R), Tryptophan, European Pharmacopoeia (EP) Reference Standard, UNII-N7U7BXP2OI component QIVBCDIJIAJPQS-VIFPVBQESA-N, UNII-X9U7434L7A component QIVBCDIJIAJPQS-VIFPVBQESA-N, L-Tryptophan, United States Pharmacopeia (USP) Reference Standard, (S)-2-Amino-3-(3-indolyl)propionic acid; L-|A-Amino-3-indolepropionic acid, 154635-35-5, L-Tryptophan, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%, L-Tryptophan, PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture, (2S)-2-azaniumyl-3-(1H-indol-3-yl)propanoate, (2S)-2-ammonio-3-(1H-indol-3-yl)propanoate, 3rzi, L-tryptophan zwitterion, 3f3a, 3qs4, 3qs5, 3qs6, AC1OCMF3, 2-amino-3-indolylpropanic acid, CHEBI:57912, CJ-00673, A837752


ID: 67

chemical graph of compound 67



InChIKey: QONLGXRPRAIDGI-UHFFFAOYSA-N
SMILES: CC(C)NCC(C1=CC2=CC=CC=C2C=C1)O.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 60975
synonyms found at PubChem are:
PRONETHALOL HYDROCHLORIDE, Pronetalol hydrochloride, 51-02-5, 2-Isopropylamino-1-(2-naphthyl)ethanol hydrochloride, Alderlin hydrochloride, Nethalide hydrochloride, Pronethalol.HCl, DL-Pronethalol hydrochloride, CCRIS 534, Naphthylisoproterenol hydrochloride, ICI 38174, AY 6204, CHEBI:82525, alpha-((Isopropylamino)methyl)-2-naphthalenemethanol hydrochloride, alpha-(((1-Methylethyl)amino)methyl)-2-naphthalenemethanol, hydrochloride, 2-[(1-methylethyl)amino]-1-naphthalen-2-ylethanol hydrochloride, Pronetalol HCl, Naphthalenemethanol, alpha-((isopropylamino)methyl)-, hydrochloride, SR-01000597857, AC1L1U9R, PRONETALOLHYDROCHLORIDE, MLS002154081, SPECTRUM1503628, SCHEMBL3203560, CHEMBL1876082, DTXSID3021194, CTK8I9459, MolPort-003-666-490, HMS1571C09, HMS1922G06, Pharmakon1600-01503628, ACM51025, CCG-39348, ICI-38174, NSC758482, 2-Naphthalenemethanol, .alpha.-[[(1-methylethyl)amino]methyl]-, hydrochloride, AKOS024458662, LS-7673, NSC-758482, NCGC00095061-01, NCGC00095061-02, CC-11092, SMR001233390, DB-051883, FT-0631217, C19513, C-16638, SR-01000597857-1, SR-01000597857-3, SR-01000597857-4, 2-(isopropylamino)-1-(2-naphthyl)ethanol hydrochloride, 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloride, 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol;hydrochloride, 2-(Isopropylamino)-1-(naphthalen-2-yl)ethanol hydrochloride, 2-(isopropylamino)-1-(naphthalen-2-yl)ethan-1-ol hydrochloride, 2-Naphthalenemethanol, alpha-(((1-methylethyl)amino)methyl)-, hydrochloride, 325-16-6, 6426-40-0, SCHEMBL14973465


ID: 68

chemical graph of compound 68



InChIKey: RGSUZUQISVAJJF-UHFFFAOYSA-N
SMILES: COC1=CC(=O)C(=CC1=O)C(C=C)c2ccccc2

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 99926
synonyms found at PubChem are:
4-Methoxydalbergione, 28396-75-0, NSC269121, NSC629750, 2-Methoxy-5-(1-phenylallyl)-4-benzoquinone, 2-Methoxy-5-(1-phenylallyl)-p-benzoquinone, NSC 269121, Spectrum_001081, SpecPlus_000079, Spectrum2_000654, Spectrum3_000201, Spectrum4_000941, Spectrum5_001903, BSPBio_001781, KBioGR_001522, KBioSS_001561, SPECTRUM201092, DivK1c_006175, SPBio_000687, AC1L418P, CHEMBL1554531, KBio1_001119, KBio2_001561, KBio2_004129, KBio2_006697, KBio3_001281, CCG-38560, NSC-269121, NSC-629750, SDCCGMLS-0066445.P001, NCGC00095497-01, NCGC00095497-02, NCI60_002183, 2-methoxy-5-(1-phenylallyl)-1,4-benzoquinone, SR-05000002505, SR-05000002505-1, 2-Methoxy-5-(1-phenyl-2-propenyl)benzo-1,4-quinone, 2-methoxy-5-(1-phenylallyl)cyclohexa-2,5-diene-1,4-dione, 2,5-Cyclohexadiene-1,4-dione, 2-methoxy-5-(1-phenyl-2-propenyl)-, 2-methoxy-5-(1-phenylprop-2-enyl)cyclohexa-2,5-diene-1,4-dione


ID: 69

chemical graph of compound 69



InChIKey: RODXRVNMMDRFIK-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(=C1)C=CC(=O)O2)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"X Liu" "TH Ma" "S Lin" "WL Na" "SG Hou" "H Yang" "LN Xu"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5280460
synonyms found at PubChem are:
scopoletin, 92-61-5, Gelseminic acid, 6-Methylesculetin, 7-Hydroxy-6-methoxy-2H-chromen-2-one, Chrysatropic acid, Scopoletine, 7-Hydroxy-6-methoxycoumarin, Murrayetin, Scopoletol, 6-O-Methylesculetin, Escopoletin, 6-Methoxy-7-hydroxycoumarin, 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one, 6-Methoxyumbelliferone, 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-, Esculetin 6-methyl ether, beta-Methylesculetin, Esculetin-6-methyl ether, .beta.-Methylesculetin, Buxuletin, UNII-KLF1HS0SXJ, COUMARIN, 7-HYDROXY-6-METHOXY-, 7-hydroxy-6-methoxychromen-2-one, 7-Hydroxy-5-methoxycoumarin, NSC 405647, CCRIS 3592, KLF1HS0SXJ, EINECS 202-171-9, NSC405647, BRN 0156296, CHEMBL71851, CHEBI:17488, RODXRVNMMDRFIK-UHFFFAOYSA-N, 7-hydroxy-6-methoxy-chromen-2-one, TNP00096, NSC-405647, S-2000, 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI), Chrysotropic Acid, Acid, Gelseminic, Scopoletin solution, 100 mM in DMSO, Acid, Chrysotropic, SMR000112541, 92-61-5 solution, 100 mM in DMSO, Gelseminic acid solution, 100 mM in DMSO, 6-Methylesculetin solution, 100 mM in DMSO, SR-01000841273, Baogongteng B, b-Methylaesculetin, beta -methylesculetin, PubChem15777, Scopoletin, >=99%, Prestwick0_000962, Prestwick1_000962, Prestwick2_000962, Prestwick3_000962, Spectrum2_001207, Spectrum3_001532, Spectrum4_001054, Spectrum5_000654, Aesculetin 6-methyl ether, D05QOR, AC1NQX27, BIDD:PXR0125, BSPBio_000963, BSPBio_002944, KBioGR_001348, 5-18-03-00203 (Beilstein Handbook Reference), 7-hydroxy-6-methoxy-coumarin, MLS002154074, MLS002472878, DivK1c_000720, SCHEMBL147702, SPECTRUM1502242, 7-hydroxy 6-methoxy coumarine, SPBio_000994, SPBio_002884, Scopoletin, analytical standard, BPBio1_001061, MEGxp0_001192, DTXSID0075368, ACon1_000143, HMS502D22, KBio1_000720, KBio3_002444, KS-00000YGS, ZINC57733, BIS1402, MolPort-000-707-493, NINDS_000720, ZX-AFC000681, HMS1571A05, HMS1921N16, HMS2098A05, HMS2268G04, ALBB-023369, BCP13342, HY-N0342, ZX-AN021883, ZX-AT021192, 6-methoxy-7-oxidanyl-chromen-2-one, BDBM50156693, CCG-39140, MFCD00006872, TD8126, Scopoletin solution, 20 mM in DMSO, AKOS000277133, CS-5791, FCH1115349, MCULE-6077230919, OR22352, RTR-029034, CAS-92-61-5, IDI1_000720, 7-hydroxy-6-methoxy-1-benzopyran-2-one, 92-61-5 solution, 20 mM in DMSO, NCGC00016349-01, NCGC00016349-02, NCGC00016349-03, NCGC00016349-04, NCGC00016349-05, NCGC00016349-06, NCGC00016349-07, NCGC00016349-08, NCGC00094973-01, NCGC00094973-02, NCGC00094973-03, 4CN-0905, AJ-09778, AK111291, AN-42608, CC-34387, LS-55217, NCI60_003834, SC-90283, ST056287, ZB002243, 7-Hydroxy-6-methoxy-2H-chromen-2-one #, Gelseminic acid solution, 20 mM in DMSO, AB0019688, AX8035441, KB-249948, TR-029034, 6-Methylesculetin solution, 20 mM in DMSO, AB00443525, FT-0631451, S0367, ST24045669, C01752, W-3522, 006S872, A844290, C-30831, SR-01000841273-3, SR-01000841273-4, 7-hydroxy-6-methoxycoumarin solution, 20 mM in DMSO, BRD-K96163925-001-06-5, BRD-K96163925-001-09-9, I14-14171, 0B4B9FAA-686D-4977-AA08-65F8E4F1977C, 7-hydroxy-6-methoxychromen-2-one solution, 20 mM in DMSO, Scopoletin, United States Pharmacopeia (USP) Reference Standard


ID: 70

chemical graph of compound 70



InChIKey: SFLOGVVDXPCWGR-UHFFFAOYSA-N
SMILES: C12=C(NC(=O)C(=O)N1)NC(=NC2=O)N

biological descriptors:

CFTR relevance: weak CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 10291
synonyms found at PubChem are:
LEUCOPTERIN, Leikopterin, Leukopterin, 492-11-5, 2-Amino-4,6,7-trihydroxypteridine, UNII-54RIE2BQ10, 54RIE2BQ10, 2-amino-5,8-dihydro-1H-pteridine-4,6,7-trione, 4,6,7(3H)-Pteridinetrione, 2-amino-5,8-dihydro-, 2-aminopteridine-4,6,7(3H,5H,8H)-trione, 2-Amino-4,6,7-trihydroxypyrimido(4,5-b)pyrazine, 2-Amino-4,6,7-trihydroxypyrimido[4,5-b]pyrazine, 2-Aminopteridine-4,6,7-triol, EINECS 207-747-3, NSC 93740, 6,7-dihydroxypterin, Spectrum_001136, SpecPlus_000324, Spectrum2_000587, Spectrum3_000761, Spectrum4_001724, Spectrum5_000488, AC1L1UW2, NCIOpen2_001382, BSPBio_002402, KBioGR_002108, KBioSS_001616, DivK1c_006420, SCHEMBL968371, SPECTRUM1500874, SPBio_000434, CHEMBL3039245, SCHEMBL12948394, KBio1_001364, KBio2_001616, KBio2_004184, KBio2_006752, KBio3_001622, 2-Amino-4,7-trihydroxypteridine, DTXSID00197707, MolPort-000-828-206, MolPort-002-511-804, SFLOGVVDXPCWGR-UHFFFAOYSA-N, NSC93740, CCG-38510, NSC-93740, ZINC18247079, AKOS006227881, AKOS022505738, FCH1191668, MCULE-6696393574, SDCCGMLS-0066681.P001, NCGC00095646-01, NCGC00095646-02, FT-0691535, 2-Amino-4,7-trihydroxypyrimido[4,5-b]pyrazine, 4,7(1H)-Pteridinetrione, 2-amino-5,8-dihydro-, 4,7(3H)-Pteridinetrione, 2-amino-5,8-dihydro-, C-55951, 2-Amino-5,8-dihydro-4,6,7(1H)-pteridinetrione #, 4,6,7(1H)-Pteridinetrione, 2-amino-5,8-dihydro-, 4,6,7(1H)-Pteridinetrione, 2-amino-5,8-dihydro- (8CI)(9CI)


ID: 71

chemical graph of compound 71



InChIKey: SQVXWIUVAILQRH-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C=C3)O

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

reference list:

"MJ Kurth" "MH Nantz" "M Eda" "EJ Niedzinski" "MJ Haddadin" "AS Verkman" "MF Springsteel" "K By" "LJ Galietta"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5320693
synonyms found at PubChem are:
Pratol, 7-Hydroxy-4'-methoxyflavone, 487-24-1, C.I. 75570, UNII-KU5R959MO7, 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-methoxyphenyl)-, 7-hydroxy-2-(4-methoxyphenyl)chromen-4-one, EINECS 207-653-2, NSC 123414, 7-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one, BRN 0237239, MLS002707301, KU5R959MO7, 7-Hydroxy-2-(4-methoxyphenyl)-4-benzopyrone, Flavone, 7-hydroxy-4'-methoxy-, SQVXWIUVAILQRH-UHFFFAOYSA-N, NSC123414, 7-Hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, NSC-123414, Flavone, 7-hydroxy-4'-methoxy- (7CI,8CI), AN-829/40761415, 487-17-2, 7-Hydroxy-4-methoxyflavone, 4hl5, 7-Hydroxy-flavone, 5h, AC1NSZS1, 4'-methoxy-7-hydroxyflavone, Oprea1_854602, CHEMBL16751, SCHEMBL534596, BDBM85573, DTXSID20197587, MolPort-002-903-705, Pratol solution, 100 mM in DMSO, TNP00065, ZINC5733557, ACM487172, AKOS004110700, CCG-208438, MCULE-4757451306, NCGC00017200-01, NCGC00017200-02, NCGC00017200-03, NCGC00142412-01, NCGC00142412-02, LS-39700, SMR001488172, ST055366, Pratol, disposable screening library format, FT-0730316, C-57549, SR-05000002252, 7-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one #, SR-05000002252-2, BRD-K35651673-001-05-9, 15W


ID: 72

chemical graph of compound 72



InChIKey: TZFWDZFKRBELIQ-UHFFFAOYSA-N
SMILES: C1=CC2=C(C=C1Cl)NC(=O)O2

biological descriptors:

CFTR relevance: strong CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 2733
synonyms found at PubChem are:
chlorzoxazone, 95-25-0, Chlorzoxazon, Paraflex, Chloroxazone, 5-Chloro-2-benzoxazolone, Biomioran, Escoflex, Myoflexin, Myoflexine, Pathorysin, Mioran, Miotran, Neoflex, Solaxin, 2(3H)-Benzoxazolone, 5-chloro-, Parafon Forte DSC, 5-Chloro-2-hydroxybenzoxazole, 5-Chloro-2-benzoxazolinone, Chlorzoxane, 5-Chlorobenzoxazolidone, 5-Chloro-2(3H)-benzoxazolone, Usaf ma-10, 5-Chlorobenzoxazol-2-one, Strifon Forte Dsc, Chlorzoxazonum, 5-Chloro-2-benzoxazolol, 5-Chlorobenzoxazolone, 2-Hydroxy-5-chlorobenzoxazole, 5-Chlorobenzo[d]oxazol-2(3H)-one, Chlorsoxazone, Clorzoxazona, Klorzoxazon, Remofleks, Nyoflex, 5-Chlorbenzoxazolin-2-on, Parafon Forte, 5-Chloro-1,3-benzoxazol-2(3H)-one, 5-chloro-3H-1,3-benzoxazol-2-one, Parafon, 5-Chloro-3(H)-2-benzoxazolone, 5-Chlorobenzoksazolon-2, 5-Chlorobenzoksazolinon-2, 5-chlorobenzoxazolin-2-one, Chlorzoxazonum [INN-Latin], Clorzoxazona [INN-Spanish], chlorzoxazona, Relaxazone, Remular, C7H4ClNO2, 5-Chlorobenzoksazolon-2 [Polish], Remular-S, 5-Chlorobenzoksazolinon-2 [Polish], UNII-H0DE420U8G, 5-chloro-2,3-dihydro-1,3-benzoxazol-2-one, NSC 26189, 2-BENZOXAZOLINONE, 5-CHLORO-, Paraflex (TN), 5-chlorobenzo[d]oxazol-2-ol, Chlorzoxazone [INN:BAN:JAN], 5-chloro-3H-benzooxazol-2-one, 5-chloro-1,3-benzoxazol-2-ol, EZE-DS, EINECS 202-403-9, component of Parafon Forte, CHEMBL1371, AI3-63119, MLS000069380, CHEBI:3655, Chlorzoxazone (JAN/USP/INN), H0DE420U8G, TZFWDZFKRBELIQ-UHFFFAOYSA-N, CAS-95-25-0, NCGC00015238-02, SMR000058269, DSSTox_CID_2813, C 4397, DSSTox_RID_76739, DSSTox_GSID_22813, CLW, 5-chloro-3-hydrobenzoxazol-2-one, Lorzone, SR-01000075207, Clorzoxazone, Phantom, Stealth, Strifon, 5-Chloro-3H-benzoxazol-2-one, Mystox MP, Prestwick_62, Chlorzoxazone,(S), Chlorzoxazone [USP:INN:BAN:JAN], Citrex (acaricide), Muscol (TN), Parafon Forte (TN), PubChem8642, 5-Chlorobenzoxazolinone, Spectrum_000148, AC1L1ECE, Opera_ID_1659, Prestwick0_000163, Prestwick1_000163, Prestwick2_000163, Prestwick3_000163, Spectrum2_001149, Spectrum3_000350, Spectrum4_000287, Spectrum5_000745, Lopac-C-4397, D08ZEB, 5-Chloro-benzooxazol-2-ol, AC1Q3KM0, AC1Q3KM1, Ortho Brand of Chlorzoxazone, 5-chloro-benzoxazolin-2-one, Lopac0_000253, SCHEMBL35177, BSPBio_000025, BSPBio_002019, KBioGR_000814, KBioSS_000628, WLN: T56 BMVOJ HG, McNeil Brand of Chlorzoxazone, DivK1c_000895, SPECTRUM1500188, SPBio_001077, SPBio_001946, BPBio1_000029, GTPL2322, DTXSID9022813, CTK6H1680, HMS502M17, KBio1_000895, KBio2_000628, KBio2_003196, KBio2_005764, KBio3_001239, KS-00000VVL, MolPort-001-759-947, MolPort-006-110-468, NINDS_000895, HMS1568B07, HMS1920O07, HMS2091E14, HMS2095B07, HMS2235I19, HMS3259I15, HMS3260D08, HMS3373P17, HMS3652K22, HMS3712B07, Pharmakon1600-01500188, Secure 360SC Insecticide-Miticide, ACT08248, ALBB-012641, BCP07916, HY-B1462, NSC26189, STR00805, Tox21_110105, Tox21_500253, BBL003952, BDBM50290811, CCG-40323, KM3336, MFCD00005717, NSC-26189, NSC756693, s4155, SBB003864, STK071582, ZINC84843283, AKOS000404381, Tox21_110105_1, component of Parafon Forte (Salt/Mix), CS-5155, DB00356, HG-0202, LP00253, MCULE-3638156868, NC00499, NSC-756693, 5-chloranyl-3H-1,3-benzoxazol-2-one, 5-chloro-1,3-benzoxazole-2(3H)-one, IDI1_000895, Chlorzoxazone 1.0 mg/ml in Acetonitrile, NCGC00015238-01, NCGC00015238-03, NCGC00015238-04, NCGC00015238-05, NCGC00015238-06, NCGC00015238-07, NCGC00015238-08, NCGC00015238-09, NCGC00015238-10, NCGC00015238-13, NCGC00093714-01, NCGC00093714-02, NCGC00093714-03, NCGC00093714-04, NCGC00260938-01, 5-Chloro-1,3-benzoxazol-2(3H)-one #, AC-12192, AN-24309, BP-11613, CPD000058269, KB-88347, LS-42267, SAM002554888, SC-07433, SBI-0050241.P004, AB0011060, AB1004047, ST2406217, AB00051947, AC 303-630, EU-0100253, FT-0620220, ST45024437, EN300-31026, 5-Chloro-2,3-dihydro-2-oxo-1,3-benzoxazole, C07931, D00771, AB00051947_05, AB00051947_06, A845253, I14-4579, SR-01000075207-1, SR-01000075207-3, SR-01000075207-5, W-100168, BRD-K98174813-001-05-7, BRD-K98174813-001-08-1, Z57183224, 5-Chloro-2(3H)-benzoxazolone; 5-Chloro-2-hydroxybenzoxazole, Chlorzoxazone, United States Pharmacopeia (USP) Reference Standard, InChI=1/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10, 32850-84-3


ID: 73

chemical graph of compound 73



InChIKey: UFULAYFCSOUIOV-UHFFFAOYSA-N
SMILES: C(CS)N

biological descriptors:

CFTR relevance: proteostasis regulator (targeting disabled autophagy and CK2 overactivation)

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

reference list:

"A Tosco" "V Raia" "G Kroemer" "L Maiuri" "VR Villella" "M Piacentini"
"S Esposito" "G Kroemer" "S Lusa" "L Salvadori" "MC Maiuri" "F De Gregorio" "E Ferrari" "G Bona" "A Di Pasqua" "S Guido" "A Tosco" "CA Leone" "V Raia" "I Sana" "A Sepe" "L Maiuri" "P Buonpensiero" "G De Rosa" "G Stoll" "A Mehta" "D De Stefano" "R Grassia"
"S Esposito" "G Kroemer" "L Salvadori" "A Zolin" "A Bossi" "MC Maiuri" "VR Villella" "F De Gregorio" "LA Pinna" "G Bona" "S Guido" "A Tosco" "CA Leone" "V Raia" "A Sepe" "L Maiuri" "M Pettoello-Mantovani" "G De Rosa" "A Venerando" "A Mehta" "D De Stefano" "R Grassia"


CID is 6058
synonyms found at PubChem are:
CYSTEAMINE, 2-Aminoethanethiol, Mercaptamine, 60-23-1, Thioethanolamine, Becaptan, Mercamine, Cysteinamine, beta-Mercaptoethylamine, 2-Mercaptoethylamine, Cysteamin, Lambraten, Lambratene, beta-Aminoethanethiol, Cystagon, Riacon, Decarboxycysteine, Mercaptoethylamine, 2-Amino-1-ethanethiol, Cisteamina, 2-Aminoethyl mercaptan, beta-Aminoethylthiol, 2-Mercaptoethanamine, Ethanethiol, 2-amino-, Mercaptamin, (2-Mercaptoethyl)amine, MEA (mercaptan), Ethanethiolamine, beta-MEA, Aminoethyl mercaptan, Mercaptamina, Mercaptaminum, Cysteamide, Mecramine, Mercamin, Merkamin, Cisteamina [Italian], Cystaran, 2-AMINO-ETHANETHIOL, Mercaptaminum [INN-Latin], Mercaptamina [INN-Spanish], 1-Amino-2-mercaptoethylamine, 2-aminoethane-1-thiol, Cysteamine [USAN:BAN], L-1573, Cysteamine (USAN), WR 347, Cystavision, C2H7NS, UNII-5UX2SD1KE2, Cysteamine bitartate, NSC 647528, Cysteamine [USAN], Mercaptamine (INN), CCRIS 3083, HSDB 7353, .beta.-Mercaptoethylamine, EINECS 200-463-0, L 1573, 5UX2SD1KE2, CHEBI:17141, UFULAYFCSOUIOV-UHFFFAOYSA-N, cysteaminium, 2-Mercaptoethylamine, polymer-bound, Mercaptamine [INN], NSC647528, NCGC00015691-03, (Mercaptoethyl)ammonium toluene-p-sulphonate, C-9500, 60-23-1 (Parent), Cystagone, b-Aminoethylthiol, 2-aminoethanethio, b-Aminoethanethiol, mercapto ethylamine, b-Mercaptoethylamine, DHL, 2-amino-ethyl thiol, CASH, .beta.-MEA, Cysteamine, ~95%, Cysteamine, free base, .beta.-Aminoethylthiol, Spectrum_001755, .beta.-Aminoethanethiol, ACMC-1AVBC, SpecPlus_000654, AC1L1LPL, Lopac-M-6500, DSSTox_CID_2875, bmse000388, CHEMBL602, D0V0LB, AC1Q54NL, DSSTox_RID_76770, DSSTox_GSID_22875, KBioSS_002235, KSC490G2L, DivK1c_006750, 156-57-0 (hydrochloride), 641022_ALDRICH, BDBM7968, GTPL7440, 3037-04-5 (tosylate), DTXSID3022875, CTK3J0325, KBio1_001694, KBio2_002235, KBio2_004803, KBio2_007371, KS-00000WES, 42954-15-4 (hydrobromide), Cysteamine, >=98.0% (RT), MolPort-001-662-635, BCP15015, ZINC8034121, EINECS 221-235-7, Tox21_113092, 16904-32-8 (di-hydrochloride), ANW-33452, HY-77591A, STK315355, AKOS003793343, CCG-204834, CS-2799, DB00847, MCULE-1838427828, NE18622, NSC-647528, RP18367, RTR-031658, CAS-60-23-1, NCGC00015691-01, NCGC00015691-02, NCGC00015691-04, NCGC00162236-01, NCGC00162236-02, AN-41805, BP-13401, KB-20296, LS-65761, NCI60_002000, SC-18413, SBI-0050727.P003, 27761-19-9 (tartrate (1:1)), 93965-19-6 (maleate (1:1)), AB0020070, DB-053562, TR-031658, A0648, FT-0611243, V0810, C01678, D03634, AB00053754_09, AB00053754_10, 106791-EP2292597A1, 106791-EP2295407A1, 106791-EP2298736A1, 213515-EP2371809A1, F0001-1576, 2DFDA1F8-7010-4225-8280-AB1C4C43F546, 139720-70-0, 2-Mercaptoethylamine, polymer-bound, 70-90 mesh, extent of labeling: 0.6-1.1 mmol/g loading, 1 % cross-linked with divinylbenzene, 2-ammonioethanethiolate, STL455134


ID: 74

chemical graph of compound 74



InChIKey: UILPJVPSNHJFIK-UHFFFAOYSA-N
SMILES: CC(=O)C1=C(C=C(C=C1)OC)O

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

reference list:

"MJ Kurth" "MH Nantz" "M Eda" "EJ Niedzinski" "MJ Haddadin" "AS Verkman" "MF Springsteel" "K By" "LJ Galietta"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 11092
synonyms found at PubChem are:
PAEONOL, 552-41-0, 2'-Hydroxy-4'-methoxyacetophenone, 1-(2-Hydroxy-4-methoxyphenyl)ethanone, Peonol, 2-Hydroxy-4-methoxyacetophenone, 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one, Resacetophenone-4-methyl ether, Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-, Paeonal, Paeonolum, 4-O-Methylresacetophenone, UNII-3R834EPI82, 4-Methoxy-2-hydroxyacetophenone, 4'-Methoxy-2'-hydroxyacetophenone, Resacetophenone, 4-O-methyl ester, EINECS 209-012-2, NSC 401442, Acetophenone, 2'-hydroxy-4'-methoxy-, BRN 1282794, 1-(2-hydroxy-4-methoxy-phenyl)ethanone, AI3-10581, CHEMBL1079227, CHEBI:69581, UILPJVPSNHJFIK-UHFFFAOYSA-N, 3R834EPI82, 1-[2-hydroxy-4-(methyloxy)phenyl]ethanone, Acetophenone, 2'-hydroxy-4'-methoxy- (7CI,8CI), 1-acetyl-2-hydroxy-4-methoxybenzene, Paeonol (Peonol), PubChem3271, ACMC-209lls, AC1L1WLK, Spectrum2_001981, Spectrum3_001686, 2-acetyl-5-methoxyphenol, 2-Acetyl-5-methoxy-phenol, AC1Q48VN, AC1Q48VO, CBiol_000986, BSPBio_003212, 4-08-00-01793 (Beilstein Handbook Reference), KSC490C8B, MLS006011902, SPECTRUM1601021, SPBio_002161, SCHEMBL1449478, ZINC1906, DTXSID1022059, CTK3J0180, KBio3_002432, 4-methoxy 2-hydroxy acetophenone, MolPort-001-537-637, HMS3656E07, 2;-Hydroxy-4;-methoxyacetophenone, ACN-S003528, ACT07801, HY-N0159, KS-000004VU, ANW-32270, BBL012127, BDBM50310718, CCG-39471, CP0063, ICCB4_000282, MFCD00008730, NSC401442, s2339, SBB066134, STK078097, AKOS000119646, AC-7982, ACN-027221, AN-1408, AS05193, MCULE-2846207321, NSC-401442, RP02462, RTC-067540, SDCCGMLS-0066845.P001, TRA0005840, 1-(2-hydroxy-4-methoxyphenyl)-ethanone, NCGC00095977-01, NCGC00095977-02, NCGC00095977-03, 1-(2-hydroxy-4-methoxy-phenyl)-ethanone, 2'-Hydroxy-4'-methoxyacetophenone, 99%, 4CN-0677, AJ-08110, AS-15489, CJ-00070, P565, SC-05288, SMR000112386, SY013508, 1-(2-Hydroxy-4-methoxyphenyl)ethanone #, 1-(4-Methoxy-2-hydroxy-phenyl)-ethanone, AB0044007, KB-146762, LS-101156, TC-067540, 1-(2-hydroxy-4-methoxyphenyl)ethane-1-one, AM20040702, FT-0602529, FT-0618875, N1847, ST24021015, ST45027685, C10712, M-2917, 552H410, Ethanone, 1-(2-hydroxy-4-methoxyphenyl)- (9CI), SR-05000002397, I06-0541, Q-100626, SR-05000002397-1, 2-HYDROXY-4-METHOXYACETOPHENONE (4,4,4-D3), BRD-K94239562-001-02-2, BRD-K94239562-001-03-0, InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H


ID: 75

chemical graph of compound 75



InChIKey: VPJJUDAXEIWYQR-UHFFFAOYSA-N
SMILES: C1CCCC2SC(NC(=O)C3=CC=CC=C3Cl)=C(C(=O)N)C1=2

biological descriptors:

CFTR relevance: strong CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"K Du" "N Pedemonte" "A Taddei" "T Ma" "VS Gopinath" "RK Guy" "H Yang" "AS Verkman" "GL Lukacs" "C Folli" "LJ Galietta" "AA Shelat"


CID is 723141
synonyms found at PubChem are:
CHEMBL210832, 2-(2-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide, 298193-32-5, 2-[(2-chlorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, BAS 00568157, CBMicro_048310, dF508act-02, AC1LF54M, AC1Q4Z7D, Cambridge id 5367707, Oprea1_211305, Oprea1_265080, SCHEMBL3110880, MolPort-000-224-232, VPJJUDAXEIWYQR-UHFFFAOYSA-N, ZINC127920, BDBM50185114, STL282684, AKOS000291649, MCULE-3529042180, ACM298193325, KB-13984, BIM-0048269.P001, KB-113545, EU-0035371, ST50003514, SR-01000404669, SR-01000404669-1, F0016-0638, 2-(2-Chlorobenzoylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acidamide, 2-[(2-chlorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzo[b]thiophene-3-carboxamide, 2-[(2-chlorophenyl)carbonylamino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbox amide, 2-{[(2-chlorophenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, 2-C-(2-chlorobenzene)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-dicarboxamide


ID: 76

chemical graph of compound 76



InChIKey: VWENUKHWZBZSLW-UHFFFAOYSA-N
SMILES: CC1CC(CC(N1C)(C)C)OC(=O)C(C2=CC=CC=C2)O.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 102428
synonyms found at PubChem are:
Eucatropine hydrochloride, 536-93-6, EUCATROPINE HCl, 1,2,2,6-tetramethylpiperidin-4-yl 2-hydroxy-2-phenylacetate hydrochloride, UNII-560X8YZ82N, 1,2,2,6-Tetramethyl-4-piperidyl mandelate hydrochloride, MLS000863285, 560X8YZ82N, SMR000058649, DSSTox_CID_25828, DSSTox_RID_81157, DSSTox_GSID_45828, Eucatropine hydrochloride [USP], EINECS 208-653-5, Eucatropinhydrochlorid, Prestwick_1058, Opera_ID_782, AC1L2SRM, AC1Q3EAR, Euphthalmine hydrochloride, NCGC00016499-01, CAS-536-93-6, AC1Q39KC, MLS000069821, MLS002222297, SCHEMBL636552, CHEMBL1372791, DTXSID6045828, HMS1570O10, Tox21_111313, Tox21_113348, 6413AF, AKOS027420446, Tox21_113348_1, API0008558, CCG-220794, Eucatropine hydrochloride (USP XXXII), NCGC00179372-03, FT-0632333, D04116, C-50809, SR-01000759140, SR-01000759140-2, 4-Mandeloyloxy-1,2,2,6-tetramethylpiperidine hydrochloride, alpha-Hydroxybenzeneacetic acid 1,2,6-tetramethyl-4-piperidinyl ester, (1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate hydrochloride, Benzeneacetic acid, alpha-hydroxy-, 1,2,2,6-tetramethyl-4-piperidinyl ester hydrochloride


ID: 77

chemical graph of compound 77



InChIKey: WIIZWVCIJKGZOK-RKDXNWHRSA-N
SMILES: C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

biological descriptors:

CFTR relevance: strong CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"Y Luo" "DY Thomas" "GW Carlile" "R Robert" "KA Teske" "JW Hanrahan" "D Zhang"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5959
synonyms found at PubChem are:
chloramphenicol, Chloromycetin, 56-75-7, Chlornitromycin, Levomycetin, Chlorocid, Halomycetin, Levomicetina, Alficetyn, Fenicol, Globenicol, Chloroamphenicol, Aquamycetin, Chloramex, Chlorocol, Detreomycin, Oleomycetin, Chloramficin, Chloramfilin, Chloroptic, Cloramicol, D-Chloramphenicol, Embacetin, Enteromycetin, Juvamycetin, Leukomycin, Sificetina, Anacetin, Chlomin, Mychel, Chloramphenicolum, Chloronitrin, Ciplamycetin, Detreomycine, Dextromycetin, Intramycetin, Laevomycetinum, Levomitsetin, Mediamycetine, Micochlorine, Novophenicol, Stanomycetin, Amphenicol, Amphicol, Amseclor, Austracil, Austracol, Biocetin, Biophenicol, Chemicetin, Chemicetina, Chlomycol, Chloramsaar, Chlorasol, Chloricol, Chlorocaps, Chlorocide, Chlorovules, Cidocetine, Cloramficin, Cloramidina, Clorocyn, Cloromisan, Clorosintex, Comycetin, Cylphenicol, Doctamicina, Econochlor, Erbaplast, Farmicetina, Hortfenicol, Isicetin, Ismicetina, Isophenicol, Kemicetina, Kemicetine, Leukomyan, Loromisin, Mastiphen, Medichol, Micloretin, Micoclorina, Microcetina, Novomycetin, Ophthochlor, Pantovernil, Rivomycin, Ambofen, Catilan, Desphen, Emetren, Enicol, Ertilen, Glorous, Kamaver, Klorita, Paraxin, Isopto fenicol, Chlora-tabs, Chlorocidin C, Chloroject L, Normimycin V, Chlorocid S, Klorocid S, Mychel-Vet, Chloramfenikol, Cloramfenicol, Novochlorocap, Sintomicetina, Synthomycetin, Chloromax, Oftalent, Otachron, Pentamycetin, Quemicetina, Romphenil, Ronphenil, Septicol, Chloro-25 vetag, Mycinol, Opclor, Otophen, Sintomicetine R, Sno-Phenicol, Chlorocidin C tetran, Cloroamfenicolo, Veticol, D-(-)-Chloramphenicol, Chloromycetny, Cloramfenicolo, Synthomycetine, Treomicetina, Chlorofair, Optomycin, Syntomycin, Tevcocin, Tifomycine, Unimycetin, Viceton, Cloranfenicol, Kloramfenikol, Tiromycetin, Cloramfen, Leukamycin, Loromisan, Tifomycin, CAF (pharmaceutical), Ak-chlor, Chloramfenikol [Czech], Chloromycetny [Polish], D-(-)-threo-Chloramphenicol, Cloramfenicolo [DCIT], Tega-Cetin, Chlorbiotic (Veterinary), I 337A, Cloroamfenicolo [Italian], Chloramphenicol crystalline, Elase-Chloromycetin, Chloramphenicol, d-, U-6062, NCI-C55709, NSC 3069, Chloroptic S.O.P., Cloramfenicol [INN-Spanish], Chloramphenicolum [INN-Latin], Chemiceticol, Cloramical, Cloromissan, D-threo-Chloramphenicol, Duphenicol, Interomycetine, Intramyctin, Loromicetina, Ophtochlor, Synthomycine, Chlorsig, Ronfenil, Tevcosin, Myscel, Opelor, Chlormycetin R, F armicetina, Ch loramex, Sno Phenicol, Vice ton, Tea-Cetin, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide, D(-)-threo-Chloramphenicol, Econochlor (TN), CAF, Chloromyxin, Amphicol (TN), Chloromycetin (TN), C11H12Cl2N2O5, CCRIS 3922, UNII-66974FR9Q1, CHEBI:17698, Chloramphenicol [INN:BAN:JAN], D-(-)-threo-1-p-Nitrophenyl-2-dichloroacetylamino-1,3-propanediol, HSDB 3027, NSC3069, CHLOROPTIC S.O.P, EINECS 200-287-4, NSC 16331, D-(-)-threo-1-p-Nitrophenyl-2-dichloracetamido-1,3-propanediol, BRN 2225532, C.A.F, 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide, AI3-25003, D-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide, Chloramphenicol (Chloromycetin), D-(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol, WIIZWVCIJKGZOK-RKDXNWHRSA-N, D-(-)-threo-1-(4-Nitrophenyl)-2-dichloroacetamido-1,3-propanediol, D-threo-(1R,2R)-1-p-Nitrophenyl-2-dichloroacetamido-1,3-propanediol, 2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide, Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))-, Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-, 66974FR9Q1, NCGC00091011-05, D-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol, DSSTox_CID_265, D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-N-(1,1'-Dihydroxy-1-p-nitrophenylisopropyl)dichloroacetamide, 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide, DSSTox_RID_75473, DSSTox_GSID_20265, Mycochlorin, Ocuphenicol, Chlorocin, Levocin, Levoplast, Levosin, Levovetin, Myclocin, Soluthor, ACETAMIDE, 2,2-DICHLORO-N-[(1R,2R)-2-HYDROXY-1-(HYDROXYMETHYL)-2-(4-NITROPHENYL)ETHYL]-, CLM, Chloramphenicole, D(-)-threo-2-dichloroacetamido-1-p-nitrophenyl-propanediol, D(-)-threo-2-dichloroacetamido-1-p-nitrophen yl-propanediol, D(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol, (-)-chloramphenicol, Acetamide, 2,2-dichloro-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, D-threo-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide, D-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-4-nitrophenethyl]acetamide, N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-2,2-dichloroace tamide, Ophthocort (Salt/Mix), Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (theta-(theta,theta))-, Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-, D-(-)-threo-, D-(-)-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-beta-(4-nitrophenyl)ethyl]acetamide, SMR000471851, Chloromyxin (Salt/Mix), CHLORAMPHENICOL LEVO, SR-01000761450, Elase-Chloromycetin (Salt/Mix), chioramphenicol, chlorocidin, cloramphenicol, D-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol, CAS-56-75-7, Kemicetine (TN), Silmycetin (TN), Tifomycine (TN), Vernacetin (TN), Alficetyn (TN), Cedoctine (TN), Chloramex (TN), Nevimycin (TN), NCGC00094620-01, Biomicin (TN), Brochlor (TN), Chlorsig (TN), Phenicol (TN), Thiamphenicol,(S), D-(-)-threo-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl))-p-nitrophenethylacetamide, D-(-)-threo-2,2-Dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)]-p-nitrophenethylacetamide, Laevomycetin (TN), Synthomycine (TN), Fenicol (TN), Medicom (TN), Renicol (TN), Veticol (TN), Golden Eye (TN), Orchadexoline (TN), Chloramphenicol [USP:INN:BAN:JAN], Chloramphenicol,(S), Isoptophenicol (TN), Oftan Chlora (TN), Chlornitromycin (TN), Chloromycetin&#174, Dispersadron C (TN), PubChem20321, CHLOROMYCETIN(R), Prestwick3_000031, CHEMBL130, D0X6IU, Epitope ID:114066, AC1L1LI3, Optrex Infected Eyes (TN), SCHEMBL16111, BSPBio_000121, WLN: WNR DYQY1QMVYGG, 4-13-00-02742 (Beilstein Handbook Reference), Chloramphenicol & VRC3375, D-2-DICHLOROACETAMIDO-1-p-NITRO-PHENYL-1,3-PROPANEDIOL, MLS001055372, MLS001066397, MLS001332385, MLS001332386, MLS002222155, ARONIS23913, BIDD:GT0145, DivK1c_000544, BPBio1_000135, D-(-)-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol, D-(-)-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol, DTXSID7020265, BDBM23447, Chloramphenicol, gamma-irradiated, CTK4B4374, HMS501L06, KBio1_000544, KS-00000XTX, BBC/192, BIC0113, MolPort-001-794-646, NINDS_000544, ZX-AFC000642, Chloramphenicol (JP15/USP/INN), Chloramphenicol (JP17/USP/INN), HMS2090M15, HMS2095G03, HMS2269N06, HMS3712G03, ZINC113382, Chloramphenicol, >=98% (HPLC), 2787-09-9, Acetamide, 2,2-dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl)-, D-(-)-threo-, Acetamide, 2,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-, BCP12150, D-(-)-threo-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenyl-ethyl)acetamide, HY-B0239, NSC-3069, RKL10087, Tox21_111306, Tox21_400061, LS-225, MFCD00078159, s1677, SBB057728, AKOS005111001, AB02994, CCG-220031, CS-2207, DB00446, MCULE-7778960570, IDI1_000544, KS-000048O2, SMP1_000065, NCGC00091011-01, NCGC00091011-02, NCGC00091011-03, NCGC00091011-04, NCGC00091011-06, NCGC00091011-08, NCGC00091011-09, 85666-84-8, AK174225, AN-23562, AS-14683, CC-25647, CPD000471851, M163, NCI60_002620, SAM002589931, SC-18476, ST024743, AB0015087, AB1009524, Chloramphenicol, puriss., 98.0-102.0%, AB00374860, Chloramphenicol 10 microg/mL in Acetonitrile, Chloramphenicol, tested according to Ph.Eur., FT-0602995, Chloramphenicol 100 microg/mL in Ethylacetate, C-3307, C00918, D00104, W-2830, AB00374860-13, AB00374860-14, AB00374860_15, Chloramphenicol, meets USP testing specifications, C-19742, Chloramphenicol, VETRANAL(TM), analytical standard, SR-01000761450-2, SR-01000761450-3, SR-01000761450-5, BRD-K08111712-001-02-7, BRD-K08111712-001-16-7, Chloramphenicol, Antibiotic for Culture Media Use Only, Alficetyn, Chlornitromycin, Chloromycetin, Chloramphenicol, Chloramphenicol, BioReagent, suitable for plant cell culture, Chloramphenicol, certified reference material, TraceCERT(R), Chloramphenicol, British Pharmacopoeia (BP) Reference Standard, Chloramphenicol, European Pharmacopoeia (EP) Reference Standard, Chloramphenicol, United States Pharmacopeia (USP) Reference Standard, D-(-)-threo-1-(p-nitrophenyl)-2-dichloroacetamido-1,3-propanediol, D-threo-N-dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propane-diol, CHLORAMPHENICOL (SEE ALSO CHLORAMPHENICOL NA SUCCINATE 982-57-0), D-( -)-threo-1-(p-nitrophenyl)-2-dichloroacetamido-1,3-propanediol, D-THREO-2-DICHLOROACETAMIDO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL, 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide, Acetamide,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl], Chloramphenicol, Biotechnology Performance Certified, suitable for plant cell culture, D-(-)-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenyl-ethyl)acetamide, D-(-)-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide, 137731-90-9, 15313-32-3, 2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-(hydroxy(oxido)amino)phenyl)ethyl)acetamide, (1R, 2R)-, 55172-72-0, 59112-59-3, Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R*,R*)-(+-)-, Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-,D-(-)-threo-, Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4- nitrophenyl)ethyl]-, [R-(R*,R*)]-, Acetamide,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-, Acetamide,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-,D-(-)-threo-, Acetamide,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-, D-(-)-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXY-METHYL)-P-NITROPHENYLETHYL]ACETAMIDE, D-(-)-threo-alpha, alpha-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide, D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA(HYDROXYMETHYL)-BETA-(4-NITROPHENYL)ETHYL]ACETAMIDE


ID: 78

chemical graph of compound 78



InChIKey: WUADCCWRTIWANL-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O

biological descriptors:

CFTR relevance: ΔF508 CFTR activation

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5280373
synonyms found at PubChem are:
biochanin A, 491-80-5, Biochanin, 4'-Methylgenistein, 5,7-Dihydroxy-4'-methoxyisoflavone, 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one, Genistein 4-methyl ether, Pratensol, Biochanine A, 5,7-Dihydrox -4'-methoxyisoflavone, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-, olmelin, Biochanin-A, 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one, 4-Methylgenistein, C16H12O5, NSC 123538, UNII-U13J6U390T, CCRIS 5449, 5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one, EINECS 207-744-7, NSC123538, Genistein 4'-methyl ether, Isoflavone, 5,7-dihydroxy-4'-methoxy-, MLS000069443, CHEMBL131921, CHEBI:17574, WUADCCWRTIWANL-UHFFFAOYSA-N, U13J6U390T, 4'-Methoxy-5,7-dihydroxy isoflavone, NSC-123538, SMR000059116, Apigenin 4-Methyl Ether, DSSTox_CID_2394, DSSTox_RID_76570, DSSTox_GSID_22394, Q-100552, CAS-491-80-5, SR-01000003021, QSO, Biochanin A, 9, Biochanin A (BCA), AC1NQWYN, Spectrum_000195, Opera_ID_621, Spectrum2_000047, Spectrum3_001098, Spectrum4_001927, Spectrum5_001624, D02UQX, D0S9YX, Oprea1_038096, SCHEMBL61258, BSPBio_002776, KBioGR_002274, KBioSS_000675, MLS001148446, MLS006011785, BIDD:ER0123, DivK1c_001027, SPBio_000173, BDBM9461, GTPL2829, DTXSID1022394, SPECTRUM10100003, Biochanin A (4-Methylgenistein), Biochanin A - 4-Methylgenistein, cid_5280373, HMS503M15, KBio1_001027, KBio2_000675, KBio2_003243, KBio2_005811, KBio3_001996, 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one, MolPort-000-424-557, NINDS_001027, HMS2232N19, HMS3369A02, HMS3656A13, TNP00319, Isoflavone,7-dihydroxy-4'-methoxy-, Tox21_202097, Tox21_302901, 5,7-Dihydrox-4''-methoxyisoflavone, BBL010523, CCG-38351, LMPK12050229, MFCD00006839, s2377, STK888295, ZINC18847037, 5,7-dihydroxy-4'-methoxy-Isoflavone, 5,7-Dihydroxy-4/'-methoxyisoflavone, AKOS002163860, API0001717, CS-3082, MCULE-6764919720, IDI1_001027, KS-00000I00, SMP1_000045, NCGC00017369-01, NCGC00017369-02, NCGC00017369-03, NCGC00017369-04, NCGC00017369-05, NCGC00017369-06, NCGC00017369-07, NCGC00017369-08, NCGC00017369-09, NCGC00017369-10, NCGC00022428-03, NCGC00022428-04, NCGC00022428-05, NCGC00178478-01, NCGC00256458-01, NCGC00259646-01, AC-22309, AJ-70675, AK155884, AN-45276, AS-17474, HY-14595, KB-79569, LS-39601, NCI60_000558, ST057580, Biochanin A, analytical reference material, AB1004489, AX8016263, B4098, FT-0663120, N1308, V0303, 5,7-dihydroxy-4'-methoxy-Isoflavone (8CI), C00814, X-2593, Isoflavone, 5,7-dihydroxy-4'-methoxy- (8CI), 491B805, 5,7-Dihydroxy-4'-methoxyisoflavone, 98% 250mg, SR-01000003021-4, SR-01000003021-5, BRD-K73303757-001-02-6, BRD-K73303757-001-12-5, I14-13389, 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one #, F1190-0491, 4H-1-Benzopyran-4-one,7-dihydroxy-3-(4-methoxyphenyl)-, 2AA2D226-B323-4AE2-B576-2D47D15F9845, Biochanin A, United States Pharmacopeia (USP) Reference Standard, 5,7-Dihydroxy-4 inverted exclamation marka-methoxyisoflavone; Genistein 4 inverted exclamation marka-methyl ether


ID: 79

chemical graph of compound 79



InChIKey: WXNXCEHXYPACJF-ZETCQYMHSA-N
SMILES: CC(C)C[C@@H](C(=O)O)NC(=O)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 70912
synonyms found at PubChem are:
N-Acetyl-L-leucine, 1188-21-2, acetyl-L-leucine, Ac-Leu-OH, N-Acetylleucine, (S)-2-Acetamido-4-methylpentanoic acid, (2S)-2-acetamido-4-methylpentanoic acid, N-acetyl-leucine, N-acetyl-Leu, Leucine, N-acetyl-, L-, n-acetyl-L-leucin, UNII-E915HL7K2O, Leucine, N-acetyl-, NSC 206316, acetyl leucine, (S)-2-Acetylamino-4-methyl-pentanoic acid, E915HL7K2O, (2S)-2-(acetylamino)-4-methylpentanoic acid, CHEBI:17786, WXNXCEHXYPACJF-ZETCQYMHSA-N, CAS-1188-21-2, DSSTox_CID_25870, DSSTox_RID_81188, DSSTox_GSID_45870, L-Acetylleucine, acetyl-leucine, NCGC00094935-01, EINECS 214-706-3, N-acetyl-(L)-leucine, PubChem10962, Spectrum_001313, AC1Q1OAJ, Maybridge1_002565, Prestwick0_000896, Prestwick1_000896, Prestwick2_000896, Prestwick3_000896, Spectrum2_000475, Spectrum3_001480, Spectrum4_000036, Spectrum5_001242, AC1Q5JR5, BSPBio_000712, BSPBio_003039, KBioGR_000471, KBioSS_001793, KSC174M9H, CHEMBL56021, DivK1c_000622, DivK1c_001317, SCHEMBL282372, SPECTRUM1502001, SPBio_000610, SPBio_002921, AC1L2F51, BPBio1_000784, DTXSID6045870, CTK0H4693, HMS501P04, HMS548M13, KBio1_000622, KBio2_001793, KBio2_004361, KBio2_006929, KBio3_002539, MolPort-001-792-394, NINDS_000622, HMS1570D14, HMS1921B16, HMS2097D14, HMS3714D14, Pharmakon1600-01502001, ZINC135384, ACT06842, Tox21_111362, ANW-17243, CCG-40254, MFCD00065131, NSC758152, SBB017526, AKOS000302149, AKOS010400978, Tox21_111362_1, MCULE-9082534218, NSC-758152, RL06123, RP23556, RTC-066514, RTC-066612, CDS1_000277, IDI1_000622, KS-0000011X, NCGC00016567-01, NCGC00016567-02, NCGC00016567-03, NCGC00016567-05, AC-22375, AJ-12258, AN-48789, BAS 16579175, BR-47478, KB-47114, SC-09640, SY013106, (2S)-2-acetamido-4-methyl-pentanoic acid, SBI-0051693.P002, AB1006929, N-Acetyl-L-leucine, ReagentPlus(R), 99%, TC-066514, TL8007017, (S)-2-Acetylamino-4-methyl-pentanoi c acid, A0098, AB00513952, AM20080126, BB 0256992, CS-0007651, FT-0629837, ST24032095, A-1460, C02710, M-6265, 33786-EP2295055A2, 33786-EP2311453A1, 33789-EP2295055A2, 33789-EP2311453A1, 34104-EP2295055A2, 34104-EP2311453A1, 74039-EP2305641A1, 74039-EP2308869A1, AB00052251_03, 118717-EP2277858A1, 118717-EP2298747A1, 188A212, N-Acetyl-L-leucine, Vetec(TM) reagent grade, 98%, BRD-K27406233-001-05-1, UNII-K76S41V71X component WXNXCEHXYPACJF-ZETCQYMHSA-N, 24160-46-1, 90243-88-2


ID: 80

chemical graph of compound 80



InChIKey: XJGFWWJLMVZSIG-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N

biological descriptors:

CFTR relevance: CFTR proteostasis regulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

reference list:

"E Caci" "U Pfeffer" "V Tomati" "N Pedemonte" "AI Esposito" "LJ Galietta" "E Sondo"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 7019
synonyms found at PubChem are:
9-AMINOACRIDINE, Acridin-9-amine, Aminacrine, 90-45-9, 9-Acridinamine, Aminoacridine, Aminacrin, Izoacridina, Monacrin, Aminoacridina, Aminoacridinum, 10-Amino-5-azaanthracene, 9-Acridinylamine, 9-Aminoakridin, Acridine, 9-amino-, 9-Aminoacridin, 9(10H)-Acridinimine, 9-Aminoakridin [Czech], Aminoacridine [INN:BAN], 9AA, UNII-78OY3Z0P7Z, NSC 13000, CCRIS 748, Acridin-9-ylamine, NSC 7571, EINECS 201-995-6, BRN 0141171, AI3-51012, 78OY3Z0P7Z, 9-AA, CHEBI:74789, XJGFWWJLMVZSIG-UHFFFAOYSA-N, acridine-9-ylamine, Aminopt, Mykocert, 110166-26-2, CS-003/03975023, WLN: T C666 BNJ IZ, MLS000780068, NSC7571, 7AD, 8AD, 9-Aminoacridine hydrochloride hydrate, acridin-9-amine;hydrate;hydrochloride, SMR000420251, iminoacridan, 5-Aminoacridin, 9-amino acridine, 4bds, 9-Amino-acridine, F2179-0009, acridin-9-yl-amine, Quench (Salt/Mix), ACMC-20mczt, Mycosert (Salt/Mix), Spectrum_001108, SpecPlus_000861, 9-Acridinamine (9CI), AC1L1NTJ, Spectrum2_001112, Spectrum3_000617, Spectrum4_000580, Spectrum5_001498, AC1Q4W9J, AC1Q51BO, Acramine Yellow (Salt/Mix), SCHEMBL14999, BSPBio_002154, KBioGR_001020, KBioSS_001588, BIDD:GT0816, CHEMBL43184, DivK1c_006957, SPECTRUM1500810, SPBio_001244, DTXSID2024456, BDBM72700, cid_2723598, CTK0G2217, KBio1_001901, KBio2_001588, KBio2_004156, KBio2_006724, KBio3_001654, KS-00000GTZ, XJGFWWJLMVZSIG-UHFFFAOYSA-, MolPort-001-738-830, HMS1921I16, HMS2092K22, HMS3715H04, Pharmakon1600-01500810, 9-acridinamine;hydrate;hydrochloride, ALBB-020726, BCP25849, HY-B1422, NSC13000, NSC28747, ZX-AN019316, ANW-75188, BBL011755, CCG-39037, NSC-13000, NSC-28747, NSC757794, SBB003606, STK387428, ZINC19014768, AKOS000120447, acridin-9-ylamine;hydrate;hydrochloride, CS-4915, DB11561, LS-1913, MCULE-4734217474, NSC-757794, NCGC00094857-01, NCGC00094857-02, NCGC00094857-03, AJ-45955, AK109135, AS-17405, CC-23490, ST093685, U978, 9-AMINOACRIDINE (5-AMINOACRIDINE), SBI-0051612.P002, AX8014518, DB-026983, KB-250613, TC-163933, A2905, FT-0621612, ST24045903, EN300-17076, M-2337, AB00052180_09, AB00052180_10, C-08694, SR-01000760844, CU-01000012501-2, SR-01000760844-2, BRD-K00535541-001-02-2, BRD-K00535541-311-04-1, 9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE, 9-Aminoacridine, matrix substance for MALDI-MS, >=99.5% (HPLC), 9-AMINOACRIDINE (SEE ALSO 9-AMINOACRIDINE HCL AND 9-AMINOACRIDINE HCL-H2O), 148651-03-0, InChI=1/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)


ID: 81

chemical graph of compound 81



InChIKey: XSDQTOBWRPYKKA-UHFFFAOYSA-N
SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N

biological descriptors:

CFTR relevance: induces depolarization

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

reference list:

"D Salinas" "N Pedemonte" "L Qian" "Y Song" "AS Verkman" "ND Sonawane" "LJ Galietta"
"SH Randell" "MR Knowles" "BR Grubb" "SE Gabriel" "RC Boucher" "ML Drumm" "M Gentzsch" "A Mengos" "JR Riordan" "AM Van Heeckeren"


CID is 16231
synonyms found at PubChem are:
AMILORIDE, Amipramidin, Midamor, 2609-46-3, Guanamprazine, Amilorida, Amipramizid, Amipramizide, Guanamprazin, Amiloridum, Amyloride, Amiloridum [INN-Latin], Amilorida [INN-Spanish], Amiloride HCL, Amiloride [INN:BAN], N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide, 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Amiprazidine, C6H8ClN7O, UNII-7DZO8EB0Z3, Amiclaran (TN), Amiloride (INN), CCRIS 6545, EINECS 220-024-7, N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid, Amiloride hydrochloride hydrate, CHEMBL945, Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, 7DZO8EB0Z3, CHEBI:2639, 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide, Amikal (Hydrochloride dihydrate), Midamor (Hydrochloride dihydrate), XSDQTOBWRPYKKA-UHFFFAOYSA-N, 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide, MK-870 (Hydrochloride dihydrate), N-amidino-3,5-diamino-6-chloro-2-pyrazinecarboxamide, NCGC00015089-08, AMIPRAMIDINE, DSSTox_CID_23853, DSSTox_RID_80077, Amiloride Hydrocholride, DSSTox_GSID_43853, AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)), 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide, Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride, 137053-86-2, CAS-2609-46-3, Amiclaran, Amilorid, (3,5-diamino-6-chloropyrazin-2-yl)-N-(???methyl)carboxamide, Biduret (TN), Spectrum_000034, Tocris-0890, 1f5l, AC1Q3POC, Prestwick0_000007, Prestwick1_000007, Prestwick2_000007, Prestwick3_000007, Spectrum2_000118, Spectrum3_000293, Spectrum4_000132, Spectrum5_000776, Lopac-A-7410, D0I0RJ, AC1L27IZ, Lopac0_000111, SCHEMBL27562, BSPBio_000013, BSPBio_001572, BSPBio_001826, KBioGR_000292, KBioGR_000544, KBioSS_000292, KBioSS_000394, MLS001060798, BIDD:GT0466, DivK1c_000182, SPBio_000136, SPBio_001934, BPBio1_000015, GTPL2421, DTXSID9043853, BCBcMAP01_000101, BDBM16173, KBio1_000182, KBio2_000292, KBio2_000394, KBio2_002860, KBio2_002962, KBio2_005428, KBio2_005530, KBio3_000583, KBio3_000584, KBio3_001326, Amiloride (Na-Ca chanel blocker), MolPort-005-934-472, NINDS_000182, 17440-83-4 (hydrochloride), Bio1_000359, Bio1_000848, Bio1_001337, Bio2_000292, Bio2_000772, HMS1791O14, HMS1989O14, HMS2089H05, HMS2213E05, HMS3355K04, ACT05635, ACT05652, BCP16815, HY-B0285, ZINC4340269, Tox21_110080, BBL028157, SBB037856, STL373007, AKOS015961348, Tox21_110080_1, API0000380, CCG-204206, CS-2297, DB00594, LS-1094, MCULE-5948863568, 2016-88-8 (anhydrous hydrochloride), IDI1_000182, IDI1_034042, NCGC00015089-01, NCGC00015089-02, NCGC00015089-03, NCGC00015089-04, NCGC00015089-05, NCGC00015089-06, NCGC00015089-07, NCGC00015089-09, NCGC00015089-11, NCGC00015089-12, NCGC00015089-13, NCGC00015089-14, NCGC00015089-15, NCGC00015089-16, NCGC00015089-17, NCGC00024443-02, NCGC00024443-05, NCGC00024443-06, NCGC00024443-07, NCGC00024443-09, AC-13631, SMR000486264, ST079279, U460, (3,5-Diamino-6-chloropyrazinoyl)guanidine, SBI-0050099.P004, N-amidino-3,5-diamino-6-chloropyrazinamide, AB00053415, FT-0703177, C06821, D07447, EN300-149459, AB00053415-24, AB00053415-25, AB00053415_26, AB00053415_27, AB00053415_28, 117188-EP2277879A1, 117188-EP2298776A1, 609A463, J-016249, BRD-K97181089-003-02-3, BRD-K97181089-310-03-0, N-amidino 3,5-diamino-6-chloro-2-pyrazinecarboxamide, F2173-0531, 3,5-diamino-N-carbamimidoyl-6-chloro-pyrazine-2-carboxamide, 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride


ID: 82

chemical graph of compound 82



InChIKey: XUIIKFGFIJCVMT-LBPRGKRZSA-N
SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5819
synonyms found at PubChem are:
L-thyroxine, levothyroxine, 51-48-9, thyroxine, thyroxin, synthroid, Tetraiodothyronine, Thyrax, 3,3',5,5'-Tetraiodo-L-thyronine, Thyratabs, Thyreoideum, Thyroxinal, Thyroxine iodine, Levothyroxin, (-)-Thyroxine, L-Thyroxin, L-T4, Thyroxine (l), Levothyroxine sodium, 3,5,3',5'-Tetraiodo-L-thyronine, levothroid, Levoxyl, DL-Thyroxin, Thyroxine (VAN), eltroxin, 3,5,3',5'-Tetraiodothyronine, Laevothyroxinum, Tetramet, T4 (Hormone), Thyroxine I 125, L-3,5,3',5'-Tetraiodothyronine, Levothyroxinum (acid), t4, Laevothyroxinum (acid), Thryroxine, l-, Oroxine, Levo-T, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine, Forthyron (TN), Thyroxine [BAN], Laevoxin, Levolet, Levothyrox, Thyroxevan, Synthroid sodium, Levothyroxinum, O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine, 3,3',5,5''-Tetraiodo-L-thyronine, CCRIS 6739, Henning, HSDB 3108, L-Thryoxin, T4 levothyroxine, 3,5,3'5'-Tetraiodo-L-thyronine, THX, UNII-Q51BO43MG4, NSC 36397, Prestwick_548, 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine, Levothyroxine (BAN), Thyroxine sodium, CHEBI:18332, O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine, L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, EINECS 200-101-1, 3-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine, beta-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, Synthroid (*Sodium salt*), BRN 2228515, CHEMBL1624, (125I)T4, (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid, Q51BO43MG4, UNII-7U4LEE5872, XUIIKFGFIJCVMT-LBPRGKRZSA-N, Levothyroxine Sodium (L-thyroxine), C15H11I4NO4, NCGC00164336-01, CPD000059176, Synthroid (TN), Levoxyl (TN), DSSTox_CID_3214, T-3850, (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid, DSSTox_RID_76927, DSSTox_GSID_23214, Eutirox, Thyroxine, L-, 7U4LEE5872, levothyroxine sodium pentahydrate, (S)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid, 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid, LT4, SMR000059176, T44, 24486-40-6, 7488-70-2, Levothyroxine [INN:BAN], Forthyron, SR-01000759430, 2ceo, CAS-51-48-9, Eltroxin (TN), Euthyrox (TN), levothyroxin natrium, Eutirox (TN), Levaxin (TN), Thyroxine, labeled with iodine-125, L-thyroxine (TN), Thyrax (TN), Thyrox (TN), Spectrum_001076, 1hk1, 1hk2, 1hk3, 1hk4, 1hk5, 1y0x, L-Thyroxine, free acid, SpecPlus_000871, Thyroxine, L-(8CI), Prestwick0_000403, Prestwick1_000403, Prestwick2_000403, Prestwick3_000403, Spectrum2_000573, Spectrum3_000611, Spectrum4_000128, Spectrum5_001500, Thyroxine, L- (8CI), bmse000923, D06RGG, Epitope ID:123889, Levothroid (*Sodiumsalt*), AC1L1L7K, BIDD:PXR0161, Levothroid (*Sodium salt*), SCHEMBL23098, BSPBio_000326, BSPBio_002142, KBioGR_000516, KBioSS_001556, MLS000028647, MLS002548901, DivK1c_006967, SPECTRUM1500774, SPBio_000386, SPBio_002265, BPBio1_000360, GTPL2635, DTXSID8023214, CTK2H7538, KBio1_001911, KBio2_001556, KBio2_004124, KBio2_006692, KBio3_001642, KS-00000HDI, MolPort-003-666-820, HMS1569A08, HMS1921I06, HMS2090P18, HMS2092K12, HMS2096A08, HMS2233J18, HMS3259M11, HMS3713A08, L-Thyroxine, >=98% (HPLC), Pharmakon1600-01500774, ZINC3830993, Tox21_112101, Tox21_302156, 3,3',5,5"-Tetraiodo-L-thyronine, BDBM50301375, CCG-38738, CT-230, GP9966, MFCD00002595, NSC757434, s2599, AKOS015905129, Tox21_112101_1, AC-7504, AM83594, AN-8921, CHM0030272, CS-1819, DB00451, NC00485, NSC-757434, SDCCGMLS-0066571.P001, 3,3'',5,5''-tetraiodo-L-thyronine, 3,5,3'',5''-tetraiodo-L-thyronine, NCGC00094852-03, NCGC00164336-02, NCGC00164336-03, NCGC00164336-05, NCGC00164336-06, NCGC00255368-01, AC-10465, AK-40208, AN-15421, BC630681, HY-18341, KB-53412, SAM002264651, SBI-0051608.P002, AB0010528, AB2000689, AX8015809, DB-006261, LS-158291, TR-031344, FT-0600821, LT00440967, ST24047479, C01829, D08125, J10324, AB00052176-08, AB00052176_09, AB00052176_10, 002T595, SR-05000001567, SR-01000759430-2, SR-05000001567-1, BRD-K30685142-001-05-5, BRD-K30685142-001-08-9, Thyroxine (T4), IRMM(R) certified Reference Material, L-Thyroxine, powder, BioReagent, suitable for cell culture, UNII-QR0BV3BRIA component XUIIKFGFIJCVMT-LBPRGKRZSA-N, Levothyroxine, United States Pharmacopeia (USP) Reference Standard, Levothyroxine, Pharmaceutical Secondary Standard; Certified Reference Material, Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, labeled with iodine-125, 1373931-44-2, 587-29-1, 587-30-4, 60833-83-2, 7200-84-2, 74-16-8, L-Thyroxine (T4) solution, 100 mug/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, L-thyroxine zwitterion, CHEBI:58448, (2S)-2-ammonio-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate


ID: 83

chemical graph of compound 83



InChIKey: YGULWPYYGQCFMP-UHFFFAOYSA-N
SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(C(C(=O)O)O)(C(=O)O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6420057
synonyms found at PubChem are:
56392-17-7, 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol 2,3-dihydroxysuccinate (2:1), Metoprolol-(+,-) (+)-tartrate salt, Prestwick_1009, AC1O4WIQ, SCHEMBL2051655, CHEMBL2062335, CTK8B7746, KS-00000XQB, MolPort-003-983-883, HMS1570C08, HMS3651I21, (A+/-)-Metoprolol (+)-tartrate, ANW-58344, AKOS016002993, RTR-019802, (.+-.)-tartaric acid; bis(metoprolol), KB-215768, 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)-propan-2-ol 2,3-dihydroxysuccinate (2:1), 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol 2,3-dihydroxysuccinate, 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemitartrate, Metoprolol tartrate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material


ID: 84

chemical graph of compound 84



InChIKey: YKPUWZUDDOIDPM-SOFGYWHQSA-N
SMILES: CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC

biological descriptors:

CFTR relevance: CFTR potentiator, increase in opening rate, decrease in closing rate

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"X Wang" "T Ai" "TC Hwang" "S Hu" "SG Bompadre" "M Li"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 1548943
synonyms found at PubChem are:
Capsaicin, 404-86-4, Zostrix, CAPSAICINE, (E)-Capsaicin, Qutenza, Styptysat, Axsain, Isodecenoic acid vanillylamide, E-CAPSAICIN, trans-8-Methyl-N-vanillyl-6-nonenamide, NGX-4010, Capsaicin [USAN], Caswell No. 158, Transacin, (E)-8-Methyl-N-vanillyl-6-nonenamide, trans-Capsaicin, NCI-C56564, NGX 4010, UNII-S07O44R1ZM, FEMA No. 3404, CCRIS 1588, CHEBI:3374, HSDB 954, C18H27NO3, Capsaicin (JAN/USP), 8-Methyl-N-Vanillyl-6-Nonenamide, 6-Nonenamide, 8-methyl-N-vanillyl-, (E)-, ZOSTRIX (TN), N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-trans-6-enamide, EINECS 206-969-8, NSC 56353, EPA Pesticide Chemical Code 070701, BRN 2816484, 8-Methyl-N-vanillyl-6-nonenamide, (E)-, (e)-n-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, CHEMBL294199, S07O44R1ZM, YKPUWZUDDOIDPM-SOFGYWHQSA-N, (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide, 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-, 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6E)-, NSC56353, Capsaicin [in oleoresin of capsicum], trans-Capsaicin-d3, NCGC00017337-02, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide, (E)-N-((4-Hydroxy-3-methoxyphenyl)-methyl)-8-methyl-6-nonenamide, (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide, DSSTox_CID_241, 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (E)-, N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide, (E)-, DSSTox_RID_75455, DSSTox_GSID_20241, Ausanil, (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide, [(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide, 6-Nonenamide, (E)-N-((4-hydroxy-3-methoxy-phenyl)methyl)-8-methyl, Capsaicin (in oleoresin of capsicum), (6E)-N-{[4-hydroxy-3-(methyloxy)phenyl]methyl}-8-methylnon-6-enamide, 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (6E)-, 8-Methyl-N-vanillyl-trans-6-nonenamide, CAPSAICIN, NATURAL, SR-05000001861, neurotoxic, Isodecenoate, Capsicin, Capsicine, Vanilloid, Mioton, N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide, N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide, Adlea, TNP00277, Capsaicin Patch, (E)-N-[(4-Hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide, ALGRX 4975, epsilon-capsaicin, Zostrix HP, Capsaicin,(S), Capsaicin(Qutenza), CAS-404-86-4, Prestwick_204, Capsaicin (Natural), depletes Substance P, 1217899-52-9, Citrus Aurantium 30%, Capsaicin [USP:INN], Citrus Aurantium Extract, 6-Nonenamide, (E)-, Prestwick2_000879, Prestwick3_000879, Spectrum5_000538, CITRUS AURANTIUM PE, D0U5CE, UPCMLD-DP092, AC1LU7K3, Bitter orange extract 30%, SCHEMBL8085, SCHEMBL8086, MR3H3, BSPBio_000957, BSPBio_001548, BSPBio_002917, MLS002154049, trans-8-Methyl-N-vanillylnon, Capsaicin, analytical standard, SPECTRUM1501128, Capsaicin, from natural source, AC1Q46B3, BPBio1_001053, GTPL2486, MEGxp0_001448, n-(4-hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, (E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE, DTXSID9020241, UPCMLD-DP092:001, UPCMLD-DP092:002, BDBM20461, BDBM86537, CHEBI:94524, HMS501B16, MolPort-001-742-263, HMS1361N10, HMS1570P19, HMS1791N10, HMS1921H11, HMS1989N10, HMS2089N11, HMS2092D21, HMS2097P19, HMS2230O23, HMS3402N10, HMS3649N15, Pharmakon1600-01501128, 8-Methyl-N-vanillyl-6E-nonenamide, NGX-1998, NGX-3781, NGX-7325, NSC_2548, ZINC1530575, Tox21_110817, Tox21_200315, BBL027836, CC0144, CCG-39908, EI-125, LMFA08020085, MFCD00017259, N0C781, NSC-56353, NSC757844, STL372889, (E)-N-(4-Hydroxy-3-methoxybenzyl), (E)8-methyl-N-vanillyl-6-Nonenamide, AKOS007930159, CS-1518, DB06774, KS-5181, LS-2138, MCULE-8056866140, NSC-757844, RTC-030399, SDCCGMLS-0066678.P001, TQ-1018, Capsaicin, >=95%, from Capsicum sp., IDI1_000354, IDI1_034018, SMP2_000337, NCGC00017337-03, NCGC00017337-04, NCGC00017337-05, NCGC00017337-06, NCGC00017337-07, NCGC00017337-08, NCGC00017337-09, NCGC00017337-10, NCGC00017337-11, NCGC00017337-12, NCGC00017337-13, NCGC00017337-18, NCGC00090853-01, NCGC00090853-02, NCGC00090853-03, NCGC00090853-04, NCGC00090853-06, NCGC00090853-07, NCGC00090853-08, NCGC00090853-09, NCGC00090853-10, NCGC00090853-11, NCGC00090853-12, NCGC00257869-01, AC-10114, AJ-26667, AN-23437, CAS_404-86-4, CJ-23980, HY-10448, N735, SC-19636, SMR000718774, ST057183, Nonenamide, 8-methyl-N-vanillyl-, (E)-, SBI-0052593.P002, TC-030399, TL8002946, 4CH-016296, FT-0082538, M1149, N1667, (E)-8-Methyl-N-vanillyl-6-nonenamide(8cl), C06866, D00250, W-5044, AB00053098-11, AB00053098_12, Capsaicin, from Capsicum sp., >=50% (HPLC), 6-Nonenamide, 8-methyl-N-vanillyl-, (E)- (8CI), I01-2469, SR-05000001861-1, SR-05000001861-4, SR-05000001861-5, SR-05000001861-6, SR-05000001861-9, BRD-K37056290-001-01-1, BRD-K50590187-001-06-6, Capsaicin, certified reference material, TraceCERT(R), N-(3-Methoxy-4-hydroxybenzyl)-8-methyl-6-nonenamide, N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Capsaicin (transdermal patch formulation, neuropathic pain), Capsaicin, European Pharmacopoeia (EP) Reference Standard, UNII-UW86K581WY component YKPUWZUDDOIDPM-SOFGYWHQSA-N, (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide #, Capsaicin, United States Pharmacopeia (USP) Reference Standard, CAPSAICIN (2444-46-4 NONIVAMIDE (SYNTHETIC CAPSAICIN)), trans-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide, Capsaicin, Pharmaceutical Secondary Standard; Certified Reference Material, Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8 -methyl-, (E)-, 912457-62-6


ID: 85

chemical graph of compound 85



InChIKey: ZZIALNLLNHEQPJ-UHFFFAOYSA-N
SMILES: C1=CC2=C(C=C1O)OC3=C2C(=O)OC4=C3C=CC(=C4)O

biological descriptors:

CFTR relevance: ΔF508 CFTR activation

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

"JP Clancy" "S Barnes" "JC Fulton" "K Backer" "M Mazur" "SM Rowe" "PA Sloane" "LC Pyle" "J Prasain"
"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5281707
synonyms found at PubChem are:
COUMESTROL, 479-13-0, Cumoestrol, Cumoesterol, Cumostrol, Coumesterol, 3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one, 7,12-Dihydroxycoumestan, Cumestrol, 3,9-Dihydroxycoumestan, UNII-V7NW98OB34, NSC 22842, CCRIS 7311, NSC22842, 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 3,9-dihydroxy-, EINECS 207-525-6, BRN 0266702, CHEMBL30707, MLS000738006, CHEBI:3908, V7NW98OB34, ZZIALNLLNHEQPJ-UHFFFAOYSA-N, 3,9-Dihydroxy-6H-benzofuro(3,2-c)(1)benzopyran-6-one, 6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-, 3,9-dihydroxybenzofuro[3,2-c]chromen-6-one, A1-00298, SMR000059001, AC1NQYXV, DSSTox_CID_2399, D02DML, NCIMech_000078, DSSTox_RID_76572, DSSTox_GSID_22399, Oprea1_222511, SCHEMBL22012, 5-19-06-00405 (Beilstein Handbook Reference), MLS000069446, BIDD:ER0114, ZINC1219, DTXSID6022399, BDBM23451, CTK8F8799, MolPort-003-846-031, HMS2235B05, HMS3374A07, 6H-Benzofuro[3, 3,9-dihydroxy-, Coumestrol, >=95.0% (HPLC), HY-N2335, Tox21_200032, CCG-35536, CCG-36200, LMPK12090018, MFCD00016885, NSC-22842, AKOS028111776, AN-6463, API0002121, CS-6343, VZ31590, 3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, delta-lactone (6CI), SMP2_000163, NCGC00018124-01, NCGC00018124-02, NCGC00018124-03, NCGC00018124-04, NCGC00018124-05, NCGC00018124-06, NCGC00023462-03, NCGC00023462-04, NCGC00257586-01, 4CN-2508, CAS-479-13-0, CC-25990, LS-35394, NCI60_001863, ZB000278, FT-0603177, ST50320052, V0359, C10205, S00280, US8552057, 3, 3,9-dihydroxy-[1]benzofuro[3,2-c]chromen-6-one, 3,9-dihydroxy-[1]benzoxolo[3,2-c]chromen-6-one, 3,9-dihydroxy-6H-benzofuro[3,2-c]chromen-6-one, 3,9-dihydroxybenzo[d]chromeno[4,3-b]furan-6-one, A827386, C-16836, 3,9-Dihydroxy-benzo[4,5]furo[3,2-c]chromen-6-one, BRD-K97509413-001-01-8, 3,9-bis(oxidanyl)-[1]benzofuro[3,2-c]chromen-6-one, 3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one #, 3,9-Dihydroxy-6H-benzofuro[3,2-c]-[1]benzopyran-6-one, 6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihdyroxy-, 6H-Benzofuro[3,2-c][1]benzopyran-6-one,3,9-dihydroxy-, Coumestrol, BioReagent, suitable for fluorescence, >=97.5% (HPLC), 2-(2,4-Dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylic Acid |A-Lactone, 3-Benzofurancarboxylic acid,4-dihydroxyphenyl)-6-hydroxy-, .delta.-lactone, 3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, .delta.-lactone, 3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, delta-lactone, 5,14-dihydroxy-8,17-dioxatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1(10),2,4,6,11(16),12,14-heptaen-9-one


ID: 86

chemical graph of compound 86



InChIKey: AAASNKNLMQBKFV-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)OC)OC)O)OC

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 97142
synonyms found at PubChem are:
1244-78-6, 3-Hydroxy-3',4',5,7-tetramethoxyflavone, NSC102049, Quercetin 5,7,3',4'-tetramethyl ether, CHEBI:85124, 3',4',5,7-Tetramethylquercetin, NSC-102049, 2-(3,4-Dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-4H-chromen-4-one, NSC 102049, Spectrum_000784, SpecPlus_000312, Spectrum2_000711, Spectrum3_001253, Spectrum4_001473, Spectrum5_000145, AC1L3XX0, BSPBio_002786, KBioGR_002045, KBioSS_001264, SPECTRUM300538, CHEMBL74675, DivK1c_006408, SPBio_000921, AC1Q6E16, SCHEMBL3135319, Flavone,4',5,7-tetramethoxy-, CTK8D4986, KBio1_001352, KBio2_001264, KBio2_003832, KBio2_006400, KBio3_002286, DTXSID40154319, ZINC1674568, CCG-38364, LMPK12112771, AKOS005145745, 3-Hydroxy-3',5,7-tetramethoxyflavone, SDCCGMLS-0066515.P001, 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy- (9CI), NCGC00095598-01, NCGC00095598-02, NCGC00178472-01, NCI60_000056, 3-hydroxy-5,7,3',4'-tetramethoxyflavone, Quercetin tetramethyl(3',4',5,7) ether, RT-002389, 3-Hydroxy-3',4', 5,7-tetramethoxyflavone, 5-hydroxy-7,3',4',5'-tetramethoxyflavone, 3-Hydroxy-3/',4/',5,7-tetramethoxyflavone, A805642, SR-05000002615, SR-05000002615-1, BRD-K08825053-001-02-9, Flavone, 3-hydroxy-3',4',5,7-tetramethoxy- (8CI), 2-(3,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxychromen-4-one, 2-(3,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-chromen-4-one, 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3-oxidanyl-chromen-4-one, 4H-1-Benzopyran-4-one,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-, 2-(3,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-1-benzopyran-4-one, 4H-1-Benzopyran-4-one, 2-(3, 4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-


ID: 87

chemical graph of compound 87



InChIKey: AAEVYOVXGOFMJO-UHFFFAOYSA-N
SMILES: CC(C)NC1=NC(=NC(=N1)SC)NC(C)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 4929
synonyms found at PubChem are:
prometryn, Prometryne, 7287-19-6, Gesagard, Prometrex, Selectin, Caparol, Uvon, Primatol Q, Mercasin, Mercazin, Merkazin, Polisin, Prometrin, Selektin, Sesagard, Gesagard 50, Gesagarde 50 Wp, Selectin 50, Caparol 80W, Promepin, Promethryn, Prometrene, Caswell No. 097, N,N'-Bis(1-methylethyl)-6-methylthio-1,3,5-triazine-2,4-diamine, UNII-1K20TB75IL, 1,3,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)-, Prometryn [ANSI:BSI:ISO], A 1114, NSC 163049, G 34161, N2,N4-Diisopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine, Prometryne [ISO-French:JMAF], 2,4-Bis(isopropylamino)-6-methylmercapto-s-triazine, 2-Methylmercapto-4,6-bis(isopropylamino)-s-triazine, HSDB 4060, s-Triazine, 2,4-bis(isopropylamino)-6-(methylthio)-, EINECS 230-711-3, 2-Methylthio-4,6-bis(isopropylamino)-s-triazine, G-34161, EPA Pesticide Chemical Code 080805, 2,4-Bis(isopropylamino)-6-(methylthio)-s-triazine, 2-(Methylthio)-4,6-bis(isopropylamino)-s-triazine, BRN 0613575, 2,4-Bis(isopropylamino)-6-methylthio-1,3,5-triazine, AI3-60366, 1K20TB75IL, CHEBI:26276, AAEVYOVXGOFMJO-UHFFFAOYSA-N, 2,4-Bis(isopropylamino)-6-methylthio-s-triazine, s-Triazine, 4,6-bis(isopropylamino)-2-methylmercapto-, 2,4-Bis(propylamino)-6-methylthio-1,3,5-triazin [German], N,N-Di-isopropyl-6-methylthio-1,3,5-triazine-2,4-diamine, N,N'-diisopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine, N,N'-Diisopropyl-6-methylthio-1,3,5-triazine-2,4-diyldiamine, N2,N4-Di-isopropyl-6-methylthio-1,3,5-triazine-2,4-diamine, 6-(methylsulfanyl)-N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine, DSSTox_CID_4272, N,N'-Bis(1-methylethyl)-6-methyl-thio-1,3,5-triazine-2,4-diamine, DSSTox_RID_77350, DSSTox_GSID_24272, Prometryn, analytical standard, W-104476, 2,4-Bis(isopropylamino)-6-(methylmercapto)-s-triazine, 2-(Methylmercapto)-4,6-bis(isopropylamino)-s-triazine, 6-methylsulfanyl-2-N,4-N-di(propan-2-yl)-1,3,5-triazine-2,4-diamine, CAS-7287-19-6, Promethryne, Cotton-Pro, Prometryn solution, Caparol 4L, Spectrum_001837, SpecPlus_000438, Cotton-Pro (Salt/Mix), Spectrum2_001887, Spectrum3_000829, Spectrum4_000669, Spectrum5_001970, Caparol 4L (Salt/Mix), AC1Q7E1J, SCHEMBL7622, BSPBio_002357, KBioGR_001077, KBioSS_002342, SPECTRUM330037, 2,4-Bis(propylamino)-6-methylthio-1,3,5-triazin, MLS002695921, DivK1c_006534, SPBio_001794, AC1L1J96, 4,6-Bis(isopropylamino)-2-(methylthio)-1,3,5-triazine, CHEMBL1880257, DTXSID4024272, AAEVYOVXGOFMJO-UHFFFAOYSA-, KBio1_001478, KBio2_002339, KBio2_004907, KBio2_007475, KBio3_001857, MolPort-002-043-491, HMS3089A14, s-Triazine, 2,4-bis(isopropylamino)-6-(methylthio)- (8CI), n,n'-diisopropyl-6-(methylsulfanyl)-1,3,5-triazin-2,4-diamin, ZINC1635499, Tox21_202338, Tox21_300807, CCG-39425, NSC163049, STK687533, AKOS005206531, MCULE-8449557554, NSC-163049, Prometryn 10 microg/mL in Cyclohexane, Prometryn 10 microg/mL in Acetonitrile, NCGC00094530-01, NCGC00094530-02, NCGC00094530-03, NCGC00094530-04, NCGC00094530-05, NCGC00094530-06, NCGC00254711-01, NCGC00259887-01, Prometryn 100 microg/mL in Acetonitrile, AJ-28509, CC-33942, CJ-26336, O632, SMR000778056, KB-258544, LS-155138, TR-023735, FT-0630367, Prometryn, PESTANAL(R), analytical standard, Bis(isopropylamino)-6-(methylthio)-S-triazine, C18542, WLN: T6N CN ENJ BS1 DMY1&1 FMY1&1, 2,4-Bis(isopropylamino)-6-(methylthio)triazine, 287P196, A837648, C-14516, s-Triazine,4-bis(isopropylamino)-6-(methylthio)-, 2-methylthio-4,6-bis(isopropylamino)-1,3,5-triazine, 2-Methylthio-4,6-bis(isopropylamino)-1,3,5triazine, BRD-K32582260-001-02-5, s-Triazine,6-bis(isopropylamino)-2-(methylmercapto)-, 2,4-Bis(isopropylamino)-6-(methylthio)-1,3,5-triazine, 2,4-Bis-(isopropylamino)-6-methylthio-1,3,5-triazine, 2-Methylthio-4,6-bis(isopropyl amino)-1,3,5-triazine, S-Triazine, 2,4-bis(isopropylamino)-6-methylmercapto-, A3964/0168949, s-Triazine, 4,6-bis(isopropylamino)-2-(methylmercapto)-, 2,4-Diamine-N,N'-bis(1-methylethyl)-6-(methylthio)triazine, 6-(methylthio)-N2,N4-di(propan-2-yl)-1,3,5-triazine-2,4-diamine, 6-methylsulfanyl-N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine, N,N'-Diisopropyl-6-(methylsulfanyl)-1,3,5-triazine-2,4-diamine, 1,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)-, 6-methylsulfanyl-N2,N4-di(propan-2-yl)-1,3,5-triazine-2,4-diamine, 1,3,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)- (9CI), Prometryn solution, 100 mug/mL in acetonitrile, PESTANAL(R), analytical standard, 83653-07-0, InChI=1/C10H19N5S/c1-6(2)11-8-13-9(12-7(3)4)15-10(14-8)16-5/h6-7H,1-5H3,(H2,11,12,13,14,15)


ID: 88

chemical graph of compound 88



InChIKey: AAFNEINEQRQMTF-LREBCSMRSA-N
SMILES: CC1(CCCC(N1C)(C)C)C.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 120729
synonyms found at PubChem are:
Pempidine tartrate, Sinapleg, Synapleg, Pempidine bitartrate, Pempidine hydrogen tartrate, UNII-THI82M7N4M, 546-48-5, Pempidina tartrato [Italian], EINECS 208-902-8, THI82M7N4M, 1,2,2,6,6-Pentamethylpiperidine tartrate, Piperidine, 1,2,2,6,6-pentamethyl-, tartrate (1:1), Pempidina tartrato, C10H21N.C4H6O6, AC1L3RDA, AC1Q5R2R, Lopac0_000939, SCHEMBL933339, API0015931, Piperidine, 1,2,2,6,6-pentamethyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1), NCGC00094245-01, LS-115858, EU-0100939, P 5114, SR-01000076249, SR-01000076249-1, 1,2,2,6,6-pentamethylpiperidine (2R,3R)-2,3-dihydroxysuccinate, (2R,3R)-2,3-dihydroxybutanedioic acid; 1,2,2,6,6-pentamethylpiperidine, (2R,3R)-2,3-dihydroxybutanedioic acid;1,2,2,6,6-pentamethylpiperidine, Piperidine, 1,2,2,6,6-pentamethyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (9CI)


ID: 89

chemical graph of compound 89



InChIKey: AAKJUGSASOCUFQ-UHFFFAOYSA-N
SMILES: CC(=CCC1=C(C2=C(C3=C1OC(C=C3)(C)C)OC(=O)C(=C2O)C4=CC=C(C=C4)O)OC)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 54676535
synonyms found at PubChem are:
Scandenin, CHEMBL1603825, KBio1_001385, AC1LCPJW, Spectrum_000746, SpecPlus_000345, Spectrum2_001906, Spectrum3_001312, Spectrum4_001469, Spectrum5_000117, BSPBio_003003, KBioGR_002017, KBioSS_001226, SPECTRUM300348, DivK1c_006441, SPBio_001872, SCHEMBL12062082, CHEBI:93435, KBio2_001226, KBio2_003794, KBio2_006362, KBio3_002223, AAKJUGSASOCUFQ-UHFFFAOYSA-N, BDBM50442909, CCG-38477, LMPK12160022, SDCCGMLS-0066849.P001, NCGC00095595-01, NCGC00095595-02, NCGC00178349-01, 2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-, 2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 4-hydroxy-3-(p-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-, BRD-K81847782-001-02-1, 2-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one, 4-Hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-2H,8H-pyrano[2,3-f]chromen-2-one #, 5084-00-4


ID: 90

chemical graph of compound 90



InChIKey: AAWZDTNXLSGCEK-LNVDRNJUSA-N
SMILES: C1[C@H](C([C@@H](CC1(C(=O)O)O)O)O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6508
synonyms found at PubChem are:
quinic acid, D-(-)-Quinic acid, 77-95-2, (-)-quinic acid, Chinic acid, Kinic acid, Chinasaure, quinate, D-QUINIC ACID, L-Quinic acid, UNII-058C04BGYI, D(-)-Quinic acid, D-(-)-QuinicAcid, L-Quinate, NSC1115, (3r,5r)-1,3,4,5-tetrahydroxycyclohexanecarboxylic acid, SpecPlus_000419, NSC59258, EINECS 201-072-8, NSC 59258, (-)-1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid, DivK1c_006515, 058C04BGYI, CHEBI:17521, (1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexanecarboxylic acid, AAWZDTNXLSGCEK-WYWMIBKRSA-N, Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (1R-(1-alpha,3-alpha,4-alpha,5-beta))-, Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (1R-(1alpha,3alpha,4alpha,5beta))-, SDCCGMLS-0066613.P001, Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (-)-, 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid (1R-(1alpha,3alpha,4alpha,5beta), Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (1theta-(1alpha,3alpha,4alpha,5beta))-, 1L-1(OH),3,4/5-Tetrahydroxycyclohexanecarboxylic acid, (1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid, Cyclohexanecarboxylicacid, 1,3,4,5-tetrahydroxy-, (1a,3R,4a,5R)-, D-(-)-Kinic Acid, D-(-)-Chinic Acid, Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (1.alpha.,3R,4.alpha.,5R)-, 36413-60-2, Quinicacid, 1L-1(OH),3,4/5-Tetrahydroxycyclohexanecarboxylate, Rel-Quinic Acid, 4gui, 4iuo, C7H12O6, (-)Quinic acid, QIC, PubChem8105, D-(-)-Quinic-acid, Spectrum_001413, AC1L1MOP, AC1Q5TBL, Spectrum2_001790, Spectrum3_001349, Spectrum4_001867, Spectrum5_000434, bmse000306, AC1Q59HD, SCHEMBL39556, BSPBio_003137, KBioGR_002336, KBioSS_001893, SPECTRUM310018, KSC645E2N, MLS002207201, SPBio_001719, CHEMBL465398, MEGxp0_001735, SCHEMBL1286207, SCHEMBL1286208, SCHEMBL7923331, D-(-)-Quinic acid, 98%, ACon1_001963, CTK5E5226, KBio1_001459, KBio2_001893, KBio2_004461, KBio2_007029, KBio3_002357, D-(&#8722;)-Quinic acid, AAWZDTNXLSGCEK-LNVDRNJUSA-N, MolPort-001-742-493, MolPort-028-750-726, KS-000014QH, NSC-1115, ZINC1764753, ANW-43810, BBL033519, CCG-38438, MFCD00003864, NSC-59258, STK801928, (-) Quinic acid, analytical standard, AKOS005622501, ZINC100009542, ZINC100076909, MCULE-1240547998, MCULE-2526162099, RTR-032721, NCGC00178246-01, NCGC00178246-02, BP-12304, LS-56752, SC-06773, SMR001306762, AB1003944, FT-0624343, N1691, Q0009, Z7206, 1,3,4,5Tetrahydroxycyclohexanecarboxylic acid, C00296, D-(-)-Quinic acid, purum, >=98.0% (T), 003D864, W-203791, 883DE888-EC82-454C-B69C-8B1F9AC6DAA9, Z2767312005, (1R,3R,4R,5R)-(-)-Tetrahydroxycyclohexanecarboxylic acid, (3R,5R)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid, (3R,5R)-1,3,4,5-tetrakis(oxidanyl)cyclohexane-1-carboxylic acid, 1,3beta,4alpha,5alpha-Tetrahydroxycyclohexane-1alpha-carboxylic acid, Quinic acid, United States Pharmacopeia (USP) Reference Standard, Quinic Acid, Pharmaceutical Secondary Standard; Certified Reference Material, Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (1alpha,3R,4alpha,5R)-, Cyclohexanecarboxylic acid,3,4,5-tetrahydroxy-, (1.alpha.,3.alpha.,4.alpha.,5.beta.)-, 35949-55-4, Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, (1.alpha., 3.alpha.,4.alpha.,5.beta.)-


ID: 91

chemical graph of compound 91



InChIKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M
SMILES: C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 5900
synonyms found at PubChem are:
Sodium salicylate, 54-21-7, Sodium 2-hydroxybenzoate, Salsonin, Clin, Enterosalicyl, Enterosalil, Entrosalyl, Glutosalyl, Kerasalicyl, Magsalyl, Alysine, Aroall, Kerosal, Nadisal, Salisod, Idocyl novum, Neo-salicyl, Diuretin, Parbocyl-rev, Benzoic acid, 2-hydroxy-, monosodium salt, Monosodium salicylate, Sodium o-hydroxybenzoate, NaSal, UNII-WIQ1H85SYP, Natrium salicylat [German], Salicylic acid, sodium salt, Monosodium 2-hydroxybenzoate, Salicylic acid Na+, Salicylic Acid, Na, CCRIS 6715, o-Hydroxybenzoic acid, sodium salt, EINECS 200-198-0, o-Hydroxybenzoic acid monosodium salt, Salicylic acid sodium salt, WIQ1H85SYP, 2-Hydroxybenzoic acid monosodium salt, NSC 202167, CHEBI:9180, Salicylic acid, monosodium salt, IN1086, sodium;2-hydroxybenzoate, 2-HYDROXYBENZOIC ACID, MONOSODIUM SALT, Benzoic acid, 2-hydroxy-, sodium salt (1:1), Natrum salicylicum, Diuratin, sodiumsalicylate, Sodium salicylate [USP:JAN], Monosodium salicylatn, Salicylsaeure-Na-salz, Sodium o-hydroxybenzoatn, Sodium 2-hydroxybenzoatn, Sodium salicylate, 99%, Spectrum2_001945, Spectrum3_000900, Spectrum4_000995, Spectrum5_001120, DSSTox_CID_1708, potassium o-hydroxybenzoate, Salicylic acid sodium saln, NPFAPI-03, EC 200-198-0, SCHEMBL4603, Monosodium 2-hydroxybenzoatn, DSSTox_RID_76287, DSSTox_GSID_21708, KBioGR_001429, 90218-97-6, KSC269G8P, SPECTRUM1500533, SPBio_002009, CHEMBL447868, DTXSID5021708, Sodium salicylate (JP17/USP), CTK1G9387, HY-B0167A, KBio3_001820, ABBQHOQBGMUPJH-UHFFFAOYSA-M, MolPort-002-324-170, Sodium salicylate, 99% 500g, HMS1920P16, HMS2092G17, KS-00000X7W, Sodium salicylate, p.a., 99.5%, Tox21_200411, [http://ChEMBL = 447868, 2-Hydroxy Benzoic acid, sodium salt, CCG-39474, MFCD00002440, RTA-01003, AKOS003051698, AKOS005766021, CS-2008, CAS-54-21-7, NCGC00094780-01, NCGC00094780-02, NCGC00257965-01, AK307396, AN-24416, Benzoic acid, 2-hydroxy-, monosodium salt, coupled with 4-amino-1-naphthalenesulfonic acid and diazotized 2-(4-aminophenyl)-1H-benzimidazol-5-amine, sodium salt, H365, KB-80645, AB1009427, FT-0631235, 1875-EP2269977A2, 1875-EP2280012A2, 1875-EP2305250A1, 1875-EP2308833A2, C07587, D00566, Sodium salicylate, ReagentPlus(R), >=99.5%, Sodium salicylate, SAJ first grade, >=99.5%, Sodium salicylate, tested according to Ph.Eur., 66873-EP2275420A1, 66873-EP2280008A2, 66873-EP2281823A2, 66873-EP2295406A1, 66873-EP2298731A1, 66873-EP2298764A1, 66873-EP2298765A1, 66873-EP2298772A1, 66873-EP2308510A1, 66873-EP2308839A1, 66873-EP2371811A2, Sodium salicylate, SAJ special grade, >=99.5%, Sodium salicylate, Vetec(TM) reagent grade, 99%, I14-7511, Sodium salicylate, meets USP testing specifications, Sodium salicylate, puriss. p.a., >=99.5% (NT), 2-Hydroxybenzoic acid sodium salt; Salicylic acid sodium salt, Sodium salicylate, European Pharmacopoeia (EP) Reference Standard, Sodium salicylate, United States Pharmacopeia (USP) Reference Standard, 18495-69-7, 94413-51-1, Sodium salicylate, puriss. p.a., Reag. Ph. Eur., 99.5-101.0% (calc. to the dried substance), salicylate de sodium, SCHEMBL8922293, HMS500P03


ID: 92

chemical graph of compound 92



InChIKey: ABGZFAWHPVNBOG-UHFFFAOYSA-N
SMILES: CC1=C(C(=C(C(=N1)C)C(=O)OC)C2=CC=C(C=C2)C(C)C)C(=O)OC

biological descriptors:

CFTR relevance: strong CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

"K Du" "N Pedemonte" "A Taddei" "T Ma" "VS Gopinath" "RK Guy" "H Yang" "AS Verkman" "GL Lukacs" "C Folli" "LJ Galietta" "AA Shelat"


CID is 19232492
synonyms found at PubChem are:
AKOS003007998


ID: 93

chemical graph of compound 93



InChIKey: ABJKIHHNDMEBNA-UHFFFAOYSA-N
SMILES: CC1=COC2=CC=CC=C2C1=O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 66569
synonyms found at PubChem are:
Methylchromone, 3-Methylchromone, Crodimyl, Spasmocromona, Cromonalgina, Diacromone, Tricromyl, 85-90-5, Chromone, 3-methyl-, 3-methyl-4H-chromen-4-one, 3-Methyl-4(4H)-chromenone, 3-Methyl-4(H)-chromen-4-one, 3-Methyl-4H-1-benzopyran-4-one, Metilcromone [DCIT], 4H-1-Benzopyran-4-one, 3-methyl-, UNII-KJ0091KAAH, 3-Methyl-gamma-benzopyrone, Methylchromone [INN:BAN], 3-Metil-cromone [Italian], Metilcromona [INN-Spanish], NSC 76095, Methylchromonum [INN-Latin], EINECS 201-641-0, BRN 0117920, KJ0091KAAH, 3-Methyl-.gamma.-benzopyrone, C10H8O2, Methylchromonum, Metilcromona, Metilcromone, 3-Metil-cromone, 3-methylchromen-4-one, Spectrum_001209, SpecPlus_000745, Spectrum5_001726, DSSTox_CID_31634, DSSTox_RID_97518, DSSTox_GSID_57845, SCHEMBL25934, KBioSS_001689, 5-17-10-00164 (Beilstein Handbook Reference), DivK1c_006841, Chromone, 3-methyl- (8CI), AC1L25O0, ZINC1707, CHEMBL2105215, DTXSID4057845, CTK5F5944, KBio1_001785, KBio2_001689, KBio2_004257, KBio2_006825, ABJKIHHNDMEBNA-UHFFFAOYSA-N, CHEBI:134790, MolPort-002-893-685, NSC76095, 4H-1-Benzopyran-4-one,3-methyl-, Tox21_113786, NSC-76095, STL356197, AKOS016356352, FCH1119537, MCULE-4780438132, CAS-85-90-5, NCGC00253661-01, CC-15616, LS-39788, ZB000395, DB-056888, FT-0603297, C-03987, SR-01000944928, SR-01000944928-1, Urea,5-dihydro-1H-imidazol-2-yl)phenyl]-N'-4-[[[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]amino]carbonyl]amino]phenyl]-, dihydrochloride


ID: 94

chemical graph of compound 94



InChIKey: ABTNETSDXZBJTE-WLHGVMLRSA-N
SMILES: COC(=O)N1CCN(C(C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.C(=C/C(=O)O)\C(=O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 6442840
synonyms found at PubChem are:
GR 89696 fumarate, 126766-32-3, GR-89696 fumarate, GR 89696, GR 89696 fumarate salt, GR 85571, 4-([3,4-DICHLOROPHENYL]ACETYL)-3-(1-PYRROLIDINYLMETHYL)-1-PIPERAZINECARBOXYLIC ACID METHYL ESTER FUMARATE, 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate salt, SMR000466287, SR-01000075500, GR 103545, 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate, AC1O5XZT, 1-((3,4-Dichlorophenyl)acetyl)-4-acetyl-2-(1-pyrrolidinylmethyl)piperazine, Methyl 4-((3,4-dichlorophenyl)acetyl)-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylate fumarate, MLS000758305, MLS001424140, SCHEMBL1282478, SCHEMBL1282479, gr89696, CHEMBL1256865, GR 89696 fumarate salt, solid, MolPort-003-941-452, HMS2051L20, HMS3261D06, HMS3267N18, Tox21_500572, MFCD00274044, AKOS024456628, 4-[(3,4-Dichlorophenyl)acetyl]-3-, CCG-101060, CCG-221876, LP00572, NC00310, NCGC00093956-01, NCGC00261257-01, 1-Piperazinecarboxylic acid, 4-((3,4-dichlorophenyl)acetyl)-3-(1-pyrrolidinylmethyl)-, methyl ester, (E)-2-butenedioate (1:1), CPD000466287, SAM001247087, RT-013118, EU-0100572, G-133, J-005434, SR-01000075500-1, SR-01000075500-3, (1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate, (E)-but-2-enedioic acid; methyl 4-[2-(3,4-dichlorophenyl)acetyl]-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate, methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate fumarate


ID: 95

chemical graph of compound 95



InChIKey: ABTXGJFUQRCPNH-UHFFFAOYSA-N
SMILES: CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 66068
synonyms found at PubChem are:
procainamide hydrochloride, Procainamide Hcl, 614-39-1, Pronestyl, Procanbid, Procapan, Procan, Procainhydrochlorid, Procan SR, Procainii chloridum, Promide hydrochloride, Procapan hydrochloride, Novocamid hydrochloride, Procaini hydrochloridum, Procamide hydrochloride, Procardyl hydrochloride, Procan-SR hydrochloride, Procaine amide hydrochloride, Supicane amide hydrochloride, Procainamide (hydrochloride), UNII-SI4064O0LX, 4-amino-N-[2-(diethylamino)ethyl]benzamide hydrochloride, CCRIS 7143, 4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride, EINECS 210-381-7, Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride, MLS000069436, CHEBI:8429, SI4064O0LX, 7699-39-0, 4-Aminobenzoesaeure-2-diethylaminoethylester hydrochlorid, p-Amino-N-(2-(diethylamino)ethyl)benzamide hydrochloride, 4-Amino-N-(2-(diethylamino)ethyl)benzamide hydrochloride, 4-Amino-N-(2-(diethylamino)ethyl)benzamide monohydrochloride, p-Amino-N-(2-(diethylamino)ethyl)benzamide monohydrochloride, SMR000059079, Procanbid (TN), Pronestyl (TN), Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, monohydrochloride, Benzamide, p-amino-N-(2-(diethylamino)ethyl)-, hydrochloride, SR-01000000022, CAS-614-39-1, (4-aminophenyl)-N-[2-(diethylamino)ethyl]carboxamide, chloride, PROCAINAMIDEHYDROCHLORIDE, Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, hydrochloride (1:1), Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1), 4-amino-N-[2-(diethylamino)ethyl]benzamide;hydrochloride, Procainamide hydrochloride [USP:JAN], Procainamide hydrochloride [USAN:JAN], Procan SR (TN), Pronestyl hydrochloride, Procainamide HCL USP, PubChem15966, Opera_ID_1543, CHEMBL605, Epitope ID:140114, AC1L24JW, C13H22ClN3O, DSSTox_CID_29382, DSSTox_RID_83497, DSSTox_GSID_49422, SCHEMBL40758, MLS001148635, 51-06-9 (Parent), SPECTRUM1500503, DTXSID2049422, CTK6E8331, ABTXGJFUQRCPNH-UHFFFAOYSA-N, MolPort-002-319-710, HMS1569C15, HMS1920L04, Pharmakon1600-01500503, ACT08464, BCP28404, HY-A0084, Tox21_202855, Tox21_500995, CCG-39233, MFCD00012998, NSC757279, s4294, SBB001067, AKOS008056264, AC-7552, AN-8900, EBD3071181, KS-5258, LP00995, MCULE-9726613752, NC00535, NE10724, NSC-757279, Procainamide hydrochloride (JP17/USP), VA11587, NCGC00094291-01, NCGC00094291-02, NCGC00094291-03, NCGC00094291-04, NCGC00094291-05, NCGC00260401-01, NCGC00261680-01, BC209722, CPD000059079, LS-25497, M850, SAM002554928, KB-304279, TR-034892, 4-Aminobenzoic acid 2-diethylaminoethylamide, EU-0100995, FT-0603493, ST50319808, VU0239777-5, BIM-0050968.0001, D00477, P 9391, 4-amino-N-(2-diethylamino-ethyl)-benzamide HCl, I01-2626, Procainamide hydrochloride, purum, >=98.0% (AT), SR-01000000022-2, SR-01000000022-6, W-105155, F0850-6742, 4-amino-N-[2-(diethylamino)ethyl]-Benzamide hydrochloride, Procainamide hydrochloride, European Pharmacopoeia (EP) Reference Standard, Procainamide hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material, Procainamide hydrochloride, United States Pharmacopeia (USP) Reference Standard, AC1LCWA9, AKOS026749765, 4-amino-N-(2-diethylaminoethyl)benzamide; hydron; chloride


ID: 96

chemical graph of compound 96



InChIKey: ABUBCBFUQXIEAU-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(=CC(=O)OC2=C1OC)C3=CC=CC=C3)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

"DY Thomas" "GW Carlile" "E Matthes" "R Robert" "SD Macknight" "JW Hanrahan" "J Liao" "J Goepp" "B Kus" "D Rotin"


CID is 4412068
synonyms found at PubChem are:
Kuhlmannin, 6-Hydroxy-7,8-dimethoxy-4-phenylcoumarin, 20972-79-6, SPBio_002203, Spectrum_000560, SpecPlus_000638, AC1N9KHM, Spectrum2_001992, Spectrum3_001261, Spectrum4_001594, Spectrum5_000308, BSPBio_002822, KBioGR_002208, KBioSS_001040, SPECTRUM240862, DivK1c_006734, CHEMBL1568181, SCHEMBL12062100, KBio1_001678, KBio2_001040, KBio2_003608, KBio2_006176, KBio3_002322, CHEBI:108605, CCG-39477, LMPK12100011, SDCCGMLS-0066486.P001, NCGC00095925-01, NCGC00095925-02, NCGC00178451-01, 6-hydroxy-7,8-dimethoxy-4-phenylchromen-2-one, SR-05000002551, SR-05000002551-1, 6-hydroxy-7,8-dimethoxy-4-phenyl-2H-chromen-2-one, BRD-K18149487-001-02-8


ID: 97

chemical graph of compound 97



InChIKey: ACGUYXCXAPNIKK-UHFFFAOYSA-N
SMILES: C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list: