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CandActCFTR used public reference

The following publication reference has been reported to contain CFTR related structural information.
"G De Rosa" "L Salvadori" "S Esposito" "A Mehta" "S Lusa" "MC Maiuri" "CA Leone" "R Grassia" "D De Stefano" "I Sana" "L Maiuri" "A Tosco" "F De Gregorio" "S Guido" "G Stoll" "V Raia" "A Sepe" "G Bona" "A Di Pasqua" "G Kroemer" "P Buonpensiero" "E Ferrari"


Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=3
ID: 12
InChIKey: WMBWREPUVVBILR-WIYYLYMNSA-N
SMILES: C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

biological descriptors:

CFTR relevance: CFTR activator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

chemical graph of compound 12



CID is 65064
synonyms found at PubChem are:
(-)-Epigallocatechin gallate, EGCG, Epigallocatechin gallate, 989-51-5, Epigallocatechin 3-gallate, Epigallocatechin-3-gallate, Tea catechin, (-)-Epigallocatechin-3-o-gallate, Teavigo, (-)-Epigallocatechol gallate, Epigallocatechin-3-monogallate, (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate, Catechin deriv., UNII-BQM438CTEL, Green tea extract, CCRIS 3729, (-)-epigallocatechin 3-gallate, C22H18O11, BQM438CTEL, CHEBI:4806, CHEMBL297453, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, WMBWREPUVVBILR-WIYYLYMNSA-N, Epigallocatechol, 3-gallate, (-)-, (-)-Epigallocatechin gallate (EGCG), [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate, DSSTox_CID_567, DSSTox_RID_78830, DSSTox_GSID_29889, Sunphenon, [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate, EGCG cpd, (-)-Epigallocatechin gallate (85% (-)-epigallocatechin gallate, 10% (-)-epigallocatechin, 5% (-)- epicatechin gallate), (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol-3-(3,4,5-trihydroxybenzoate), CAS-989-51-5, SMR000449288, epigallo-catechin gallate, SR-01000759328, L-Epigallocatechin gallate, PF-EGCg 90, Epigallocate, NVP-XAA 723, (-)-EGCG, Epigallocic acid, Teavigo;, EGCG analogs, GTPs,Anagen, 2kdh, 3oob, 4awm, EGCG, Anagen, KDH, Epigallocatcchin Gallate, Spectrum_000316, SpecPlus_000277, Spectrum2_000168, Spectrum3_000244, Spectrum4_001541, Spectrum5_000102, Galloyl-L-epigallocatechol, D0E9DB, D0U2BH, AC1L22IG, AC1Q5X0Z, (-)-Epigallocatechin gallat, (-)-Epigallocatehin gallate, SCHEMBL35258, BSPBio_001628, KBioGR_002002, KBioSS_000796, SPECTRUM210239, cid_65064, EPIGALOCATECHIN GALLATE, MLS000758300, MLS001424000, DivK1c_006373, Green tea polyphenols, Anagen, SPBio_000035, Epigallocatechin gallate(EGCG), Epigallocatechin monogallate, B, GTPL7002, MEGxp0_001166, Epigallocatechin gallate, Anagen, DTXSID1029889, ACon1_001054, KBio1_001317, KBio2_000796, KBio2_003364, KBio2_005932, KBio3_001128, AOB2839, (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, EGCG solution, 20 mM in DMSO, MolPort-001-741-358, (-)-EpigallocatechinGallateHydrate, HMS2051K21, HMS3649E08, ZINC3870412, Tox21_201468, Tox21_303457, BDBM50070942, CCG-38378, FR-109, LMPK12030005, MFCD00075940, s2250, AKOS015918182, ACN-035233, CS-1258, DB12116, DS-9030, EBD2138593, LS-2197, MCULE-3341525983, MCULE-7760530136, NC00078, SDCCGMLS-0066550.P001, (-)-Epigallocatechin gallate, >=95%, Epigallocatechin gallate analogs, Anagen, KS-0000132O, NCGC00164319-01, NCGC00164319-02, NCGC00164319-03, NCGC00164319-04, NCGC00164319-06, NCGC00257243-01, NCGC00259019-01, AN-15867, BP-30205, CPD000449288, HY-13653, K791, SAM001247031, SC-47284, ST097428, AB0014381, KB-206444, E0694, FT-0082796, FT-0604392, N1874, C09731, W-5069, (-)-Epigallocatechin gallate, >=97.0% (HPLC), (-)-Epigallocatechin gallate, analytical standard, 989E515, Epigallocatechin Gallate solution, 20 mM in DMSO, Gallic acid, 3-ester with epigallocatechol, (-)-, SR-01000946601, epigallocatechin-3-gallate solution, 20 mM in DMSO, I14-7747, Q-100914, SR-01000759328-5, SR-01000759328-6, SR-01000946601-1, (-)-EPIGALLOCATECHIN GALLATE (GREEN TEA EXTRACT), (-)-Epigallocatechin Gallate solution, 20 mM in DMSO, (-)-cis-3,3',4',5,5',7-Hexahydroxy-flavane-3-gallate, ANTIOXIDANT MODEL (TRAMP) -EPIGALLOCATECHIN GALLATE, UNII-T432289GYZ component WMBWREPUVVBILR-WIYYLYMNSA-N, (-)-Epigallocatechin gallate, >=80% (HPLC), from green tea, (-)-Epigallocatechin Gallate, disposable screening library format, Epigallocatechin gallate, primary pharmaceutical reference standard, (-)-Epigallocatechin-3-O-gallate, United States Pharmacopeia (USP) Reference Standard, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxyb enzoate, [5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 2,3,4-trihydroxybenzoate, Epigallocatechin gallate, Pharmaceutical Secondary Standard; Certified Reference Material, (-)-cis-3,4-Dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2H)-benzopyran-3-yl Gallate, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate, (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl-3,4,5-trihydroxybenzoate, 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, 3,4-Dihydro-5,7-dihydroxy-2R-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3R-yl-3,4,5-trihydroxybenzoate, 863-65-0, Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, (2R-cis)-, Benzoic acid, 3,4,5-trihydroxy-,(2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
ID: 2817
InChIKey: ZJONSYFOVDKINV-UHFFFAOYSA-N
SMILES: C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=C(C(=C(C=C4)O)O)O

biological descriptors:

CFTR relevance: proteostasis regulator (targeting disabled autophagy and CK2 overactivation)

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

chemical graph of compound 2817



CID is 44134699
synonyms found at PubChem are:
(-) EPIGALLOCATECHIN GALLATE, BDBM84980, AC-390, AKOS015963174, BC215524, A845931, [5,7-bis(oxidanyl)-2-[3,4,5-tris(oxidanyl)phenyl]-3,4-dihydro-2H-chromen-3-yl] 2,3,4-tris(oxidanyl)benzoate, 2,3,4-trihydroxybenzoic acid [5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl] ester, 5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 2,3,4-trihydroxybenzoate
ID: 73
InChIKey: UFULAYFCSOUIOV-UHFFFAOYSA-N
SMILES: C(CS)N

biological descriptors:

CFTR relevance: proteostasis regulator (targeting disabled autophagy and CK2 overactivation)

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

chemical graph of compound 73



CID is 6058
synonyms found at PubChem are:
CYSTEAMINE, 2-Aminoethanethiol, Mercaptamine, 60-23-1, Thioethanolamine, Becaptan, Mercamine, Cysteinamine, beta-Mercaptoethylamine, 2-Mercaptoethylamine, Cysteamin, Lambraten, Lambratene, beta-Aminoethanethiol, Cystagon, Riacon, Decarboxycysteine, Mercaptoethylamine, 2-Amino-1-ethanethiol, Cisteamina, 2-Aminoethyl mercaptan, beta-Aminoethylthiol, 2-Mercaptoethanamine, Ethanethiol, 2-amino-, Mercaptamin, (2-Mercaptoethyl)amine, MEA (mercaptan), Ethanethiolamine, beta-MEA, Aminoethyl mercaptan, Mercaptamina, Mercaptaminum, Cysteamide, Mecramine, Mercamin, Merkamin, Cisteamina [Italian], Cystaran, 2-AMINO-ETHANETHIOL, Mercaptaminum [INN-Latin], Mercaptamina [INN-Spanish], 1-Amino-2-mercaptoethylamine, 2-aminoethane-1-thiol, Cysteamine [USAN:BAN], L-1573, Cysteamine (USAN), WR 347, Cystavision, C2H7NS, UNII-5UX2SD1KE2, Cysteamine bitartate, NSC 647528, Cysteamine [USAN], Mercaptamine (INN), CCRIS 3083, HSDB 7353, .beta.-Mercaptoethylamine, EINECS 200-463-0, L 1573, 5UX2SD1KE2, CHEBI:17141, UFULAYFCSOUIOV-UHFFFAOYSA-N, cysteaminium, 2-Mercaptoethylamine, polymer-bound, Mercaptamine [INN], NSC647528, NCGC00015691-03, (Mercaptoethyl)ammonium toluene-p-sulphonate, C-9500, 60-23-1 (Parent), Cystagone, b-Aminoethylthiol, 2-aminoethanethio, b-Aminoethanethiol, mercapto ethylamine, b-Mercaptoethylamine, DHL, 2-amino-ethyl thiol, CASH, .beta.-MEA, Cysteamine, ~95%, Cysteamine, free base, .beta.-Aminoethylthiol, Spectrum_001755, .beta.-Aminoethanethiol, ACMC-1AVBC, SpecPlus_000654, AC1L1LPL, Lopac-M-6500, DSSTox_CID_2875, bmse000388, CHEMBL602, D0V0LB, AC1Q54NL, DSSTox_RID_76770, DSSTox_GSID_22875, KBioSS_002235, KSC490G2L, DivK1c_006750, 156-57-0 (hydrochloride), 641022_ALDRICH, BDBM7968, GTPL7440, 3037-04-5 (tosylate), DTXSID3022875, CTK3J0325, KBio1_001694, KBio2_002235, KBio2_004803, KBio2_007371, KS-00000WES, 42954-15-4 (hydrobromide), Cysteamine, >=98.0% (RT), MolPort-001-662-635, BCP15015, ZINC8034121, EINECS 221-235-7, Tox21_113092, 16904-32-8 (di-hydrochloride), ANW-33452, HY-77591A, STK315355, AKOS003793343, CCG-204834, CS-2799, DB00847, MCULE-1838427828, NE18622, NSC-647528, RP18367, RTR-031658, CAS-60-23-1, NCGC00015691-01, NCGC00015691-02, NCGC00015691-04, NCGC00162236-01, NCGC00162236-02, AN-41805, BP-13401, KB-20296, LS-65761, NCI60_002000, SC-18413, SBI-0050727.P003, 27761-19-9 (tartrate (1:1)), 93965-19-6 (maleate (1:1)), AB0020070, DB-053562, TR-031658, A0648, FT-0611243, V0810, C01678, D03634, AB00053754_09, AB00053754_10, 106791-EP2292597A1, 106791-EP2295407A1, 106791-EP2298736A1, 213515-EP2371809A1, F0001-1576, 2DFDA1F8-7010-4225-8280-AB1C4C43F546, 139720-70-0, 2-Mercaptoethylamine, polymer-bound, 70-90 mesh, extent of labeling: 0.6-1.1 mmol/g loading, 1 % cross-linked with divinylbenzene, 2-ammonioethanethiolate, STL455134