previous compound ID: 1083 next compound
InChIKey: JLTNCZQNGBLBGO-MOPGFXCFSA-N
SMILES: CC1(C=CC2=C3C(=C(C=C2O1)O)C(=O)[C@@H]4[C@H](O3)COC5=CC(=C(C=C45)OC)OC)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"SD Macknight" "JW Hanrahan" "GW Carlile" "E Matthes" "J Goepp" "R Robert" "D Rotin" "B Kus" "J Liao" "DY Thomas"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1083



CID is 442826 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/442826

CID is 442826
synonyms found at PubChem are:
alpha-Toxicarol, TOXICAROL, 82-09-7, CHEBI:9643, AC1L9DGQ, CHEMBL508992, SCHEMBL4742046, ZINC1684799, LMPK12060027, AKOS032949012, 4CN-2964, C10537