previous compound ID: 1153 next compound
InChIKey: KFEAUMZKRNJEDU-BTJKTKAUSA-N
SMILES: CC1=C(C2=C(N1)C=CC(=C2)O)CCN.C(=C\C(=O)O)\C(=O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53


Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"DY Thomas" "GW Carlile" "J Liao" "R Robert" "JW Hanrahan" "B Kus" "SD Macknight" "D Rotin" "J Goepp" "E Matthes"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1153




CID is 9836150 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/9836150

CID is 9836150
synonyms found at PubChem are:
2-Methylserotonin maleate, 2-Methylserotonin maleate salt, 78263-91-9, EU-0100813, SCHEMBL1320833, CHEMBL1491258, AOB5681, MolPort-035-944-445, HMS3262D07, Tox21_500813, AKOS025142140, CCG-222117, LP00813, NCGC00094146-01, NCGC00261498-01, LS-194105, 2-Methylserotonin maleate, >=95% (HPLC), M-109, SR-01000075557-1