previous compound ID: 132 next compound
InChIKey: AHVKNBRJVKCGKJ-UHFFFAOYSA-N
SMILES: CC1(C2C1CC(C(C2)O)(C)O)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"R Robert" "B Kus" "GW Carlile" "DY Thomas" "SD Macknight" "J Liao" "E Matthes" "D Rotin" "J Goepp" "JW Hanrahan"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 132



CID is 89242 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/89242

CID is 89242
synonyms found at PubChem are:
carane-3,4-diol, 3,4-DIHYDROXYCARANE, 3,7,7-trimethylbicyclo[4.1.0]heptane-3,4-diol, 57526-47-3, 19898-58-9, 19898-59-0, 19898-60-3, 3,7,7-Trimethylbicyclo(4.1.0)heptane-3,4-diol, SPBio_001682, 22556-08-7, 57457-02-0, EINECS 243-414-9, EINECS 243-415-4, EINECS 243-417-5, EINECS 243-418-0, EINECS 245-075-2, EINECS 260-745-4, EINECS 260-788-9, trans-3,4-caranediol, AC1L3HFY, Spectrum2_001701, Spectrum3_001142, Spectrum4_001992, AC1Q77XI, SCHEMBL76167, BSPBio_002663, KBioGR_002551, SPECTRUM1505274, CHEMBL3039109, CTK0I1170, KBio3_002163, AHVKNBRJVKCGKJ-UHFFFAOYSA-N, 3,7,7-trimethylnorcarane-3,4-diol, CCG-38783, (1alpha,3alpha,4beta,6alpha)-3,7,7-Trimethylbicyclo(4.1.0)heptane-3,4-diol, (1alpha,3beta,4alpha,6alpha)-3,7,7-Trimethylbicyclo(4.1.0)heptane-3,4-diol, (1alpha,3beta,4beta,6alpha)-3,7,7-Trimethylbicyclo(4.1.0)heptane-3,4-diol, AKOS006272464, SDCCGMLS-0066905.P001, (1alpha,3alpha,4alpha,6alpha)-3,7,7-Trimethylbicyclo(4.1.0)heptane-3,4-diol, (1S-(1alpha,3alpha,4alpha,6alpha))-3,7,7-Trimethylbicyclo(4.1.0)heptane-3,4-diol, (1S-(1alpha,3beta,4alpha,6alpha))-3,7,7-Trimethylbicyclo(4.1.0)heptane-3,4-diol, NCGC00095704-01, NCGC00095704-02, 19898-61-4, 4,7,7-trimethylbicyclo[4.1.0]heptane-3,4-diol, SR-05000002403, SR-05000002403-1