previous compound ID: 1396 next compound
InChIKey: MMQONYKUNYFDEI-LLPMONEMSA-N
SMILES: CC(=O)O[C@@H]1CC2[C@@](C3[C@@]1(C45C(O4)C(=O)O[C@H]([C@@]5(CC3)C)C6=COC=C6)C)(C(=O)CCC2(C)C)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"J Liao" "SD Macknight" "D Rotin" "E Matthes" "DY Thomas" "J Goepp" "JW Hanrahan" "R Robert" "GW Carlile" "B Kus"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1396



CID is 6708717 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/6708717

CID is 6708717
synonyms found at PubChem are:
KBio2_003788, Spectrum_000740, SpecPlus_000607, Spectrum2_000747, Spectrum3_000064, Spectrum4_001345, Spectrum5_000249, BSPBio_001847, KBioGR_001869, KBioSS_001220, SPECTRUM100290, 2,3-DIHYDROISOGEDUNIN, DivK1c_006703, SPBio_000734, SCHEMBL14196992, KBio1_001647, KBio2_001220, KBio2_006356, KBio3_001047, CCG-40155, SDCCGMLS-0066328.P001, NCGC00178959-01, SR-05000002719, SR-05000002719-1