previous compound ID: 1498 next compound
InChIKey: NMUSYJAQQFHJEW-OEXCPVAWSA-N
SMILES: C1=NC(=NC(=O)N1C2[C@H]([C@H]([C@H](O2)CO)O)O)N

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"R Robert" "D Rotin" "GW Carlile" "JW Hanrahan" "J Liao" "DY Thomas" "B Kus" "E Matthes" "J Goepp" "SD Macknight"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1498



CID is 6420049 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/6420049

CID is 6420049
synonyms found at PubChem are:
Azacytidine-5, Prestwick_972, AC1O4WIL, Prestwick0_000866, Prestwick1_000866, Prestwick2_000866, SPBio_002832, SCHEMBL16187746, HMS1570N13, 4-amino-1-[(3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one