previous compound ID: 1510 next compound
InChIKey: NPYOKEDYJXYSTA-UHFFFAOYSA-N
SMILES: CC1(C=CC2=C3C(=CC(=C2O1)OC)C(=O)C(=CO3)C4=CC5=C(C=C4OC)OCO5)C

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53


Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"JW Hanrahan" "B Kus" "R Robert" "DY Thomas" "SD Macknight" "GW Carlile" "D Rotin" "J Liao" "J Goepp" "E Matthes"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1510




CID is 3428129 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/3428129

CID is 3428129
synonyms found at PubChem are:
Ichthynone, 24340-62-3, KBio1_001675, Spectrum_000753, SpecPlus_000635, Spectrum2_000758, Spectrum3_000142, Spectrum4_001421, Spectrum5_000242, AC1MP1K4, BSPBio_001844, KBioGR_001862, KBioSS_001233, DivK1c_006731, SPBio_000776, SCHEMBL9924621, CHEMBL3039125, ACon1_001745, CHEBI:92492, KBio2_001233, KBio2_003801, KBio2_006369, KBio3_001044, DTXSID50392386, CCG-39041, LMPK12050122, SDCCGMLS-0066457.P001, NCGC00178961-01, NCGC00178961-02, BRD-K28167849-001-02-1, 6-methoxy-3-(6-methoxy-1,3-benzodioxol-5-yl)-8,8-dimethylpyrano[2,3-h]chromen-4-one