previous compound ID: 1558 next compound
InChIKey: ODHSWYNEXJIJEI-ZHVFSVHYSA-N
SMILES: CC(=O)OC1[C@@]2(C=C3C(CC[C@@]4(C3CC(=O)O[C@H]4C5=COC=C5)C)[C@@](C2=O)([C@H](C1(C)C)CC(=O)OC)C)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"B Kus" "J Goepp" "JW Hanrahan" "GW Carlile" "DY Thomas" "R Robert" "E Matthes" "D Rotin" "J Liao" "SD Macknight"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1558



CID is 6708546 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/6708546

CID is 6708546
synonyms found at PubChem are:
HUMILIN A, KBio2_001056, Spectrum_000576, SpecPlus_000089, Spectrum2_000245, Spectrum3_000026, Spectrum4_001308, Spectrum5_000095, BSPBio_001691, KBioGR_001715, KBioSS_001056, DivK1c_006185, SPBio_000030, CHEMBL3039257, KBio1_001129, KBio2_003624, KBio2_006192, KBio3_000811, NCGC00179083-01