previous compound ID: 1673 next compound
InChIKey: PCHPORCSPXIHLZ-UHFFFAOYSA-N
SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53


Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"E Matthes" "D Rotin" "J Goepp" "SD Macknight" "B Kus" "J Liao" "GW Carlile" "JW Hanrahan" "R Robert" "DY Thomas"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1673




CID is 8980 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/8980

CID is 8980
synonyms found at PubChem are:
DIPHENHYDRAMINE HYDROCHLORIDE, 147-24-0, Dimedrol, Diphenhydramine HCl, Carphenamine, Bendylate, Carphenex, Cathejell, Denydryl, Diphamine, Eldadryl, Fenylhist, Noctomin, Paradryl, Restamin, Ambenyl, Felben, Prodryl, Allergival, Allergan, Benzhydramine hydrochloride, Dobacen hydrochloride, Bena, Sedopretten, Benzantin, Dimedrolum, Halbmond, Histacyl, Wehydryl, Dimedrol hydrochloride, Resmin, Vena, Benzantin hydrochloride, Sekundal-D, Diphenhydramine.HCl, Difenhydramine hydrochloride, 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, Vicks Formula 44, Diphenylhydramine hydrochloride, Caladryl, Benadryl Preservative Free, NCI-C56075, UNII-TC2D6JAD40, SK-Diphenhydramine, Sleep-Eze-3, Diphenhydramine (hydrochloride), Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride, CCRIS 2383, Diphenhydramine HCl (Benadryl), Benadryl hydrochloride, 2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride, EINECS 205-687-2, NSC 33299, Tylenol PM Tablets/Caplets, TC2D6JAD40, 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride, MLS000028428, Tylenol Cold Night Time Liquid, Bayer Select Night Time Pain Relief, beta-Dimethylaminoethyl benzhydryl ether hydrochloride, 2-(benzhydryloxy)-N,N-dimethylethanamine hydrochloride, Benzhydrol, beta-dimethylaminoethyl ether hydrochloride, CPD000058353, SMR000058353, Dimethylamine benzhydryl ester hydrochloride, Benadryl (TN), DSSTox_CID_537, alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride, N-[2-Diphenylmethoxyethyl]-N,N-dimethylamine, DSSTox_RID_75646, DSSTox_GSID_20537, [2-(diphenylmethoxy)ethyl]dimethylamine hydrochloride, Dipjemhist, 2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine hydrochloride, Asdrin, CHEBI:4637, 8052-21-9, SR-01000003069, NCGC00015335-09, 2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride, CAS-147-24-0, Benocten, Benzehist, Daedalon, Hydryllin, Rohydra, Valdrene, Se dopretten, [2-(diphenylmethoxy)ethyl]dimethylamine, chloride, Secundal-D, Benzhydramine HCl, 2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride, Prestwick_177, component of Caladryl, Benadril hydrochloride, Dimedrol-hydrochloride, Diphenhydramine hydrochloride [BAN:JAN], ACMC-209tgi, Opera_ID_152, component of Bena-Fedrin, Diphenhydramine hydrochloride [USP:BAN:JAN], Diphenhydramine hydrochloride preservative free, Diphenydramine hydrochloride, difenhydramine h ydrochloride, CHEMBL1620, REGID_for_CID_8980, SCHEMBL17071, KSC492K5J, MLS000758216, MLS001148114, MLS001423951, MLS002222180, ARONIS25348, SPECTRUM1500256, AC1L1S27, Jsp002743, DTXSID4020537, CTK3J2554, HY-B0303A, EBD1627, Diphenhydramine Hydrochloride,(S), MolPort-000-837-708, PCHPORCSPXIHLZ-UHFFFAOYSA-N, HMS1568M11, HMS1920I06, LS-67, Pharmakon1600-01500256, BCP13546, KS-00000X1C, NSC33299, Tox21_112991, Tox21_201472, Tox21_300611, Tox21_500377, ANW-42448, CCG-39755, Diphenhydramine Hcl Preservative Free, MFCD00012479, NSC-33299, NSC756729, s1866, AKOS005287308, AC-3449, CS-2340, LP00377, MCULE-3867814648, NC00060, NSC-756729, RTX-012323, KS-0000477U, NCGC00024414-05, NCGC00093809-01, NCGC00093809-02, NCGC00093809-03, NCGC00093809-04, NCGC00093809-05, NCGC00254264-01, NCGC00259023-01, NCGC00261062-01, AN-12960, AS-12088, BC205545, Diphenhydramine hydrochloride (JP17/USP), SAM001247024, SC-80236, WLN: 1N1 & 2OYR & R & GH, AB0011241, AB1009368, TL8001037, D0423, EU-0100377, FT-0652576, O-benzhydryldimethylaminoethanol hydrochloride, ST24039533, ST45054142, Diphenhydramine hydrochloride, >=98% (HPLC), C07784, D 3630, D00669, Diphenhydramine hydrochloride, analytical standard, 2-benzhydryloxyethyl-N,N-dimethylammonium chloride, 2-benzhydryloxy-N,N-dimethylethanamine hydrochloride, Q-201003, SR-01000003069-2, 2-benzhydryloxy-N,N-dimethyl-ethanamine hydrochloride, 2-Diphenylmethoxy-N,N-dimethylethanamine hydrochloride, beta-dimethylaminoethyl benzhydryl ether hydroch loride, SR-01000003069-10, .beta.-Dimethylaminoethyl benzhydryl ether hydrochloride, alpha-(2-dimethylaminoethoxy)diphenylmethane hydrochloride, N,N-dimethyl-2-(diphenylmethoxy)ethylamine hydrochloride, 2-(benzhydryloxy)-N,N-dimethylethan-1-amine hydrochloride, 2-(diphenylmethoxy)-N,N-dimethylethanamine h ydrochloride, beta-Dimethylaminoethanol diphenylmethyl ether hydrochloride, Ethylamine,N-dimethyl-2-(diphenylmethoxy)-, hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylaminehydrochloride, Ethanamine, 2-(diphenylmet hoxy)-N,N,dimethyl-, hydrochloride, Ethanamine, 2-(diphenylmethoxy)-N,N,dimethyl-, hydrochloride, Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride, Diphenhydramine Hydrochloride 1.0 mg/ml in Methanol (as free base), Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1), .alpha.-Hydroxydiphenylmethane-.beta.-dimethylaminoethyl ether hydrochloride, alpha-hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochlori de, Diphenhydramine hydrochloride, European Pharmacopoeia (EP) Reference Standard, Diphenhydramine hydrochloride, United States Pharmacopeia (USP) Reference Standard, 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride; N-(2-Diphenylmethoxyethyl)-N,Ndimethylamine hydrochloride, Benzhydramine hydrochloride; 2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride; N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride, Diphenhydramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Diphenhydramine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material, AC1LCWFA, AKOS015914870, Diphenhydramine hydrochloride, 99% 50g, I14-6747, 2-benzhydryloxy-N,N-dimethylethanamine; hydron; chloride, MolPort-000-730-996, SBB057437, AKOS025116949, 2-(diphenylmethoxy)-N,N-dimethylethanaminium chloride