previous compound ID: 1837 next compound
InChIKey: QLKKMNXYROCXRE-BCRILHLVSA-N
SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)O)NC5=C4C=CC(=C5)OC)O.Cl

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"DY Thomas" "D Rotin" "B Kus" "E Matthes" "R Robert" "J Liao" "GW Carlile" "J Goepp" "JW Hanrahan" "SD Macknight"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 1837



CID is 17751039 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/17751039

CID is 17751039
synonyms found at PubChem are:
Reserpic acid hydrochloride, UNII-YK1DUA2LXK, YK1DUA2LXK, Reserpinic acid hydrochloride, 1910-70-9, Reserpic acid, monohydrochloride, NSC-118178, MLS002154083, C22H28N2O5.ClH, CHEMBL1710474, HMS1571E09, SMR001233392, Yohimban-16-carboxylic acid, 18-hydroxy-11,17-dimethoxy-, hydrochloride (1:1), (3beta,16beta,17alpha,18beta,20alpha)-, X6839