previous compound ID: 2249 next compound
InChIKey: UQOQENZZLBSFKO-POPPZSFYSA-N
SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H](C=CC1=O)C/C=C\CCCC(=O)O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"E Matthes" "SD Macknight" "J Liao" "J Goepp" "DY Thomas" "JW Hanrahan" "GW Carlile" "B Kus" "R Robert" "D Rotin"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 2249



CID is 5280884 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/5280884

CID is 5280884
synonyms found at PubChem are:
prostaglandin J2, PGJ2, 9-Deoxy-delta-9-prostaglandin D2, 9-Deoxy-delta-9-pgd2, 60203-57-8, 8-epi-15-J2t-IsoP, CHEBI:27485, UQOQENZZLBSFKO-POPPZSFYSA-N, Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)-, 11-oxo-15S-hydroxy-5Z,9,13E-prostatrienoic acid, (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid, 11-oxo-15S-hydroxy-5Z,9,13E-prostatrienoic acid-cyclo[8S,12R], PGJ2 (Prostaglandin J2), SR-05000002330, AC1NQXQ1, D0Y6OX, BSPBio_001498, BML1-G07, GTPL1885, SCHEMBL5700581, CHEMBL1397260, DTXSID4041105, MolPort-003-959-398, HMS1361K20, HMS1791K20, HMS1989K20, HMS3402K20, HMS3648L18, LMFA03010019, ZINC12496015, AKOS024418774, IDI1_033968, SMP2_000100, NCGC00161294-01, NCGC00161294-02, NCGC00161294-03, LS-176073, C05957, 11-oxo-15S-hydroxy-5Z,8Z,13E-prostatrienoate, 11-oxo-15S-hydroxy-5Z,8Z,13E-prostatrienoic acid, SR-05000002330-2, SR-05000002330-3, BRD-K56811497-001-03-2, (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid, (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-cyclopent-2-en-1-yl]hept-5-enoic acid, (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid