previous compound ID: 2278 next compound
InChIKey: UXEQRVDJXHNPFC-YZWLQPDGSA-N
SMILES: CC(C)/C(=C/1\C2[C@]([C@@H](OC1=O)C3=COC=C3)(C([C@H]([C@@]45[C@]26[C@@H]([C@]7(C(C8(CC7([C@]4([C@H]8CC(=O)OC)C)OC(O5)(O6)C)C)OC(=O)C)OC)OC)OC)OC(=O)C(C)C)C)/OC

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"B Kus" "JW Hanrahan" "D Rotin" "SD Macknight" "E Matthes" "R Robert" "J Goepp" "J Liao" "DY Thomas" "GW Carlile"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 2278



CID is 6857763 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/6857763

CID is 6857763
synonyms found at PubChem are:
CHUKRASIN METHYL ETHER, CHEMBL3039293, Spectrum5_000166, BSPBio_001772, SPECTRUM100615, BDBM50442888, CCG-38641, SDCCGMLS-0066454.P001, NCGC00179018-01, SR-05000002783, SR-05000002783-1