previous compound ID: 2403 next compound
InChIKey: VWTYVHKMUKFWST-UHFFFAOYSA-N
SMILES: CC1=NN(C(=O)C1)C(=S)N

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 32

Galietta LJ et. al. 2001 (paper)
Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.
The Journal of biological chemistry, page 19723-8, volume 276, issue 23, year 2001
"MH Nantz" "EJ Niedzinski" "MJ Kurth" "AS Verkman" "K By" "LJ Galietta" "M Eda" "MJ Haddadin" "MF Springsteel"
DOI: 10.1074/jbc.M101892200
PMID: 11262417


Reference Into Function: Compounds of the 7,8-benzoflavone class, which are structurally intermediate between flavones and benzo[c]quinoliziniums, were effective CFTR activators with the most potent being 2-(4-pyridinium)benzo[h]4H-chromen-4-one bisulfate (UCcf-029). Compounds of the novel structural class of fused pyrazolo heterocycles were also strong CFTR activators with the most potent being 3-(3-butynyl)-5-methoxy-1-phenylpyrazole-4-carbaldehyde (UCcf-180).


chemical graph of compound 2403



CID is 698523 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/698523

CID is 698523
synonyms found at PubChem are:
3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbothioamide, 4,5-dihydro-3-methyl-5-oxopyrazole-1-carbothioamide, 27130-71-8, AC1LF6R8, TimTec1_002882, ARONIS021521, KS-00004CZG, MolPort-001-516-264, HMS1542C22, STK024341, AKOS000488187, ZINC100007276, FCH1196902, ST040649, BB0275820, 3-methyl-5-oxo-4H-pyrazole-1-carbothioamide, 1-(aminothioxomethyl)-3-methyl-2-pyrazolin-5-one, SR-01000493659, SR-01000493659-1, A1037/0048578