previous compound ID: 2681 next compound
InChIKey: YDOTUXAWKBPQJW-NSLWYYNWSA-N
SMILES: CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=CNC7=CC=CC(=C67)C5=C4)C)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"E Matthes" "SD Macknight" "D Rotin" "JW Hanrahan" "DY Thomas" "R Robert" "J Liao" "GW Carlile" "J Goepp" "B Kus"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 2681



CID is 134551 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/134551

CID is 134551
synonyms found at PubChem are:
alpha-Ergocryptine, Ergocryptine, Ergocryptine-alpha, 511-09-1, alpha-Ergokryptine, UNII-6WFB60157B, NSC 169479, Ergokryptine, CHEMBL1403281, CHEBI:10276, YDOTUXAWKBPQJW-NSLWYYNWSA-N, 12'-Hydroxy-5'alpha-isobutyl-2'-isopropylergotaman-3',6',18-trione, 6WFB60157B, EINECS 208-121-2, 12'-hydroxy-2'-(1-methylethyl)-5'alpha-(2-methylpropyl)ergotaman-3',6',18-trione, 12'-hydroxy-5'alpha-(2-methylpropyl)-3',6',18-trioxo-2'-(propan-2-yl)ergotaman, BRN 0078810, alpha ergocryptine, 12'-Hydroxy-2'-(1-methylethyl)-5'-alpha-(2-methylpropyl)ergotaman-3',6',18-trione, Prestwick_1063, Prestwick0_000727, Prestwick1_000727, Prestwick2_000727, Prestwick3_000727, Biomol-NT_000068, D06PXY, AC1L34SL, SCHEMBL78951, BSPBio_000654, GTPL271, MLS002153977, SPBio_002593, BPBio1_000720, BPBio1_001360, HMS1570A16, HMS2097A16, HMS2232C08, Ergotaman-3',6',18-trione, 12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'.alpha.)-, BDBM50390993, ZINC59796557, AKOS024282675, NSC 407319, SMR001233314, ST057581, C07545, C-44227, BRD-K74212935-001-03-1, UNII-2J09Y26C6I component YDOTUXAWKBPQJW-NSLWYYNWSA-N, (5'|A)-12'-Hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione, 12 inverted exclamation marka-Hydroxy-2 inverted exclamation marka-(1-methylethyl)-5 inverted exclamation marka-|A-(2-methylpropyl)ergotaman-3 inverted exclamation marka,6 inverted exclamation marka,18-trione, Ergotaman-3',6',18-trione, 12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'alpha)- (9CI)