previous compound ID: 2818 next compound
InChIKey: ZJRFCXHKYQVNFK-HPUCVXDUSA-M
SMILES: C1C2[C@@H](C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"R Robert" "SD Macknight" "J Liao" "D Rotin" "GW Carlile" "B Kus" "J Goepp" "DY Thomas" "JW Hanrahan" "E Matthes"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 2818



CID is 11957455 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/11957455

CID is 11957455
synonyms found at PubChem are:
8-Bromo-cGMP sodium, HMS3260I22, Tox21_500130, CCG-221434, LP00130, NCGC00260815-01, EU-0100130, 8-Bromoguanosine-3',5'-cyclophosphate sodium, B 1381