previous compound ID: 306 next compound
InChIKey: CABYWQOCCVFNHX-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=C4C=C(C(=O)C(=C4)Br)Br)NO3

biological descriptors:

CFTR relevance: CFTR inhibitor/ potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

ReferenceID: 58


Cui G et. al. 2016 (paper)
Potentiators exert distinct effects on human, murine, and Xenopus CFTR.
American journal of physiology. Lung cellular and molecular physiology, page L192-207, volume 311, issue 2, year 2016
"G Cui" "N Khazanov" "H Senderowitz" "BR Imhoff" "DT Infield" "BB Stauffer" "NA McCarty"
DOI: 10.1152/ajplung.00056.2016
PMID: 27288484


Reference Into Function: VX-770, NPPB, GlyH-101, P1, P2, and P3 all exhibited ortholog-specific behavior in that they potentiated hCFTR, mCFTR, and xCFTR with different efficacies.


chemical graph of compound 306




CID is 44241539 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/44241539

CID is 44241539
synonyms found at PubChem are:
iOWH-032, 1191252-49-9, IOWH032, 3-(3,5-Dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide, UNII-8Y3GDT6YWV, 8Y3GDT6YWV, IOWH 032, C22H15Br2N3O4, SCHEMBL1114552, KS-00000SAW, EX-A327, DSFNLJXHXBIKDS-UHFFFAOYSA-N, MolPort-035-395-840, HMS3653C14, AOB87123, BCP08439, 2156AH, s7329, ZINC68151296, AKOS024259261, AKOS026750509, ZINC145673230, CD-1778, CS-1744, DB12959, NCGC00386303-01, 4CA-0651, AK151417, BC600405, HY-18337, SC-94667, AX8288033, KB-308544, FT-0732295, 3-(3,5-dibromo-4-oxocyclohexa-2,5-dien-1-ylidene)-N-(4-phenoxybenzyl)-2,3-dihydro-1,2,4-oxadiazole-5-carboxamide, 3-[3,5-Dibromo-4-(4-methoxybenzyloxy)phenyl]-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide