previous compound ID: 636 next compound
InChIKey: FSNITHOUQGJHTR-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C(C=C)C2=CC(=O)C(=CC2=O)OC

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53


Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"J Goepp" "SD Macknight" "E Matthes" "R Robert" "D Rotin" "JW Hanrahan" "J Liao" "DY Thomas" "B Kus" "GW Carlile"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 636




CID is 364106 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/364106

CID is 364106
synonyms found at PubChem are:
4,4'-Dimethoxydalbergione, NSC629751, 2-Methoxy-5-(1-(4-methoxyphenyl)-2-propenyl)benzo-1,4-quinone, Spectrum_000021, SpecPlus_000153, AC1Q6BVY, Spectrum2_000597, Spectrum3_000682, Spectrum5_001863, AC1L7O5Y, BSPBio_002403, KBioSS_000381, SPECTRUM201448, DivK1c_006249, SPBio_000474, CHEMBL1436980, CTK7A2184, KBio1_001193, KBio2_000381, KBio2_002949, KBio2_005517, KBio3_001623, CCG-38518, NSC-629751, NCGC00095719-01, NCGC00095719-02, SR-05000002539, SR-05000002539-1, 2-methoxy-5-[1-(4-methoxyphenyl)allyl]-1,4-benzoquinone, 2-methoxy-5-[1-(4-methoxyphenyl)prop-2-enyl]cyclohexa-2,5-diene-1,4-dione