previous compound ID: 962 next compound
InChIKey: INGCLXPSKXSYND-BTJKTKAUSA-N
SMILES: CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)O.C(=C\C(=O)O)\C(=O)O

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53


Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"GW Carlile" "B Kus" "R Robert" "DY Thomas" "JW Hanrahan" "J Liao" "D Rotin" "E Matthes" "SD Macknight" "J Goepp"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 962




CID is 11957480 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/11957480

CID is 11957480
synonyms found at PubChem are:
BRL 54443 maleate, BRL 54443 maleate salt, 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol maleate, 1197333-54-2, EU-0100207, D0S2BB, SCHEMBL4799792, CHEMBL1256797, MolPort-003-940-420, BRL 54443 maleate salt, solid, HMS3260J15, Tox21_500207, BN0117, CCG-221511, LP00207, NCGC00093680-01, NCGC00260892-01, B173, B-173, J-004192, SR-01000075573-1, 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol maleate salt