previous compound ID: 980 next compound
InChIKey: IPMRJRMWTMGXAM-UHFFFAOYSA-N
SMILES: CCOC(=O)C(=O)C1(C(C(=O)C2=C(C=C(C=C2O1)OC)OC)C3=CC=CC=C3)C(=O)OCC

biological descriptors:

CFTR relevance: unspecified

Category:
Influence on CFTR function unknown
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53

Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"D Rotin" "DY Thomas" "JW Hanrahan" "R Robert" "B Kus" "J Goepp" "J Liao" "GW Carlile" "SD Macknight" "E Matthes"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.


chemical graph of compound 980



CID is 6708763 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/6708763

CID is 6708763
synonyms found at PubChem are:
2-ETHOXYCARBONYL-2-ETHOXYOXALOYLOXYDIHYDROCHRYSIN DIMETHYL ETHER, KBio2_003581, Spectrum_000533, SpecPlus_000751, AC1O8FNK, Spectrum2_001932, Spectrum3_000706, Spectrum4_001491, Spectrum5_000221, BSPBio_002491, KBioGR_002121, KBioSS_001013, SPECTRUM200141, DivK1c_006847, SPBio_001963, CHEMBL1414316, KBio1_001791, KBio2_001013, KBio2_006149, KBio3_001711, CCG-39433, NCGC00095815-01, NCGC00095815-02, ethyl 2-(2-ethoxy-2-oxoacetyl)-5,7-dimethoxy-4-oxo-3-phenyl-3H-chromene-2-carboxylate