Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=23ID: 20 InChIKey: UFSKUSARDNFIRC-UHFFFAOYSA-NSMILES: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
biological descriptors:
CFTR relevance: CFTR corrector
Category: Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155526648 synonyms found at PubChem are:
CHEMBL4458933, BDBM50506078
ID: 3095 InChIKey: NTZREEWWCNFIMJ-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NC(=O)CC)SC=2))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155561108 synonyms found at PubChem are:
CHEMBL4566690, BDBM50506071
ID: 3079 InChIKey: CCUBJOCYQZTYNE-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=3(N=C(N(C2(CCCCC2))CCO)SC=3))C)NC(=O)C(C)(C)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155553069 synonyms found at PubChem are:
CHEMBL4544312, BDBM50506065
ID: 3089 InChIKey: KHNUPLUQJFLSLN-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=3(N=C(N(C2(=CC(C(=O)C)=CC=C2))CCO)SC=3))C)NC(=O)C(C)(C)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155560887 synonyms found at PubChem are:
CHEMBL4574818, BDBM50506073
ID: 3099 InChIKey: PGPPITSUVBAOTE-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NCCO)SC=2))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 11220250 synonyms found at PubChem are:
CHEMBL4556068, SCHEMBL4528106, BDBM50506069, N-[5-[2-(2-hydroxyethylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
ID: 3102 InChIKey: QJYUHPGRNQQGGG-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=3(N=C(NC2(CCCCC2))SC=3))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 11348293 synonyms found at PubChem are:
CHEMBL4465048, SCHEMBL4523451, BDBM50506074, N-[5-[2-(cyclohexylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
ID: 3108 InChIKey: XTWGHYUHSFTZLL-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=3(N=C(N(C2(CCCCC2))CCO)SC=3))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155511230 synonyms found at PubChem are:
CHEMBL4435663, BDBM50506063
ID: 3092 InChIKey: MJUVRTYWUMPBTR-UHFFFAOYSA-NSMILES: CC(C)(CO)C1=CC2=CC(=C(C=C2N1CC(CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 46199801 synonyms found at PubChem are:
Tezacaftor (Racemate), SCHEMBL322363, HMS3652D20, HMS3748O05, AKOS026750399, NCGC00389346-01, 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxaMide, 1226709-85-8, DA-47741, CS-0009162, FT-0772351, 1-(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)-N-[1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)INDOL-5-YL]CYCLOPROPANE-1-CARBOXAMIDE
ID: 3113 InChIKey: ZACBDYXCOJIDOO-UHFFFAOYSA-NSMILES: S(=O)(=O)(NC=1(SC=C(N=1)C=2(SC(NC(=O)C)=NC=2C)))C=C
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155567860 synonyms found at PubChem are:
CHEMBL4589961
ID: 3088 InChIKey: JWENNUJIMLMAJH-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NC(=O)C=C)SC=2))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155528709 synonyms found at PubChem are:
CHEMBL4461468, BDBM50506070
ID: 3106 InChIKey: WWUPCEYMTCIFHX-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NCCO)SC=2))C)NC(=O)OC(C)(C)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155518122 synonyms found at PubChem are:
CHEMBL4445768, BDBM50506064
ID: 3112 InChIKey: ZAAVGWLFVJKADF-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=3(N=C(N(C2(=CC(C(=O)C)=CC=C2))CCO)SC=3))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155546020 synonyms found at PubChem are:
CHEMBL4531023, BDBM50506062
ID: 3078 InChIKey: BHNLPHFGIMIKBX-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NC(=O)C=CC(C)C)SC=2))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155565175 synonyms found at PubChem are:
CHEMBL4580215, BDBM50506060
ID: 3103 InChIKey: VMMNKJYKNQCTSD-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=3(N=C(NC2(CCC(C)CC2))SC=3))C)NC(=O)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155545735 synonyms found at PubChem are:
CHEMBL4529879, BDBM50506068
ID: 3080 InChIKey: DBGTUHVUTOSJOJ-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=3(N=C(NC2(=CC(C(=O)O)=CC=C2))SC=3))C)NC(=O)C(C)(C)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155535344 synonyms found at PubChem are:
CHEMBL4471507, BDBM50506077
ID: 3114 InChIKey: ZEQRQXRPMGQNBI-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NCCO)SC=2))C)NC(=O)C3(=CC=CC=C3))
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155519200 synonyms found at PubChem are:
CHEMBL4447091, BDBM50506076
ID: 3104 InChIKey: VXNBNOYDTNSYQP-UHFFFAOYSA-NSMILES: [Br]CC(=O)NC=1(SC=C(N=1)C=2(SC(NC(=O)C)=NC=2C))
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155567806 synonyms found at PubChem are:
CHEMBL4590346, BDBM50506072
ID: 3107 InChIKey: XGZWWMRJMWUREF-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NCCC(=O)O)SC=2))C)NC(=O)C(C)(C)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155561063 synonyms found at PubChem are:
CHEMBL4574879, BDBM50506075
ID: 3100 InChIKey: PPTPXEJJDHXBKP-UHFFFAOYSA-NSMILES: S1(C(=NC(=C1C=2(N=C(NCC(=O)O)SC=2))C)NC(=O)C(C)(C)C)
biological descriptors:
CFTR relevance: to be classified
Category: Influence on CFTR function to be classified
Order of interaction to be classified
subcellular compartment to be classified
CID is 155521426 synonyms found at PubChem are:
CHEMBL4450239, BDBM50506066
ID: 7 InChIKey: PURKAOJPTOLRMP-UHFFFAOYSA-NSMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
biological descriptors:
CFTR relevance: CFTR stimulator
Category: Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment