previous compound ID: 7 next compound
InChIKey: PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

biological descriptors:

CFTR relevance: CFTR stimulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

ReferenceID: 95
"JM Pilewski" "JC Davies" "SH Donaldson" "M Griese" "E Tullis" "JA Lekstrom-Himes" "Group. VX11-661-101 Study" "L Viswanathan" "LT Wang" "J Cooke"
ReferenceID: 94
"D Grenet" "P Bonnette" "IM Pranke" "I Sermet-Gaudelus" "JP Jais" "M Mesbahi" "F Le Pimpec-Barthes" "A Hinzpeter" "N Stremler-Le Bel" "A Carsin" "A Edelman" "A Hatton" "M Thumerel" "V Urbach" "J Mazenq" "M Fayon" "E Girodon-Boulandet" "J Simonin"
ReferenceID: 35
"Y Sohma" "WY Lin" "TC Hwang"
ReferenceID: 112
"SB Donnola" "B Kaminski" "TJ Sferra" "K Kutney" "CA Flask" "R Gubitosi-Klug" "K McBennett" "M O'Riordan"
ReferenceID: 100
"P Jordan" "AM Matos" "CA Loureiro" "FR Pinto" "P Matos" "JD Santos" "CM Farinha"
ReferenceID: 110
"HGM Arets" "AC de Kiviet" "S Michel" "HGM Heijerman" "RW Hofland" "CK van der Ent" "KM de Winter-de Groot" "MMM van Oirschot-van de Ven" "MA Kruijswijk" "S Schotman" "BL Aalbers"
ReferenceID: 97
"JC Davies" "S Cunningham" "S Tian" "group. ARRIVAL study" "CE Wainwright" "D Campbell" "J Schneider" "M Rosenfeld" "LT Wang" "M Higgins" "C McKee"
ReferenceID: 111
"I Loukou" "AG Kaditis" "A Petrocheilou"
ReferenceID: 108
"F Ravanetti" "C Giorgio" "S Palese" "P Vergani" "C Mirabelli" "C Zamperini" "L Delang" "M Kissova" "G Maga" "A Mancini" "E Langron" "S Bertoni" "M Radi" "K Lanko" "J Neyts" "L Ragionieri" "G Fontò" "S Tassini" "E Crespan" "G Tagliavini" "E Dreassi"
ReferenceID: 59
"JF Dekkers" "CK van der Ent" "KM de Winter-de Groot" "E Kruisselbrink" "AM Vonk" "P Van Mourik" "G Berkers" "I Bronsveld" "JM Beekman" "HR de Jonge" "HM Janssens"
ReferenceID: 58
"H Senderowitz" "BR Imhoff" "G Cui" "DT Infield" "N Khazanov" "NA McCarty" "BB Stauffer"
ReferenceID: 67
"E Matthes" "R Robert" "Y Luo" "GW Carlile" "DY Thomas" "K Dejgaard" "J Goepp" "JW Hanrahan" "A Billet"
ReferenceID: 113
"AT Claudio" "S Carson" "K Montemayor" "NE West" "N Lechtzin" "MS Christianson"
ReferenceID: 46
"EJ Sorscher" "A Rab" "KL Kirk" "JS Hong" "W Wang"
ReferenceID: 91
"RA Frizzell" "M Ashlock" "M Miller" "PA Negulescu" "S Hadida" "J McCartney" "JJ Wine" "F Van Goor" "ER Olson" "KS Straley" "PD Grootenhuis" "JH Stack" "CJ Decker" "B Burton"
ReferenceID: 101
"M Piacentini" "A Tosco" "VR Villella" "V Raia" "L Maiuri" "G Kroemer"
ReferenceID: 96
"EP Ingenito" "A Munck" "JL Taylor-Cousar" "CK van der Ent" "A Moeller" "J Lekstrom-Himes" "Y Lu" "C Simard" "JS Elborn" "EF McKone" "LT Wang" "C McKee"
ReferenceID: 107
"C Coraux" "L Froux" "F Becq" "E Sage"
ReferenceID: 98
"Y Sohma" "HI Yeh" "X Zou" "L Qiu" "K Conrath" "TC Hwang"
ReferenceID: 99
"BW Ramsey" "J Savage" "JL Taylor-Cousar" "E Tullis" "SM Rowe" "F Xuan" "CM McKee" "SM Moskowitz" "G Marigowda" "EF McKone" "MA Mall" "D Waltz"
ReferenceID: 106
"BR Imhoff" "G Cui" "NA McCarty" "EJ Sorscher" "A Rab" "JS Hong" "BB Stauffer"

chemical graph of compound 7





CID is 16220172
synonyms found at PubChem are:
Ivacaftor, 873054-44-5, VX-770, Kalydeco, Ivacaftor (VX-770), N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, VX 770, VX770, UNII-1Y740ILL1Z, Kalydeco (TN), CHEBI:66901, N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide, 1Y740ILL1Z, 3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-, Ivacaftor [USAN:INN], ivacaftorum, 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-, Ivacaftor D18, Tube715, Ivacaftor (USAN/INN), VX-770 - Ivacaftor, D0W7WC, MLS006011119, SCHEMBL351373, GTPL4342, QUI135, VX-770, Ivacaftor, Kalydeco, CHEMBL2010601, DTXSID00236281, EX-A441, QCR-155, MolPort-009-194-229, PURKAOJPTOLRMP-UHFFFAOYSA-N, BCPP000199, HMS3654E10, AOB31714, ABP000259, BDBM50032693, s1144, VX-770/VX770, ZINC52509463, AKOS015994762, AKOS032950001, BCP9000799, CS-0497, DB08820, EX-7211, LE-0002, KS-0000063W, NCGC00242480-01, 4CA-0661, AC-28324, AN-16981, BC660099, HY-13017, KB-81476, SC-95534, SMR004702900, AB0008116, AB2000007, FT-0696681, X7565, A25626, D09916, W-5681, AB01565806_02, VX770, VX 770, Ivacaftor, 873054-44-5, N-(2,4-ditert-butyl-5-hydroxy-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, 1134822-00-6, 1174930-71-2, 1413431-05-6, Kalydeco|||N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide