previous compound ID: 7 next compound
InChIKey: PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

biological descriptors:

CFTR relevance: CFTR stimulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

ReferenceID: 96
"J Lekstrom-Himes" "C Simard" "JL Taylor-Cousar" "LT Wang" "EP Ingenito" "Y Lu" "A Moeller" "C McKee" "EF McKone" "A Munck" "JS Elborn" "CK van der Ent"
ReferenceID: 67
"GW Carlile" "R Robert" "A Billet" "JW Hanrahan" "K Dejgaard" "J Goepp" "E Matthes" "Y Luo" "DY Thomas"
ReferenceID: 97
"JC Davies" "D Campbell" "S Tian" "LT Wang" "M Higgins" "C McKee" "S Cunningham" "group. ARRIVAL study" "J Schneider" "M Rosenfeld" "CE Wainwright"
ReferenceID: 112
"CA Flask" "R Gubitosi-Klug" "K McBennett" "SB Donnola" "TJ Sferra" "M O'Riordan" "B Kaminski" "K Kutney"
ReferenceID: 100
"P Jordan" "P Matos" "FR Pinto" "AM Matos" "JD Santos" "CM Farinha" "CA Loureiro"
ReferenceID: 95
"JC Davies" "SH Donaldson" "JA Lekstrom-Himes" "LT Wang" "Group. VX11-661-101 Study" "J Cooke" "M Griese" "L Viswanathan" "JM Pilewski" "E Tullis"
ReferenceID: 58
"NA McCarty" "G Cui" "H Senderowitz" "DT Infield" "N Khazanov" "BB Stauffer" "BR Imhoff"
ReferenceID: 35
"TC Hwang" "Y Sohma" "WY Lin"
ReferenceID: 59
"P Van Mourik" "HM Janssens" "E Kruisselbrink" "AM Vonk" "JM Beekman" "I Bronsveld" "JF Dekkers" "KM de Winter-de Groot" "G Berkers" "CK van der Ent" "HR de Jonge"
ReferenceID: 108
"G Tagliavini" "C Giorgio" "C Mirabelli" "P Vergani" "S Bertoni" "E Langron" "K Lanko" "J Neyts" "S Tassini" "L Ragionieri" "C Zamperini" "E Crespan" "E Dreassi" "A Mancini" "F Ravanetti" "L Delang" "M Radi" "S Palese" "G Fontò" "M Kissova" "G Maga"
ReferenceID: 98
"X Zou" "HI Yeh" "TC Hwang" "L Qiu" "Y Sohma" "K Conrath"
ReferenceID: 106
"NA McCarty" "JS Hong" "EJ Sorscher" "G Cui" "BB Stauffer" "BR Imhoff" "A Rab"
ReferenceID: 99
"JL Taylor-Cousar" "G Marigowda" "F Xuan" "BW Ramsey" "SM Rowe" "SM Moskowitz" "MA Mall" "J Savage" "EF McKone" "D Waltz" "CM McKee" "E Tullis"
ReferenceID: 101
"M Piacentini" "VR Villella" "V Raia" "G Kroemer" "L Maiuri" "A Tosco"
ReferenceID: 113
"K Montemayor" "S Carson" "N Lechtzin" "MS Christianson" "NE West" "AT Claudio"
ReferenceID: 107
"E Sage" "F Becq" "C Coraux" "L Froux"
ReferenceID: 111
"A Petrocheilou" "AG Kaditis" "I Loukou"
ReferenceID: 94
"M Mesbahi" "IM Pranke" "J Simonin" "A Carsin" "A Hatton" "J Mazenq" "D Grenet" "F Le Pimpec-Barthes" "A Edelman" "M Fayon" "I Sermet-Gaudelus" "A Hinzpeter" "N Stremler-Le Bel" "M Thumerel" "E Girodon-Boulandet" "V Urbach" "P Bonnette" "JP Jais"
ReferenceID: 110
"RW Hofland" "BL Aalbers" "MMM van Oirschot-van de Ven" "AC de Kiviet" "S Michel" "HGM Arets" "KM de Winter-de Groot" "HGM Heijerman" "S Schotman" "CK van der Ent" "MA Kruijswijk"
ReferenceID: 91
"S Hadida" "J McCartney" "PA Negulescu" "JJ Wine" "JH Stack" "M Ashlock" "KS Straley" "M Miller" "F Van Goor" "B Burton" "RA Frizzell" "ER Olson" "PD Grootenhuis" "CJ Decker"
ReferenceID: 46
"JS Hong" "EJ Sorscher" "KL Kirk" "W Wang" "A Rab"

chemical graph of compound 7





CID is 16220172
synonyms found at PubChem are:
Ivacaftor, 873054-44-5, VX-770, Kalydeco, Ivacaftor (VX-770), N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, VX 770, VX770, UNII-1Y740ILL1Z, Kalydeco (TN), CHEBI:66901, N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide, 1Y740ILL1Z, 3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-, Ivacaftor [USAN:INN], ivacaftorum, 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-, Ivacaftor D18, Tube715, Ivacaftor (USAN/INN), VX-770 - Ivacaftor, D0W7WC, MLS006011119, SCHEMBL351373, GTPL4342, QUI135, VX-770, Ivacaftor, Kalydeco, CHEMBL2010601, DTXSID00236281, EX-A441, QCR-155, MolPort-009-194-229, PURKAOJPTOLRMP-UHFFFAOYSA-N, BCPP000199, HMS3654E10, AOB31714, ABP000259, BDBM50032693, s1144, VX-770/VX770, ZINC52509463, AKOS015994762, AKOS032950001, BCP9000799, CS-0497, DB08820, EX-7211, LE-0002, KS-0000063W, NCGC00242480-01, 4CA-0661, AC-28324, AN-16981, BC660099, HY-13017, KB-81476, SC-95534, SMR004702900, AB0008116, AB2000007, FT-0696681, X7565, A25626, D09916, W-5681, AB01565806_02, VX770, VX 770, Ivacaftor, 873054-44-5, N-(2,4-ditert-butyl-5-hydroxy-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, 1134822-00-6, 1174930-71-2, 1413431-05-6, Kalydeco|||N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide