previous compound ID: 7 next compound
InChIKey: PURKAOJPTOLRMP-UHFFFAOYSA-N
SMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

biological descriptors:

CFTR relevance: CFTR stimulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

reference list:

ReferenceID: 113
"MS Christianson" "AT Claudio" "K Montemayor" "S Carson" "NE West" "N Lechtzin"
ReferenceID: 110
"S Michel" "MA Kruijswijk" "MMM van Oirschot-van de Ven" "RW Hofland" "AC de Kiviet" "HGM Arets" "BL Aalbers" "KM de Winter-de Groot" "S Schotman" "HGM Heijerman" "CK van der Ent"
ReferenceID: 96
"A Munck" "A Moeller" "C Simard" "LT Wang" "JS Elborn" "EP Ingenito" "C McKee" "JL Taylor-Cousar" "CK van der Ent" "J Lekstrom-Himes" "EF McKone" "Y Lu"
ReferenceID: 98
"K Conrath" "Y Sohma" "TC Hwang" "L Qiu" "HI Yeh" "X Zou"
ReferenceID: 58
"BB Stauffer" "H Senderowitz" "DT Infield" "N Khazanov" "G Cui" "BR Imhoff" "NA McCarty"
ReferenceID: 91
"PA Negulescu" "PD Grootenhuis" "M Miller" "S Hadida" "J McCartney" "M Ashlock" "B Burton" "F Van Goor" "KS Straley" "JJ Wine" "ER Olson" "RA Frizzell" "CJ Decker" "JH Stack"
ReferenceID: 46
"KL Kirk" "JS Hong" "A Rab" "EJ Sorscher" "W Wang"
ReferenceID: 59
"P Van Mourik" "JM Beekman" "I Bronsveld" "HM Janssens" "HR de Jonge" "E Kruisselbrink" "JF Dekkers" "KM de Winter-de Groot" "AM Vonk" "G Berkers" "CK van der Ent"
ReferenceID: 35
"WY Lin" "Y Sohma" "TC Hwang"
ReferenceID: 99
"D Waltz" "MA Mall" "J Savage" "E Tullis" "SM Rowe" "SM Moskowitz" "CM McKee" "JL Taylor-Cousar" "G Marigowda" "EF McKone" "BW Ramsey" "F Xuan"
ReferenceID: 112
"SB Donnola" "K Kutney" "M O'Riordan" "CA Flask" "TJ Sferra" "R Gubitosi-Klug" "K McBennett" "B Kaminski"
ReferenceID: 111
"A Petrocheilou" "AG Kaditis" "I Loukou"
ReferenceID: 106
"BB Stauffer" "JS Hong" "A Rab" "G Cui" "BR Imhoff" "EJ Sorscher" "NA McCarty"
ReferenceID: 94
"V Urbach" "P Bonnette" "IM Pranke" "M Fayon" "JP Jais" "A Hatton" "J Simonin" "A Edelman" "M Mesbahi" "I Sermet-Gaudelus" "A Hinzpeter" "N Stremler-Le Bel" "E Girodon-Boulandet" "A Carsin" "J Mazenq" "F Le Pimpec-Barthes" "M Thumerel" "D Grenet"
ReferenceID: 100
"CM Farinha" "P Jordan" "P Matos" "AM Matos" "CA Loureiro" "JD Santos" "FR Pinto"
ReferenceID: 95
"JM Pilewski" "LT Wang" "SH Donaldson" "JC Davies" "JA Lekstrom-Himes" "L Viswanathan" "M Griese" "E Tullis" "J Cooke" "Group. VX11-661-101 Study"
ReferenceID: 108
"P Vergani" "C Mirabelli" "S Bertoni" "A Mancini" "S Palese" "L Delang" "G Fontò" "G Tagliavini" "C Zamperini" "E Crespan" "F Ravanetti" "G Maga" "E Dreassi" "L Ragionieri" "E Langron" "K Lanko" "M Radi" "S Tassini" "M Kissova" "C Giorgio" "J Neyts"
ReferenceID: 107
"C Coraux" "E Sage" "L Froux" "F Becq"
ReferenceID: 101
"L Maiuri" "VR Villella" "M Piacentini" "V Raia" "A Tosco" "G Kroemer"
ReferenceID: 97
"J Schneider" "M Rosenfeld" "LT Wang" "group. ARRIVAL study" "D Campbell" "CE Wainwright" "JC Davies" "M Higgins" "S Cunningham" "S Tian" "C McKee"
ReferenceID: 67
"JW Hanrahan" "E Matthes" "R Robert" "A Billet" "K Dejgaard" "Y Luo" "DY Thomas" "J Goepp" "GW Carlile"

chemical graph of compound 7





CID is 16220172
synonyms found at PubChem are:
Ivacaftor, 873054-44-5, VX-770, Kalydeco, Ivacaftor (VX-770), N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, VX 770, VX770, UNII-1Y740ILL1Z, Kalydeco (TN), CHEBI:66901, N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide, 1Y740ILL1Z, 3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-, Ivacaftor [USAN:INN], ivacaftorum, 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-, Ivacaftor D18, Tube715, Ivacaftor (USAN/INN), VX-770 - Ivacaftor, D0W7WC, MLS006011119, SCHEMBL351373, GTPL4342, QUI135, VX-770, Ivacaftor, Kalydeco, CHEMBL2010601, DTXSID00236281, EX-A441, QCR-155, MolPort-009-194-229, PURKAOJPTOLRMP-UHFFFAOYSA-N, BCPP000199, HMS3654E10, AOB31714, ABP000259, BDBM50032693, s1144, VX-770/VX770, ZINC52509463, AKOS015994762, AKOS032950001, BCP9000799, CS-0497, DB08820, EX-7211, LE-0002, KS-0000063W, NCGC00242480-01, 4CA-0661, AC-28324, AN-16981, BC660099, HY-13017, KB-81476, SC-95534, SMR004702900, AB0008116, AB2000007, FT-0696681, X7565, A25626, D09916, W-5681, AB01565806_02, VX770, VX 770, Ivacaftor, 873054-44-5, N-(2,4-ditert-butyl-5-hydroxy-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, 1134822-00-6, 1174930-71-2, 1413431-05-6, Kalydeco|||N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide