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CandActCFTR used public reference

The following publication reference has been reported to contain CFTR related structural information.
"W Namkung" "P Khloya" "DK Jeon" "S Jo" "S Kumar" "HK Lee" "Y Seo" "PK Sharma" "J Park"


Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=18

ID: 2874
InChIKey: ACMPJJXJGXDZQQ-UHFFFAOYSA-N
SMILES: C1=CC=C(OC)C(OC)=C1C1CC(C2=C(O)C=CC(Cl)=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 2874




ID: 2892
InChIKey: CJFNUDMDMGMQSU-UHFFFAOYSA-N
SMILES: C1=CC=C(OC)C(OC)=C1C1CC(C2=C(O)C(O)=CC=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: strong CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 2892




ID: 2933
InChIKey: IOEFAGPRYUOIGM-UHFFFAOYSA-N
SMILES: C1=CC(OC)=C(OC)C=C1C1CC(C2=C(O)C=CC(C)=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2933




ID: 2922
InChIKey: GYKFXFYRHJPFGH-UHFFFAOYSA-N
SMILES: C1=CC(OC)=C(OC)C=C1C1CC(C2=C(O)C=CC(Cl)=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2922




ID: 2968
InChIKey: MGASRLPRYQFEOV-UHFFFAOYSA-N
SMILES: C1=CC(OC)=C(OC)C=C1C1CC(C2=C(O)C=CC=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 2968




ID: 2979
InChIKey: NTGHLTJGUCFIPS-UHFFFAOYSA-N
SMILES: C1=CC(OC)=CC(OC)=C1C1CC(C2=C(O)C=CC(C)=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2979




ID: 3065
InChIKey: YWPPDWBQKYEYCU-UHFFFAOYSA-N
SMILES: C1=CC=C(OC)C(OC)=C1C1CC(C2=C(O)C=CC=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 3065




ID: 2935
InChIKey: ISSNGBUFJXTJKY-UHFFFAOYSA-N
SMILES: C1=CC(OC)=CC(OC)=C1C1CC(C2=C(O)C=CC=C2O)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 2935




ID: 2960
InChIKey: LJBFRHUDVJSADK-UHFFFAOYSA-N
SMILES: C1=CC(OC)=C(OC)C=C1C1CC(C2=C(O)C(O)=CC=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: strong CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 2960




ID: 2882
InChIKey: BFBZAASQFWNNIU-UHFFFAOYSA-N
SMILES: C1=CC(OC)=CC(OC)=C1C1CC(C2=C(O)C=CC=C2OC)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2882




ID: 3010
InChIKey: RTBMADYWNFZUHP-UHFFFAOYSA-N
SMILES: C1=CC=C(OC)C(OC)=C1C1CC(C2=C(O)C=CC=C2OC)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 3010




ID: 3018
InChIKey: SPJAGELQBZMCPJ-UHFFFAOYSA-N
SMILES: C1=CC(OC)=C(OC)C=C1C1CC(C2=C(O)C=CC=C2O)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 3018




ID: 3057
InChIKey: XGJKADGASPPCCX-UHFFFAOYSA-N
SMILES: C1=CC(OC)=CC(OC)=C1C1CC(C2=C(O)C=CC=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 3057




ID: 2916
InChIKey: GALYZWCGYCEXNA-UHFFFAOYSA-N
SMILES: C1=CC(OC)=CC(OC)=C1C1CC(C2=C(O)C(O)=CC=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: strong CFTR potentiator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 2916




ID: 3060
InChIKey: XOQDICYZWFFYGC-UHFFFAOYSA-N
SMILES: C1=CC=C(OC)C(OC)=C1C1CC(C2=C(O)C=CC(C)=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 3060




ID: 3025
InChIKey: UNOWBPZMWCFSSM-UHFFFAOYSA-N
SMILES: C1=CC(OC)=C(OC)C=C1C1CC(C2=C(O)C=CC=C2OC)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 3025




ID: 3053
InChIKey: WVGUWJOVXKGXTK-UHFFFAOYSA-N
SMILES: C1=CC=C(OC)C(OC)=C1C1CC(C2=C(O)C=CC=C2O)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 3053




ID: 2978
InChIKey: NRWHTHBUNDPHEF-UHFFFAOYSA-N
SMILES: C1=CC(OC)=CC(OC)=C1C1CC(C2=C(O)C=CC(Cl)=C2)=NN1C1=CC=C(S(N)(=O)=O)C=C1

biological descriptors:

CFTR relevance: inactive

Category:
Influence on CFTR function none
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2978