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CandActCFTR used public reference

The following publication reference has been reported to contain CFTR related structural information.
"JR_3rd Yates" "JM Gottesfeld" "A Schmidt" "AP Rodrigues" "D Herman" "WE Balch" "WR Skach" "JR Riordan" "J Matteson" "T Okiyoneda" "DM Hutt" "JW Kelly" "RA Frizzell" "M Gentzsch" "Y Matsumura" "PJ Thomas" "W Kellner" "G Manning" "GL Lukacs" "B Hoch" "JM Pilewski" "S Noel" "EJ Sorscher"


Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=4
ID: 21
InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

biological descriptors:

CFTR relevance: CFTR proteostasis regulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

chemical graph of compound 21



CID is 5311
synonyms found at PubChem are:
Vorinostat, 149647-78-9, SAHA, suberoylanilide hydroxamic acid, Zolinza, N-hydroxy-N'-phenyloctanediamide, Suberanilohydroxamic acid, N1-hydroxy-N8-phenyloctanediamide, SAHA cpd, MK-0683, MK0683, Vorinostat [USAN], Octanediamide, N-hydroxy-N'-phenyl-, CCRIS 8456, Vorinostat (SAHA, MK0683), N-Hyrdroxy-N'-phenyloctanediamide, Vorinostat MSD, UNII-58IFB293JI, Zolinza (TN), OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, SHH, N'-hydroxy-N-phenyloctanediamide, CHEMBL98, Vorinostat (JAN/USAN), 58IFB293JI, SKI390, CHEBI:45716, WAEXFXRVDQXREF-UHFFFAOYSA-N, WIN64652, NSC701852, SAHA, Suberoylanilide hydroxamic acid, NSC-701852, NCGC00168085-01, NCGC00168085-02, SW-064652, 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide, Zolinza (TN) (Merck), DSSTox_CID_21133, DSSTox_RID_79632, DSSTox_GSID_41133, N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide, SMR000486344, NHNPODA, CAS-149647-78-9, SR-05000000373, Vorinostat [USAN:INN], vorinostatum, HSDB 7930, 4lxz, N-Hydroxy-N'-phenyl octanediamide, Zolinza; SAHA, Vorinostat (SAHA), Vorinostat - SAHA, MK 0683, 1zz1, Merck brand of Vorinostat, cc-95, D0E7PQ, AC1L1K2K, cid_5311, SCHEMBL9018, Vorinostat (HDAC inhibitor), Suberoylanilidehydroxamic Acid, MLS001065855, MLS006011941, GTPL6852, Zolinza, MK-0683, SAHA, DTXSID6041133, BDBM19149, CTK8B4125, AOB6083, n-hydroxy-n'-phenyl-octanediamide, QCR-121, SUBERANILOHYDROXAMINIC ACID, SYN3006, 1t69, MolPort-003-850-293, N-hydroxy-N''-phenyloctanediamide, BCPP000018, HMS2219L20, HMS3264D20, HMS3327C12, HMS3650D09, HMS3654G11, HMS3715E22, Pharmakon1600-01502267, BCP01858, KS-00000H3B, N1-hydroxy-N8-phenyl-octanediamide, SAHA, >=98% (HPLC), Vorinostat,SAHA,Zolinza,MK-0683, ZINC1543873, Tox21_112605, Tox21_113623, Vorinostat,CAS:149647-78-9, ANW-43951, MFCD00945317, NSC748799, NSC759852, Octanediamide, N1-hydroxy-N8-phenyl, s1047, SK1390, AKOS015966648, Octanediamide, N1-hydroxy-N8-phenyl-, Tox21_112605_1, AC-1923, AN-5256, CCG-208659, CS-0589, DB02546, DG-0025, MCULE-4234367506, NSC-748799, NSC-759852, RP29421, Suberoylanilide hydroxamic acid (SAHA), NCGC00168085-03, NCGC00168085-04, NCGC00168085-05, NCGC00168085-13, BC677687, BP-30216, HY-10221, KB-60639, SC-20040, AB0009911, LS-186548, LS-186997, LS-187780, RT-015807, AM20030018, FT-0082592, FT-0650593, D06320, K-4759, AB00375377-07, AB00375377-08, AB00375377-09, AB01644613_25, 647S789, P111011, Vorinostat, SAHA, suberoylanilide hydroxamic acid, SR-05000000373-2, SR-05000000373-6, SR-05000000373-8, W-201327, BRD-K81418486-001-01-2, BRD-K81418486-001-10-3, BRD-K81418486-001-12-9, BRD-K81418486-001-13-7, BRD-K81418486-001-17-8, BRD-K81418486-001-18-6, Z1541632802
ID: 2932
InChIKey: INVTYAOGFAGBOE-UHFFFAOYSA-N
SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2932



CID is 4261
synonyms found at PubChem are:
Entinostat, ms-275, 209783-80-2, SNDX-275, MS 275, MS-27-275, SNDX 275, MS 27-275, Histone Deacetylase Inhibitor I, Entinostat (USAN/INN), Entinostat (MS-275), UNII-1ZNY4FKK9H, 1ZNY4FKK9H, CHEMBL27759, pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate, pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate, INVTYAOGFAGBOE-UHFFFAOYSA-N, MS275, N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide, pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate, Entinostat (MS-275,SNDX-275), IN1470, NSC706995, BAY86-5274, NSC-706995, BAY 86-5274, pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate, pyridin-3-ylmethyl{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate, 3-Pyridinylmethyl ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)carbamate, Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3-pyridinylmethyl ester, W-201831, 3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide, pyridin-3-ylmethyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate, Carbamic acid, [[4-[[(2-aminophenyl)carbaonyl]phenyl]methyl]-, 3-pyridinylmethyl ester, N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester, 442532-99-2, entinostatum, pyridin-3-ylmethyl (4-((2-aminophenyl)carbamoyl)benzyl)carbamate, N-(2-aminophenyl)-4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzamide, 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, PubChem24433, AC1L1HRM, AC1Q5NOI, Entinostat [USAN:INN], MS-275 (Entinostat), MS-275 - Entinostat, D0M8FD, benzamide-type inhibitor, 3, MLS006010183, SCHEMBL148309, GTPL7007, DTXSID0041068, BDBM19410, CTK8F0220, AOB2570, EX-A038, SYN3039, CHEBI:132082, MolPort-005-942-713, BCPP000155, HMS3648K12, HMS3654O11, ACT06782, BCP01824, MS-275,Entinostat,SNDX-275/, ZINC1488870, ABP000145, BN0881, GP3697, s1053, AKOS024262667, AC-8968, AN-1299, BCP9000967, Carbamic acid, 3-pyridinylmethyl ester, CCG-208680, CS-0511, DB11841, Entinostat (MS-275, SNDX-275), RL02591, KS-0000063I, NCGC00165833-01, NCGC00165833-02, NCGC00165833-03, NCGC00165833-04, NCGC00165833-13, AJ-26331, AK158952, AS-17906, BC654076, HY-12163, KB-55107, MS27-275, NCI60_038022, SMR004458705, MS-275, A HDAC1 and HDAC3 inhibitor, AB0021206, AX8140473, KB-302728, LS-185285, RT-013958, ST2406823, FT-0667871, V2451, D09338, W-5370, 48247-EP2298768A1, 48247-EP2305643A1, 48247-EP2308868A1, 48247-EP2311494A1, 48247-EP2311840A1, 783M802, A815057, MS-275,Entinostat, SNDX-275, MS-27-275, SR-01000946382, Entinostat, SNDX-275, MS-27-275, MS-275, SR-01000946382-1, BRD-K77908580-001-02-1, BRD-K77908580-001-04-7, (pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate, [4-(2-Amino-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester, N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]-3-pyridinylmethyl ester, carbamic acid, Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester
ID: 3011
InChIKey: RTKIYFITIVXBLE-QEQCGCAPSA-N
SMILES: C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 3011



CID is 444732
synonyms found at PubChem are:
trichostatin A, 58880-19-6, Trichostatin A (TSA), TSA, Trichostatin, UNII-3X2S926L3Z, CHEBI:46024, (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide, GNF-PF-1011, RTKIYFITIVXBLE-QEQCGCAPSA-N, 3X2S926L3Z, 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide, Q-201864, Tricostatin A, (2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide, 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE, 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-, 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-, TSN, trichostatine a, Trichlostatin A, (2E,4E,6R)-7-(4-dimethylaminophenyl)-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid, (2E,4E,6R)-7-(4-Dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxo-hepta-2,4-dienamide, Trichostatin A,TSA, Trichostatin A/TSA, Antibiotic A-300, (R)-Trichostatin A, NCGC_TSA, 1c3r, 3f0r, Trichostatin-A - TSA, AC1L9GSU, A 300, D0NF6F, SCHEMBL19886, MLS006011095, SGCTO-002, SCHEMBL675951, GTPL7005, DTXSID6037063, CHEBI:93196, MolPort-003-959-819, MolPort-044-724-267, ZX-AFC000233, BCPP000035, HMS1362L09, HMS1792L09, HMS1990L09, HMS3403L09, HMS3649O20, BCP01776, EX-A1665, ABP000141, BDBM50005711, LMPK01000055, MFCD03848392, s1045, Trichostatin A from Streptomyces sp., AKOS015899840, ZINC100014731, A-300-I, CCG-208142, CCG-208681, CS-0499, DB04297, RL04219, NCGC00162453-01, NCGC00162453-02, NCGC00162453-03, NCGC00162453-04, NCGC00162453-05, NCGC00162453-15, 3C10, HY-15144, KB-81257, LS-74195, M984, SC-73346, SMR004702883, A8183, M02571, W-5309, 880T196, SR-05000013796, SR-05000013796-3, BRD-K68202742-001-04-1, BRD-K68202742-001-05-8, I14-11732, Trichostatin A, >=98% (HPLC), from Streptomyces sp., UNII-30RHG284Z4 component RTKIYFITIVXBLE-QEQCGCAPSA-N, Trichostatin A??, Vetec(TM) reagent grade, from Streptomyces sp., >=98%, (2E,4E,6R)-7-(4-dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide, (6R)-N-Hydroxy-4,6-dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienamide, (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide, 7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide, 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- (9CI), 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [R-(E,E)]-
ID: 2943
InChIKey: JTDYUFSDZATMKU-UHFFFAOYSA-N
SMILES: C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2943



CID is 5186
synonyms found at PubChem are:
scriptaid, 287383-59-9, Scriptide, 6-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide, GCK 1026, GNF-PF-2024, CGK1026, IN1099, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide, CHEMBL96051, SB-556629, 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide, JTDYUFSDZATMKU-UHFFFAOYSA-N, N-Hydroxy-1,3-dioxo-1H-benz(de)isoquinoline-2(3H)-hexan amide, N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide, Scriptaid(GCK1026), AC1L1JSF, scriptaid and CGK1026, D0J8OC, AC1Q6JL7, CBDivE_004422, Scriptaid, >=95%, solid, SCHEMBL780490, SCHEMBL780491, GTPL7505, CHEBI:92401, CTK8A6808, KS-00002WSH, DTXSID70274458, MolPort-000-434-144, HMS3269C11, HMS3653D06, 1h-benz[de]isoquinoline-2(3h)-hexanamide, n-hydroxy-1,3-dioxo-, BCP06506, CGK-1026, EX-A1108, ZINC3873638, ANW-62572, BDBM50328678, s8043, SBB039068, STL259803, AKOS000267387, CCG-208690, CS-1014, EG-0074, MCULE-6788459337, QC-8209, NCGC00159564-01, AJ-46378, BAS 00383114, BC600420, HY-15489, AB0097168, AX8233431, KB-144449, RT-015680, FT-0674544, ST45174702, SJ000016636, W-5105, AB00075588-01, SR-01000398526, J-017229, SR-01000398526-1, BRD-K22503835-001-03-7, BRD-K22503835-001-05-2, I14-11722, N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexananmide, 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide, 6-(1,3-DIOXO-1H,3H-BENZO[DE]ISOQUINOLIN-2-YL)-N-HYDROXYHEXANAMIDE