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CandActCFTR used public reference

The following publication reference has been reported to contain CFTR related structural information.
"E Caci" "LJ Galietta" "AS Verkman" "K Du" "GL Lukacs" "N Pedemonte" "O Zegarra-Moran"


Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=31

ID: 8
InChIKey: RDOBOPJBMQURAT-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=C(C=CC(=C4)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 8



CID is 1144671
synonyms found at PubChem are:
Corr-4a, RDOBOPJBMQURAT-UHFFFAOYSA-N, 421580-53-2, ST075396, N-(2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, MLS000561131, Oprea1_189688, Oprea1_471654, SCHEMBL837666, CHEMBL260775, DTXSID00360737, MolPort-001-986-142, ZINC888741, AKOS001665304, MCULE-2724995336, BAS 02936954, KB-57187, SMR000156156, EU-0078205, MLS-0094194.0001, SR-01000492559, SR-01000492559-1, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2' -yl]-benzamide, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzami, N-[2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]benzamide, N-{2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, N-(5-{2-[(5-chloro-2-methoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thia zol-2-yl))benzamide

ID: 2038
InChIKey: RYAXABNGWYEGTO-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)C2=CN=C(N2)SCC(=O)NC3=NC(=CS3)C4=CC=C(C=C4)Br

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2038



CID is 1008236
synonyms found at PubChem are:
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-[(5-phenyl-1H-imidazol-2-yl)sulfanyl]acetamide, AC1LJXGB, Oprea1_477754, Oprea1_602653, SCHEMBL837694, MolPort-002-704-370, MolPort-003-819-155, ZINC1062392, STK793160, AKOS001014760, AKOS001741629, MCULE-8210024769, EU-0052043, A1954/0082128, N~1~-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-[(4-phenyl-1H-imidazol-2-yl)sulfanyl]acetamide

ID: 243
InChIKey: BKQOOFNCLBQRBE-UHFFFAOYSA-N
SMILES: CCC1=CC=C(C=C1)NC2=NC3=CC=CC=C3C(=C2)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 243



CID is 672890
synonyms found at PubChem are:
N-(4-ethylphenyl)-4-methylquinolin-2-amine, AC1LDR0E, Oprea1_705013, SCHEMBL837756, ZINC34772, MolPort-002-562-123, STK762924, AKOS001622833, MCULE-7925097098, ST050514, KB-309009, (4-ethylphenyl)(4-methyl(2-quinolyl))amine, N-(4-ethylphenyl)-N-(4-methyl-2-quinolyl)amine, SR-01000450823, SR-01000450823-1, A2274/0095834

ID: 2033
InChIKey: RXJXEVKNSVYHAS-UHFFFAOYSA-N
SMILES: CCOC1=CC=CC=C1NC2=NC(=CS2)C3=CC(=C(C=C3)OC)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2033



CID is 2901912
synonyms found at PubChem are:
4-(3,4-dimethoxyphenyl)-N-(2-ethoxyphenyl)-1,3-thiazol-2-amine, AC1MEE05, Oprea1_076959, SCHEMBL837871, MolPort-002-207-231, ZINC4123323, AKOS001665688, MCULE-1836070818, EU-0078226, SR-01000492597, SR-01000492597-1

ID: 1768
InChIKey: PUUSUCIKMFPDJV-LICLKQGHSA-N
SMILES: C/C(=N\NC1=NC2=CC=CC=C2S1)/C3=CC=C(C=C3)[N+](=O)[O-]

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1768



CID is 9599955
synonyms found at PubChem are:
SCHEMBL837616, MolPort-001-019-312, MolPort-019-769-514, STK019006, AKOS001003897, MCULE-3946246525, ST085538, SR-01000117575, SR-01000117575-1, A1470/0064855, [(1E)-2-(4-nitrophenyl)-1-azaprop-1-enyl]benzothiazol-2-ylamine, 2-{(2E)-2-[1-(4-nitrophenyl)ethylidene]hydrazinyl}-1,3-benzothiazole

ID: 32
InChIKey: DHKIZPIDZINAAO-UHFFFAOYSA-N
SMILES: CCOC1=CC=CC=C1NC2=NC(=CS2)C3=C(N=C(S3)NC(=O)C4=CC=CC=C4)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 32



CID is 1144666
synonyms found at PubChem are:
MLS000561135, Oprea1_004830, Oprea1_493857, SCHEMBL837737, CHEMBL1451149, MolPort-001-986-136, ZINC888726, AKOS000562160, MCULE-3678609376, BAS 02936934, SMR000156160, ST075397, EU-0078236, SR-01000492602, SR-01000492602-1, N-[2-(2-Ethoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzamide, N-(5-{2-[(2-ethoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thiazol-2-yl)) benzamide

ID: 22
InChIKey: XWSYQZVZZMFGFW-UHFFFAOYSA-N
SMILES: CC1=NC(=NC2=C1C=C(C=C2)OC)NC3=NC(=O)C=C(N3)CSC4=NC5=CC=CC=C5N4

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 22



CID is 1386410
synonyms found at PubChem are:
MLS000587783, STK562693, 362000-44-0, SMR000211743, 6-(1H-Benzoimidazol-2-ylsulfanylmethyl)-2-(6-methoxy-4-methyl-quinazolin-2-ylamino)-pyrimidin-4-ol, 6-(1H-benzimidazol-2-ylsulfanylmethyl)-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-1H-pyrimidin-4-one, 6-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]pyrimidin-4-ol, Corr-3a, AC1LR1AE, Oprea1_443670, Oprea1_685675, SCHEMBL837686, CHEMBL1374384, BDBM68023, cid_1386410, CTK8I4173, DTXSID30362587, MolPort-000-717-537, MolPort-002-553-491, HMS2527M03, STK017630, ZINC15987756, AKOS005378152, AKOS005488273, MCULE-9390583364, KB-44178, SR-01000450464, SR-01000450464-1, 4-pyrimidinol, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-2-quinazolinyl)amino]-, 6-(1H-benzimidazol-2-ylsulfanylmethyl)-2-[(6-methoxy-4-methyl-quinazolin-2-yl)amino]-1H-pyrimidin-4-one, 6-(1H-Benzoimidazol-2-ylsulfanylmethyl)-2-(6-methoxy-4-methylquinazolin-2-ylamino)pyrimidin-4-ol, 6-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]pyrimidin-4(3H)-one, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-2-quinazolinyl)amino]-1H-pyrimidin-4-one, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-quinazolin-2-yl)amino]-1H-pyrimidin-4-one

ID: 1989
InChIKey: RPLMZGXPHOMMKL-UHFFFAOYSA-N
SMILES: CC1=CC(=NC2=CC=CC=C12)NC3=CC(=C(C=C3)OC)Cl

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1989



CID is 5081580
synonyms found at PubChem are:
N-(3-chloro-4-methoxyphenyl)-4-methylquinolin-2-amine, AC1NO3BT, Oprea1_614253, SCHEMBL10110706, ZINC267820, AKOS001630614, MCULE-7228228500, EU-0071518, SR-01000432777, SR-01000432777-1

ID: 1834
InChIKey: QKDQGTSCWBVSJB-LICLKQGHSA-N
SMILES: C/C(=N\NC1=NC2=CC=CC=C2S1)/C3=CC(=CC=C3)[N+](=O)[O-]

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1834



CID is 9599956
synonyms found at PubChem are:
SCHEMBL837829, MolPort-001-019-870, STK069670, AKOS001011591, MCULE-7505161073, A1470/0064856, 1-(3-nitrophenyl)-1-ethanone 1-(1,3-benzothiazol-2-yl)hydrazone, 2-{(2E)-2-[1-(3-nitrophenyl)ethylidene]hydrazinyl}-1,3-benzothiazole

ID: 2808
InChIKey: ZGZXKIHFNHZFBL-UHFFFAOYSA-N
SMILES: CCCC1(NC(=S)N(N1)C2=NC3=CC=CC=C3S2)CCC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2808



CID is 885368
synonyms found at PubChem are:
2-(1,3-benzothiazol-2-yl)-5,5-dipropyl-1,2,4-triazolidine-3-thione, AC1LHCX4, Oprea1_717603, SCHEMBL838385, MolPort-001-679-743, ZINC457579, STK016145, AKOS024348547, MCULE-9221241446

ID: 668
InChIKey: FZHKNEWQWRWDJI-UHFFFAOYSA-N
SMILES: CC1=C(N=CC=C1)NC2=NC(=CS2)C3=CC(=C(C=C3)OC)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 668



CID is 4416391
synonyms found at PubChem are:
AC1N9U4M, Oprea1_174232, SCHEMBL838280, MolPort-008-345-333, ZINC6391717, STK947466, AKOS005641136, MCULE-1699686726, EU-0013908, 4-(4-methoxy-3-methylphenyl)-N-(3-methylpyridin-2-yl)thiazol-2-amine, [4-(4-Methoxy-3-methyl-phenyl)-thiazol-2-yl]-(3-methyl-pyridin-2-yl)-amine, 4-(4-methoxy-3-methylphenyl)-N-(3-methylpyridin-2-yl)-1,3-thiazol-2-amine, N-[4-(4-methoxy-3-methylphenyl)-1,3-thiazol-2-yl]-3-methylpyridin-2-amine

ID: 1992
InChIKey: RQDZWPNXMNHDEV-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1)C2=CSC(=N2)NC3=CC=CC=C3C)[N+](=O)[O-]

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1992



CID is 668615
synonyms found at PubChem are:
4-(4-methyl-3-nitrophenyl)-N-(2-methylphenyl)-1,3-thiazol-2-amine, AC1LDKHW, Oprea1_817366, SCHEMBL838060, ZINC28955, MolPort-002-701-974, STK674259, AKOS005593465, MCULE-5793033014, ST041610, EU-0018371, AB01289638-01, SR-01000519656, SR-01000519656-1, A1772/0075123, [4-(4-methyl-3-nitrophenyl)(1,3-thiazol-2-yl)](2-methylphenyl)amine

ID: 855
InChIKey: HLWMLYNEZWIYMO-UHFFFAOYSA-N
SMILES: CC1=CC2=C(C=C1)N=C(C=C2C)NC3=C(C=CC(=C3)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 855



CID is 740915
synonyms found at PubChem are:
N-(5-chloro-2-methoxyphenyl)-4,6-dimethylquinolin-2-amine, (5-Chloro-2-methoxy-phenyl)-(4,6-dimethyl-quinolin-2-yl)-amine, AC1LERUI, BAS 01238481, Oprea1_491077, Oprea1_810748, SCHEMBL838087, MolPort-001-521-465, ZINC178556, STK078550, AKOS000602076, MCULE-3171750851, EU-0043833, SR-01000482932, SR-01000482932-1

ID: 2012
InChIKey: RSRFPGRMZHUKON-UHFFFAOYSA-N
SMILES: CC1=C(C=C2C(=C1)C(=NC(=N2)NC3=NC(=O)C(=C(N3)C)C)C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2012



CID is 695250
synonyms found at PubChem are:
AC1LEZVW, Oprea1_293092, Oprea1_437607, SCHEMBL838117, ZINC69303, MolPort-000-738-821, STK096804, AKOS000622026, MCULE-8185619622, BAS 01306736, EU-0073379, SR-01000450181, SR-01000450181-1, A2237/0094179, 5,6-Dimethyl-2-(4,6,7-trimethyl-quinazolin-2-ylamino)-1H-pyrimidin-4-one, 5,6-dimethyl-2-[(4,6,7-trimethyl-2-quinazolinyl)amino]-4(1H)-pyrimidinone, 5,6-dimethyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]-1H-pyrimidin-4-one, 5,6-dimethyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]pyrimidin-4(1H)-one

ID: 2659
InChIKey: XZMHJYWMCRQSSI-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=CC=CC(=C4)C(=O)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2659



CID is 2230879
synonyms found at PubChem are:
N-[2-(3-Acetyl-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzamide, N-{2-[(3-acetylphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, Compound 4c, BAS 01247286, AC1M33KG, SCHEMBL837699, MolPort-000-690-616, ZINC2878845, STK027021, AKOS000565149, MCULE-5215377073, EU-0009712, J3.654.387F, SR-01000477244, SR-01000477244-1, N-(3-Acetylphenyl)-N'-benzoyl-4'-methyl-4,5'-bithiazole-2,2'-diamine, N-[5-[2-(3-acetylanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide

ID: 2530
InChIKey: WWYMZGJMIXWAPQ-UHFFFAOYSA-N
SMILES: CC1=CC(=C(C=C1)OC)NC2=NC3=CC=CC=C3C(=C2)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2530



CID is 619056
synonyms found at PubChem are:
N-(2-methoxy-5-methylphenyl)-4-methylquinolin-2-amine, AC1LDIDG, CBMicro_015601, Oprea1_744257, SCHEMBL838120, ZINC84816, MolPort-000-807-871, WWYMZGJMIXWAPQ-UHFFFAOYSA-N, STK378457, AKOS001744412, MCULE-5379874838, BIM-0015389.P001, ST4054371, SR-01000529067, SR-01000529067-1, (2-methoxy-5-methylphenyl)(4-methyl(2-quinolyl))amine, A2226/0093758, N-(2-Methoxy-5-methylphenyl)-4-methyl-2-quinolinamine #, N-(2-methoxy-5-methylphenyl)-N-(4-methyl-2-quinolyl)amine, Quinolin-2-amine, 4-methyl-N-(2-methoxy-5-methylphenylamino)-

ID: 1755
InChIKey: PSWDQTMAUUQILQ-UHFFFAOYSA-N
SMILES: CC1=C(NC(=NC1=O)NC2=NC3=C(C=C(C=C3)OC)C(=N2)C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1755



CID is 695253
synonyms found at PubChem are:
2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-one, BAS 01306739, AC1LEZW5, Oprea1_303578, Oprea1_615758, SCHEMBL837878, SCHEMBL16440038, MolPort-000-468-849, MolPort-000-821-834, STK091241, ZINC18142425, AKOS000622058, MCULE-3781917844, ST50103857, SR-01000450184, SR-01000450184-1, 2-(6-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-pyrimidin-4-ol, 2-(6-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-1H-pyrimidin-4-one, 2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethyl-1H-pyrimidin-4-one, 2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylhydropyrimidin-4-one

ID: 1196
InChIKey: KQQDWFXHLGVZKX-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=C(C=C3)C(C)(C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1196



CID is 5235339
synonyms found at PubChem are:
AC1NR6JX, Oprea1_271611, AKOS002939780, 4-tert-butyl-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzamide

ID: 229
InChIKey: BIDZCDUCZHIKMO-VCHYOVAHSA-N
SMILES: C/C(=N\NC1=NC2=CC=CC=C2S1)/C3=CC=C(C=C3)Cl

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 229



CID is 9599957
synonyms found at PubChem are:
SCHEMBL838475, STK666972, AKOS001003898, MCULE-8836018202, A1470/0064857, 2-{(2E)-2-[1-(4-chlorophenyl)ethylidene]hydrazinyl}-1,3-benzothiazole

ID: 873
InChIKey: HQNGOCGBIGVSGF-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)NC2=NC3=CC=CC=C3C(=C2)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 873



CID is 747013
synonyms found at PubChem are:
(4-Methyl-quinolin-2-yl)-p-tolyl-amine, 4-methyl-N-(4-methylphenyl)quinolin-2-amine, CBMicro_024252, AC1LF53B, MixCom6_001276, Oprea1_019134, Oprea1_601484, SCHEMBL837706, MolPort-001-932-877, HMS1613G22, ZINC191182, CCG-11399, STL383350, AKOS000631231, MCULE-2719777287, BAS 00437680, BIM-0024146.P001, EU-0078385, SR-01000493924, SR-01000493924-1

ID: 509
InChIKey: DRKXOTFIYYKGMI-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CS3)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 509



CID is 734128
synonyms found at PubChem are:
N-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]thiophene-2-carboxamide, (E)-N-(4-(3,4-dimethylphenyl)thiazol-2(3H)-ylidene)thiophene-2-carboxamide, 313374-94-6, AC1LED22, Oprea1_191452, SCHEMBL838040, IFLab1_000229, MolPort-002-274-721, MolPort-003-009-184, HMS1412K09, ZINC4031545, STL230210, AKOS000928713, AKOS024573936, MCULE-3709003538, IDI1_008448, EU-0067591, SR-01000394931, SR-01000394931-1, Z28298877, F0013-0146

ID: 1128
InChIKey: JXZCUTPQSYPHMT-UHFFFAOYSA-N
SMILES: CC1=CC(=NC2=CC=CC=C12)NC3=CC=C(C=C3)Br

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1128



CID is 768745
synonyms found at PubChem are:
N-(4-bromophenyl)-4-methylquinolin-2-amine, GNF-Pf-268, (4-Bromo-phenyl)-(4-methyl-quinolin-2-yl)-amine, 324526-70-7, AC1LGCGR, BAS 00437701, CBMicro_025025, Oprea1_246881, Oprea1_826009, MLS001077237, SCHEMBL838429, CHEMBL600111, MolPort-001-932-878, HMS2789N21, ZINC248679, CCG-12150, STL383355, AKOS003192686, MCULE-3821665810, SMR000473020, BIM-0025121.P001, N-(4-bromophenyl)-N-(4-methyl-2-quinolyl)amine, SR-01000400434, SR-01000400434-1

ID: 514
InChIKey: DSSOOOVNLBRAPY-UHFFFAOYSA-N
SMILES: CC(C)(C)C1CCC2(CC1)NC(=S)N(N2)C3=NC4=CC=CC=C4S3

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 514



CID is 608835
synonyms found at PubChem are:
2-Benzothiazol-2-yl-8-tert-butyl-1,2,4-triaza-spiro[4.5]decane-3-thione, AC1LO30S, Oprea1_280562, SCHEMBL837825, DSSOOOVNLBRAPY-UHFFFAOYSA-N, MolPort-002-710-202, ZINC1067812, STK764818, AKOS001746223, A2544/0108255, 1,2,4-Triazaspiro[4.5]decane-3-thione, 2-(2-benzothiazolyl)-8-tert-butyl-, 2-(1,3-benzothiazol-2-yl)-8-tert-butyl-1,2,4-triazaspiro[4.5]decane-3-thione, 2-(benzo[d]thiazol-2-yl)-8-tert-butyl-1,2,4-triazaspiro[4.5]decane-3-thione, 3-(1,3-benzothiazol-2-yl)-8-tert-butyl-1,3,4-triazaspiro[4.5]decane-2-thione

ID: 1515
InChIKey: NSFHBVDUKHPTKG-ATVHPVEESA-N
SMILES: CC(C)C/C(=N\NC1=NC(=CS1)C2=CC=CC=C2)/C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1515



CID is 5776947
synonyms found at PubChem are:
AC1NXCUP, SCHEMBL838235, AKOS001588113, AKOS024374137, ST51013503, 2-((2Z)-3,5-dimethyl-1,2-diazahex-2-enylidene)-4-phenyl-1,3-thiazoline, N-[(Z)-4-methylpentan-2-ylideneamino]-4-phenyl-1,3-thiazol-2-amine

ID: 2690
InChIKey: YFCWKIXGWIMLAM-UHFFFAOYSA-N
SMILES: CC1=CC(=C2C(=CC(=NC2=C1)NC3=CC=CC=C3)C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2690



CID is 740918
synonyms found at PubChem are:
4,5,7-trimethyl-N-phenylquinolin-2-amine, AC1LERUR, Oprea1_716671, SCHEMBL837742, MolPort-002-944-470, ZINC178560, STK091440, AKOS001640147, MCULE-4314803191, EU-0010423, Phenyl-(4,5,7-trimethyl-quinolin-2-yl)-amine

ID: 471
InChIKey: DLLKDLFPBARGCC-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=CC=CC=C4OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 471



CID is 1117191
synonyms found at PubChem are:
N-[2-(2-Methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzamide, MLS000561133, AC1LLWE7, Oprea1_308767, Oprea1_707648, SCHEMBL837888, CHEMBL1306491, MolPort-000-690-613, HMS2197B19, HMS3331I07, ZINC853329, AKOS000565400, MCULE-7647996207, BAS 01247205, SMR000156158, SR-01000477242, SR-01000477242-1, N-(2-(2-Methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, N-[5-[2-(2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide

ID: 1703
InChIKey: PIZNEGCCPRNJRI-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)NC3=CC(=C(C=C3OC)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1703



CID is 1042146
synonyms found at PubChem are:
N-(4-chloro-2,5-dimethoxyphenyl)-4-(4-methylphenyl)-1,3-thiazol-2-amine, AC1LKEUW, Oprea1_542866, SCHEMBL838374, MolPort-002-700-652, PIZNEGCCPRNJRI-UHFFFAOYSA-N, ZINC714794, STK756856, AKOS005615864, MCULE-3036794854, EU-0084914, AG-205/37049196, A1661/0070755, N-(4-chloro-2,5-dimethoxyphenyl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]amine

ID: 187
InChIKey: AXEGYQIJLMUXKW-UHFFFAOYSA-N
SMILES: C1=CN=C(N=C1)NC2=NC(=CS2)C3=CC(=C(C=C3)O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 187



CID is 751856
synonyms found at PubChem are:
MLS000715725, 4-[2-(pyrimidin-2-ylamino)-1,3-thiazol-4-yl]benzene-1,2-diol, SMR000277242, AC1LFD7J, Oprea1_396000, SCHEMBL837838, CHEMBL240333, cid_751856, BDBM50504, MolPort-001-998-511, HMS2625L11, KUC106812N, ZINC202220, CCG-22209, STK066459, AKOS000563358, MCULE-8776135083, BAS 04880533, KSC-11-237-16, 4-[2-(2-pyrimidylamino)thiazol-4-yl]pyrocatechol, 4-[2-(2-pyrimidinylamino)-4-thiazolyl]benzene-1,2-diol, 4-[2-(pyrimidin-2-ylamino)thiazol-4-yl]benzene-1,2-diol, 1,2-Benzenediol, 4-[2-(2-pyrimidinylamino)-4-thiazolyl]-, 4-[2-(Pyrimidin-2-ylamino)-thiazol-4-yl]-benzene-1,2-diol

ID: 45
InChIKey: JZJXEPNQMCFBIS-UHFFFAOYSA-N
SMILES: C=CC1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=CC=C3

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

chemical graph of compound 45



CID is 683025
synonyms found at PubChem are:
Corr-2b, AC1LEAGY, SCHEMBL837831, ZINC48933, ST007156, EU-0084361, Phenyl-[4-(4-vinyl-phenyl)-thiazol-2-yl]-amine, SR-01000511692, 4-(4-ethenylphenyl)-N-phenyl-1,3-thiazol-2-amine, phenyl[4-(4-vinylphenyl)(1,3-thiazol-2-yl)]amine, SR-01000511692-1, A0861/0040368

ID: 1525
InChIKey: NVMIBYLXLVBCEV-UHFFFAOYSA-N
SMILES: CC1=NC(=NC2=C1C=CC(=C2)OC)NC3=NC(=O)C=C(N3)C4=CC=CC=C4

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1525



CID is 1002841
synonyms found at PubChem are:
MLS000777862, SMR000414248, 2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-6-phenylpyrimidin-4-ol, 2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-6-phenyl-pyrimidin-4-ol, 2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-6-phenyl-1H-pyrimidin-4-one, ChemDiv1_003480, AC1LJM74, Oprea1_047289, Oprea1_372553, SCHEMBL837873, CHEMBL1565526, BDBM54369, cid_1002841, HMS596O04, MolPort-000-400-930, MolPort-000-783-773, NVMIBYLXLVBCEV-UHFFFAOYSA-N, HMS2756K04, STK087243, STL436005, ZINC18117526, AKOS001711415, AKOS002821881, CCG-121222, MCULE-9742179113, AB00132382-08, SR-01000431115, SR-01000431115-1, 2-(7-Methoxy-4-methylquinazolin-2-ylamino)-6-phenylpyrimidin-4-ol, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-6-phenyl-1H-pyrimidin-4-one, 2-[(7-methoxy-4-methyl-quinazolin-2-yl)amino]-6-phenyl-1H-pyrimidin-4-one

ID: 2384
InChIKey: VSJZZGYSZUIAFS-UHFFFAOYSA-N
SMILES: CC(=O)NC1=CC=C(C=C1)NC2=NC(=CS2)C3=CC(=C(C=C3)OC)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2384



CID is 1117211
synonyms found at PubChem are:
AC1LLWFV, Oprea1_137180, Oprea1_825573, SCHEMBL837656, MolPort-000-690-671, ZINC853352, AKOS002382724, MCULE-1907627141, SR-01000477289, SR-01000477289-1, N-[4-[[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]amino]phenyl]acetamide