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CandActCFTR used public reference

The following publication reference has been reported to contain CFTR related structural information.
"GL Lukacs" "O Zegarra-Moran" "E Caci" "K Du" "LJ Galietta" "N Pedemonte" "AS Verkman"


Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=31

ID: 8
InChIKey: RDOBOPJBMQURAT-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=C(C=CC(=C4)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 8



CID is 1144671
synonyms found at PubChem are:
Corr-4a, RDOBOPJBMQURAT-UHFFFAOYSA-N, 421580-53-2, ST075396, N-(2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, MLS000561131, Oprea1_189688, Oprea1_471654, SCHEMBL837666, CHEMBL260775, DTXSID00360737, MolPort-001-986-142, ZINC888741, AKOS001665304, MCULE-2724995336, BAS 02936954, KB-57187, SMR000156156, EU-0078205, MLS-0094194.0001, SR-01000492559, SR-01000492559-1, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2' -yl]-benzamide, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzami, N-[2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]benzamide, N-{2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, N-(5-{2-[(5-chloro-2-methoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thia zol-2-yl))benzamide

ID: 2038
InChIKey: RYAXABNGWYEGTO-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)C2=CN=C(N2)SCC(=O)NC3=NC(=CS3)C4=CC=C(C=C4)Br

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2038



CID is 1008236
synonyms found at PubChem are:
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-[(5-phenyl-1H-imidazol-2-yl)sulfanyl]acetamide, AC1LJXGB, Oprea1_477754, Oprea1_602653, SCHEMBL837694, MolPort-002-704-370, MolPort-003-819-155, ZINC1062392, STK793160, AKOS001014760, AKOS001741629, MCULE-8210024769, EU-0052043, A1954/0082128, N~1~-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-[(4-phenyl-1H-imidazol-2-yl)sulfanyl]acetamide

ID: 243
InChIKey: BKQOOFNCLBQRBE-UHFFFAOYSA-N
SMILES: CCC1=CC=C(C=C1)NC2=NC3=CC=CC=C3C(=C2)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 243



CID is 672890
synonyms found at PubChem are:
N-(4-ethylphenyl)-4-methylquinolin-2-amine, AC1LDR0E, Oprea1_705013, SCHEMBL837756, ZINC34772, MolPort-002-562-123, STK762924, AKOS001622833, MCULE-7925097098, ST050514, KB-309009, (4-ethylphenyl)(4-methyl(2-quinolyl))amine, N-(4-ethylphenyl)-N-(4-methyl-2-quinolyl)amine, SR-01000450823, SR-01000450823-1, A2274/0095834

ID: 2033
InChIKey: RXJXEVKNSVYHAS-UHFFFAOYSA-N
SMILES: CCOC1=CC=CC=C1NC2=NC(=CS2)C3=CC(=C(C=C3)OC)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2033



CID is 2901912
synonyms found at PubChem are:
4-(3,4-dimethoxyphenyl)-N-(2-ethoxyphenyl)-1,3-thiazol-2-amine, AC1MEE05, Oprea1_076959, SCHEMBL837871, MolPort-002-207-231, ZINC4123323, AKOS001665688, MCULE-1836070818, EU-0078226, SR-01000492597, SR-01000492597-1

ID: 1768
InChIKey: PUUSUCIKMFPDJV-LICLKQGHSA-N
SMILES: C/C(=N\NC1=NC2=CC=CC=C2S1)/C3=CC=C(C=C3)[N+](=O)[O-]

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1768



CID is 9599955
synonyms found at PubChem are:
SCHEMBL837616, MolPort-001-019-312, MolPort-019-769-514, STK019006, AKOS001003897, MCULE-3946246525, ST085538, SR-01000117575, SR-01000117575-1, A1470/0064855, [(1E)-2-(4-nitrophenyl)-1-azaprop-1-enyl]benzothiazol-2-ylamine, 2-{(2E)-2-[1-(4-nitrophenyl)ethylidene]hydrazinyl}-1,3-benzothiazole

ID: 32
InChIKey: DHKIZPIDZINAAO-UHFFFAOYSA-N
SMILES: CCOC1=CC=CC=C1NC2=NC(=CS2)C3=C(N=C(S3)NC(=O)C4=CC=CC=C4)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 32



CID is 1144666
synonyms found at PubChem are:
MLS000561135, Oprea1_004830, Oprea1_493857, SCHEMBL837737, CHEMBL1451149, MolPort-001-986-136, ZINC888726, AKOS000562160, MCULE-3678609376, BAS 02936934, SMR000156160, ST075397, EU-0078236, SR-01000492602, SR-01000492602-1, N-[2-(2-Ethoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzamide, N-(5-{2-[(2-ethoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thiazol-2-yl)) benzamide

ID: 22
InChIKey: XWSYQZVZZMFGFW-UHFFFAOYSA-N
SMILES: CC1=NC(=NC2=C1C=C(C=C2)OC)NC3=NC(=O)C=C(N3)CSC4=NC5=CC=CC=C5N4

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 22



CID is 1386410
synonyms found at PubChem are:
MLS000587783, STK562693, 362000-44-0, SMR000211743, 6-(1H-Benzoimidazol-2-ylsulfanylmethyl)-2-(6-methoxy-4-methyl-quinazolin-2-ylamino)-pyrimidin-4-ol, 6-(1H-benzimidazol-2-ylsulfanylmethyl)-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-1H-pyrimidin-4-one, 6-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]pyrimidin-4-ol, Corr-3a, AC1LR1AE, Oprea1_443670, Oprea1_685675, SCHEMBL837686, CHEMBL1374384, BDBM68023, cid_1386410, CTK8I4173, DTXSID30362587, MolPort-000-717-537, MolPort-002-553-491, HMS2527M03, STK017630, ZINC15987756, AKOS005378152, AKOS005488273, MCULE-9390583364, KB-44178, SR-01000450464, SR-01000450464-1, 4-pyrimidinol, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-2-quinazolinyl)amino]-, 6-(1H-benzimidazol-2-ylsulfanylmethyl)-2-[(6-methoxy-4-methyl-quinazolin-2-yl)amino]-1H-pyrimidin-4-one, 6-(1H-Benzoimidazol-2-ylsulfanylmethyl)-2-(6-methoxy-4-methylquinazolin-2-ylamino)pyrimidin-4-ol, 6-[(1H-benzimidazol-2-ylsulfanyl)methyl]-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]pyrimidin-4(3H)-one, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-2-quinazolinyl)amino]-1H-pyrimidin-4-one, 6-[(1H-benzimidazol-2-ylthio)methyl]-2-[(6-methoxy-4-methyl-quinazolin-2-yl)amino]-1H-pyrimidin-4-one

ID: 1989
InChIKey: RPLMZGXPHOMMKL-UHFFFAOYSA-N
SMILES: CC1=CC(=NC2=CC=CC=C12)NC3=CC(=C(C=C3)OC)Cl

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1989



CID is 5081580
synonyms found at PubChem are:
N-(3-chloro-4-methoxyphenyl)-4-methylquinolin-2-amine, AC1NO3BT, Oprea1_614253, SCHEMBL10110706, ZINC267820, AKOS001630614, MCULE-7228228500, EU-0071518, SR-01000432777, SR-01000432777-1

ID: 1834
InChIKey: QKDQGTSCWBVSJB-LICLKQGHSA-N
SMILES: C/C(=N\NC1=NC2=CC=CC=C2S1)/C3=CC(=CC=C3)[N+](=O)[O-]

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1834



CID is 9599956
synonyms found at PubChem are:
SCHEMBL837829, MolPort-001-019-870, STK069670, AKOS001011591, MCULE-7505161073, A1470/0064856, 1-(3-nitrophenyl)-1-ethanone 1-(1,3-benzothiazol-2-yl)hydrazone, 2-{(2E)-2-[1-(3-nitrophenyl)ethylidene]hydrazinyl}-1,3-benzothiazole

ID: 2808
InChIKey: ZGZXKIHFNHZFBL-UHFFFAOYSA-N
SMILES: CCCC1(NC(=S)N(N1)C2=NC3=CC=CC=C3S2)CCC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2808



CID is 885368
synonyms found at PubChem are:
2-(1,3-benzothiazol-2-yl)-5,5-dipropyl-1,2,4-triazolidine-3-thione, AC1LHCX4, Oprea1_717603, SCHEMBL838385, MolPort-001-679-743, ZINC457579, STK016145, AKOS024348547, MCULE-9221241446

ID: 668
InChIKey: FZHKNEWQWRWDJI-UHFFFAOYSA-N
SMILES: CC1=C(N=CC=C1)NC2=NC(=CS2)C3=CC(=C(C=C3)OC)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 668



CID is 4416391
synonyms found at PubChem are:
AC1N9U4M, Oprea1_174232, SCHEMBL838280, MolPort-008-345-333, ZINC6391717, STK947466, AKOS005641136, MCULE-1699686726, EU-0013908, 4-(4-methoxy-3-methylphenyl)-N-(3-methylpyridin-2-yl)thiazol-2-amine, [4-(4-Methoxy-3-methyl-phenyl)-thiazol-2-yl]-(3-methyl-pyridin-2-yl)-amine, 4-(4-methoxy-3-methylphenyl)-N-(3-methylpyridin-2-yl)-1,3-thiazol-2-amine, N-[4-(4-methoxy-3-methylphenyl)-1,3-thiazol-2-yl]-3-methylpyridin-2-amine

ID: 1992
InChIKey: RQDZWPNXMNHDEV-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1)C2=CSC(=N2)NC3=CC=CC=C3C)[N+](=O)[O-]

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1992



CID is 668615
synonyms found at PubChem are:
4-(4-methyl-3-nitrophenyl)-N-(2-methylphenyl)-1,3-thiazol-2-amine, AC1LDKHW, Oprea1_817366, SCHEMBL838060, ZINC28955, MolPort-002-701-974, STK674259, AKOS005593465, MCULE-5793033014, ST041610, EU-0018371, AB01289638-01, SR-01000519656, SR-01000519656-1, A1772/0075123, [4-(4-methyl-3-nitrophenyl)(1,3-thiazol-2-yl)](2-methylphenyl)amine

ID: 855
InChIKey: HLWMLYNEZWIYMO-UHFFFAOYSA-N
SMILES: CC1=CC2=C(C=C1)N=C(C=C2C)NC3=C(C=CC(=C3)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 855



CID is 740915
synonyms found at PubChem are:
N-(5-chloro-2-methoxyphenyl)-4,6-dimethylquinolin-2-amine, (5-Chloro-2-methoxy-phenyl)-(4,6-dimethyl-quinolin-2-yl)-amine, AC1LERUI, BAS 01238481, Oprea1_491077, Oprea1_810748, SCHEMBL838087, MolPort-001-521-465, ZINC178556, STK078550, AKOS000602076, MCULE-3171750851, EU-0043833, SR-01000482932, SR-01000482932-1

ID: 2012
InChIKey: RSRFPGRMZHUKON-UHFFFAOYSA-N
SMILES: CC1=C(C=C2C(=C1)C(=NC(=N2)NC3=NC(=O)C(=C(N3)C)C)C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2012



CID is 695250
synonyms found at PubChem are:
AC1LEZVW, Oprea1_293092, Oprea1_437607, SCHEMBL838117, ZINC69303, MolPort-000-738-821, STK096804, AKOS000622026, MCULE-8185619622, BAS 01306736, EU-0073379, SR-01000450181, SR-01000450181-1, A2237/0094179, 5,6-Dimethyl-2-(4,6,7-trimethyl-quinazolin-2-ylamino)-1H-pyrimidin-4-one, 5,6-dimethyl-2-[(4,6,7-trimethyl-2-quinazolinyl)amino]-4(1H)-pyrimidinone, 5,6-dimethyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]-1H-pyrimidin-4-one, 5,6-dimethyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]pyrimidin-4(1H)-one

ID: 2659
InChIKey: XZMHJYWMCRQSSI-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=CC=CC(=C4)C(=O)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2659



CID is 2230879
synonyms found at PubChem are:
N-[2-(3-Acetyl-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzamide, N-{2-[(3-acetylphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, Compound 4c, BAS 01247286, AC1M33KG, SCHEMBL837699, MolPort-000-690-616, ZINC2878845, STK027021, AKOS000565149, MCULE-5215377073, EU-0009712, J3.654.387F, SR-01000477244, SR-01000477244-1, N-(3-Acetylphenyl)-N'-benzoyl-4'-methyl-4,5'-bithiazole-2,2'-diamine, N-[5-[2-(3-acetylanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide

ID: 2530
InChIKey: WWYMZGJMIXWAPQ-UHFFFAOYSA-N
SMILES: CC1=CC(=C(C=C1)OC)NC2=NC3=CC=CC=C3C(=C2)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2530



CID is 619056
synonyms found at PubChem are:
N-(2-methoxy-5-methylphenyl)-4-methylquinolin-2-amine, AC1LDIDG, CBMicro_015601, Oprea1_744257, SCHEMBL838120, ZINC84816, MolPort-000-807-871, WWYMZGJMIXWAPQ-UHFFFAOYSA-N, STK378457, AKOS001744412, MCULE-5379874838, BIM-0015389.P001, ST4054371, SR-01000529067, SR-01000529067-1, (2-methoxy-5-methylphenyl)(4-methyl(2-quinolyl))amine, A2226/0093758, N-(2-Methoxy-5-methylphenyl)-4-methyl-2-quinolinamine #, N-(2-methoxy-5-methylphenyl)-N-(4-methyl-2-quinolyl)amine, Quinolin-2-amine, 4-methyl-N-(2-methoxy-5-methylphenylamino)-

ID: 1755
InChIKey: PSWDQTMAUUQILQ-UHFFFAOYSA-N
SMILES: CC1=C(NC(=NC1=O)NC2=NC3=C(C=C(C=C3)OC)C(=N2)C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1755



CID is 695253
synonyms found at PubChem are:
2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-one, BAS 01306739, AC1LEZW5, Oprea1_303578, Oprea1_615758, SCHEMBL837878, SCHEMBL16440038, MolPort-000-468-849, MolPort-000-821-834, STK091241, ZINC18142425, AKOS000622058, MCULE-3781917844, ST50103857, SR-01000450184, SR-01000450184-1, 2-(6-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-pyrimidin-4-ol, 2-(6-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-1H-pyrimidin-4-one, 2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethyl-1H-pyrimidin-4-one, 2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylhydropyrimidin-4-one

ID: 1196
InChIKey: KQQDWFXHLGVZKX-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=C(C=C3)C(C)(C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1196



CID is 5235339
synonyms found at PubChem are:
AC1NR6JX, Oprea1_271611, AKOS002939780, 4-tert-butyl-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzamide

ID: 229
InChIKey: BIDZCDUCZHIKMO-VCHYOVAHSA-N
SMILES: C/C(=N\NC1=NC2=CC=CC=C2S1)/C3=CC=C(C=C3)Cl

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 229



CID is 9599957
synonyms found at PubChem are:
SCHEMBL838475, STK666972, AKOS001003898, MCULE-8836018202, A1470/0064857, 2-{(2E)-2-[1-(4-chlorophenyl)ethylidene]hydrazinyl}-1,3-benzothiazole

ID: 873
InChIKey: HQNGOCGBIGVSGF-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)NC2=NC3=CC=CC=C3C(=C2)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 873



CID is 747013
synonyms found at PubChem are:
(4-Methyl-quinolin-2-yl)-p-tolyl-amine, 4-methyl-N-(4-methylphenyl)quinolin-2-amine, CBMicro_024252, AC1LF53B, MixCom6_001276, Oprea1_019134, Oprea1_601484, SCHEMBL837706, MolPort-001-932-877, HMS1613G22, ZINC191182, CCG-11399, STL383350, AKOS000631231, MCULE-2719777287, BAS 00437680, BIM-0024146.P001, EU-0078385, SR-01000493924, SR-01000493924-1

ID: 509
InChIKey: DRKXOTFIYYKGMI-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CS3)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 509



CID is 734128
synonyms found at PubChem are:
N-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]thiophene-2-carboxamide, (E)-N-(4-(3,4-dimethylphenyl)thiazol-2(3H)-ylidene)thiophene-2-carboxamide, 313374-94-6, AC1LED22, Oprea1_191452, SCHEMBL838040, IFLab1_000229, MolPort-002-274-721, MolPort-003-009-184, HMS1412K09, ZINC4031545, STL230210, AKOS000928713, AKOS024573936, MCULE-3709003538, IDI1_008448, EU-0067591, SR-01000394931, SR-01000394931-1, Z28298877, F0013-0146

ID: 1128
InChIKey: JXZCUTPQSYPHMT-UHFFFAOYSA-N
SMILES: CC1=CC(=NC2=CC=CC=C12)NC3=CC=C(C=C3)Br

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1128



CID is 768745
synonyms found at PubChem are:
N-(4-bromophenyl)-4-methylquinolin-2-amine, GNF-Pf-268, (4-Bromo-phenyl)-(4-methyl-quinolin-2-yl)-amine, 324526-70-7, AC1LGCGR, BAS 00437701, CBMicro_025025, Oprea1_246881, Oprea1_826009, MLS001077237, SCHEMBL838429, CHEMBL600111, MolPort-001-932-878, HMS2789N21, ZINC248679, CCG-12150, STL383355, AKOS003192686, MCULE-3821665810, SMR000473020, BIM-0025121.P001, N-(4-bromophenyl)-N-(4-methyl-2-quinolyl)amine, SR-01000400434, SR-01000400434-1

ID: 514
InChIKey: DSSOOOVNLBRAPY-UHFFFAOYSA-N
SMILES: CC(C)(C)C1CCC2(CC1)NC(=S)N(N2)C3=NC4=CC=CC=C4S3

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 514



CID is 608835
synonyms found at PubChem are:
2-Benzothiazol-2-yl-8-tert-butyl-1,2,4-triaza-spiro[4.5]decane-3-thione, AC1LO30S, Oprea1_280562, SCHEMBL837825, DSSOOOVNLBRAPY-UHFFFAOYSA-N, MolPort-002-710-202, ZINC1067812, STK764818, AKOS001746223, A2544/0108255, 1,2,4-Triazaspiro[4.5]decane-3-thione, 2-(2-benzothiazolyl)-8-tert-butyl-, 2-(1,3-benzothiazol-2-yl)-8-tert-butyl-1,2,4-triazaspiro[4.5]decane-3-thione, 2-(benzo[d]thiazol-2-yl)-8-tert-butyl-1,2,4-triazaspiro[4.5]decane-3-thione, 3-(1,3-benzothiazol-2-yl)-8-tert-butyl-1,3,4-triazaspiro[4.5]decane-2-thione

ID: 1515
InChIKey: NSFHBVDUKHPTKG-ATVHPVEESA-N
SMILES: CC(C)C/C(=N\NC1=NC(=CS1)C2=CC=CC=C2)/C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1515



CID is 5776947
synonyms found at PubChem are:
AC1NXCUP, SCHEMBL838235, AKOS001588113, AKOS024374137, ST51013503, 2-((2Z)-3,5-dimethyl-1,2-diazahex-2-enylidene)-4-phenyl-1,3-thiazoline, N-[(Z)-4-methylpentan-2-ylideneamino]-4-phenyl-1,3-thiazol-2-amine

ID: 2690
InChIKey: YFCWKIXGWIMLAM-UHFFFAOYSA-N
SMILES: CC1=CC(=C2C(=CC(=NC2=C1)NC3=CC=CC=C3)C)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2690



CID is 740918
synonyms found at PubChem are:
4,5,7-trimethyl-N-phenylquinolin-2-amine, AC1LERUR, Oprea1_716671, SCHEMBL837742, MolPort-002-944-470, ZINC178560, STK091440, AKOS001640147, MCULE-4314803191, EU-0010423, Phenyl-(4,5,7-trimethyl-quinolin-2-yl)-amine

ID: 471
InChIKey: DLLKDLFPBARGCC-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=CC=CC=C4OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 471



CID is 1117191
synonyms found at PubChem are:
N-[2-(2-Methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzamide, MLS000561133, AC1LLWE7, Oprea1_308767, Oprea1_707648, SCHEMBL837888, CHEMBL1306491, MolPort-000-690-613, HMS2197B19, HMS3331I07, ZINC853329, AKOS000565400, MCULE-7647996207, BAS 01247205, SMR000156158, SR-01000477242, SR-01000477242-1, N-(2-(2-Methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, N-[5-[2-(2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide

ID: 1703
InChIKey: PIZNEGCCPRNJRI-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)NC3=CC(=C(C=C3OC)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1703



CID is 1042146
synonyms found at PubChem are:
N-(4-chloro-2,5-dimethoxyphenyl)-4-(4-methylphenyl)-1,3-thiazol-2-amine, AC1LKEUW, Oprea1_542866, SCHEMBL838374, MolPort-002-700-652, PIZNEGCCPRNJRI-UHFFFAOYSA-N, ZINC714794, STK756856, AKOS005615864, MCULE-3036794854, EU-0084914, AG-205/37049196, A1661/0070755, N-(4-chloro-2,5-dimethoxyphenyl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]amine

ID: 187
InChIKey: AXEGYQIJLMUXKW-UHFFFAOYSA-N
SMILES: C1=CN=C(N=C1)NC2=NC(=CS2)C3=CC(=C(C=C3)O)O

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 187



CID is 751856
synonyms found at PubChem are:
MLS000715725, 4-[2-(pyrimidin-2-ylamino)-1,3-thiazol-4-yl]benzene-1,2-diol, SMR000277242, AC1LFD7J, Oprea1_396000, SCHEMBL837838, CHEMBL240333, cid_751856, BDBM50504, MolPort-001-998-511, HMS2625L11, KUC106812N, ZINC202220, CCG-22209, STK066459, AKOS000563358, MCULE-8776135083, BAS 04880533, KSC-11-237-16, 4-[2-(2-pyrimidylamino)thiazol-4-yl]pyrocatechol, 4-[2-(2-pyrimidinylamino)-4-thiazolyl]benzene-1,2-diol, 4-[2-(pyrimidin-2-ylamino)thiazol-4-yl]benzene-1,2-diol, 1,2-Benzenediol, 4-[2-(2-pyrimidinylamino)-4-thiazolyl]-, 4-[2-(Pyrimidin-2-ylamino)-thiazol-4-yl]-benzene-1,2-diol

ID: 45
InChIKey: JZJXEPNQMCFBIS-UHFFFAOYSA-N
SMILES: C=CC1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=CC=C3

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction binds to CFTR
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

chemical graph of compound 45



CID is 683025
synonyms found at PubChem are:
Corr-2b, AC1LEAGY, SCHEMBL837831, ZINC48933, ST007156, EU-0084361, Phenyl-[4-(4-vinyl-phenyl)-thiazol-2-yl]-amine, SR-01000511692, 4-(4-ethenylphenyl)-N-phenyl-1,3-thiazol-2-amine, phenyl[4-(4-vinylphenyl)(1,3-thiazol-2-yl)]amine, SR-01000511692-1, A0861/0040368

ID: 1525
InChIKey: NVMIBYLXLVBCEV-UHFFFAOYSA-N
SMILES: CC1=NC(=NC2=C1C=CC(=C2)OC)NC3=NC(=O)C=C(N3)C4=CC=CC=C4

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 1525



CID is 1002841
synonyms found at PubChem are:
MLS000777862, SMR000414248, 2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-6-phenylpyrimidin-4-ol, 2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-6-phenyl-pyrimidin-4-ol, 2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-6-phenyl-1H-pyrimidin-4-one, ChemDiv1_003480, AC1LJM74, Oprea1_047289, Oprea1_372553, SCHEMBL837873, CHEMBL1565526, BDBM54369, cid_1002841, HMS596O04, MolPort-000-400-930, MolPort-000-783-773, NVMIBYLXLVBCEV-UHFFFAOYSA-N, HMS2756K04, STK087243, STL436005, ZINC18117526, AKOS001711415, AKOS002821881, CCG-121222, MCULE-9742179113, AB00132382-08, SR-01000431115, SR-01000431115-1, 2-(7-Methoxy-4-methylquinazolin-2-ylamino)-6-phenylpyrimidin-4-ol, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-6-phenyl-1H-pyrimidin-4-one, 2-[(7-methoxy-4-methyl-quinazolin-2-yl)amino]-6-phenyl-1H-pyrimidin-4-one

ID: 2384
InChIKey: VSJZZGYSZUIAFS-UHFFFAOYSA-N
SMILES: CC(=O)NC1=CC=C(C=C1)NC2=NC(=CS2)C3=CC(=C(C=C3)OC)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

chemical graph of compound 2384



CID is 1117211
synonyms found at PubChem are:
AC1LLWFV, Oprea1_137180, Oprea1_825573, SCHEMBL837656, MolPort-000-690-671, ZINC853352, AKOS002382724, MCULE-1907627141, SR-01000477289, SR-01000477289-1, N-[4-[[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]amino]phenyl]acetamide