previous compound ID: 13 next compound
InChIKey: BNRNXUUZRGQAQC-UHFFFAOYSA-N
SMILES: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment ER & Golgi (Translation, quality control, trafficking, PTM)

reference list:

ReferenceID: 55
"Y Luo" "KA Teske" "GW Carlile" "JW Hanrahan" "R Robert" "DY Thomas" "D Zhang"
ReferenceID: 53
"J Goepp" "E Matthes" "B Kus" "SD Macknight" "GW Carlile" "JW Hanrahan" "J Liao" "R Robert" "DY Thomas" "D Rotin"
ReferenceID: 45
"C Pavel" "Y Luo" "GW Carlile" "JW Hanrahan" "N Liu" "J Liao" "R Robert" "DY Thomas" "SM Anjos" "D Zhang"

chemical graph of compound 13





CID is 5212
synonyms found at PubChem are:
sildenafil, 139755-83-2, Revatio, VIAGRA, Sildenafil [INN:BAN], UK-92480, UNII-3M7OB98Y7H, Aphrodil (TN), Sildenafil (INN), UK-92,480-10, C22H30N6O4S, HSDB 7305, CHEMBL192, 3M7OB98Y7H, CHEBI:9139, UK 92480-10, 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine, BNRNXUUZRGQAQC-UHFFFAOYSA-N, Caverta, 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, NCX-911, Revatio (TN), Viagra (TN), 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-(ethyloxy)-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, Piperazine, 1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-, SMR000752512, 171599-83-0 (citrate), SR-05000001934, NCGC00159496-02, mysildecard, Aphrodil, Vizarsin, Rhucin, Sildenafil#, 1udt, 1xos, 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo(4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, Rhucin (TN), Spectrum_001555, SpecPlus_000798, AC1L1JUI, Spectrum2_001648, Spectrum3_001892, Spectrum4_000586, Spectrum5_001508, D08KTT, D0Z7ZM, Cambridge id 7030299, SCHEMBL1895, BSPBio_003424, KBioGR_001052, KBioSS_002035, MLS001240224, MLS001304737, MLS006011565, BIDD:GT0352, DivK1c_006894, SPECTRUM1504099, SPBio_001775, GTPL4743, SCHEMBL5795456, SCHEMBL8100377, Jsp002373, DTXSID6023579, BDBM14390, KBio1_001838, KBio2_002035, KBio2_004603, KBio2_007171, KBio3_002927, KS-00000XMX, 2h42, MolPort-002-885-861, HMS1684K08, HMS1922B19, HMS2089M12, HMS2093O17, HMS2233L22, HMS3372N07, HMS3715P17, Sildenafil 1.0 mg/ml in Methanol, ACT02662, BCP05337, AC-938, CCG-21806, CCG-39076, s4684, STL483201, STL483720, ZINC19796168, AKOS008901403, AKOS025397193, CS-1577, DB00203, MCULE-2481702478, NCGC00095099-01, NCGC00095099-02, NCGC00095099-03, NCGC00095099-04, NCGC00370976-03, 5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, AN-15436, AS-48884, BAS 04213629, BC202768, HY-15025, M901, SC-83326, SMR004703325, SBI-0051920.P002, AB0015440, LS-111655, FT-0601554, C07259, D08514, W-2194, AB00052444-02, AB00052444-03, AB00052444_04, AB00052444_05, 755S832, SR-01000504734, I06-0023, J-007309, SR-01000504734-1, SR-05000001934-1, SR-05000001934-2, BRD-K50128260-001-01-6, BRD-K79759585-001-02-1, BRD-K79759585-048-01-4, 4-((4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydr, Z1522567175, Sildenafil solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, 5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (Sildenafil or Viagra), 5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one(Sildenafil), 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-Ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-Ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1-methyl-3-n-propyl-1.6-dihydro-7H-pyrazolo[4,3-d]Pyrimidin-7-one, 5-[2-ethoxy-5-(4-methylpiperazine-1-sulfonyl)phenyl]-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one