previous compound ID: 27 next compound
InChIKey: AUYYCJSJGJYCDS-LBPRGKRZSA-N
SMILES: C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O

biological descriptors:

CFTR relevance: medium CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 53


Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"SD Macknight" "E Matthes" "J Goepp" "D Rotin" "J Liao" "DY Thomas" "R Robert" "JW Hanrahan" "GW Carlile" "B Kus"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.

ReferenceID: 55


Carlile GW et. al. 2007 (paper)
Correctors of protein trafficking defects identified by a novel high-throughput screening assay.
Chembiochem : a European journal of chemical biology, page 1012-20, volume 8, issue 9, year 2007
"KA Teske" "Y Luo" "DY Thomas" "D Zhang" "R Robert" "JW Hanrahan" "GW Carlile"
DOI: 10.1002/cbic.200700027
PMID: 17497613


Reference Into Function: the appearance of the mutant protein at the cell surface is measured. We used this assay to screen a library of 2000 compounds and have isolated several classes of trafficking correctors that had not previously been identified.


chemical graph of compound 27




CID is 5920 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/5920

CID is 5920
synonyms found at PubChem are:
liothyronine, triiodothyronine, 3,3',5-Triiodo-L-thyronine, 6893-02-3, Liothyronin, Tresitope, 3,5,3'-triiodothyronine, L-Liothyronine, triothyrone, Liothyroninum, Liotironina, 3,5,3'-Triiodo-L-thyronine, L-T3, T3, Triiodo-L-thyronine, Lyothyronine, 3,3',5-Triiodothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, L-3,5,3'-Triiodothyronine, 3,5,3'TRIIODOTHYRONINE, (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid, T3 (amino acid), T3 (Hormone), L-3,3',5-TriioDOThyronine, T3 liothyronine, Liothyronine [INN:BAN], Euthroid-1, Euthroid-2, Euthroid-3, Thyrolar-1, Thyrolar-2, Thyrolar-3, Liotironina [INN-Spanish], Tri-Thyrotope, Euthroid-0.5, Thyrolar-0.5, Liothyronine (INN), T3 (VAN), Triiodothyronine, l-, Thyrolar-0.25, THYROID HORMONE, 3,5,3'-Tri-iodo-L-thyronine, CHEBI:18258, T3 (Triiodothyronine), Triiodothyronine (T3), L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Triomet-131, T3 (LIOTRIX), Liothyroninum [INN-Latin], CHEMBL1544, UNII-06LU7C9H1V, 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylalanine, (S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid, 06LU7C9H1V, 3,3',5-Triiodothyronine, L-, HSDB 3110, Triiodo-thyroninum, AUYYCJSJGJYCDS-LBPRGKRZSA-N, EINECS 229-999-3, MFCD00002593, NSC 80203, 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine, BRN 2710227, 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine, L-triiodothyronine, L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine, Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L-, Cytomel (TN), DSSTox_CID_3216, DSSTox_RID_76928, DSSTox_GSID_23216, TRIIODOTHYRONINE (T3 OR LIOTHYRONINE, ACTIVE) (6-11%), CAS-6893-02-3, SR-05000000455, Cyronine, NSC-46046, C15H12I3NO4, 1xzx, Tertroxin (TN), 5714-08-9, Prestwick_135, PubChem20012, Spectrum_001445, Prestwick0_000853, Prestwick1_000853, Prestwick2_000853, Prestwick3_000853, Spectrum2_001984, Spectrum3_001887, Spectrum4_000326, Spectrum5_001793, T-3, Liothyroninum[INN-Latin], L-T3|||L-Liothyronine, D0D8QI, D0S6JG, Epitope ID:131324, AC1L1LF0, SCHEMBL8300, NCIStruc1_000449, Liothyronine modified release, REGID_for_CID_5920, BSPBio_000865, BSPBio_003394, KBioGR_000671, KBioGR_002568, KBioSS_001925, KBioSS_002577, 3,3'5-Triiodo-L-thyronine, MLS000028458, 3,5,3'-triodo-L-thyronine, SPBio_002167, SPBio_002786, BPBio1_000953, GTPL2634, L-3,3',5-triiodo-Thyronine, 3,3',5-Trichloro-L-thyromine, 3,3\',5-triiodo-L-thyronine, DTXSID8023216, BCBcMAP01_000192, BDBM18860, CTK1A2555, HY-A0070A, KBio2_001925, KBio2_002568, KBio2_004493, KBio2_005136, KBio2_007061, KBio2_007704, KBio3_002897, KBio3_003046, (2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid, cMAP_000088, MolPort-003-850-717, HMS1570L07, HMS2097L07, HMS2235A22, HMS3714L07, ZINC3830999, Tox21_110029, Tox21_301943, ANW-60592, CT-833, NCGC00013556, 3,5,3'-triiodo-L-thyronine (T3), Thyronine, 3,3',5-triiodo-, L-, AKOS016003266, 3,3',5-Triiodo-L-thyronine, 95%, AM83597, CCG-220853, CS-4141, DB00279, SMP1_000179, NCGC00013556-01, NCGC00013556-02, NCGC00013556-03, NCGC00013556-04, NCGC00096669-01, NCGC00096669-02, NCGC00255336-01, [125I]T3, AS-17446, KB-28438, KB-99685, LS-16137, SC-11044, SMR000058402, SBI-0206718.P001, DB-021796, Thyronine, 3,3',5-triiodo-, L-(6CI), TR-031350, Thyronine, 3,3',5-triiodo-, L- (6CI), C02465, D08128, 893T023, SR-01000003143, SR-01000003143-4, SR-05000000455-2, SR-05000000455-3, 3,5,3 inverted exclamation marka-Triiodo-L-thyronine, BRD-K89152108-001-03-3, 3,3',5-Triiodo-L-thyronine, >=95% (HPLC), powder, Z2216208625, L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(9CI), UNII-O48UO55HR0 component AUYYCJSJGJYCDS-LBPRGKRZSA-N, L-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-Alanine, L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- (9CI), Liothyronine, United States Pharmacopeia (USP) Reference Standard, 3,3',5 Triiodothyronine (T3), IRMM(R) certified Reference Material, (2S)-2-AMINO-3-[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]PROPANOIC ACID, (S)-2-Amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoicacid, Liothyronine, Pharmaceutical Secondary Standard; Certified Reference Material, 3,3',5-Triiodo-L-thyronine (T3) solution, 100 mug/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, 57164-27-9, 7013-53-8, (2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate, AC1OFCLR, CHEBI:533015, 3,3',5-triiodo-L-thyronine zwitterion, 4-(3-iodo-4-hydroxy-phenoxy)-3,5-diiodophenylalanine, (S)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid