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CandActCFTR used public reference

The following publication reference has been reported to contain CFTR related structural information.
"N Pedemonte" "LJ Galietta" "E Sondo" "AI Esposito" "V Tomati" "E Caci" "U Pfeffer"


Below you will find all the structures identified in the publication. Be warned that this does not imply any activity. n=5

ID: 3
InChIKey: FJNFVCAHHFNREI-UHFFFAOYSA-N
SMILES: CC(C1=NC2=CC=CC=C2C(=N1)OC3CCCCC3)N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 3



CID is 11957831
synonyms found at PubChem are:
815592-21-3, 4-(cyclohexyloxy)-2-(1-(4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl)ethyl)quinazoline, CFcor-325, VRT-325, 4-(Cyclohexyloxy)-2-(1-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl}ethyl)quinazoline, ACMC-20p1e2, GTPL4340, SCHEMBL3822809, VRT325, CHEMBL1257047, CTK9A5799, DTXSID00474707, VRT 325, MolPort-006-415-015, KS-000000GF, AKOS030228615, 4-cyclohexyloxy-2-[1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]ethyl]quinazoline, KB-01359, KB-34900, A1-01884, 4-(Cyclohexyloxy)-2-(1-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxyphenyl)sulfonyl]-1-piperazinyl}ethyl)quinazoline

ID: 80
InChIKey: XJGFWWJLMVZSIG-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N

biological descriptors:

CFTR relevance: CFTR proteostasis regulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

chemical graph of compound 80



CID is 7019
synonyms found at PubChem are:
9-AMINOACRIDINE, Acridin-9-amine, Aminacrine, 90-45-9, 9-Acridinamine, Aminoacridine, Aminacrin, Izoacridina, Monacrin, Aminoacridina, Aminoacridinum, 10-Amino-5-azaanthracene, 9-Acridinylamine, 9-Aminoakridin, Acridine, 9-amino-, 9-Aminoacridin, 9(10H)-Acridinimine, 9-Aminoakridin [Czech], Aminoacridine [INN:BAN], 9AA, UNII-78OY3Z0P7Z, NSC 13000, CCRIS 748, Acridin-9-ylamine, NSC 7571, EINECS 201-995-6, BRN 0141171, AI3-51012, 78OY3Z0P7Z, 9-AA, CHEBI:74789, XJGFWWJLMVZSIG-UHFFFAOYSA-N, acridine-9-ylamine, Aminopt, Mykocert, 110166-26-2, CS-003/03975023, WLN: T C666 BNJ IZ, MLS000780068, NSC7571, 7AD, 8AD, 9-Aminoacridine hydrochloride hydrate, acridin-9-amine;hydrate;hydrochloride, SMR000420251, iminoacridan, 5-Aminoacridin, 9-amino acridine, 4bds, 9-Amino-acridine, F2179-0009, acridin-9-yl-amine, Quench (Salt/Mix), ACMC-20mczt, Mycosert (Salt/Mix), Spectrum_001108, SpecPlus_000861, 9-Acridinamine (9CI), AC1L1NTJ, Spectrum2_001112, Spectrum3_000617, Spectrum4_000580, Spectrum5_001498, AC1Q4W9J, AC1Q51BO, Acramine Yellow (Salt/Mix), SCHEMBL14999, BSPBio_002154, KBioGR_001020, KBioSS_001588, BIDD:GT0816, CHEMBL43184, DivK1c_006957, SPECTRUM1500810, SPBio_001244, DTXSID2024456, BDBM72700, cid_2723598, CTK0G2217, KBio1_001901, KBio2_001588, KBio2_004156, KBio2_006724, KBio3_001654, KS-00000GTZ, XJGFWWJLMVZSIG-UHFFFAOYSA-, MolPort-001-738-830, HMS1921I16, HMS2092K22, HMS3715H04, Pharmakon1600-01500810, 9-acridinamine;hydrate;hydrochloride, ALBB-020726, BCP25849, HY-B1422, NSC13000, NSC28747, ZX-AN019316, ANW-75188, BBL011755, CCG-39037, NSC-13000, NSC-28747, NSC757794, SBB003606, STK387428, ZINC19014768, AKOS000120447, acridin-9-ylamine;hydrate;hydrochloride, CS-4915, DB11561, LS-1913, MCULE-4734217474, NSC-757794, NCGC00094857-01, NCGC00094857-02, NCGC00094857-03, AJ-45955, AK109135, AS-17405, CC-23490, ST093685, U978, 9-AMINOACRIDINE (5-AMINOACRIDINE), SBI-0051612.P002, AX8014518, DB-026983, KB-250613, TC-163933, A2905, FT-0621612, ST24045903, EN300-17076, M-2337, AB00052180_09, AB00052180_10, C-08694, SR-01000760844, CU-01000012501-2, SR-01000760844-2, BRD-K00535541-001-02-2, BRD-K00535541-311-04-1, 9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE, 9-Aminoacridine, matrix substance for MALDI-MS, >=99.5% (HPLC), 9-AMINOACRIDINE (SEE ALSO 9-AMINOACRIDINE HCL AND 9-AMINOACRIDINE HCL-H2O), 148651-03-0, InChI=1/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)

ID: 8
InChIKey: RDOBOPJBMQURAT-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=C(C=CC(=C4)Cl)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

chemical graph of compound 8



CID is 1144671
synonyms found at PubChem are:
Corr-4a, RDOBOPJBMQURAT-UHFFFAOYSA-N, 421580-53-2, ST075396, N-(2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, MLS000561131, Oprea1_189688, Oprea1_471654, SCHEMBL837666, CHEMBL260775, DTXSID00360737, MolPort-001-986-142, ZINC888741, AKOS001665304, MCULE-2724995336, BAS 02936954, KB-57187, SMR000156156, EU-0078205, MLS-0094194.0001, SR-01000492559, SR-01000492559-1, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2' -yl]-benzamide, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzami, N-[2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]benzamide, N-{2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, N-(5-{2-[(5-chloro-2-methoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thia zol-2-yl))benzamide

ID: 21
InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

biological descriptors:

CFTR relevance: CFTR proteostasis regulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

chemical graph of compound 21



CID is 5311
synonyms found at PubChem are:
Vorinostat, 149647-78-9, SAHA, suberoylanilide hydroxamic acid, Zolinza, N-hydroxy-N'-phenyloctanediamide, Suberanilohydroxamic acid, N1-hydroxy-N8-phenyloctanediamide, SAHA cpd, MK-0683, MK0683, Vorinostat [USAN], Octanediamide, N-hydroxy-N'-phenyl-, CCRIS 8456, Vorinostat (SAHA, MK0683), N-Hyrdroxy-N'-phenyloctanediamide, Vorinostat MSD, UNII-58IFB293JI, Zolinza (TN), OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, SHH, N'-hydroxy-N-phenyloctanediamide, CHEMBL98, Vorinostat (JAN/USAN), 58IFB293JI, SKI390, CHEBI:45716, WAEXFXRVDQXREF-UHFFFAOYSA-N, WIN64652, NSC701852, SAHA, Suberoylanilide hydroxamic acid, NSC-701852, NCGC00168085-01, NCGC00168085-02, SW-064652, 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide, Zolinza (TN) (Merck), DSSTox_CID_21133, DSSTox_RID_79632, DSSTox_GSID_41133, N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide, SMR000486344, NHNPODA, CAS-149647-78-9, SR-05000000373, Vorinostat [USAN:INN], vorinostatum, HSDB 7930, 4lxz, N-Hydroxy-N'-phenyl octanediamide, Zolinza; SAHA, Vorinostat (SAHA), Vorinostat - SAHA, MK 0683, 1zz1, Merck brand of Vorinostat, cc-95, D0E7PQ, AC1L1K2K, cid_5311, SCHEMBL9018, Vorinostat (HDAC inhibitor), Suberoylanilidehydroxamic Acid, MLS001065855, MLS006011941, GTPL6852, Zolinza, MK-0683, SAHA, DTXSID6041133, BDBM19149, CTK8B4125, AOB6083, n-hydroxy-n'-phenyl-octanediamide, QCR-121, SUBERANILOHYDROXAMINIC ACID, SYN3006, 1t69, MolPort-003-850-293, N-hydroxy-N''-phenyloctanediamide, BCPP000018, HMS2219L20, HMS3264D20, HMS3327C12, HMS3650D09, HMS3654G11, HMS3715E22, Pharmakon1600-01502267, BCP01858, KS-00000H3B, N1-hydroxy-N8-phenyl-octanediamide, SAHA, >=98% (HPLC), Vorinostat,SAHA,Zolinza,MK-0683, ZINC1543873, Tox21_112605, Tox21_113623, Vorinostat,CAS:149647-78-9, ANW-43951, MFCD00945317, NSC748799, NSC759852, Octanediamide, N1-hydroxy-N8-phenyl, s1047, SK1390, AKOS015966648, Octanediamide, N1-hydroxy-N8-phenyl-, Tox21_112605_1, AC-1923, AN-5256, CCG-208659, CS-0589, DB02546, DG-0025, MCULE-4234367506, NSC-748799, NSC-759852, RP29421, Suberoylanilide hydroxamic acid (SAHA), NCGC00168085-03, NCGC00168085-04, NCGC00168085-05, NCGC00168085-13, BC677687, BP-30216, HY-10221, KB-60639, SC-20040, AB0009911, LS-186548, LS-186997, LS-187780, RT-015807, AM20030018, FT-0082592, FT-0650593, D06320, K-4759, AB00375377-07, AB00375377-08, AB00375377-09, AB01644613_25, 647S789, P111011, Vorinostat, SAHA, suberoylanilide hydroxamic acid, SR-05000000373-2, SR-05000000373-6, SR-05000000373-8, W-201327, BRD-K81418486-001-01-2, BRD-K81418486-001-10-3, BRD-K81418486-001-12-9, BRD-K81418486-001-13-7, BRD-K81418486-001-17-8, BRD-K81418486-001-18-6, Z1541632802

ID: 2061
InChIKey: SCKYRAXSEDYPSA-UHFFFAOYSA-N
SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O

biological descriptors:

CFTR relevance: CFTR proteostasis regulator

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several

chemical graph of compound 2061



CID is 2749
synonyms found at PubChem are:
CICLOPIROX, 29342-05-0, Loprox, Penlac, Ciclopiroxum, Batrafen, HOE 296b, Stieprox, Terit, Ciclopiroxum [INN-Latin], cyclopirox, Mycoster, Ciclopirox gel, cyclopyroxolamine, Loprox cream, HOE-296b, Loprox Gel, Ciclopirox Olamin, Ciclopirox-Olamin, Dafnegin-CSC, 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-, 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, Loprox Shampoo, 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone, UNII-19W019ZDRJ, Penlac nail lacquer, Ciclopirox [USAN:BAN:INN], Loprox (TN), Penlac (TN), Ciclopirox (Penlac), Ciclopirox (USP/INN), EINECS 249-577-2, HOE-296, 19W019ZDRJ, 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one, C12H17NO2, CHEBI:453011, SCKYRAXSEDYPSA-UHFFFAOYSA-N, 2(1H)-Pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-, 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE, 6-cyclohexyl-1-hydroxy-4-methyl-pyridin-2-one, 6-Cyclohexyl-1-hydroxy-4-methyl-2-(1H)-pyridone, (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone), W-106995, MLS002153867, CNL8, SMR001233223, Ciclopirox [USAN:USP:INN:BAN], Batrafen (TN), Stieprox (TN), 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one, AC1L1EDN, Prestwick0_000541, Prestwick1_000541, Prestwick2_000541, Prestwick3_000541, Spectrum2_000146, Spectrum3_000351, Spectrum4_000288, Spectrum5_000747, D07GRH, CHEMBL1413, SCHEMBL34424, BSPBio_000581, BSPBio_002041, KBioGR_000816, cid_38911, KSC563C4H, BIDD:GT0080, SPBio_000252, SPBio_002502, BPBio1_000641, ZINC1145, DTXSID9048564, BDBM66087, CTK4G3143, KBio3_001261, MolPort-003-845-943, HMS3656I12, BCP28530, HY-B0450, KS-00000L3N, AN-773, BG0571, s2528, AKOS015895717, AB06517, CS-2561, DB01188, KS-5085, NCGC00017112-04, NCGC00017112-05, NCGC00017112-06, NCGC00017112-08, NCGC00017112-11, NCGC00178850-01, NCGC00178850-02, AC-24195, AJ-07970, AK544043, BC205517, CC-25776, SC-17361, SBI-0206690.P002, AB0011605, AB2000628, KB-270156, LS-174247, TL8002303, 1-hydroxy-4-methyl-6-cyclohexyl-2-pyridone, FT-0602961, 6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone, D03488, 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one, AB00053438_09, AB00053438_10, AB00053438_11, 342C050, A819878, C-10474, 6-Cyclohexenyl-1-hydroxy-4-methyl-2(1h)-pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H)-pyridinone, Batrafen; Loprox;Mycoster;Stieprox;HOE 296b;Penlac, I06-0862, SR-05000001589-5, 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H )-pyridinone, 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone #, BRD-K13044802-213-04-1, BRD-K13044802-213-09-0, 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one, 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone, 2-azanylethanol;6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one