Reference Into Function: A screening of a small-molecule library identified 9-aminoacridine and ciclopirox, which were significantly more effective than corr-4a and VRT-325. […] These conflicting data appeared to be correlated with different gene expression signatures generated by these treatments in the cell line and in primary bronchial epithelial cells.
Below you will find all the structures identified in the publication. Be warned that this does not imply any activity.
n=5
ID: 3
InChIKey: FJNFVCAHHFNREI-UHFFFAOYSA-N
SMILES: CC(C1=NC2=CC=CC=C2C(=N1)OC3CCCCC3)N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC
biological descriptors:
CFTR relevance: CFTR corrector
Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment
CID is 11957831 the link to PubChem record is
https://pubchem.ncbi.nlm.nih.gov/compound/11957831
CID is
11957831
synonyms found at PubChem are:
815592-21-3, 4-(cyclohexyloxy)-2-(1-(4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl)ethyl)quinazoline, CFcor-325, VRT-325, 4-(Cyclohexyloxy)-2-(1-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl}ethyl)quinazoline, ACMC-20p1e2, GTPL4340, SCHEMBL3822809, VRT325, CHEMBL1257047, CTK9A5799, DTXSID00474707, VRT 325, MolPort-006-415-015, KS-000000GF, AKOS030228615, 4-cyclohexyloxy-2-[1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]ethyl]quinazoline, KB-01359, KB-34900, A1-01884, 4-(Cyclohexyloxy)-2-(1-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxyphenyl)sulfonyl]-1-piperazinyl}ethyl)quinazoline
ID: 80
InChIKey: XJGFWWJLMVZSIG-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N
biological descriptors:
CFTR relevance: CFTR proteostasis regulator
Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several
CID is 7019 the link to PubChem record is
https://pubchem.ncbi.nlm.nih.gov/compound/7019
CID is
7019
synonyms found at PubChem are:
9-AMINOACRIDINE, Acridin-9-amine, Aminacrine, 90-45-9, 9-Acridinamine, Aminoacridine, Aminacrin, Izoacridina, Monacrin, Aminoacridina, Aminoacridinum, 10-Amino-5-azaanthracene, 9-Acridinylamine, 9-Aminoakridin, Acridine, 9-amino-, 9-Aminoacridin, 9(10H)-Acridinimine, 9-Aminoakridin [Czech], Aminoacridine [INN:BAN], 9AA, UNII-78OY3Z0P7Z, NSC 13000, CCRIS 748, Acridin-9-ylamine, NSC 7571, EINECS 201-995-6, BRN 0141171, AI3-51012, 78OY3Z0P7Z, 9-AA, CHEBI:74789, XJGFWWJLMVZSIG-UHFFFAOYSA-N, acridine-9-ylamine, Aminopt, Mykocert, 110166-26-2, CS-003/03975023, WLN: T C666 BNJ IZ, MLS000780068, NSC7571, 7AD, 8AD, 9-Aminoacridine hydrochloride hydrate, acridin-9-amine;hydrate;hydrochloride, SMR000420251, iminoacridan, 5-Aminoacridin, 9-amino acridine, 4bds, 9-Amino-acridine, F2179-0009, acridin-9-yl-amine, Quench (Salt/Mix), ACMC-20mczt, Mycosert (Salt/Mix), Spectrum_001108, SpecPlus_000861, 9-Acridinamine (9CI), AC1L1NTJ, Spectrum2_001112, Spectrum3_000617, Spectrum4_000580, Spectrum5_001498, AC1Q4W9J, AC1Q51BO, Acramine Yellow (Salt/Mix), SCHEMBL14999, BSPBio_002154, KBioGR_001020, KBioSS_001588, BIDD:GT0816, CHEMBL43184, DivK1c_006957, SPECTRUM1500810, SPBio_001244, DTXSID2024456, BDBM72700, cid_2723598, CTK0G2217, KBio1_001901, KBio2_001588, KBio2_004156, KBio2_006724, KBio3_001654, KS-00000GTZ, XJGFWWJLMVZSIG-UHFFFAOYSA-, MolPort-001-738-830, HMS1921I16, HMS2092K22, HMS3715H04, Pharmakon1600-01500810, 9-acridinamine;hydrate;hydrochloride, ALBB-020726, BCP25849, HY-B1422, NSC13000, NSC28747, ZX-AN019316, ANW-75188, BBL011755, CCG-39037, NSC-13000, NSC-28747, NSC757794, SBB003606, STK387428, ZINC19014768, AKOS000120447, acridin-9-ylamine;hydrate;hydrochloride, CS-4915, DB11561, LS-1913, MCULE-4734217474, NSC-757794, NCGC00094857-01, NCGC00094857-02, NCGC00094857-03, AJ-45955, AK109135, AS-17405, CC-23490, ST093685, U978, 9-AMINOACRIDINE (5-AMINOACRIDINE), SBI-0051612.P002, AX8014518, DB-026983, KB-250613, TC-163933, A2905, FT-0621612, ST24045903, EN300-17076, M-2337, AB00052180_09, AB00052180_10, C-08694, SR-01000760844, CU-01000012501-2, SR-01000760844-2, BRD-K00535541-001-02-2, BRD-K00535541-311-04-1, 9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE, 9-Aminoacridine, matrix substance for MALDI-MS, >=99.5% (HPLC), 9-AMINOACRIDINE (SEE ALSO 9-AMINOACRIDINE HCL AND 9-AMINOACRIDINE HCL-H2O), 148651-03-0, InChI=1/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
ID: 8
InChIKey: RDOBOPJBMQURAT-UHFFFAOYSA-N
SMILES: CC1=C(SC(=N1)NC(=O)C2=CC=CC=C2)C3=CSC(=N3)NC4=C(C=CC(=C4)Cl)OC
biological descriptors:
CFTR relevance: CFTR corrector
Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment
CID is 1144671 the link to PubChem record is
https://pubchem.ncbi.nlm.nih.gov/compound/1144671
CID is
1144671
synonyms found at PubChem are:
Corr-4a, RDOBOPJBMQURAT-UHFFFAOYSA-N, 421580-53-2, ST075396, N-(2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide, MLS000561131, Oprea1_189688, Oprea1_471654, SCHEMBL837666, CHEMBL260775, DTXSID00360737, MolPort-001-986-142, ZINC888741, AKOS001665304, MCULE-2724995336, BAS 02936954, KB-57187, SMR000156156, EU-0078205, MLS-0094194.0001, SR-01000492559, SR-01000492559-1, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2' -yl]-benzamide, N-[2-(5-Chloro-2-methoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-benzami, N-[2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]benzamide, N-{2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl}benzamide, N-(5-{2-[(5-chloro-2-methoxyphenyl)amino](1,3-thiazol-4-yl)}-4-methyl(1,3-thia zol-2-yl))benzamide
ID: 21
InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
biological descriptors:
CFTR relevance: CFTR proteostasis regulator
Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several
CID is 5311 the link to PubChem record is
https://pubchem.ncbi.nlm.nih.gov/compound/5311
CID is
5311
synonyms found at PubChem are:
Vorinostat, 149647-78-9, SAHA, suberoylanilide hydroxamic acid, Zolinza, N-hydroxy-N'-phenyloctanediamide, Suberanilohydroxamic acid, N1-hydroxy-N8-phenyloctanediamide, SAHA cpd, MK-0683, MK0683, Vorinostat [USAN], Octanediamide, N-hydroxy-N'-phenyl-, CCRIS 8456, Vorinostat (SAHA, MK0683), N-Hyrdroxy-N'-phenyloctanediamide, Vorinostat MSD, UNII-58IFB293JI, Zolinza (TN), OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, SHH, N'-hydroxy-N-phenyloctanediamide, CHEMBL98, Vorinostat (JAN/USAN), 58IFB293JI, SKI390, CHEBI:45716, WAEXFXRVDQXREF-UHFFFAOYSA-N, WIN64652, NSC701852, SAHA, Suberoylanilide hydroxamic acid, NSC-701852, NCGC00168085-01, NCGC00168085-02, SW-064652, 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide, Zolinza (TN) (Merck), DSSTox_CID_21133, DSSTox_RID_79632, DSSTox_GSID_41133, N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide, SMR000486344, NHNPODA, CAS-149647-78-9, SR-05000000373, Vorinostat [USAN:INN], vorinostatum, HSDB 7930, 4lxz, N-Hydroxy-N'-phenyl octanediamide, Zolinza; SAHA, Vorinostat (SAHA), Vorinostat - SAHA, MK 0683, 1zz1, Merck brand of Vorinostat, cc-95, D0E7PQ, AC1L1K2K, cid_5311, SCHEMBL9018, Vorinostat (HDAC inhibitor), Suberoylanilidehydroxamic Acid, MLS001065855, MLS006011941, GTPL6852, Zolinza, MK-0683, SAHA, DTXSID6041133, BDBM19149, CTK8B4125, AOB6083, n-hydroxy-n'-phenyl-octanediamide, QCR-121, SUBERANILOHYDROXAMINIC ACID, SYN3006, 1t69, MolPort-003-850-293, N-hydroxy-N''-phenyloctanediamide, BCPP000018, HMS2219L20, HMS3264D20, HMS3327C12, HMS3650D09, HMS3654G11, HMS3715E22, Pharmakon1600-01502267, BCP01858, KS-00000H3B, N1-hydroxy-N8-phenyl-octanediamide, SAHA, >=98% (HPLC), Vorinostat,SAHA,Zolinza,MK-0683, ZINC1543873, Tox21_112605, Tox21_113623, Vorinostat,CAS:149647-78-9, ANW-43951, MFCD00945317, NSC748799, NSC759852, Octanediamide, N1-hydroxy-N8-phenyl, s1047, SK1390, AKOS015966648, Octanediamide, N1-hydroxy-N8-phenyl-, Tox21_112605_1, AC-1923, AN-5256, CCG-208659, CS-0589, DB02546, DG-0025, MCULE-4234367506, NSC-748799, NSC-759852, RP29421, Suberoylanilide hydroxamic acid (SAHA), NCGC00168085-03, NCGC00168085-04, NCGC00168085-05, NCGC00168085-13, BC677687, BP-30216, HY-10221, KB-60639, SC-20040, AB0009911, LS-186548, LS-186997, LS-187780, RT-015807, AM20030018, FT-0082592, FT-0650593, D06320, K-4759, AB00375377-07, AB00375377-08, AB00375377-09, AB01644613_25, 647S789, P111011, Vorinostat, SAHA, suberoylanilide hydroxamic acid, SR-05000000373-2, SR-05000000373-6, SR-05000000373-8, W-201327, BRD-K81418486-001-01-2, BRD-K81418486-001-10-3, BRD-K81418486-001-12-9, BRD-K81418486-001-13-7, BRD-K81418486-001-17-8, BRD-K81418486-001-18-6, Z1541632802
ID: 2061
InChIKey: SCKYRAXSEDYPSA-UHFFFAOYSA-N
SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O
biological descriptors:
CFTR relevance: CFTR proteostasis regulator
Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment several
CID is 2749 the link to PubChem record is
https://pubchem.ncbi.nlm.nih.gov/compound/2749
CID is
2749
synonyms found at PubChem are:
CICLOPIROX, 29342-05-0, Loprox, Penlac, Ciclopiroxum, Batrafen, HOE 296b, Stieprox, Terit, Ciclopiroxum [INN-Latin], cyclopirox, Mycoster, Ciclopirox gel, cyclopyroxolamine, Loprox cream, HOE-296b, Loprox Gel, Ciclopirox Olamin, Ciclopirox-Olamin, Dafnegin-CSC, 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-, 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, Loprox Shampoo, 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone, UNII-19W019ZDRJ, Penlac nail lacquer, Ciclopirox [USAN:BAN:INN], Loprox (TN), Penlac (TN), Ciclopirox (Penlac), Ciclopirox (USP/INN), EINECS 249-577-2, HOE-296, 19W019ZDRJ, 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one, C12H17NO2, CHEBI:453011, SCKYRAXSEDYPSA-UHFFFAOYSA-N, 2(1H)-Pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-, 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE, 6-cyclohexyl-1-hydroxy-4-methyl-pyridin-2-one, 6-Cyclohexyl-1-hydroxy-4-methyl-2-(1H)-pyridone, (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone), W-106995, MLS002153867, CNL8, SMR001233223, Ciclopirox [USAN:USP:INN:BAN], Batrafen (TN), Stieprox (TN), 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one, AC1L1EDN, Prestwick0_000541, Prestwick1_000541, Prestwick2_000541, Prestwick3_000541, Spectrum2_000146, Spectrum3_000351, Spectrum4_000288, Spectrum5_000747, D07GRH, CHEMBL1413, SCHEMBL34424, BSPBio_000581, BSPBio_002041, KBioGR_000816, cid_38911, KSC563C4H, BIDD:GT0080, SPBio_000252, SPBio_002502, BPBio1_000641, ZINC1145, DTXSID9048564, BDBM66087, CTK4G3143, KBio3_001261, MolPort-003-845-943, HMS3656I12, BCP28530, HY-B0450, KS-00000L3N, AN-773, BG0571, s2528, AKOS015895717, AB06517, CS-2561, DB01188, KS-5085, NCGC00017112-04, NCGC00017112-05, NCGC00017112-06, NCGC00017112-08, NCGC00017112-11, NCGC00178850-01, NCGC00178850-02, AC-24195, AJ-07970, AK544043, BC205517, CC-25776, SC-17361, SBI-0206690.P002, AB0011605, AB2000628, KB-270156, LS-174247, TL8002303, 1-hydroxy-4-methyl-6-cyclohexyl-2-pyridone, FT-0602961, 6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone, D03488, 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one, AB00053438_09, AB00053438_10, AB00053438_11, 342C050, A819878, C-10474, 6-Cyclohexenyl-1-hydroxy-4-methyl-2(1h)-pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H)-pyridinone, Batrafen; Loprox;Mycoster;Stieprox;HOE 296b;Penlac, I06-0862, SR-05000001589-5, 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H )-pyridinone, 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone #, BRD-K13044802-213-04-1, BRD-K13044802-213-09-0, 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone, 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one, 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone, 2-azanylethanol;6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one
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