previous compound ID: 3 next compound
InChIKey: FJNFVCAHHFNREI-UHFFFAOYSA-N
SMILES: CC(C1=NC2=CC=CC=C2C(=N1)OC3CCCCC3)N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

reference list:

ReferenceID: 42
"HR de Jonge" "B Kus" "P Lesimple" "N Liu" "H Balghi" "DY Thomas" "GW Carlile" "JW Hanrahan" "J Liao" "BJ Scholte" "D Rotin" "R Robert" "M Wilke"
ReferenceID: 84
"D Zhang" "RG Linington" "SM Anjos" "KA Teske" "DY Thomas" "RM Centko" "GW Carlile" "HM Sampson" "RJ Andersen" "CA Gray" "JW Hanrahan" "J Liao" "L Yan" "R Robert" "DE Williams" "RA Keyzers"
ReferenceID: 15
"TW Loo" "Y Wang" "DM Clarke" "MC Bartlett"
ReferenceID: 53
"JW Hanrahan" "E Matthes" "B Kus" "J Goepp" "J Liao" "SD Macknight" "D Rotin" "DY Thomas" "R Robert" "GW Carlile"
ReferenceID: 73
"E Caci" "V Tomati" "U Pfeffer" "E Sondo" "LJ Galietta" "AI Esposito" "N Pedemonte"
ReferenceID: 82
"P Lesimple" "SM Anjos" "H Balghi" "DY Thomas" "R Phillipe" "F Ciciriello" "GW Carlile" "HM Sampson" "F Dantzer" "JW Hanrahan" "P Ferraro" "D Waller" "J Goepp" "J Liao" "R Robert" "DL Zhang"
ReferenceID: 72
"B Woodworth" "PA Sloane" "Y Li" "A Jurkevante" "J Collawn" "J Fortenberry" "LC Pyle" "M Mazur" "SM Rowe" "L Fan" "K Varga" "JP Clancy" "J Fulton" "EJ Sorscher"
ReferenceID: 57
"CE Bear" "LJ Huan" "P Kim Chiaw" "M Ramjeesingh" "L Wellhauser"
ReferenceID: 80
"J Joubran" "J Rader" "PD Grootenhuis" "F Van Goor" "S Hadida" "J González" "E Olson" "LR Makings" "R Tung" "T Knapp" "P Negulescu" "D Cao" "JH Stack" "T Neuberger" "V Panchenko" "A Singh" "KS Straley" "A Hazlewood" "M Miller"

chemical graph of compound 3




CID is 11957831
synonyms found at PubChem are:
815592-21-3, 4-(cyclohexyloxy)-2-(1-(4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl)ethyl)quinazoline, CFcor-325, VRT-325, 4-(Cyclohexyloxy)-2-(1-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl}ethyl)quinazoline, ACMC-20p1e2, GTPL4340, SCHEMBL3822809, VRT325, CHEMBL1257047, CTK9A5799, DTXSID00474707, VRT 325, MolPort-006-415-015, KS-000000GF, AKOS030228615, 4-cyclohexyloxy-2-[1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]ethyl]quinazoline, KB-01359, KB-34900, A1-01884, 4-(Cyclohexyloxy)-2-(1-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxyphenyl)sulfonyl]-1-piperazinyl}ethyl)quinazoline