previous compound ID: 3 next compound
InChIKey: FJNFVCAHHFNREI-UHFFFAOYSA-N
SMILES: CC(C1=NC2=CC=CC=C2C(=N1)OC3CCCCC3)N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

reference list:

ReferenceID: 42
"J Liao" "N Liu" "B Kus" "H Balghi" "GW Carlile" "BJ Scholte" "P Lesimple" "HR de Jonge" "M Wilke" "D Rotin" "JW Hanrahan" "R Robert" "DY Thomas"
ReferenceID: 72
"L Fan" "A Jurkevante" "M Mazur" "J Collawn" "J Fulton" "SM Rowe" "J Fortenberry" "LC Pyle" "B Woodworth" "PA Sloane" "EJ Sorscher" "JP Clancy" "Y Li" "K Varga"
ReferenceID: 53
"J Liao" "B Kus" "SD Macknight" "D Rotin" "GW Carlile" "JW Hanrahan" "J Goepp" "E Matthes" "R Robert" "DY Thomas"
ReferenceID: 84
"J Liao" "DE Williams" "D Zhang" "HM Sampson" "SM Anjos" "GW Carlile" "L Yan" "KA Teske" "CA Gray" "RJ Andersen" "RM Centko" "JW Hanrahan" "RA Keyzers" "RG Linington" "R Robert" "DY Thomas"
ReferenceID: 15
"Y Wang" "MC Bartlett" "DM Clarke" "TW Loo"
ReferenceID: 73
"E Caci" "LJ Galietta" "V Tomati" "U Pfeffer" "E Sondo" "AI Esposito" "N Pedemonte"
ReferenceID: 57
"M Ramjeesingh" "P Kim Chiaw" "CE Bear" "LJ Huan" "L Wellhauser"
ReferenceID: 80
"S Hadida" "V Panchenko" "JH Stack" "A Singh" "M Miller" "T Knapp" "P Negulescu" "F Van Goor" "J Joubran" "R Tung" "J González" "A Hazlewood" "LR Makings" "D Cao" "E Olson" "T Neuberger" "PD Grootenhuis" "J Rader" "KS Straley"
ReferenceID: 82
"J Liao" "H Balghi" "HM Sampson" "SM Anjos" "GW Carlile" "R Phillipe" "DL Zhang" "D Waller" "J Goepp" "P Lesimple" "F Ciciriello" "P Ferraro" "JW Hanrahan" "F Dantzer" "R Robert" "DY Thomas"

chemical graph of compound 3





CID is 11957831
synonyms found at PubChem are:
815592-21-3, 4-(cyclohexyloxy)-2-(1-(4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl)ethyl)quinazoline, CFcor-325, VRT-325, 4-(Cyclohexyloxy)-2-(1-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl}ethyl)quinazoline, ACMC-20p1e2, GTPL4340, SCHEMBL3822809, VRT325, CHEMBL1257047, CTK9A5799, DTXSID00474707, VRT 325, MolPort-006-415-015, KS-000000GF, AKOS030228615, 4-cyclohexyloxy-2-[1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]ethyl]quinazoline, KB-01359, KB-34900, A1-01884, 4-(Cyclohexyloxy)-2-(1-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxyphenyl)sulfonyl]-1-piperazinyl}ethyl)quinazoline