previous compound ID: 24 next compound
InChIKey: ZQSIJRDFPHDXIC-UHFFFAOYSA-N
SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O

biological descriptors:

CFTR relevance: medium CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction unknown
subcellular compartment unknown

reference list:

ReferenceID: 41


Pyle LC et. al. 2010 (paper)
Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescue.
American journal of respiratory cell and molecular biology, page 607-16, volume 43, issue 5, year 2010
"JC Fulton" "LC Pyle" "JP Clancy" "SM Rowe" "PA Sloane" "J Prasain" "S Barnes" "K Backer" "M Mazur"
DOI: 10.1165/rcmb.2009-0281OC
PMID: 20042712


Reference Into Function: Quercetin-induced, dose-dependent hyperpolarization of the nasal potential difference was also seen in normal human subjects. Quercetin activates CFTR-mediated anion transport in respiratory epithelia in vitro and in vivo, and may be useful in studies intended to detect the rescue of ΔF508 CFTR by nasal potential difference.

ReferenceID: 53


Carlile GW et. al. 2015 (paper)
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, page 16-25, volume 14, issue 1, year 2015
"DY Thomas" "GW Carlile" "SD Macknight" "R Robert" "B Kus" "E Matthes" "D Rotin" "J Goepp" "J Liao" "JW Hanrahan"
DOI: 10.1016/j.jcf.2014.06.001
PMID: 24974227


Reference Into Function: These studies show that ibuprofen is a CFTR corrector and that it causes correction by COX-1 inhibition.

ReferenceID: 55


Carlile GW et. al. 2007 (paper)
Correctors of protein trafficking defects identified by a novel high-throughput screening assay.
Chembiochem : a European journal of chemical biology, page 1012-20, volume 8, issue 9, year 2007
"Y Luo" "KA Teske" "DY Thomas" "GW Carlile" "R Robert" "D Zhang" "JW Hanrahan"
DOI: 10.1002/cbic.200700027
PMID: 17497613


Reference Into Function: the appearance of the mutant protein at the cell surface is measured. We used this assay to screen a library of 2000 compounds and have isolated several classes of trafficking correctors that had not previously been identified.


chemical graph of compound 24




CID is 5281708 the link to PubChem record is https://pubchem.ncbi.nlm.nih.gov/compound/5281708

CID is 5281708
synonyms found at PubChem are:
daidzein, 486-66-8, 4',7-Dihydroxyisoflavone, Daidzeol, 7,4'-Dihydroxyisoflavone, 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, Diadzein, 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-, 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one, 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, UNII-6287WC5J2L, CCRIS 7600, K 251b, 4,7-Dihydroxyisoflavone, EINECS 207-635-4, BRN 0231523, CHEMBL8145, 4',7-Dihydroxy-iso-flavone, d-(+)-alpha-methylbenzylamine, 4′,7-Dihydroxyisoflavone, CHEBI:28197, ZQSIJRDFPHDXIC-UHFFFAOYSA-N, 6287WC5J2L, Daidzein,(S), 7-Hydroxy-3-(4-hydroxy-phenyl)-chromone, DSSTox_CID_2310, DSSTox_RID_76543, DSSTox_GSID_22310, Q-200924, CAS-486-66-8, SMR000326832, Daidzein (6CI), SR-01000075492, NPI 031E, PubChem9841, AC1NQYXY, Spectrum_000255, Tocris-1417, BiomolKI_000060, Spectrum2_000053, Spectrum3_000191, Spectrum4_001964, Spectrum5_000857, Lopac-D-7802, 4 ,7-Dihydroxyisoflavone, BiomolKI2_000066, D0N9CG, D0SY2M, UPCMLD-DP052, 4',7-dihydroxy isoflavone, 4',7-dihydroxy-Isoflavone, Lopac0_000412, Oprea1_182317, Oprea1_305345, SCHEMBL19814, BSPBio_001741, Daidzein, analytical standard, KBioGR_002432, KBioSS_000735, SPECTRUM200789, 5-18-04-00089 (Beilstein Handbook Reference), MLS000859973, MLS001304056, MLS006011853, BIDD:ER0120, DivK1c_001023, SPBio_000205, Daidzein, >=98%, synthetic, Isoflavone, 4',7-dihydroxy-, BIMB2005, BMK1-F12, GTPL2828, MEGxm0_000123, NPI-031E, d-(+)-alpha-methylbenzyl amine, DTXSID9022310, UPCMLD-DP052:001, ACon0_001477, ACon1_000543, BDBM23420, HMS503M07, K-251b, KBio1_001023, KBio2_000735, KBio2_003303, KBio2_005871, KBio3_001241, KS-00000MGD, AOB5524, OR1035T, 4',7-Dihydroxyisoflavone, 97%, MolPort-000-003-017, NINDS_001023, ZX-AFC000144, 7,4'-Dihydroxy-isoflavone (3a), HMS1922P18, HMS2233H24, HMS3261C06, HMS3267J04, HMS3370C03, HMS3468L18, HMS3649B20, HMS3655A18, ALBB-015933, BCP28286, HY-N0019, ZX-AN014640, ZX-AT022124, Tox21_201444, Tox21_303650, Tox21_500412, BBL010490, BS0244, CCG-38357, CD-190, LMPK12050038, MFCD00016954, s1849, SBB066056, STK801626, ZINC18847034, Daidzein (4',7-Dihydroxyisoflavone), 7-hydroxy-3-(4-hydroxyphenyl)-4H-, AKOS002385052, Isoflavone, 4',7-dihydroxy- (8CI), AC-6035, ACN-034764, CS-2332, Daidzein, purum, >=98.0% (TLC), KS-5260, LP00412, LS-2143, MCULE-8239511422, SDCCGMLS-0066422.P001, IDI1_001023, SMP1_000089, NCGC00015365-01, NCGC00015365-02, NCGC00015365-03, NCGC00015365-04, NCGC00015365-05, NCGC00015365-06, NCGC00015365-07, NCGC00015365-08, NCGC00015365-09, NCGC00015365-10, NCGC00015365-11, NCGC00015365-12, NCGC00015365-13, NCGC00015365-14, NCGC00015365-15, NCGC00015365-16, NCGC00015365-17, NCGC00015365-18, NCGC00025156-01, NCGC00025156-02, NCGC00025156-03, NCGC00025156-04, NCGC00025156-05, NCGC00025156-06, NCGC00025156-07, NCGC00025156-08, NCGC00025156-09, NCGC00025156-10, NCGC00168978-01, NCGC00168978-02, NCGC00257367-01, NCGC00258995-01, NCGC00261097-01, AJ-70673, AK-94232, AN-45238, CC-17424, KB-49550, SC-46504, ST057515, AB0010476, AB1004493, BB 0259520, D2668, EU-0100412, FT-0080019, FT-0603419, FT-0665448, N1862, R1341, 7-hydroxy-3-(4-hydroxyphenyl)-chromen-4-one, 7-Hydroxy-3-(4-hydroxy-phenyl)-chromen-4-one, 7-HYDROXY-3-(4-HYDROXYPHENYL)CHROMONE, C10208, D 7802, D17500, S00273, US8552057, 7, AB00052712-08, AB00052712_10, 486D668, C-15745, Daidzein, primary pharmaceutical reference standard, I06-0011, SR-01000075492-1, SR-01000075492-3, SR-01000075492-7, SR-01000075492-8, BRD-K42095107-001-02-3, BRD-K42095107-001-05-6, BRD-K42095107-001-08-0, SR-01000075492-12, 80E3ED75-D852-4D97-9BD6-B5ADE7EA25A1, 7-Hydroxy-3-(4-hydroxy-phenyl)-4H-1-benzo-pyran-4-one, UNII-71B37NR06D component ZQSIJRDFPHDXIC-UHFFFAOYSA-N, Daidzein, United States Pharmacopeia (USP) Reference Standard, Daidzein, Pharmaceutical Secondary Standard; Certified Reference Material, 4 inverted exclamation marka,7-Dihydroxyisoflavone; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 7-Hydroxy-3-(4-hydroxyphenyl)chromone