previous compound ID: 3 next compound
InChIKey: FJNFVCAHHFNREI-UHFFFAOYSA-N
SMILES: CC(C1=NC2=CC=CC=C2C(=N1)OC3CCCCC3)N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC

biological descriptors:

CFTR relevance: CFTR corrector

Category:
Influence on CFTR function enhances CFTR function
Order of interaction indirect
subcellular compartment Apical membrane & subapical compartment

reference list:

ReferenceID: 82
"P Ferraro" "F Dantzer" "HM Sampson" "DY Thomas" "GW Carlile" "J Goepp" "F Ciciriello" "DL Zhang" "J Liao" "H Balghi" "JW Hanrahan" "P Lesimple" "D Waller" "R Robert" "SM Anjos" "R Phillipe"
ReferenceID: 57
"P Kim Chiaw" "M Ramjeesingh" "L Wellhauser" "LJ Huan" "CE Bear"
ReferenceID: 80
"T Knapp" "LR Makings" "R Tung" "E Olson" "J Joubran" "V Panchenko" "J Rader" "A Singh" "P Negulescu" "PD Grootenhuis" "S Hadida" "T Neuberger" "KS Straley" "M Miller" "F Van Goor" "A Hazlewood" "D Cao" "J González" "JH Stack"
ReferenceID: 15
"TW Loo" "DM Clarke" "Y Wang" "MC Bartlett"
ReferenceID: 53
"B Kus" "SD Macknight" "DY Thomas" "GW Carlile" "JW Hanrahan" "R Robert" "D Rotin" "J Goepp" "E Matthes" "J Liao"
ReferenceID: 42
"DY Thomas" "GW Carlile" "N Liu" "BJ Scholte" "J Liao" "M Wilke" "HR de Jonge" "B Kus" "H Balghi" "JW Hanrahan" "P Lesimple" "R Robert" "D Rotin"
ReferenceID: 84
"RG Linington" "HM Sampson" "DY Thomas" "GW Carlile" "RJ Andersen" "RA Keyzers" "D Zhang" "J Liao" "CA Gray" "DE Williams" "JW Hanrahan" "KA Teske" "R Robert" "SM Anjos" "RM Centko" "L Yan"
ReferenceID: 72
"L Fan" "J Collawn" "J Fortenberry" "JP Clancy" "K Varga" "A Jurkevante" "LC Pyle" "PA Sloane" "B Woodworth" "J Fulton" "SM Rowe" "M Mazur" "EJ Sorscher" "Y Li"
ReferenceID: 73
"LJ Galietta" "AI Esposito" "N Pedemonte" "E Caci" "V Tomati" "E Sondo" "U Pfeffer"

chemical graph of compound 3





CID is 11957831
synonyms found at PubChem are:
815592-21-3, 4-(cyclohexyloxy)-2-(1-(4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl)ethyl)quinazoline, CFcor-325, VRT-325, 4-(Cyclohexyloxy)-2-(1-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxybenzene)sulfonyl]piperazin-1-yl}ethyl)quinazoline, ACMC-20p1e2, GTPL4340, SCHEMBL3822809, VRT325, CHEMBL1257047, CTK9A5799, DTXSID00474707, VRT 325, MolPort-006-415-015, KS-000000GF, AKOS030228615, 4-cyclohexyloxy-2-[1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]ethyl]quinazoline, KB-01359, KB-34900, A1-01884, 4-(Cyclohexyloxy)-2-(1-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)ethyl)quinazoline, 4-(cyclohexyloxy)-2-(1-{4-[(4-methoxyphenyl)sulfonyl]-1-piperazinyl}ethyl)quinazoline